Gene TBK1 (Human)
TBK1
Sequence
Protein domains of TBK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | TBK1.AA | IKK | 9-293 | 53 | 8.8e-187 | 626.81 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 9-293 Range on HMM: 1-297/297 Sequence Identity: 53% (160 aa) WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK-------NIVKLFAIEEE---TTTRHKVLIMEFCPCGSLYTVL | ..|.|||||..||...||||||. .|.|..|..|..|. .|..||||..|.|||. ||..|..|||. ......|..||.|..|.||..| WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL EEPSNAYGLPE-SEFLIVLRDVVGGMNHLR-ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQK ..|.|..||.| .|||.|.||.. ||.||. .||||||||||||||...||||...||.||||.|||..|||.|.|.|||||||||||||||||||.||| NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK KYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCW .|.||||.||.||||||.|||.|||.|...|||..|.|..|.|.||||...|||...|||..||...|..|.|..... ...|.....||..|..|| PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW |
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Kinase | TBK1.AA | S_TKc | 9-310 | 22 | 2e-52 | 181.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-310 Range on HMM: 1-231/231 Sequence Identity: 22% (71 aa) WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPC--GSLYTVLEEPSNA-- . . ...|.|| . |...|||||| ..|||. . . .|| ..||| .|.|||||. . .. | ..||.|. |.|...... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL -YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA-TV ...|| . ... .. ..... ..||.|||.|| ||. . |..||| ||.| .. || .|. | . .|| . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC DLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA-E | ||.|...| ..| ||. . ..|.|.| . . ..|. | || .. . .. | DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE TSDILHRMV .| . WDIKCHPWF |
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Kinase | TBK1.AA | CAMK | 14-222 | 20 | 8.3e-46 | 145.15 | In-house | 1-335 (425) | Show / Hide |
Range on Protein: 14-222 Range on HMM: 1-335/425 Sequence Identity: 20% (68 aa) ILGQGATANVFRGRHKKTG------------DLFAIKVFNN----------------ISFL---------RPVDVQ--MREFEVLKK-------LNHKNI .||.|. . |....||.|. .|||. . |.. ||.| . .|| |..|| |.|.|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLFAIEEE-----------TTTR-------HKVLIM---EFCPCG----SLYTVLEEPSN------------AYGLPESEFLIVLRDVVGGMNHLRENG .||. . | | .. | ...| |.|. | |. . | .. ..|.| . | .. ..... ... IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKPGNIMRVIGEDGQ-------------SVYKLTDFGAARELED------------------------DEQFVSLYGTEEYLH-PDMYER----- |||||.|| ||. . .|.. |..||| |..... .. . || || | . .. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ----AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR . .. || .| ||.|| | .| .||. MQNAT---DEEKPYYGPKCDMWSCGVILYIMLCGYPPFY |
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Kinase | TBK1.AA | Pkinase | 9-243 | 25 | 2.5e-45 | 161.37 | Pfam | 1-236 (293) | Show / Hide |
Range on Protein: 9-243 Range on HMM: 1-236/293 Sequence Identity: 25% (64 aa) WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCG----SLYTVLE-E . . ..|.|. . |....||.||...|.|... . .|.. | | ...|.|||.|||.|. . |. . . ..||.|..| .|..... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTW PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQS---VYKLTDFGAARE--LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ .... ..| | ... .. |.... ..||.|||.|| ||. | ..|. | |..||| |. . .. . .. || .|. | | .| .. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--IDNNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAP---EV--IR--GG KKYGATVDLWSIGVTFYHAATGSLPFRPF---EGPRRNKEVMYKIITGKPS ..|| || ||.|...| ..| .||. .. .. ......| .... QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH |
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Kinase | TBK1.AA | ULK | 9-176 | 26 | 2.5e-38 | 131.4 | In-house | 1-214 (329) | Show / Hide |
Range on Protein: 9-176 Range on HMM: 1-214/329 Sequence Identity: 26% (56 aa) WLLSDILGQGATANVFRGRHKKT----GDLFAIKV-----FNNISFLRP----VDVQMREFEVLKKLN----HKN----IVKLFAIEEETTTRHKVLIME . |...||.|. . |..||.||| . ..|.|. .|... ... . ..| ...|||. ||| ||||. . |... . .||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME FCPCGSLYTVLE------EPS-NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE---------DGQSVYKLTDFGAARELEDD---- .|. | | . .. |. . |.|.| ...... . |. .|....|.|||||| ||. | . |.|..||| |. ...| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ EQFVSLY------GT ..... || QMMMTCVNEKRLCGT |
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Kinase | TBK1.AA | ULK | 9-176 | 25 | 3.8e-38 | 132.97 | In-house | 1-210 (324) | Show / Hide |
Range on Protein: 9-176 Range on HMM: 1-210/324 Sequence Identity: 25% (53 aa) WLLSDILGQGATA-NVFRGRHKKT---GDLFAIKVFN-----NISFLRP----VDVQMREFEVLKKLN---HKN--IVKLFAIEEETTTRHKVLIMEFCP . |...||.|. . |..||.||| . ..|.|. . ... ... . ...| ...|||. |.| ||||. . |... . .|||.|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN CGSLYTVLE------EPS-NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE---------DGQSVYKLTDFGAARELEDD----EQF .| | . .. | . |.|.| ...... . |. .|....|.|||||| ||. | . |.|..||| |. .... .. GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC VSLY------GT .. || QTCVNEKRIKGT |
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Kinase | TBK1.AA | STE | 9-224 | 21 | 4.9e-38 | 131.93 | In-house | 1-274 (359) | Show / Hide |
Range on Protein: 9-224 Range on HMM: 1-274/359 Sequence Identity: 21% (63 aa) WLLSDILGQGATANVFRGRHKK---------------TGDLFAIKVFN----------------NISFLRPVDVQMREFEVLKKLN--HKNIVKLFAIEE | . ...|.||. |......| ||...|||. | .... .. ..| ...||.| |.|||| . .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF ETTTR-----HKVLIMEFCPCGSLYTVLEEPSNAYG-----------LPESEFLIVLRDVVGG-MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF . . ..||... ||| .... . .|||. ...|... | ...| ...|.||||||.||. ||.|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF GAARELED-----------------DEQFVSLYGTEEYLHPDMYER---AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPF | . |.| ... .. || . | . .. . |.|.. .| ||.| | . ||| |. |. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM |
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Kinase | TBK1.AA | CAMKL | 9-222 | 27 | 3.4e-37 | 116.15 | In-house | 1-237 (297) | Show / Hide |
Range on Protein: 9-222 Range on HMM: 1-237/297 Sequence Identity: 27% (66 aa) WLLSDILGQGATANVFRGRH-KKTGDLFAIKVFN-NISFLRPVDVQM-------------REFEVLKKLN---HKNIVKLFAIEEETTT----RHKVLIM . . . ||.|. . | ..| . || |||. . . ..|. .. || . .|.|| |.||.||. . | .. . .|.| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EFCPCGS--LYTVLEEPSNAY-GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEE | |. |. |. ... . .||.| | .| ..|.. ..||||||||| ||. . |.| .. |..||| . . .. .. . |. . EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL--LDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR | | ..... ... .| || ||.||. | .| |||. YMAPEIFQGN-----NKPYDGPKVDIWSCGVILYAMVCGYLPFD |
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Kinase | TBK1.AA | Ciliate-E2 | 9-242 | 20 | 1.2e-32 | 109.32 | In-house | 1-304 (365) | Show / Hide |
Range on Protein: 9-242 Range on HMM: 1-304/365 Sequence Identity: 20% (66 aa) WLLSDILGQGATANVFRGRHKKTGDLFA-----------------------IKVF--NNISFLRPVDVQMREFE----------VLKKLNHKNIVKLFAI . ..|||. . |......|.. .|| .|.. |.| .. .. .||| . .|..|||.||.|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAY-----GLPESEFL-IVLRDVVG--------------GMNHLRENG-IVHRDIKPGNIMRVIGEDG .|... . |.||.| |.|. .. .| . | | . | . | ....| ... |.|||||| ||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ QSVYKLTDFGAARELEDD--------------------------------EQFVSLYGTEEYLHPDMYE-RAVLRKDHQKKYGATVDLWSIGVTFYHAAT |..||| .... || ..| ...|| .|. | ... || |. .|.||.||..| . ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GSLPFRPFEGPRRNKEVMYKIITGKP | .|| ...| .. GKPPF-------------QQQIKQCK |
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Kinase | TBK1.AA | CAMK-Unique | 9-221 | 18 | 1.1e-30 | 98.42 | In-house | 1-293 (363) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-293/363 Sequence Identity: 18% (55 aa) WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-------------------MREFEVLKKLNHKNIVKLFAI-----EEET------- . . |.|.|. |... ..||...|.|.... . . .| .|| ...|...| ||.||. . . .. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --TTR---HKVLIMEFCPCGSLYTVLEEPSN-----------------AYGLPE--SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG---- | | . ...||.|..| |. .. . . . | .. . . . .. ... ...|||||.|. ||| .. IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------QSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHP---------DMYERAVLRKDHQKKYGATV----DLWSIGVTFYHAATGSLPF .. ||.||| ..... . . ||..|. | .| .|. . .|. . |.||.||. | ..|..|| RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN---MQCYDQQCSPASDIWSLGVIMYYMLCGCPPF |
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Kinase | TBK1.AA | Dicty2 | 9-176 | 35 | 4.1e-27 | 91.53 | In-house | 1-170 (264) | Show / Hide |
Range on Protein: 9-176 Range on HMM: 1-170/264 Sequence Identity: 35% (63 aa) WLLS-DILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQ---MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS ... ...|.|| . |..| |..||| ||| .| . . . . | |.. |||||| |||| || . | .| |.|. |||..... YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKY--IEHIETENHLYIILEYIENGSLSKIIKK-- NAYG-LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQ-SVYKLTDFGAARELE--DDEQFVSLYGT .| .||| | .. | | | ..|..||||| || | .| | ||.||| | .. || . || --FGCFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANIL--ITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGT |
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Kinase | TBK1.AA | TKL | 15-222 | 16 | 1.4e-26 | 92.68 | In-house | 1-290 (364) | Show / Hide |
Range on Protein: 15-222 Range on HMM: 1-290/364 Sequence Identity: 16% (50 aa) LGQGATANVFRGRHKK--------TGDLFAIKVFNNIS-FLRPV-----------------------DVQMREFEVLKKLN--HKNIVKLFAIEEETTTR .|.|. . |..|... || |.|.|. . .. . .|.|.. ... | |||.. .. . . . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -----------HKVLIMEFCPCGS-LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG--------IVHRDIKPGNIMRVIGEDGQSV-------- . ..||.||.|| |.... . .. .|. |||.| .. |.|||.|. ||. . |... | CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNIL--VDENWTNVSNYMYNPN ----YKLTDFGAARELEDDE--------------------QFVSLYGTEEYLHPDMYERAVLRKD--------HQKKYGATVDLWSIGVTFYHAATGSLP |..||| .|... .. . . || .. | . . . .. ....| .| .| |. .. .|. .| ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP FR .. YY |
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Kinase | TBK1.AA | TyrKc | 9-306 | 19 | 8.4e-12 | -31.82 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-306 Range on HMM: 1-280/280 Sequence Identity: 19% (67 aa) WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL--NHKNIVKLFAIEEET-----TTRHKVLIMEFCPCGSLYTVLEEP | ..|| || |..|. | |.|. .. . . ||| ....|| .|.|||.|... . ..||..| |.| | .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-------EQFVSLY--GTE----------EYLHP . |. ...| .. ||..| .....|||. |.. .||.. . | .||| .|...|| . .. |. | . RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL--VGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-- DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP----RRNKEVMYKIITG----KPSG----AISGVQKAENGPIDWSGDMPVSCSLS .|. | || ||. . | . | .|. |.||. .. .| .| . . -----------NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F RGLQVLLTPVLANILEADQEKCWGFD----QFFAETSDIL | .. . .| ..|| .| |.| ... ----VCCPDEMYQIM----KQCWHEDPEDRPTFSEIHECF |
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Kinase | TBK1.AA | Pkinase_Tyr | 53-136 | 27 | 5e-10 | 34.58 | Pfam | 51-137 (270) | Show / Hide |
Range on Protein: 53-136 Range on HMM: 51-137/270 Sequence Identity: 27% (24 aa) MREFEVLKKL-NHKNIVKLFAIEEETTTR-HKVLIMEFCPCGSLYTVLEEP-SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDI ||| ...|.| .|.|||.| .. . . ..||..|.|.|.. | .. .. |. .. | ... ||..| .....|||. MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | TBK1.AA | ULK | 193-222 | 36 | 6.9e-07 | 20.18 | In-house | 225-257 (329) | Show / Hide |
Range on Protein: 193-222 Range on HMM: 225-257/329 Sequence Identity: 36% (12 aa) DH--QKKYG-ATVDLWSIGVTFYHAATGSLPFR .. ||.|. ...|.||.|. || .| ||. GQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY |
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Kinase | TBK1.AA | ULK | 193-222 | 36 | 1e-06 | 19.82 | In-house | 221-253 (324) | Show / Hide |
Range on Protein: 193-222 Range on HMM: 221-253/324 Sequence Identity: 36% (12 aa) DH--QKKYG-ATVDLWSIGVTFYHAATGSLPFR .. ||.|. . .|.||.|. || .|. ||. GQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF |