Gene TEC (Human)

TEC

Species: Human
Alias: MGC126760, MGC126762, TEC, PSCTK4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4p11,

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
TEC.NA RNA Sugen Kinome 3620 None Fasta, JSON
TEC.AA Protein Sugen Kinome 631 None Fasta, JSON
TEC.kin_dom Protein Kinase Domain Sugen Kinome 250 None Fasta, JSON

Protein domain

Protein domains of TEC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BTK TEC.AA BTK 113-149 54 3e-24 87.81 SMART 1-37 (37) Show / Hide 
Range on Protein: 113-149
Range on HMM: 1-37/37
Sequence Identity: 54% (20 aa)

NNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLF
||..|.||||.||.||...||.||.|.||||.... .
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
PH TEC.AA PH 5-113 24 4.4e-19 70.63 SMART 1-82 (82) Show / Hide 
Range on Protein: 5-113
Range on HMM: 1-82/82
Sequence Identity: 24% (27 aa)

TILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVK
.|.|  | |.|         ..|.| |||. ..|.||. .      ||.|..|.....| .              |...|  .|.|....|..... |..
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK----KPKGSIPLSDCTVRE-P-------------CFEIHH-DRTYYFQCESEEEMQEWMQ

KLKEEIKNN
 ... |.||
AIQKAIHNN
PH TEC.AA PH 5-111 22 3.8e-17 64.46 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5-111
Range on HMM: 1-92/92
Sequence Identity: 22% (24 aa)

TILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDAN-TLYIFAPSPQSRDLWV
 |.|  | |..      .  ..|.| |||. . | ||. .   .  || |..|.........|        ... ||...  . |.|..|.|..... |.
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDN-------KRPHCFQIRT-DRRTYYFQAESEEEMNDWM

KKLKEEIK
. ... ..
QAIQSACR
BTK TEC.AA BTK 118-149 50 2.4e-14 58.78 Pfam 1-32 (32) Show / Hide 
Range on Protein: 118-149
Range on HMM: 1-32/32
Sequence Identity: 50% (16 aa)

IKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLF
.||||.|| .|...||.||.|.|||| .... 
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
SH3 TEC.AA SH3 182-238 39 8.4e-20 73.03 SMART 1-58 (58) Show / Hide 
Range on Protein: 182-238
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

EIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDK-YGNEGYIPSNYVTGKK
. |.|.||.|| .  .| ...|. ...|||.| .||..| .  |.||..|||||. ..
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 TEC.AA SH3_1 185-231 36 1.2e-18 65.85 Pfam 1-49 (49) Show / Hide 
Range on Protein: 185-231
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

VAMYDFQAAEGHDLRLERGQEYLILEKNDV-HWWRARDKYGN-EGYIPS
|| ||.|| .. .| ...| .. ..||.|  .||..|.. .. ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 TEC.AA SH3_2 183-234 16 1.7e-05 22.18 Pfam 1-65 (68) Show / Hide 
Range on Protein: 183-234
Range on HMM: 1-65/68
Sequence Identity: 16% (11 aa)

IVVAMYDFQA-AEGHD-----LRLERGQEYLIL---EKNDVHWWRA-RD-KYGNE--GYIPSNYV
 .... |... .   .     |....|.   ..   .|.. .||.. .  . | .  |..||..|
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWV
SH2 TEC.AA SH2 247-330 32 5.6e-36 107.46 Pfam 1-81 (81) Show / Hide 
Range on Protein: 247-330
Range on HMM: 1-81/81
Sequence Identity: 32% (28 aa)

WYCRNMNRSKAEQLLRS-EDKEGGFMVRDSS-QPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYH
||.....|..||.||.. . ..| |.||.|. .|| ||.|....     .. ..||.|..| .   .||....| |.|..|..|..
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY
SH2 TEC.AA SH2 245-336 34 2.2e-31 111.52 SMART 1-87 (87) Show / Hide 
Range on Protein: 245-336
Range on HMM: 1-87/87
Sequence Identity: 34% (33 aa)

YEWYCRNMNRSKAEQLLRSE-DKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAE--KHAFGSIPEIIEYHKHNAAG
..||  |..|..|||||...  ..| |.||||.. || |..|. .|      ....||.|... .  .|||..|  .. | |. |......||. |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------GKVKHYRIRRNDD--GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase TEC.AA Tec 370-621 73 1.9e-215 722.07 In-house 1-254 (254) Show / Hide 
Range on Protein: 370-621
Range on HMM: 1-254/254
Sequence Identity: 73% (186 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV--LL
||||.|||||.||||.|||||.||.||||.|.||.|.||||||||||||||.|||||||||||.||.|||||||.||.|||||.||....||....  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

SMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFE
.|||||||||.||||..|||||||||||||....|||||||||.|||||||||||.|.||||||||||||.|||.|||||||.|||||||||..|.||.|
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

KYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDE
...|.|||..|..|||||.|.|.|...|..| .||.||||.||.|..|||.| |
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase TEC.AA Pkinase_Tyr 370-619 45 2.2e-147 499.81 Pfam 1-270 (270) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-270/270
Sequence Identity: 45% (124 aa)

LTFMRELGSGLFGVVRLGKWR-----AQYKVAIKAIREGAMCE----EDFIEEAKVMMKL-THPKLVQLYGVCT-QQKP--IYIVTEFMERGCLLNFLRQ
.||...||.| ||.|..|.|.      ...||.| ..|||| |    |||..|||.|..|  ||..|.|||||| |..|  ||||.|.|. |.||..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYV-LDDQY-TSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSF
.   .....   ||.||.....||||||.. .||||||||||||.| .|||..|||.||..  ||.| ....|.|.|.||..||..||..|..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEVFTEGRMP-FEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTI
||||||.|| |..| ..  .|.||. ..  .|.|. .|....  .|..|..||...|| ||.|..... .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TEC.AA TyrKc 370-619 41 4.3e-134 452.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-280/280
Sequence Identity: 41% (117 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL--THPKLVQLYGVCTQQ-------KPIYIVTEFMERGCLLNFLRQRQGH
.|. ..||.| ||.|..|.|.  ..||.| ..|.|  .|||..||..|.||   || .|.||||||||       .|..||.|.|. |.|...|| ....
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDD-------QYTSSS---GAK--FPVKWCPPEVFNYSRFSSKSDV
.. . |||.| ....|||||... .||||||||||||.| ..||.||||..|.. ||       .| ...   |.|  .|..|..||..||..|..||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGVLMWEVFTEGRMPFEK-----YTNYEVVTMVTRGHRLYQPKL--------ASNYVYEVMLRCWQEKPEGRPSFEDLLRTI
|||||.|||.|| | .| .       .|.||.  | .|.|. ||.         ..  .|..|..||.|.|| ||.|... . .
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TEC.AA Src 370-619 49 1.9e-123 416.39 In-house 1-255 (255) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-255/255
Sequence Identity: 49% (126 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR-QRQGH-FSRDVLL
... |.||.| || |  |.|. . |||.| ...| |  |.| .||..| || |.|||||| ||.| .|||||||.|..|.|| .|. ...|.  .   |.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

SMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVL--DDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMP
.|   | |||.|||.. .||||||||| ||.|  |.|| ||| || .   || |....|||||.||  || .|| ||. ||||||||.|..|..| ||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

FEKYTNYEVVTMVTRGHRLYQPKLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTI
 .  || ||...| || |. .|.    ..|| .||.||...|| || || |    
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TEC.AA SFK-Src 370-623 47 2.9e-117 349.2 In-house 1-259 (259) Show / Hide 
Range on Protein: 370-623
Range on HMM: 1-259/259
Sequence Identity: 47% (123 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLS
    . |||| || |  |.|  .  ||.|  . ||| .| | .|| || || ||.|.||| |||   ||||.|| |  | || .|.. .|.  |   |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQ--YTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPF
|  .|  || ||| . |.|||||||| || .  |.|| ||||.| . .|.  ||   |||||.||  ||  |..||| ||||||||.|| |. | ||.|.
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

EKYTNYEVVTMVTR--GHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELV
.  || ||.  | |  | |.  |.   .  |..|. |||..|. || || |.  ...  
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase TEC.AA TK 370-619 24 1.8e-116 392.19 In-house 1-486 (486) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

LTFMRELGSGLFG---VVRLGKWRAQ--------------------------YKVAIKAIREG-AMCEEDFIE--------------EAKVMMKLT----
.|. ..||.| ||   .|..|.|| .                           .||.| ..|| || .|.|..              || .|...     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLVQLYGVCTQQ------------KPIYIVTEFMERGC----LLNFLRQRQGH--------------------------------------------
 || .|.|||||||.            .|..||.|.|. |.    |...||.. ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSRDVLLSMCQDVCEGMEYLERN------SFIHRDLAARNCLVSEAGV-----------VKVSDFG---
                               ..   || ||.....|||||...       |.|||||||||||.| .|           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MARYV-LDDQYTSSS------------------------GAKFPVKWCPPEVFN---------YSRFSSKSDVWSFGVLMWEVFTEGRMPFEK-Y
     .||..  || |...|                        |.|.|..|..||..|         | .|..|||||||||||||.|| |..|.    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------YEVVTMVTRG--------------HRLYQPKLAS--------------NYVYEVMLRCWQEKPEGRPSFEDLLRTI
.|          ||. ...||              .|. ||....                .|..|..||...|| ||.|..|.. .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TEC.AA UTK 370-619 35 3.6e-103 349.06 In-house 1-296 (296) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-296/296
Sequence Identity: 35% (105 aa)

LTFMRELGSGLFGVVRLGKWRA------QYKVAIKAIREGAM---CEE---DFIEEAK---VMMKLT-HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF
. ..|.||.| ||.|......       . .||.|. ...|.    .|   ||.|||.   .|...  ||....|.|||||..|..||||.||.| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG-------VVKVSDFG---MARYVL----------DDQYTSSSGAK
||       ... ... . .|.|. |. .||.||..  |.||||||||||| . .       |.|..|||   |.|.|           .. |....  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVKWCPPEVFNYS-RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRG--HRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTI
 |..|. ||....  ||..|||||||||..||..| ||.|.. ..| .|.. |..|  .|. .|.  .  ||..|.|||.  |. ||.||||. ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TEC.AA Frk 370-623 46 1.8e-98 333.42 In-house 1-260 (260) Show / Hide 
Range on Protein: 370-623
Range on HMM: 1-260/260
Sequence Identity: 46% (120 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR--QRQGHFSR-DVL
. ..|.|||| || |  |.|  .  ||.| .. |.|  .||. ||..| || ||||.||| ||| ..||||.|| |..| |...|.  ...|.  .   |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMAR-YVLDDQ--YTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGR
. |   |  || |||   .||||||||| || |  ..|. |||.||  . |..  | |  ||.||.||  ||  ||..|. ||||||||.|. |. | ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELV
||.   || ||..|| .| |. ||      .||.|| ||...|. || || |   ...  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TEC.AA Src-Unclassified 370-619 39 4.5e-96 325.47 In-house 1-284 (284) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-284/284
Sequence Identity: 39% (113 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREG---AMCEEDFI--------EEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ
.   |.|| | || | .||||    ||.|  |.|    |  | |         .||..| |. |..||.||.||.| .|.||.||.|  | || .||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GHFSRDVLL-------------SMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG-----VVKVSDFGMA--RYVLDDQYTSSSGAKFPVKWCPPEVFN
|      ..             ..   |  ||.||| .  .|||||||| |. .       |||| ||| |  . . || |    ||.||.||  || | 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQP--KLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTI
|  || ||||||.|.| ||..| |. |     | ||.  | || |.  |  ..   |.|| .|..|| . |. || |. |    
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase TEC.AA SrcB 370-620 46 2.6e-95 322.89 In-house 1-251 (251) Show / Hide 
Range on Protein: 370-620
Range on HMM: 1-251/251
Sequence Identity: 46% (116 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRDVLLS
| . . ||.| || | .| .. . |||.|....|.|  | |..|| || .| | .||.|| | |.  ||||.||.|..|||| ||.  .| . | . |. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEK
|   . ||| |.||  .||||| | | ||||. . |. |||.|| . |. ||   |||||.||  ||  |.  |  ||||||||.|. |. | ||.|.  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

YTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTID
 || ||.. . || |. .|    . .|..| .||.|.|| || |. |   .|
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase TEC.AA Abl 370-619 46 3.7e-95 317.91 In-house 1-252 (252) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-252/252
Sequence Identity: 46% (116 aa)

LTFMRELGSGLFGVVRLGKW-RAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV-LL
..    || | .| |  | | | .  ||.|...| .|  ..|..|| .| .. || |||| ||||.  | ||.||||  | ||..||. . .    | ||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

SMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFE
 |   .  ||.|||...|||||||||||||.|  .||| |||.|| . || ||   |||||.||  ||   | .|||||||| ||||.||. | |  |. 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

KYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTI
     .|   . .|.|. .|.   . |||.|..||| ..  ||||... ...
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase TEC.AA Csk 370-619 45 6.9e-91 308.25 In-house 1-251 (251) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-251/251
Sequence Identity: 45% (114 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREG-AMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQK-PIYIVTEFMERGCLLNFLRQR-QGHFSRDVL
|.   . | | || |..|... . |||.| |..      . |. ||.|| .| || |||| ||  .||  .|||.|.| .| |...|| | . ...|. |
LHLGECIGHGEFGDVMQGEYQNR-KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQL

LSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPF
|    ||||||.||| . |.|||||||| ||||  | |||||| |.     |  |.|| |||.||  || .  ..||.||||||||.|.||..  || |.
LKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSG-KFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPY

EKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTI
 .    .||  | .| |   |      ||.||  ||.  |  ||.|. ..   
PRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase TEC.AA S_TKc 370-623 24 2.1e-55 191.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 370-623
Range on HMM: 1-231/231
Sequence Identity: 24% (65 aa)

LTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMER--GCLLNFLRQRQGH-----F
 ...|..|.| ||.|......  . .|||| |.      |... | ....|  || .|.||.|.   . .|.|.|...   | |. ....|..|     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS-KSDVWSFGVLMWEVFT
.  .  .... .|...||. .. .|||||   | |..|  ..|..|||.|| .        .       ...|||.    ..  |.|.||.|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

EGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLR-----TIDELV
 |. ||.   .....  . .          |  . . . .|.|  || ||.  ..|.      ... .
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TEC.AA Pkinase 370-619 23 2.9e-46 164.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 370-619
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

LTFMRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAMCEEDFIE-----EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERG----CLLNFLR-QRQ
... | .||| ||.|......   | ||.| |.     ..  ..     |...| .| ||  |.||....  . ||.|.|..| |     |  ... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHF--SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVV----KVSDFGMAR---YVLDDQYTSSSGAKFPVKWCPPEVFN-YSRFSSKSDV
| |  | ... ...  ...|.||. ....|||||   |.|... |..    |..||| |.   |  .  .|.  |  .   ...||| . ..  ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGVLMWEVFTEGRMPFEKY------TNYEVVTMVTRGHRLYQPK--------------------LASNYVYEVMLRCWQEKPEGRPSFEDLLRT--I
||.|....|... || ||         . .... .. ..   ..                      ..|    ... .|.. .|. ||..|..|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF