Gene TESK2 (Human)

TESK2

Species: Human
Alias: TESK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p34.1,

Classification

Group: TKL
Family: LISK
Subfamily: TESK

Sequence

Name Sequence Type Origin Length Description Download
TESK2.NA RNA Sugen Kinome 3093 None Fasta, JSON
TESK2.AA Protein Sugen Kinome 571 None Fasta, JSON
TESK2.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of TESK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TESK2.AA TESK 62-311 65 1.8e-207 661.92 In-house 1-292 (292) Show / Hide 
Range on Protein: 62-311
Range on HMM: 1-292/292
Sequence Identity: 65% (192 aa)

EKIGSGFFSEVFKVRHRASGQVMALKMNT---LSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLD-SNLHLPWTVRVKLA
|||||||||||.|||||||||||.||||.   ...||.|||.||||||.|.|||||||||||||||||||||||||.|.|||||. |.|||.||....||
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

YDIAVGLSYLHFKGIFHRDLTSKNCLIK-RDENGYSAVVADFGLA----------------------------------EKIPDVSMGSEK--LAVVGSP
||||.|.||||.||.|||||||||||.. ||.|.|.|||.|||||                                  ||||...|.|.|  .||||||
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSP

FWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEE
.||||||||.|.|.|||||||.||.||||||||||||||.||||.|||||.||..|.. |||..||||.|.|||||||.||.|.||.|.|| 
YWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase TESK2.AA LISK 63-309 46 3.5e-170 557.35 In-house 1-296 (296) Show / Hide 
Range on Protein: 63-309
Range on HMM: 1-296/296
Sequence Identity: 46% (139 aa)

KIGSGFFSEVFKVRHRASGQVMALKMNT-------LSSNRANMLKEVQLMNRLSHPNILRFMGVCVH-QGQLHALTEYINSGNLEQLLD-SNL---HLPW
.||.|||..|.|..||..|||||.||..       . ... .||.|||.|..|.||||..|||||.| .||||..||||| |.|.|.|. ...   .|||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

TVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIK-RDENGYSAVVADFGLA------------------------------EKIPDVSMGSEK--LAVV
..|||.|.||| |.||||...|.||||.|||||.. .|.|.....|.|||.|                              .|||. .|...|  ....
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTE--NFGLDYDAFQ-HMVGD-CPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
|.|.|||||.|... |.|..||||.||.|||||.|..|||||.|||.  .|||||..|. ....| |||.||.|.|.||..||| |||| || ..|
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase TESK2.AA TKL 64-309 27 3.6e-82 279.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 64-309
Range on HMM: 1-364/364
Sequence Identity: 27% (102 aa)

IGSGFFSEVFKVRHRA--------SGQVMALKMNTLSS-----------------------------NRANMLKEVQLMNRLSHPNILRFMG--------
||||.|.||.| ..|         .|...| |.    .                             .|    .|. .|.||.||||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VCVH----QGQLHALTEYINSGN-LEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHF--------KGIFHRDLTSKNCLIKRDENGYS-----------A
 ||.|    .|||.  .||.  |. |..|.       | .|...|.||| |..|||         ..| ||||.|||.|.... . .|           .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGLAEKIP---DVSMGS--------------EKLAVVGSPFWMAPEVLRDE----------------PYNEKADVFSYGIILCEIIARIQADPDYL
 ..||||.  .    . ....               .  ..|.| ||||||||..                .|.||.||.|.||.|.||..| .   || 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PRTENFGLDYDAFQHMVGD----------------------CPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
.... |. ...... ||.|                      |||.. .|   |...||. |||| || |.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TESK2.AA LISK-DD1 101-309 34 1.7e-70 240.54 In-house 44-290 (290) Show / Hide 
Range on Protein: 101-309
Range on HMM: 44-290/290
Sequence Identity: 34% (85 aa)

EVQLMNR---LSHPNILRFMGVCVH-------------QGQLHALTEYINSGNLEQLLDS-------------NLHLPWTVRVKLAYDIAVGLSYLHFKG
|..       ..|||| .| |.|.|              . |. .||.|. |.| ..| .               ..||. |||.|.||| . .||| |.
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IFHRDLTSKNCLIKRDEN---GYSAVVADFGLAEKIPDVSMGSEK--LAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRT--E
| |||| ||| |.  |||    . . | |||.| ..   . ....  .  .|.. ||||||. .. |.. .||||.|. | |.| |   |.....|.   
IIHRDLKSKNILV--DENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMN

NFGLDYDAFQH-MV-GD--CPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
 |..|...|..  . .|  ||..|. |...||. ||. |||| ||  ||
CFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase TESK2.AA TKL-Unique 60-250 32 1.3e-51 177.83 In-house 1-222 (290) Show / Hide 
Range on Protein: 60-250
Range on HMM: 1-222/290
Sequence Identity: 32% (73 aa)

TCEKIGSGFFSEVFKVRH-RASGQVMALKMNTLSSNR--ANMLKEVQLMNRLS-HPNILRFMGVCV----HQGQLHALTEYINSGNLEQLLD--------
  .|||.| ...|.|. . . .  .  .. | .|||.   .  .|| .|..|  ||||...||.|.    .....   .||.. |.|  .|.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--SNLHLPWTVRVKLAYDIAVGLSYLHFKG--IFHRDLTSKNCLIKRD--ENGYSAVVADFGLAEKIPDVSMGSEKL--------AVVGSPFWMAPEVLR
  .|. |.. .|||.| ||| |. |||...  | ||||.|.| |. ..  .. ... ..||||. |. . .. . .          ..||..||||||||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-KFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

D--EPYNEKADVFSYGIILCEII
.  . |.||.||.|.||.| ||.
MNFCQYSEKSDVYSFGIVLWEIA
Kinase TESK2.AA Dicty4 60-249 37 1.1e-46 153.82 In-house 3-210 (277) Show / Hide 
Range on Protein: 60-249
Range on HMM: 3-210/277
Sequence Identity: 37% (80 aa)

TCEKIGSGFFSEVFKVRHRASGQVMALKMN-----TLSSNRAN-MLKEVQLMNRLSHPNILRFMGVCV----HQGQLHALTEYINSGNLEQLLDS-----
. ..||.| |.||.| . |  |.  | |.      ....|. |  .||| .|  ..||||. ||| |     | | .   |||  .|||. || .     
IEQRIGKGSFGEVYKGTWR--GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--NLHLPWTVRVK---LAYDIAVGLSYLHFKG--IFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSE-KLAVVGSPFWMAPEVLRDEPYNEK
  .  |.|. . .   .| |.| |. .||     | |||| | | |.  |.| . . |.||||.  .  ... .    ...|.| ||||||.. .|||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV--DKN-WRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

ADVFSYGIILCEI
|||.|.||.| ||
ADVYSFGIVLWEI
Kinase TESK2.AA TK 62-309 15 1.9e-46 153.25 In-house 5-486 (486) Show / Hide 
Range on Protein: 62-309
Range on HMM: 5-486/486
Sequence Identity: 15% (74 aa)

EKIGSGFFS---EVFKV-------------------------RHRASGQVMALKMNTLSSNRANML----------------KEVQLMNRLS-----HPN
.|.|.| |    ||.|                          ...   .  | || .. .. . .                 .|.. |  ..     |||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

ILRFMGVCVHQ------------GQLHALTEYINSGN----LEQLLDSNLH-------------------------------------------------
|.|. |||...            . .  ..|| . |.    | . | .. .                                                 
IVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDL

---------------------------LPWTVRVKLAYDIAVGLSYLHFK------GIFHRDLTSKNCLIKRD--------ENGYSAVVADFGLAE----
                           |.   ..  ...|| |..||| |      .. ||||   |||. ..        ..|. . .|||||.     
IKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG

-KIPDVSMGSEKLAVV------------------------GSPF---WMAPEVLRDEP---------YNEKADVFSYGIILCEIIARIQADPDY------
    |.  ...  ..                         |  .   |||||.|.|           . .| ||.|.|. . ||  . |. .        
VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQD

----------LPRTENFGL-------DYDAFQHMV--GDCPP-------------DFLQL-TFNCCNMDPKLRPSFVEIGKTL
          . . .. |        .      |    .||.             .....    |.. ||. ||.| .. . |
VWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TESK2.AA LIMK 216-309 48 1.3e-44 149.84 In-house 192-287 (287) Show / Hide 
Range on Protein: 216-309
Range on HMM: 192-287/287
Sequence Identity: 48% (47 aa)

VVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVG--DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
||| |.||||| ..   |.|| ||||.||..|||| |..|.||..|||  |||.   |       .||| | ...| || |||  ||.|..  . |
VVGNPYWMAPEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL
S_TKc TESK2.AA S_TKc 58-313 25 1.6e-44 155.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 58-313
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

DFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINS--GNLEQLLDSNLH------LP
    .|||.| |..|.|.||. .|...|.|.        ....|.|.. .  |||| .. .|... . |.  .||..   |.| ...... .      .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNE-KADVFSYGIILCE
  .  ...| |. .| |.| .|| ||||   | |. .        ..||||| ..           ..|.|..||||||   .|.  |.|. | |.|| |
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGK-----TLEEIL
 ...    |           ..  |....   .|.....  .|...||. ||.  |. .      . . .
MLCGYPPFP----------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TESK2.AA LIMK 62-201 44 1.5e-42 142.7 In-house 5-144 (287) Show / Hide 
Range on Protein: 62-201
Range on HMM: 5-144/287
Sequence Identity: 44% (64 aa)

EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRA--NMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNL-HLPWTVRVKLAY
|. | |||  ..|| ||..| || .|     .  .  . ||||  |  | ||..| | ||      |. .||||  | |. .. .    .||  ||..| 
EVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRVRFAR

DIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLA
||| | ||||  .| |||| | |||.. |    | ||||||||
DIACGMSYLHSMCIIHRDLNSHNCLVREDR---SVVVADFGLA
Kinase TESK2.AA Pkinase 62-246 30 6.1e-41 145.83 Pfam 5-202 (293) Show / Hide 
Range on Protein: 62-246
Range on HMM: 5-202/293
Sequence Identity: 30% (62 aa)

EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLK------EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSG----NLEQLLD--SNLHL-
.||||| |..|.| .|. .|.. |.|   ..... ....      |.|.|.||.||||.|. ...   . ..  .|| . |     |  ..   ..  . 
RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-PWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIK-RDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLR-DEPYNEKADVFSYGII
 .. .  . .| |. || |.| .|| |||| . |.||. ..... .  ..|||||...     .|    ..|.|..|||||.| ...|  |.|..|.|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

L
|
L
Kinase TESK2.AA MLK 60-252 28 1.9e-40 138.05 In-house 3-232 (291) Show / Hide 
Range on Protein: 60-252
Range on HMM: 3-232/291
Sequence Identity: 28% (66 aa)

TCEKIGSGFFSEVFKVRHRASG---QVMALKMNT--------LSSNRANMLKEVQLMNRLSHPN----ILRFMGVCVHQGQ-LHALTEYINSGNLEQLLD
. |.|||| | .|.| | |.      . |.|. .         .. . .. .|. . ..|||||    | .|.|||  ... .  ..||.  | |  .| 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

SN--------------LHLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKR---DENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWM
..                 .  . .. |...| |..||| .    | |||| |.| || .   | ..  ....|||.. .. .    . .    |.. ||
GARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTYAWM

APEVL---RDEPYNEKADVFSYGIILCEIIAR
||||.   | |.|.||.||.|.|..| |...|
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase TESK2.AA DRK 100-252 39 4.2e-40 133.54 In-house 46-198 (258) Show / Hide 
Range on Protein: 100-252
Range on HMM: 46-198/258
Sequence Identity: 39% (61 aa)

KEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQ-LLDSNLHLPWTVRVKLAYDIAVGLSYLHFKG--IFHRDLTSKNCLIKRDENGYSAVVA
.|. || .| ||||  ||| |         .||.  | | . |.|  . . |  . ... |.| |. |||     | |||| | | |.  ||. .   ||
REINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV--DEH-WQVKVA

DFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIAR
||||. .   .         .| | | ||||||...| |||||.|..|.| |.. |
DFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR
TyrKc TESK2.AA TyrKc 58-309 26 3.9e-39 137.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 58-309
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

DFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRL--SHPNILRFMGVCVHQ-------GQLHALTEYINSGNLEQLLDSNLH-
    .|.|.|.| ||.| . .   .  | ||   .. |. ...| ..| .|  .||||.|. |||..|       ..|  ..||   |.| . | .. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDV-------SMGS------EK--LAVVGSPFWMAPEVLRDEP
|..   .. ...|| | .||| |.. ||||   |||....     . ..||||. .| |        .. .      .|  | .     |||||....  
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECINYGK

YNEKADVFSYGIILCEIIARIQADPDY-----LPRTENFGLDYDA-FQHMVGD--------CPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
...| ||.|.|. . ||  . |  .       .. .| . .  .        .        ||..  |.   |.. ||. ||.| || . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TESK2.AA Pkinase_Tyr 62-250 29 2e-36 123.97 Pfam 5-208 (270) Show / Hide 
Range on Protein: 62-250
Range on HMM: 5-208/270
Sequence Identity: 29% (62 aa)

EKIGSGFFSEVFKVRHR----ASGQVMALKMN--TLSSN---RANMLKEVQLMNRL-SHPNILRFMGVCV-HQGQ--LHALTEYINSGNLEQLLDS----
.|.|.| | ||.| . .      ..  | ||   . ..    |. ...|...|  | .||||.|..|||. ....  .   .||   |.|   | .    
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPD-----VSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADV
. .|.    .. ...|| |..||. |.. ||||  .|||...   .  . ..|||||  | .     .. |. || .    .|||||....  ...| ||
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPI----KWMAPECINYGKFTTKSDV

FSYGIILCEII
 |.|. . ||.
WSFGVLMWEIF
Kinase TESK2.AA DRK 280-311 46 2e-07 21.22 In-house 227-258 (258) Show / Hide 
Range on Protein: 280-311
Range on HMM: 227-258/258
Sequence Identity: 46% (15 aa)

CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEE
||| . ||   | | ||  |||. |. . || 
CPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase TESK2.AA Dicty4 279-311 42 1e-06 18.39 In-house 243-277 (277) Show / Hide 
Range on Protein: 279-311
Range on HMM: 243-277/277
Sequence Identity: 42% (15 aa)

DCPPDFLQLTFNCCNMDPKLRPSFVEIGKT--LEE
.||| . .|   | . ||. |||| || .   ||.
WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase TESK2.AA TKL-Unique 279-309 41 4e-06 17.88 In-house 260-290 (290) Show / Hide 
Range on Protein: 279-309
Range on HMM: 260-290/290
Sequence Identity: 41% (13 aa)

DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
.||...  |   |.. ||  |||| || . |
HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase TESK2.AA MLK 279-309 41 1.1e-05 15.88 In-house 261-291 (291) Show / Hide 
Range on Protein: 279-309
Range on HMM: 261-291/291
Sequence Identity: 41% (13 aa)

DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
.||. . .|  .| |.||. |||| .| . |
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase TESK2.AA Pkinase 281-309 22 0.036589 8.73 Pfam 263-293 (293) Show / Hide 
Range on Protein: 281-309
Range on HMM: 263-293/293
Sequence Identity: 22% (7 aa)

PPDFLQLTFNCCNMDPKLRPSFVEIGKT--L
.......  .|...||| ||.. .| .   .
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TESK2.AA Pkinase_Tyr 279-309 38 0.10004 6.47 Pfam 240-270 (270) Show / Hide 
Range on Protein: 279-309
Range on HMM: 240-270/270
Sequence Identity: 38% (12 aa)

DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTL
.||..  .|   | . ||. ||.| ||   |
NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL