Gene TIE2 (Human)
TIE2
Sequence
Protein domains of TIE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ig_Tie2_1 | TIE2.AA | Ig_Tie2_1 | 23-118 | 67 | 9.3e-77 | 253.61 | Pfam | 1-99 (99) | Show / Hide |
Range on Protein: 23-118 Range on HMM: 1-99/99 Sequence Identity: 67% (67 aa) AMDLILINSLPLVSDAET-SLTCIASGWRPHEPI-TIGRDFEALMNQHQD-PLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKM .||.||||..|.|||||| |||||||.|.||||| |||.||...|||||| |.|...|..|.|.||||||.||.|.|.|||.|..||||.|.||.|||| IMDVILINPDPVVSDAETPSLTCIASDWHPHEPILTIGQDFPRPMNQHQDLPQEFPHDEPRPWPKKVVWKWEKRSHIFGAYYCQIRVRGQARRIYTMKM |
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| EGF_2 | TIE2.AA | EGF_2 | 224-251 | 32 | 5.3e-07 | 25.38 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 224-251 Range on HMM: 1-29/29 Sequence Identity: 32% (10 aa) CTACMN-NGVCHED-TGECICPPG-FMGRTC | | . .|.| . .| | |..| . | .| C--CNGHHGTCNNQGCGKCQCDDGWWQGDHC |
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| EGF | TIE2.AA | EGF | 219-252 | 32 | 1e-06 | 29.14 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 219-252 Range on HMM: 1-32/32 Sequence Identity: 32% (13 aa) ECNHLCTACMNN-----GVCHEDTGECICP-PGFMGRTCE || | .. |.|. . .| || ||..| .|| ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE |
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| Laminin_EGF | TIE2.AA | Laminin_EGF | 230-268 | 23 | 0.000774 | 16.72 | Pfam | 10-59 (59) | Show / Hide |
Range on Protein: 230-268 Range on HMM: 10-59/59 Sequence Identity: 23% (12 aa) N-GVCHE-------DTGECI-CPPGFMGRTCEKACELHTFGR---TCKERC | . |. ||.| | ....|| |. |. ..|. . . | NDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCDR-CKPGYWGDPWCDPPQGC |
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| EGF | TIE2.AA | EGF | 224-250 | 27 | 0.001146 | 15.32 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 224-250 Range on HMM: 1-36/36 Sequence Identity: 27% (10 aa) CTA----CMNNGVCHED--TGECICPPG---FMGRT |. |...| |.. . .|.|||| . |.. CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF | TIE2.AA | EGF | 267-299 | 23 | 0.072199 | 10.33 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 267-299 Range on HMM: 1-32/32 Sequence Identity: 23% (9 aa) RCSGQEGCKSYV-----FCLPDPYGCSCA-TGWKGLQCN |. .| |. | | |. |..| .| ECA---PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE |
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| EGF | TIE2.AA | EGF | 268-297 | 25 | 7.516007 | 2.57 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 268-297 Range on HMM: 1-36/36 Sequence Identity: 25% (9 aa) CSGQ-EGCKSYVFCLPDP--YGCSCATG---WKGLQ |. . .|. .|.. | | | |. | ..| . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF_2 | TIE2.AA | EGF_2 | 264-298 | 27 | 23.837123 | 1.45 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 264-298 Range on HMM: 1-29/29 Sequence Identity: 27% (11 aa) CKERCSG-QEGCKSYVFCLPDPYG---CSCATG-WKGLQC | |.| .. | .. | |.| | | | .| C---CNGHHGTCNNQ--------GCGKCQCDDGWWQGDHC |
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| EGF_2 | TIE2.AA | EGF_2 | 315-340 | 38 | 9e-06 | 21.59 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 315-340 Range on HMM: 1-29/29 Sequence Identity: 38% (12 aa) CSCNN-GEMCDRFQG---CLCSPG-WQGLQC | ||. .. |... | | |..| ||| .| C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC |
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| EGF | TIE2.AA | EGF | 310-341 | 28 | 0.395978 | 1.89 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 310-341 Range on HMM: 1-32/32 Sequence Identity: 28% (11 aa) DCKLRCSCNNGE-----MCDRFQGCLCS-PGWQGLQCE .| | .| | | | ||..| .|| ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE |
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| EGF_2 | TIE2.AA | EGF_2 | 302-311 | 36 | 0.538532 | 6.6 | Pfam | 19-29 (29) | Show / Hide |
Range on Protein: 302-311 Range on HMM: 19-29/29 Sequence Identity: 36% (4 aa) CHPG-FYGPDC |..| ..|..| CDDGWWQGDHC |
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| EGF | TIE2.AA | EGF | 329-339 | 35 | 2.071507 | 4.44 | Pfam | 23-36 (36) | Show / Hide |
Range on Protein: 329-339 Range on HMM: 23-36/36 Sequence Identity: 35% (5 aa) CLCSPG---WQGLQ | | || ..| . CQCPPGYLGYTGKR |
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| Laminin_EGF | TIE2.AA | Laminin_EGF | 315-342 | 28 | 23.386204 | 0.82 | Pfam | 1-42 (59) | Show / Hide |
Range on Protein: 315-342 Range on HMM: 1-42/59 Sequence Identity: 28% (12 aa) CSCN-NG----EMCDR-------FQG-CL-CSPGWQGLQCER | || .| . ||. ..| |. | .. .| .|.| CDCNPHGSVNDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCDR |
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| FN3 | TIE2.AA | FN3 | 444-528 | 18 | 0.00097 | 19.67 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 444-528 Range on HMM: 1-69/69 Sequence Identity: 18% (18 aa) LPKPLNA--PNVIDTGHN------FAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPR----TEYELCVQLVRRGEGGEG . | | . | |.. . ... . .| . |. .|. |.| |||| |. | ....||| PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP----------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| FN3 | TIE2.AA | FN3 | 543-625 | 15 | 5.5e-07 | 30.46 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 543-625 Range on HMM: 1-69/69 Sequence Identity: 15% (15 aa) LPPPRG---LNLLPKSQT------TLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR----EQYVVRARVNTK-AQGEW .||.. | . . . | ...|.|.| |. . . .|.| .|..| |. .. ..|| PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| FN3 | TIE2.AA | FN3 | 639-721 | 17 | 8.9e-14 | 53.02 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 639-721 Range on HMM: 1-69/69 Sequence Identity: 17% (17 aa) PPQPEN---IKISNITHS------SAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPE----TAYQVDIFAENN--IGSS |. |.| ......| . |...||. ...|. | ..||.| | |.. . |.| |.. PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| Kinase | TIE2.AA | Tie | 832-1092 | 85 | 2.9e-230 | 709.12 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 832-1092 Range on HMM: 1-267/267 Sequence Identity: 85% (228 aa) EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS |||||||.||.||||||.|..|||.||||||.||||||.|||||.||.|||||||||.||||||||||.||||||.||||||||||||.|||||||.... EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT T------ASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYG | ||||||||.|||||||||||.||||||.||||||||||||.||||.||||||||||.||||||||||||||||||||||||||||.||||||| TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL |||||||||||||||||||||||||||||||.|.|.|||||||||||||||..|||||.||||.|.| VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL |
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| TyrKc | TIE2.AA | TyrKc | 824-1092 | 40 | 4.90000000001e-141 | 475.75 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 824-1092 Range on HMM: 1-280/280 Sequence Identity: 40% (122 aa) IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG-HHPNIINLLGACEHR-------GYLYLAIEYAPHGNLLDFLR |.. ...|||.||.| |.. | .. |.| .||.| ..|| |....|||| |||||..|.|.| . . |.. ||.|||.|.|.|| ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVY--------VKKT----MGR--LP |.| |. ..||.|. ..|.||.||..|..|||||||||.|||||...||.|||||| . . .... |. || KHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG-----MTCAELYEKLPQGYRLEKPLN--------CDDEVYDLMRQCWREKPYERPSFAQI .||||.|..||...|| |||||.||..||| ..|..|| | |. .|..|.. ||||...| | | ||.|..|.|||.|.| .||.|..| IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI LVSL . HECF |
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| Pkinase_Tyr | TIE2.AA | Pkinase_Tyr | 824-1092 | 44 | 6.1e-140 | 474.57 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 824-1092 Range on HMM: 1-270/270 Sequence Identity: 44% (125 aa) IKFQDVIGEGNFGQVLKARIK--KDGLRMDAAIKRMKEYASKDD--HRDFAGELEVLCKLGHHPNIINLLGACE-HRGY--LYLAIEYAPHGNLLDFLRK |.| ..|||.||.| |.. | .|. ... |.| .||.|.... ..|| |......|||||||..|.|.| ... .|. ||.|||.|||.||| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK SRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY-VKKTMGRLPVRWMAIESLNY | . |. ..||......|.||.||..|..|||||||||.||.|| |.||.||||.| . | .|.. |.||..||| |..|| HR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY SVYTTNSDVWSYGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL ...|| |||||.|||.|||...|..| | ||. .|.||.. .|||...| || ||.||||.|||...| .||.|..|. | GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | TIE2.AA | TK | 824-1092 | 25 | 2.2e-119 | 402.12 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 824-1092
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)
IKFQDVIGEGNFG---QVLKARIK-----------------------KDGLRMDAAIKRMKEY--ASKDDHRD--------------FAGELEVLCK-LG
|.. ...|||.|| .| |.. . |.| ... |.| .|| .|.....| .| |....| ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
HHPNIINLLGACEHR------------GYLYLAIEYAPHGN----LLDFLRKSRVLETDPAFAIAN----------------------------------
|||||..|.|.| . . ... ||.|||. |.|.|||.| ..... ..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------STASTLSSQQLLH-------------------FAADVARGMDYLSQK------QFIHRDLAARNILVGENYV-----------AKIADFGLSR-
..|. ..||. .....|.|| ||..| .|.||||||||.|||||.| .|||||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----------------------------------GQEVYVKKTMGRLPVRWMAIESLN---------YSVYTTNSDVWSYGVLLWEIVSLG-GTPYCGMT
.|. | ... |.||.|||| |.|| | ..|| |||||.|||.|||...| ...| ||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
---------CAELYEKLPQG--------------YRLEKPLNCD--------------DEVYDLMRQCWREKPYERPSFAQILVSL
..|..|.| .| .|...| .| .|.||||.|||...| .||.|.|.. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | TIE2.AA | FGFR | 824-1092 | 43 | 7.79999999999e-114 | 384.48 | In-house | 1-293 (293) | Show / Hide |
Range on Protein: 824-1092
Range on HMM: 1-293/293
Sequence Identity: 43% (128 aa)
IKFQDVIGEGNFGQVLKARIK---KD--GLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
..||| |||| .| | .| . |.| .|. .. .| | |.|.. | |.|||||||.| | || .||..|||| ||||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
VLETDPAFAIA-------NSTAST--------LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYVKKTMGRL
. | . . ... . |.. .| .| |||||.|| . |||||||||.||...|| ||.||||.|. . | |.| |||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL
PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|. ||| |.| |||. ||||||||||||| .||.|| . |||. | |.|.||| || |.| .|.|||..|| .||.|.|. .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
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| Kinase | TIE2.AA | TK-Unique | 824-1092 | 40 | 4.1e-111 | 375.45 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 824-1092
Range on HMM: 1-294/294
Sequence Identity: 40% (118 aa)
IKFQDVIGEGNFGQVLKARIKK----DGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG-YLYLAIEYAPHGNLLDFLRKSR
....||||||.|||| .. ... .. . .|.| |..|.. |..|| |.... .|| ||||...||.| . ....||.| |||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
VLETDP--------AFAIANSTAST--LSSQQLLHFAADVARGMDYLSQ--KQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKK-TMGRLPV
.. |. .... .| .|...|.||| ..|.|| ||.. |...||||.|||.|..|..|.||.|||..| .||... . ||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI
RWMAIESLN--YSVY-TTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNC-DDEVYDLMRQCWREKPYERPSFAQILVSL
|||| ||| . .| || |||||.|||.|||..||..|| || ... |....|||...| .| .|.| ||..||...| |||||.||. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
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| Kinase | TIE2.AA | Src | 824-1092 | 37 | 2.9e-90 | 306.2 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 824-1092
Range on HMM: 1-255/255
Sequence Identity: 37% (104 aa)
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD
||. . .|.|.|| | .. .. ... |.| .|. . .| | ... || |.....|. | | || ||.|||.|.|
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------
PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE----VYVKKTMGRLPVRWMAIESLNYSVYTTNS
... ..|. .||. .|| ||.||.||.....|||||||||.||||| |.|.||||| | . .|. .. ..|..|.| | .|| ..|. |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS
DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYD-LMRQCWREKPYERPSFAQILVSL
||||.|.||.|||. | .|| ||| .| ... .|||. .| || ||.|. .|.|||...| .|| |. . |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
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| Kinase | TIE2.AA | UTK | 824-1092 | 33 | 5.2e-89 | 302.02 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 824-1092 Range on HMM: 1-296/296 Sequence Identity: 33% (101 aa) IKFQDVIGEGNFGQVLKARIKKDG---LRMDAAIKRMK-EYASKDDHR---DFAGELE---VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF ... . .|.|.||.| ||| ... . || |.| . . .. .... || | .. .. .|||...|.| | . .....||.. |.|... VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRKSRV-LETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGEN-------YVAKIADFG---LSRGQE------------ ||..| .. |.. |.|..|.|.|||| ||....|.||||||||.||... .|.|||||| .||. LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY VYVKKTMGRLPVRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG--YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQ | . .|.|.|||| |.|.. .|| |||||.||..|||.. | .|| ||. ... . . | ||...| | ..||.||..||. | |||.| . YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED ILVSL .. . LVQQM |
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| Kinase | TIE2.AA | RTKB | 824-1092 | 36 | 3.2e-83 | 280.38 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 824-1092 Range on HMM: 1-264/264 Sequence Identity: 36% (99 aa) IKFQDVIGEGNFGQVLKARIKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLE .. |.| ||.| .| .. . | |..| || .. || |. |. || |||.| ..| | . . | .|.. .||| |.||..| . VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR-GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNS- .| .|...||. |. ..|.|| .|.|.. |||||.|||.||. . ||.|||..| .. ...| |||..|||.||. .. ||| | HNPQ---------SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSG DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL ||||.|| ||| ||||||| ... . | |.||.|| .....|..|| . . .||.|. .. .. DVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
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| Kinase | TIE2.AA | Fer | 824-1093 | 28 | 3.3e-79 | 269.35 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 824-1093 Range on HMM: 1-283/283 Sequence Identity: 28% (84 aa) IKFQDVIGEGNFGQVLKAR-----IKKDGLRM---DAAIKRMKEY-ASKDDHRDFAGELEVLCK-LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF .......|||.|| | |.| .|. .. . . |..|. |.|. ..| | .. . . |||.. . | | .. ... .|....|.|... VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY LRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE-NYVAK--IADFGLSRG----QEVYVKK-TMGRLPVRWM |.|. |.| ... .....|.||.|| .|. ||||.||||.|... . . | |.|||.|| .. | .| .. ..|.||. LKKNKNK--------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWL AIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG----MTCAEL-----YEKLPQGYRLEKPLNCDDEVYDLMR-QCWREKPYERPSFAQILVSLN | |.... .|....||||.||..||| . | .|| | |..... . ||.. |... .|.. .| ||| ..| .||....| |. APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | TIE2.AA | VEGFR | 936-1092 | 50 | 4.6e-72 | 245.73 | In-house | 170-332 (332) | Show / Hide |
Range on Protein: 936-1092 Range on HMM: 170-332/332 Sequence Identity: 50% (82 aa) LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG----QEVYVKKTM-GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE | .. |. .. |||||..|. . |||||||||||. ||.| || ||||.| ||.|. |||| .|||.||. |||| ||||||||.||| LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE IVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL | |||| || | |.. .| |||...| | |.|. | .||.. | |||.|. . | IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL |
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| Kinase | TIE2.AA | Ret | 941-1094 | 49 | 4.4e-66 | 224.69 | In-house | 137-293 (293) | Show / Hide |
Range on Protein: 941-1094 Range on HMM: 137-293/293 Sequence Identity: 49% (78 aa) LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGT .. || . .|| ||| .||||||||.|| | . || ||||.| |||. .|.|| ||||||| |||| |||||.|||.|||| .|. IISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGAN PYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR || | . |.. | ||| . | || |.| .|||||.. | ||.|. | . . PYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK |
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| Kinase | TIE2.AA | S_TKc | 824-1096 | 25 | 9.3e-47 | 162.58 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 824-1096 Range on HMM: 1-231/231 Sequence Identity: 25% (71 aa) IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPH--GNLLDFLRKSRVLE .. ..||.| ||.| |.| || |||..| ... |...| | |||||..|...... ..||. ||... |.|.|...| . YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTT-NSD .. . .. . .... ......|. ....||||| |||. | . ||.||||.| | .|| | | |.. .| LR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV-----SLNRML .|| |..|.| .. | .|.. . .....|. ..|. |..|.|.. | .||. ..| . . WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | TIE2.AA | Pkinase | 824-1092 | 22 | 1.5e-46 | 165.69 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 824-1092
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD--DHRDFA-GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG----NLLDFLRK
... .||.|.||.| |.. |..| |.|..| |. | ... |.... .| .||||. |....| ....|. ||...| | |...
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST
SRVLETDPAFAIANSTASTL--SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA----KIADFGLSRG--QEVYVKKTMGRLPVRWMAIE
. .. | ... ... ..||..|. .. .||||| |||. .|.. ||.||||.. .. | ..|| |
--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE
SLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM----TCAELYEKLPQGYRLEKPLNCD-----------------------DEVYDLMRQCWREKPY
.. .. |.. .|.||.|..|.| .. | .|..| . .. .... . . . . ... .| |... |.. .|.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK
ERPSFAQILVS--L
.||...||| . .
KRPTAEQILQHPWF
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| Kinase | TIE2.AA | VEGFR | 824-918 | 37 | 1.5e-18 | 66.68 | In-house | 1-101 (332) | Show / Hide |
Range on Protein: 824-918 Range on HMM: 1-101/332 Sequence Identity: 37% (38 aa) IKFQDVIGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEH---RGYLYLAIEYAPHGNLLDFLRKS .| ..|.| ||||..| |.| | |..|| | . || ||..| .||| | |.||.| | | .|| ..|||...|| LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK R | R |
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| Kinase | TIE2.AA | Ret | 824-918 | 35 | 1.4e-16 | 53.14 | In-house | 1-100 (293) | Show / Hide |
Range on Protein: 824-918 Range on HMM: 1-100/293 Sequence Identity: 35% (36 aa) IKFQDVIGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEY-ASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG--YLYLAIEYAPHGNLLDFLRKS . |. ||| ||||.|| .|. |.| |. |. .| |...| |. ||..| |.||| . . | .||. | | ||| | LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLL-KQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS R | R |
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