Gene Trad (Human)

Trad

Species: Human
Alias: Trad, FLJ16443, TRAD, KALRN, duo, Hs.162189, DUET, HAPIP
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q13.3-q21,

Classification

Group: CAMK
Family: Trio

Sequence

Name Sequence Type Origin Length Description Download
Trad.NA RNA Sugen Kinome 10835 None Fasta, JSON
Trad.AA Protein Sugen Kinome 2986 None Fasta, JSON
Trad.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of Trad.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SEC14 Trad.AA SEC14 38-177 22 1.2e-32 115.75 SMART 1-184 (184) Show / Hide 
Range on Protein: 38-177
Range on HMM: 1-184/184
Sequence Identity: 22% (42 aa)

ILKEKVAFVSGGR-------DKRGGPILTFPARS------NHDRIRQEDLRKLVTYLASVPSE--------DVCKRGFTVIIDMRGSK--------WDLI
 ...  ....|||       ||.| |.. |.|.       .|. ...| || .| .. .. ..        . .. ||..|.||.|..        |...
EHECGKHYMPGGRHGTRQGYDKDGRPVYYFRAGRHDPKGMMHSCTMHEFLRYHVYVMEKMCQHCPMCMEKMPGGQCGFHWIFDMKGWSMSHFWSPDWGWY

KPLLKTLQEAFPAEIHVALIIKPDN------FWQKQKTNFGSSKFIFETSMVS---------VEGLTKLVDPSQLTEEFDGSLD
. .....|...|. .| ..||.|        .| |.   | ..|. .   .|.         .| |.| .||..|.||. |..|
RKMWQIFQDHYPERLHKVYIINPPWWMFFFWVWWKMIKPFLDEKTREKIHFVGPNKVDDNDWKEELHKYIDPECLPEEWGGTCD
SPEC Trad.AA SPEC 191-307 18 2.2e-11 45.05 SMART 1-104 (104) Show / Hide 
Range on Protein: 191-307
Range on HMM: 1-104/104
Sequence Identity: 18% (22 aa)

EEFFNSAVHLLSRLEDLQEMLARKEFP--VDVEGSRRLIDEHTQLKK--KVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLD
..|.  .  |.. ... ...|. ....   |.|. ..|...| ...|  .  .. |..|...||.|.|                        ..|   ||
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQE-----------------YGHYDADEIQERLD

KLHSTRQHLHQMWHVRKLKLD
.|.. ...|...|  |. .|.
ELNQRWEELCELWEERRQRLE
Spectrin Trad.AA Spectrin 188-235 15 0.051088 10.64 Pfam 1-51 (109) Show / Hide 
Range on Protein: 188-235
Range on HMM: 1-51/109
Sequence Identity: 15% (8 aa)

LSLEEFFNSAVHLLSRLEDLQEMLARKEF-PVDVEGSRRLID--EHTQLKK
. |..|.. . .|.. ...  ..|.  .. . |.|. . | .   | ....
HHLQQFQRDCDDLEQWIQEKEQWLSSEDYWGKDLEEVQALQKQWKHQAFEA
Spectrin Trad.AA Spectrin 279-308 26 0.067048 10.2 Pfam 80-109 (109) Show / Hide 
Range on Protein: 279-308
Range on HMM: 80-109/109
Sequence Identity: 26% (8 aa)

PKITSLLDKLHSTRQHLHQMWHVRKLKLDQ
. |.. .. |.. ...|...|  || || .
EEIQERMEELNQRWEQLCELWEERKQKLEE
SPEC Trad.AA SPEC 313-415 19 7.5e-12 46.61 SMART 1-104 (104) Show / Hide 
Range on Protein: 313-415
Range on HMM: 1-104/104
Sequence Identity: 19% (21 aa)

RLFEQDAEKMFDWISHNKELFLQSHTEIG--VSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEA-GHYASQQIKQISTQLDQEWKSFAAALDE
. | .|.. . .|..  .   | |....|   . . . .|| .|  |     .    .. .   . .| .. |||....|..  ..|.|.|..  ....|
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

RSTILA
|   | 
RRQRLE
Spectrin Trad.AA Spectrin 310-416 22 1e-06 27.81 Pfam 1-109 (109) Show / Hide 
Range on Protein: 310-416
Range on HMM: 1-109/109
Sequence Identity: 22% (25 aa)

FQLRLFEQDAEKMFDWISHNKELFLQSHTEI-GVSYQYALDLQT--QHNHFAMNSMNAYVNINRIMSVASRL-SEAGHYASQQIKQISTQLDQEWKSFAA
 .|. | .|.. .  ||.   | .| |  .. | ... .  ||   .|  |  .  .   ... .  .| .|  ..||..|..|..   .|.| |..  .
HHLQQFQRDCDDLEQWIQEK-EQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQLCE

ALDERSTILAM
...||   |  
LWEERKQKLEE
SPEC Trad.AA SPEC 418-533 11 0.005978 5.81 SMART 1-104 (104) Show / Hide 
Range on Protein: 418-533
Range on HMM: 1-104/104
Sequence Identity: 11% (14 aa)

AVFHQKAEQFLSGVDAWCKMCSEGGLP--SEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVL
  ||........ .|   ...|   ..     ....  ...||.. . . .|. .  .. ... . | .  .. ..... .               .|. 
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEM-EAHQPRVDQLNQQGQQLIQEYGHYDADEIQERL-------------DELN

HHQRRLESIWQHRKVRLH
.. ..|.  |. |. || 
QRWEELCELWEERRQRLE
SPEC Trad.AA SPEC 539-641 26 3.8e-15 57.56 SMART 1-104 (104) Show / Hide 
Range on Protein: 539-641
Range on HMM: 1-104/104
Sequence Identity: 26% (28 aa)

CVFQQDVQQVLDWIENHGEAFLSKHTGVG--KSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQT-GECDPEEIYKAARHLEVRIQDFVRRVEQ
  |..|......|...     | ... .|  |.|  ..||||.|..||.  ..     |.| ....|| |  |. | .|| .  ..|. | ..  ...|.
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

RKLLLD
|.  |.
RRQRLE
Spectrin Trad.AA Spectrin 536-642 29 0.000107 20.63 Pfam 1-109 (109) Show / Hide 
Range on Protein: 536-642
Range on HMM: 1-109/109
Sequence Identity: 29% (33 aa)

LQLCVFQQDVQQVLDWIENHGEAFLSKHTGV-GKSLHRARALQK--RHDDFEEVAQNTYTNADKLLEAAEQL-AQTGECDPEEIYKAARHLEVRIQDFVR
..|  ||.|..... ||.   |..|     . ||.|  ..||||  .|..||.  ..  .. ..| | |..| .. |  |.||| .   .|. | ..  .
HHLQQFQRDCDDLEQWIQEK-EQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQLCE

RVEQRKLLLDM
..|.||  |  
LWEERKQKLEE
SPEC Trad.AA SPEC 644-766 19 6.1e-05 23.67 SMART 1-104 (104) Show / Hide 
Range on Protein: 644-766
Range on HMM: 1-104/104
Sequence Identity: 19% (24 aa)

VSFHTHTKELWTWMEDLQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIE
  ||   .||  ||.. .. .  |  .  .....||.|.|..|. ..   .|  . ... ... ||| ..                     .     .|.
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEM-EAHQPRVDQLNQQGQQLIQE--------------------YGHYDADEIQ

SVLQQLDDAQVQMEELFHERKIKLD
  |..|...  . .||  ||. .|.
ERLDELNQRWEELCELWEERRQRLE
Spectrin Trad.AA Spectrin 646-688 20 6.689526 2.75 Pfam 6-48 (109) Show / Hide 
Range on Protein: 646-688
Range on HMM: 6-48/109
Sequence Identity: 20% (9 aa)

FHTHTKELWTWMEDLQKEMLEDVC-ADSVDAVQELIKQFQQQQT
|. . ..|  |...  . .  .   . ....||.| ||. ..|.
FQRDCDDLEQWIQEKEQWLSSEDYWGKDLEEVQALQKQW-KHQA
SPEC Trad.AA SPEC 893-1003 22 6.2e-11 43.58 SMART 1-104 (104) Show / Hide 
Range on Protein: 893-1003
Range on HMM: 1-104/104
Sequence Identity: 22% (25 aa)

RHLQAEVKQVLGWIRNGESMLNASLVNA--SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQ
........... |... |  | .|   .   .|.....||..|..|.  .    |. .... .| . |  |.      .||||||.|.|  ...  .|..
QQFHRDCDELEQWMDEKE-QLLSSDDYGDSKDLESVQALQKKHQAFEKEM--EAHQPRVDQLNQQGQQLIQE------YGHYDADEIQERLDELNQRWEE

LMLKMEDRLKLVN
|  ..|.| .  .
LCELWEERRQRLE
Spectrin Trad.AA Spectrin 890-1004 24 0.000676 17.64 Pfam 1-109 (109) Show / Hide 
Range on Protein: 890-1004
Range on HMM: 1-109/109
Sequence Identity: 24% (29 aa)

LQLRHLQAEVKQVLGWIRNGESMLNASLVN-ASSLSEAEQLQR--EHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVL-LQAGHYDADAIRECAEKVA
..|. .| ...... ||.  | .| .|    . .|.|...||.   |..|.  |.   | . .|.         . |. | ...||.|...|.|  | . 
HHLQQFQRDCDDLEQWIQEKEQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAA--HQDRVQQLN-------EQAQKLIIDEGHHDSEEIQERMEELN

LHWQQLMLKMEDRLKLVNA
 .|.||   .|.| .   .
QRWEQLCELWEERKQKLEE
SPEC Trad.AA SPEC 1133-1235 20 2e-12 48.49 SMART 1-104 (104) Show / Hide 
Range on Protein: 1133-1235
Range on HMM: 1-104/104
Sequence Identity: 20% (22 aa)

VVFERSAKQALDWIQETGEFYLSTHTSTG--ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEK-GHIHATEIRKWVTTVDKHYRDFSLRMGK
  | | ......|..|.    | ... .|   . |. |.|.|.  .|.   .. ...|. |.|... .... || .| ||..... .......   .. .
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

YRYSLE
 |  ||
RRQRLE
Spectrin Trad.AA Spectrin 1130-1222 23 3.6e-07 29.84 Pfam 1-95 (109) Show / Hide 
Range on Protein: 1130-1222
Range on HMM: 1-95/109
Sequence Identity: 23% (23 aa)

QQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLK--EYGEFRVPAKQTKEKVKLLIQLADSF-VEKGHIHATEIRKWVTTVDKHYRD
...  | | ..... ||||. | .||.    |.. ||.|.|.|   . .|.    . ...|. | ..|. . .. ||  . ||....  ..... .
HHLQQFQRDCDDLEQWIQEK-EQWLSSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQ
RhoGEF Trad.AA RhoGEF 1285-1455 29 8.9e-59 202.5 SMART 1-211 (211) Show / Hide 
Range on Protein: 1285-1455
Range on HMM: 1-211/211
Sequence Identity: 29% (63 aa)

IMAELLQTEKAYVRDLHECLETYLWEMTSGV--EEIPPGILNKEHIIFG-NIQEIYDFHNNIFLKELEKYEQL------------------PEDVGHCFV
.. ||.|||..||||||.....|. .| . .   ..|.   .. ..||| ||.|||.|| ..||.|||.. ..                  ....|.||.
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFH-RRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFM

TW---ADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLAN---------SISSYLIKPVQRITKYQLLLKELLTCCE---EGKGELKDGL
 |   .. |.|| .||.|.|.. ... .     .   |........  .|         .....||||.||||||.|||||.| ...   . . .|.. |
KWFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKAL

EVMLSVPKKAND
..| .|... |.
DCMKDVAQHCNE
RhoGEF Trad.AA RhoGEF 1285-1455 31 4.5e-48 166.87 Pfam 1-196 (196) Show / Hide 
Range on Protein: 1285-1455
Range on HMM: 1-196/196
Sequence Identity: 31% (63 aa)

IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKE--HIIFGNIQEIYDFHNNIFLKELEK-----YE--QLPED--VGHCF--VT-WADKFQ
.. |..|||..|||||  ..| |. ..        |.||. .  |.||.||.|||.||.. ||..||.           ...  .|.||  .  ... |.
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA---NPPILSPDEIHTIFSNIEEIYEFHQR-FLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFK

MYVTYCKNKPDSNQLILEHAGT--FFDEIQQRHGLANS---------ISSYLIKPVQRITKYQLLLKELLTCCEE-----GKGELKDGLEVMLSVPKKAN
||..||.|.| . .|. ..  .  .|... ..  .  .         ..|.||||||||..|.||||||| ....      . .|.  ||.| .| ...|
MYSEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE-NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHIN

D
.
E
PH Trad.AA PH 1475-1580 16 1e-11 44.86 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1475-1580
Range on HMM: 1-92/92
Sequence Identity: 16% (18 aa)

LILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEG-DPCKFALWSGRTPSSDNKTVLKASNIETKQEWIK
.|..  . ..     ... ..|...||.  |.. |. |       | .| ..  |.. ||..... .|. | ...       .. ...|.. | ...|..
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR----RTYYFQAESEEEMNDWMQ

NIREVIQ
 |.... 
AIQSACR
PH Trad.AA PH 1469-1582 15 1.5e-10 42.32 SMART 1-82 (82) Show / Hide 
Range on Protein: 1469-1582
Range on HMM: 1-82/82
Sequence Identity: 15% (18 aa)

LDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK
.  .| |  .             . ..|...||. .|.. |.           .| ..  |.. |.| .      | ...          ...... |..
VIKEGWLYKKS----------K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P-----CFEIHH-DR-----TYYFQCESEEEM

QEWIKNIREVIQER
|||.. |...|.. 
QEWMQAIQKAIHNN
SH3 Trad.AA SH3 1649-1710 24 1.1e-08 36.15 SMART 1-58 (58) Show / Hide 
Range on Protein: 1649-1710
Range on HMM: 1-58/58
Sequence Identity: 24% (15 aa)

ELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISH
.  ..| |. | .. ||... |.....||.    .||. .|        ||..||. . . .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNR--TGQEGWFPSNYVEEID
SH3_1 Trad.AA SH3_1 1652-1703 26 2e-08 31.54 Pfam 1-49 (49) Show / Hide 
Range on Protein: 1652-1703
Range on HMM: 1-49/49
Sequence Identity: 26% (14 aa)

VVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPL-EGLVPS
|.| |. | ...||... | .....|.  . ..|. .|   .     ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNT---GQEGWFPS
SH3_2 Trad.AA SH3_2 1650-1709 15 0.00017 18.63 Pfam 1-68 (68) Show / Hide 
Range on Protein: 1650-1709
Range on HMM: 1-68/68
Sequence Identity: 15% (11 aa)

LTVVLQDFSA-GHSSE-----LTIQVGQTVELLE-RPSERPGWCLV-RT--TERSPPLEGLVPSSALCIS
. .|..|. .    .|     |....|....... .  ....|... .|  . |     |..||... . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRR-M-RGWFPSQWVEEC
RhoGEF Trad.AA RhoGEF 1933-2103 31 6.3e-55 189.7 SMART 1-211 (211) Show / Hide 
Range on Protein: 1933-2103
Range on HMM: 1-211/211
Sequence Identity: 31% (67 aa)

VLNELVQTEKDYVKDLGIVVEGFMKRIEEKG----VPEDMRGKDKIVFG-NIHQIYDWHKDFFLAELEKCIQE------------------QDRLAQLFI
|..||.|||..||.|| |.|...||.... .    .|   . . ...|| ||. ||. |..|.. |||..|.|                  .||....|.
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLD-ELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFM

KH---ERKLHIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEINQ---------RLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAV
|.   |. ...|  ||.|.|... . ..       .......|.  ..         ||||.||||||.||||||.||||. |......  .  |..||.
KWFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKAL

ELMCLVPKRCND
..|. |...||.
DCMKDVAQHCNE
RhoGEF Trad.AA RhoGEF 1933-2103 28 4.5e-54 187.48 Pfam 1-196 (196) Show / Hide 
Range on Protein: 1933-2103
Range on HMM: 1-196/196
Sequence Identity: 28% (56 aa)

VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR-GKDKIVFGNIHQIYDWHKDFFLAELEK--CIQEQ-----DR--LAQLF--IK-HERKLHIYV
|..|..|||..||.|| |..|..||..... .|. .  .. ...|.||..||..|..| | .||.  .....     ..  ....|  .| ... ...|.
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCANPPILSPDEIHTIFSNIEEIYEFHQRF-LEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMYS

WYCQNKPRSEYIVAEY---DAYFEEVKQEINQ-------RLT-LSDFLIKPIQRITKYQLLLKDFLRYSEK-AGL-ECSDIEKAVELMCLVPKRCND
 ||.|.|...... ..   . .|..  .....       ||. |..|||||.|||..|.||||. |.....     . .|..||.|.|  | ...|.
EYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKENDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHINE
PH Trad.AA PH 2117-2226 17 5.2e-08 31.54 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2117-2226
Range on HMM: 1-92/92
Sequence Identity: 17% (19 aa)

LTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDN-DPCKFALMNRETSERVVLQAANADIQQ
.. .| |...             .. |.| ..||.. ... .          |  |.|| .. . ... .|| .|. | . . .  .....||....  .
VIKEGWLHKKG----------KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR-RTYYFQAESEEEMN

AWVQDINQVLE
 |.|.|.... 
DWMQAIQSACR
PH Trad.AA PH 2123-2228 15 2e-06 28.95 SMART 1-82 (82) Show / Hide 
Range on Protein: 2123-2228
Range on HMM: 1-82/82
Sequence Identity: 15% (16 aa)

LLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDIN
.. . . |. .       | |.| ..||.. ... .             | || .. . ..| .      | . . .   . ..|. ... .| |.| |.
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P-----CFEIHH-DR--TYYFQCESEEEMQEWMQAIQ

QVLETQ
.... .
KAIHNN
SH3 Trad.AA SH3 2324-2385 17 0.000266 18.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 2324-2385
Range on HMM: 1-58/58
Sequence Identity: 17% (11 aa)

SSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLT
  . .. || |  ..|. ...|....||  . .. . .           |||.|.. .....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR----TGQEGWFPSNYVEEID
SH3_2 Trad.AA SH3_2 2325-2384 16 0.36192 6.98 Pfam 1-68 (68) Show / Hide 
Range on Protein: 2325-2384
Range on HMM: 1-68/68
Sequence Identity: 16% (12 aa)

SMAVIKDYYA-LKENE-----ICVSQGEVVQVL---AVNQQNMCLV-YQ--PASDHSPAAE--GWVPGSILAPL
 . |..|| .  ..||     . .  |.|. |.     .. | ... .            .  ||.| ......
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG------GRRMRGWFPSQWVEEC
I-set Trad.AA I-set 2471-2565 32 7e-27 93.73 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2471-2565
Range on HMM: 1-92/92
Sequence Identity: 32% (31 aa)

PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV
|.|. .. ||..  |.|. ..|.| | |.|...|.  .| .     .|  . ..  ..|. || | |  | |.|.|||.|||  |. ...|...|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Trad.AA IG 2477-2566 27 1.8e-14 55.3 SMART 1-58 (58) Show / Hide 
Range on Protein: 2477-2566
Range on HMM: 1-58/58
Sequence Identity: 27% (26 aa)

LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS---GIYTCIATNDHGTTST--SATVKVQ
   ||  .|.|| |.| |      .|.|.                           | | |. |.||   |.|.| ||  ||...   ..|..||
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 Trad.AA IGc2 2483-2555 32 2.8e-14 54.67 SMART 1-56 (56) Show / Hide 
Range on Protein: 2483-2555
Range on HMM: 1-56/56
Sequence Identity: 32% (24 aa)

LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG
. |..|.|.|.. |.| |.|.|.      |.               .. ||.| |  | |||.|||.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP---------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Trad.AA V-set 2471-2565 17 7e-06 22.2 Pfam 1-128 (128) Show / Hide 
Range on Protein: 2471-2565
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

PEFLVP--LV----DVTCLLGDTVILQCKVC-----------------GRP--------KPTITWKGPDQNILDTDNSSATYTVSSCDS-GEITLKICNL
.... .         ||  .|..| |.|..                  ..|        .  . .. .....  ..  . ..|.|.. | .  .|.| ||
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

MPQDSGIYTCIATN-DHGTTSTSATVKV
 | |||.|.| ..| ....  .. .. |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
FN3 Trad.AA FN3 2569-2651 22 1.8e-13 52.03 SMART 1-69 (69) Show / Hide 
Range on Protein: 2569-2651
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PAAPNR---PIAQERSCT------SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPG----CPYQFRVSASNP--WGIS
| .| .   . . . . |      || |.| ||           .|.||                   ....|.||      |.|||.| |    |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase Trad.AA Trio 2684-2938 57 2e-242 630.06 In-house 1-258 (258) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-258/258
Sequence Identity: 57% (149 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFY
||...||||||||.|..|.||||....|.||....|..|||..||...|||||||....||||||.|..|||||||.|||.||..||......|..|..|
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

IRDIMEALQYLHNCRVAHLDIKPENLLIDLRIP-VPRVKLIDLEDAVQISGH--FHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
.....||..|||||...||||||||.... ... .|..|..|..||.|...|  ...||..|||||.|||.|||.|||.|||||||||||||||||.|||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
.|||..|||.|.||.|||||..|||.||..|..||...||||...||.|..||||||.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase Trad.AA DAPK 2686-2938 41 4.2e-104 287.6 In-house 1-264 (264) Show / Hide 
Range on Protein: 2686-2938
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

ELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKE-------QAAHEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMN--HDEL
   |.|||.|..|.||.|| | |. | ||. |  ...           || | |. .. ||  |.||. ||  |  |||||.   | | ||. .   . |
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPEN-LLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVML
 || ..  .. | |.. |||  ...|||.||.| .| | .|| ...|.||   .  |     .    | ||. |||...  | || ||.|||||.||.||
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
|| |||| . | ||  |. .|  .|. ||| ..|  |.|||   |  | ..|.||. ||||||.
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase Trad.AA MLCK 2684-2938 37 8.7e-97 255.43 In-house 1-257 (257) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLM-NHDELMEEKVA
|  . |.|||.|.|| .|| |.| | .|.||.   | |.||   .|   .  |.||  | .|| .|.... ..|.|. . | |...     ..| |. |.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

FYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFH-IHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
.|.| | |.....|  ...|||.|||| ..       ..|.||   | .. ..   .  . | |||.||||..  ||...||.||.||..|..||| |||
HYMRQICEGVHHMHWQNIVHLDLKPENIMC-QTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPF

LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
. .. .||  ||  ..  |  | | ..|. |.|||  .| .| ..|.||..|||||||
MGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase Trad.AA CAMK 2689-2938 20 3.1e-96 310.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 2689-2938
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

EIGRGRFSIVKKCIHKATR------------KDVAVKFVSKK-----------------------------MKKKEQAAHEAALLQHLQ-------HPQY
..|||.|..||.|||| |             . ||.|...||                              |....  .| .....||       ||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLHDTYESPTS-------------------YILIL---ELMDDG----RLLDYLMNH---------------DELMEEKVAFYIRDIMEALQYLHNCRV
| |...||.|.                    .....   |... |    .|.||.  |                 . |. ...|.| | .|..|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHLDIKPENLLIDLRIPVP--------------RVKLIDLEDAVQISG------------------------HFHIHHLLGNPEFAA-PEVIQG------
.|.|.||||.|.| . .                 .|.||   | .. .                            .   | ||..| |||..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPVSLGTDIWSIGVLTYVMLSGVSPFLDE-------------SKEETCINVCRVDFSFPHEYFCG------------VSNA--------ARD
         ...  .|.||.||..|.||.| .|| ..             . .|.. .... ...||..|| .            .|.         ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FINVILQEDFRRRPTAATCLQHPWL
.|. .|| |  .|.|.. ||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Trad.AA DAPK 2684-2938 41 4.4e-88 254.14 In-house 1-264 (264) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMK-------KKEQAAHEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDEL
|    ||| | |..||||  | | |. | ||. |          . |    |   |. .. ||  ||||| ||  |  .|||||   | | |.|   . |
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVML
 ||  . .|  | ......|  ...|.|.||||  | |  .| ||.|.||   | .|     .  ..| ||| |||..   | .| || ||||| ||..|
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
|| |||| . |.||  |. .| . |  |||   |. | |||   |  | ..| | . |||||| 
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase Trad.AA DRAK 2688-2938 36 4.3e-79 245.31 In-house 3-259 (259) Show / Hide 
Range on Protein: 2688-2938
Range on HMM: 3-259/259
Sequence Identity: 36% (93 aa)

NEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKK---EQAAHEAALLQHLQH-PQYITLHDTYESPTSYILILELMDDGRLLD--YLMNHDELMEEKVA
 | |||.| .| ||||| | .. | ||. |  . .   .   || | |   |  |. | ||. ||  .  ||.||.   | . .   . . . . |. | 
KERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDVQ

FYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFL
  .|.|.|...|||.  ..||| || | |     |   .|..|   .  |     .  . | |.. |||. .  |... ||.|||||||||||...|||.
RCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPFV

DESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
 . | ||  |.  .  ... | | ..|. |.|||  ..  .   |.||  ||.||||
GDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase Trad.AA S_TKc 2684-2938 29 1.7e-73 251.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDD--GRLLDYLMNHDE------L
|. |..||.| |. |.||.|| | . ||.| ..      |..  | ..|.. .||  ..|.|.... ... ...|..|   | |.||. ..        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSL-GTDIWSIGVLTYVML
 |  ..||.. | .||.|.|. .. | |.||||.|.|      ..|..|   | |.      ... | |.. ||||.   . .    |.||.|.. | ||
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQ-------HPWL
.|  ||     ... .....             |  |.|||. .|| | ..||||  .||       |||.
CGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Trad.AA Pkinase 2684-2938 29 1.5e-67 235.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQ---AAH--EAALLQHLQHPQYITLHDTYESPTSYILILELMDDG----RLLDYLM--NH
|. .  ||.| |. |.||.|| |.| |||| ..|. .|...   ...  |......|.||  ..|.|..|..... ...|... |     | ||..  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DEL--MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVP--RVKLIDLEDAVQ--ISGHFHIHHLLGNPEFAAPEVIQ-GIPVSLGTDIWS
  .   |. . ||.. | ..|.|.|.... | |.||||.||| . ...  .||..|   | |  .      ... | |...|||||. | . .   |.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVLTYVMLSGVSPFLDE------SKEETCINVCRVDFSFPHEYFCGVS-----------------NAARDFINVILQEDFRRRPTAATCLQHPWL
.|.. | ||.|  || ..      .. .   .. . ...|. .. | .|                  ...|||. .|. |  .||||. .|||||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Trad.AA CAMK-Unique 2684-2938 20 2.5e-56 184.39 In-house 1-363 (363) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-363/363
Sequence Identity: 20% (76 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSK---KMKKKEQ------------------AAHEAALLQHLQHPQYITLHDT----YESPT-------
|. .. || | |..|..|. ..|.|  |.| | |   . ||. |                  .  |..... . ||  | | |.    .. ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------SYILILELMDDGRLLDYLMN--------------------HDELME--EKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIP-----
         . ...|. ..| |.|...                        . |    ..|... . .|. |.|.  . | |.|.||...  . .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------VPRVKLIDLEDAVQISGHFHIH---HLLGNPEFAAP--------------EVIQ----GIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKE-
          ..||.|   ......    |      | |...||              |||     . ..|   ||||.||..| ||.| .||  |... 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETCINVCRVDF-SFPHEYFCG---VSNAARDFINVILQEDFRRRPTAATCLQHPWL
       |.  . |  |. .|. ... |   .|..| ||.   .. |   | .|.  |.|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase Trad.AA Ciliate-E2 2684-2938 21 4.1e-52 177.18 In-house 1-365 (365) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YTELNEIGRGRFSIVKKCIHKATRK------------------DVAVKFVSKKMKKK---EQAAHEAALLQ----------------HLQHPQYITLHDT
|  .. ||.| |..|.|| .. ..|                   |..|.. .|..||   ||   |  ...                .|.||  | ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--SPTSYILILELMDDGRLLDYL------------------MNHDELMEEKVA--------FYIRDIMEALQYLHNCR-VAHLDIKPENLLIDLRIPV
..  . ... |..|. . | |.||.                  ...   . ....        |||. |..||.|||.   . | ||||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PRVKLIDLEDAVQIS------------GHFHIHH---------------------LLGNPEFAAPEVIQGIP---------VSLGTDIWSIGVLTYVMLS
  .|.||.  . ...            . .   .                     ..|.|.. |||...| .          .   ||||.||. | ||.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GVSPFLDESKEETCINVCRVDFSFPHEY------------FCGVSNAARDFINV----ILQEDFRRRPT-AATCLQHPWL
|  ||      .  |  | .||..|.              .  .|. . |.|.     .|| |   |.| .  .|.|||.
GKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Trad.AA RSK 2684-2938 26 1.4e-49 171.01 In-house 1-278 (278) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-278/278
Sequence Identity: 26% (75 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAA-----HEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDE---
  .| ..| | .....||.|..|..  |.| ..|.. .. | .      |   |.. | ||  .|||.... ..   ||.|..  | |.. | ..     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPV-PRVKLIDLEDAVQ--ISGHFHIHHLLGNPEFAAPEVIQ-GI-PV--SLGTDIWSIG
..|. ..||.. |  |...||   . | |.|||| | | .     ..||.|   . |  ..  .  .   .  |..|||..  .  ..  .   |.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLTYVMLSGVSPFLD---ESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPT-----AATCLQHPWL
|| | ||.| .||     ....|.  .... .||....    .|..|.|.|.  |. |  .|..     |.  .||||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Trad.AA CAMKL 2684-2812 27 1.2e-34 107.93 In-house 1-161 (297) Show / Hide 
Range on Protein: 2684-2812
Range on HMM: 1-161/297
Sequence Identity: 27% (44 aa)

YTELNEIGRGRFSIVKKCIH-KATRKDVAVKFVSKKMKKKEQAAH----------------EAALLQHLQ---HPQYITLHDTYESPTS------YILIL
|. . ..|.| |. || ..| . |.. ||.|.. || ..... ..                |......|.   ||  | |....| |.       . |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELMDDGR--LLDYLMNHDE----LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID
|. . |   |.||. .| .    . |.   .| | |..|..|.|.....| ||||||.|.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD
Kinase Trad.AA CAMKL 2842-2938 31 5.8e-22 66.75 In-house 195-297 (297) Show / Hide 
Range on Protein: 2842-2938
Range on HMM: 195-297/297
Sequence Identity: 31% (35 aa)

GNPEFAAPEVIQG--IPVS-LGTDIWSIGVLTYVMLSGVSPFLDES---------KEETCINVCRVDF-SFPHEYFCGVSNAARDFINVILQEDFRRRPT
| |...|||..||   |     .||||.||. |.|. |  || |..         ...  |...   .  ..|     ||  .||.|  .|| .  .|||
GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYH-----VS-DCRDLIRKMLQVNPEKRPT

AATCLQHPWL
.   ..|||.
IHQIMNHPWM
Kinase Trad.AA TyrKc 2684-2938 21 1e-09 -65.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 2684-2938
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHL--QHPQYITLHDTYESP-------TSYILILELMDDGRLLDYLMNHDE
 | . ..|.| | .| |.. |    .|||| . |. . .|   .|| .. .|  .||  . |.    ..         . ...|.|. | |.||| .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVK-MLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKL------IDLEDA-------VQIS------GH--FHIHHLLGNPEFAAPEVI
 |  ..   .  .| .  .|||  .. | |.   | |.. .    .||        |..|          ..      |.  . |  .       |||.|
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-------APECI

QGIPVSLGTDIWSIGVLTYVMLS-GVSPFLD-----ESKEETCINVCRVDFSFPHEY-----FCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
.    .  .|.|| ||. . ... | .|  .      | .|   .| . .   . ..     | . . .  . .    .||   ||| ...  |  .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Trad.AA Pkinase_Tyr 2684-2772 26 3.3e-05 18.27 Pfam 1-101 (270) Show / Hide 
Range on Protein: 2684-2772
Range on HMM: 1-101/270
Sequence Identity: 26% (27 aa)

YTELNEIGRGRFSIVKKCIHK----ATRKDVAVKFVSKKMKKKE--QAA--HEAALLQHL-QHPQYITLHDTYE-----SPTSYILILELMDDGRLLDYL
 | . ..|.| |  |.|.. |     |. .|||| .  .  ...  ...  .||... .| .||  . |.         .  ......|.|  | |||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

MNH
 .|
RKH