Gene TIF1b (Human)

TIF1b

Species: Human
Alias: TRIM28, KAP1, TIF1b, RNF96, FLJ29029, TIF1B, TF1B
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19q13.43,

Classification

Group: Atypical
Family: TIF1

Sequence

Name Sequence Type Origin Length Description Download
TIF1b.NA RNA Sugen Kinome 2989 None Fasta, JSON
TIF1b.AA Protein Sugen Kinome 835 None Fasta, JSON

Protein domain

Protein domains of TIF1b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RING TIF1b.AA RING 65-120 23 9.2e-10 39.67 SMART 1-23 (23) Show / Hide 
Range on Protein: 65-120
Range on HMM: 1-23/23
Sequence Identity: 23% (13 aa)

CGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVC
| .| |       |..||| |  |  |.                        ||.|
CPICLE-------PVVLPCGH-FCY-CI------------------------CPIC
Zf-C3HC4 TIF1b.AA zf-C3HC4 65-92 24 5e-06 18.42 Pfam 1-33 (48) Show / Hide 
Range on Protein: 65-92
Range on HMM: 1-33/48
Sequence Identity: 24% (8 aa)

CGVCRERLRPEREPRLLPCLHS-----ACSACL
| .|.. . .. .| ..||.|.      |..|.
CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCI
BBOX TIF1b.AA BBOX 148-195 27 1.1e-14 56.01 SMART 1-51 (51) Show / Hide 
Range on Protein: 148-195
Range on HMM: 1-51/51
Sequence Identity: 27% (14 aa)

DANQCCTSCEDNAPATSYC-VECSEPLCETCVEA--HQRVKYTKDHTVRST
.. . |.......||. .| ..|...||..| |.  ||..|....|.|.. 
HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL
Zf-B_box TIF1b.AA zf-B_box 149-195 27 2.6e-09 41.49 Pfam 1-45 (45) Show / Hide 
Range on Protein: 149-195
Range on HMM: 1-45/45
Sequence Identity: 27% (13 aa)

ANQCCTSCEDNAPATSYCVECSEPLCETCVEA-HQRVKYTKDHTVRST
 . .|  ...  |.. || .|....|| |... |.. . .|.|||.. 
QM-YCPEHPE-EPLEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI
BBOX TIF1b.AA BBOX 204-245 33 3.8e-14 54.24 SMART 1-51 (51) Show / Hide 
Range on Protein: 204-245
Range on HMM: 1-51/51
Sequence Identity: 33% (17 aa)

ERTVYCNVHK-HEPLVLFC-ESCDTLTCRDCQLN-AH------KDHQYQFL
.| ..| .|. |||...|| |.|... |.|| .   |      ..||...|
HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL
Zf-B_box TIF1b.AA zf-B_box 205-245 30 3.2e-08 37.22 Pfam 1-45 (45) Show / Hide 
Range on Protein: 205-245
Range on HMM: 1-45/45
Sequence Identity: 30% (14 aa)

RTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKD-----HQYQFL
.  ||  |. ||| ..|..|... |.|| .. ||.     |... .
QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNGFKKHTVVPI
BBC TIF1b.AA BBC 252-378 29 1.3e-41 145.5 SMART 1-132 (132) Show / Hide 
Range on Protein: 252-378
Range on HMM: 1-132/132
Sequence Identity: 29% (39 aa)

QRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVS-----DVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHIL
.|. | .....| .||.......|.... |.||      . ...|. ...... ..|..||.|......| ....|..|..|..|..|||..|...||..
HREKLEQHLTKLRKKHWECEDAMKQIQNIIQQVQPGHVDENHEDVEQCIRAHFDDLMNWLNRRKKMMLMDLDEQCENKQKWLMQQMQTMTQKQEQLEHCC

RFASWALESDNNTALLLSKKLIYFQLHRALKM
.|. |||.....|..|.|||||.||.....|.
QFCQWALNMGDCTEFLQSKKLIIFQCCHLHKQ
PHD TIF1b.AA PHD 627-672 37 6.1e-16 51.39 Pfam 1-54 (54) Show / Hide 
Range on Protein: 627-672
Range on HMM: 1-54/54
Sequence Identity: 37% (20 aa)

ICRVCQK-----PGDLVMCN-QCEFCFHLDCHLPALQ--DVPGEEWSCSLCHVL
.|.||||     .||.. |  .|. .||..|| | |.  ..|..|| |  | . 
YCCVCQKCDWDDDGDMICCDNGCPRWFHQYCHGPPLEPEEIPEGEWYCPRCKCC
PHD TIF1b.AA PHD 627-670 33 8.7e-12 46.4 SMART 1-39 (39) Show / Hide 
Range on Protein: 627-670
Range on HMM: 1-39/39
Sequence Identity: 33% (15 aa)

ICRVCQKPGDLVMCN-QCEFCFHLDCHLPALQDVPGEEWSCSLCH
.| ||.| | .. |. .|. ..|. |. |.|  .| . | |. | 
YC-VCGK-G-MIQCDPGCDRWYHQ-CLGPPLE-PPDG-WYCPRCR
RING TIF1b.AA RING 628-669 16 0.033195 1.32 SMART 1-23 (23) Show / Hide 
Range on Protein: 628-669
Range on HMM: 1-23/23
Sequence Identity: 16% (7 aa)

CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLC
| .|      ...  |   |.  |              | .|
CPICLE----PVVLPCGH-FCY-CI-------------CPIC
Zf-C3HC4 TIF1b.AA zf-C3HC4 646-669 16 9.228867 0.36 Pfam 27-48 (48) Show / Hide 
Range on Protein: 646-669
Range on HMM: 27-48/48
Sequence Identity: 16% (4 aa)

CFHLDCHLPALQDVPGEEWSCSLC
.|. .| .  ..    ....| .|
WFCHSCIKRWWNH--SGNTQCPIC
BROMO TIF1b.AA BROMO 697-801 22 5.1e-11 43.84 SMART 1-118 (118) Show / Hide 
Range on Protein: 697-801
Range on HMM: 1-118/118
Sequence Identity: 22% (28 aa)

SPANQRKCERVLLALFCHEPCR------------PLHQLATDST----FSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFK---QFNKLTE
.|. |.||...| ...||.  .            | .|. ...        |.    .||  |. .|..      .|..||..|. .||.   ..|.  .
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQY---QSMEEFVDDFMLMFNNCMTYNE--P

DKADVQSIIGLQRFFETRMNEAFG
|    .  . ||.||| ...|.. 
DSEVYKMAKKLQKFFEEKWREFPP