Gene TAF1L (Human)

TAF1L

Species: Human
Alias: MGC134910, TAF2A2, TAF1L
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9p21.1,

Classification

Group: Atypical
Family: TAF1

Sequence

Name Sequence Type Origin Length Description Download
TAF1L.NA RNA Sugen Kinome 6216 None Fasta, JSON
TAF1L.AA Protein Sugen Kinome 1826 None Fasta, JSON

Protein domain

Protein domains of TAF1L.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TBP-binding TAF1L.AA TBP-binding 21-86 37 5.1e-33 115.05 Pfam 1-77 (77) Show / Hide 
Range on Protein: 21-86
Range on HMM: 1-77/77
Sequence Identity: 37% (29 aa)

SDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESV----LDDECKKHLAGLGALGLGSLITEL--------TANEEL
||.|...... ...|.|.|.|||||...||||....    ||.|||.||..|...||||...|.        |.... 
SDDDNDNERN-SRGFNLTGFLFGNIDEHGQLEDDDFREQGLDEECKEHLSSLSKMGLGSMLHEVNLLAKSERTDSDDA
DUF3591 TAF1L.AA DUF3591 584-1047 40 7.6e-258 867.68 Pfam 1-494 (494) Show / Hide 
Range on Protein: 584-1047
Range on HMM: 1-494/494
Sequence Identity: 40% (203 aa)

WNL--SNDEYYFPKQQ----GLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSV--QPLLKHIKKKAKMREQERQA
.|.  |||||| ....      | |.|.. |.||.||..|..|...........|.||||....|.     .|| . .  .  |||.|.|...||.||..
FNIIFSNDEYYDMLKENHQNKVRQTIGNLNIEHSMPALRLQWPYYKVKLNKREARSFHRPHFQFYI-----RPGTQIWVRFSKLKHRKRKHDKREKERMG

SGGGELFFMRTPQDLTGKD-GDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCK-YGETVYCHT---SPF--LGSLHPGQLLQALENNLFR
....|.|.|||..|||..| ...||.||.||. |.|...||..||.|||..| ..|.. |... .||| ..|.   |||  .|..|||.  ..|.||..|
KDISEVFKMRTTKDLTLGDNSPVILMEYCEEYPPVMSNFGMGSKIINYYRKKHMEDTHRPKLDDIGETHVLHPQDKSPFWNFGHVHPGEIVPTLYNNMYR

APVYLHKMPETDFLIIRTRQ------GYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAF-PSHSESSI
||.. ||...||||.||...       ||.|.  ..|.|||..|..|||||.||.........|....|||||..|....||...||.|.| | ..|...
APIFKHKPEPTDFLCIRSTTPGGHGQKYYLRNIDHMFCVGQTFPVMEVPGPHSRKVTNMSKNRLKMIVYRLFWGQKSPRHRISIHDITKHFFPDQNEMQN

RKRLKLCADFKRTG-MD-SNWWVLKSDFRLPTE-EEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAP-----EEENEEDF---QMKIDDEVHAAP
|.||| .....|.| || ..||.||....||.| ||||. ..||.||.|.||....|.|.||||.....|..      |...|..   |||||.|.. ||
RQRLKEFMKYQRDGGMDNQGWWKLKEGETLPDEFEEIRKMITPEDCCLYESMQVGQQHLEDAGYNNTDEFKRDYQQIQEDDDEETKKVQMKIDLEQMMAP

WNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKI-PNKPTQQKDDKEPQA-VKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV
|||||.|| |..||..|.. |..||||||||||.... ..|.. .| ...||. .||.|.||.|..|.....|..|..|..|||||||.....|.....
WNTTRNFINATQGKAMLQLHGEGDPTGCGEGFSFIRTKSMKGGFLKQGEGPQDKPKKAVAGTRAKERGGHSYNVAQQQRLYGVPEEEIRRIWYWQKRSL
DUF3591 TAF1L.AA DUF3591 1074-1096 38 6.463577 0.29 Pfam 469-494 (494) Show / Hide 
Range on Protein: 1074-1096
Range on HMM: 469-494/494
Sequence Identity: 38% (10 aa)

VAEHQERY---KEECQRIFDLQNKVL
||. |. |    ||  || . | . |
VAQQQRLYGVPEEEIRRIWYWQKRSL
BROMO TAF1L.AA BROMO 1397-1505 26 2.4e-34 121.37 SMART 1-118 (118) Show / Hide 
Range on Protein: 1397-1505
Range on HMM: 1-118/118
Sequence Identity: 26% (32 aa)

RTDPMVTLSSILESIINDMRDL--------PNTHPFHTPVNAKV--VKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLT
. . .  ....|..... ..|         | . ||. ||..|   . |||.||..||||.| ....... | |.||| . ..|...|  |||.| ..  
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

QISQSMLDLCDEKLKEKED
. .. . ... ||..| ..
KMAKKLQKFFEEKWREFPP
Bromodomain TAF1L.AA Bromodomain 1408-1491 30 3.3e-24 81.26 Pfam 1-89 (89) Show / Hide 
Range on Protein: 1408-1491
Range on HMM: 1-89/89
Sequence Identity: 30% (27 aa)

LESIIN--DMRDLPNTHPFHTPV--NAKVVKDYYKIITRPMDLQTLRENVRKCLYP-SREEFREHLELIVKNSATYNGPKHSLTQISQS
.. |..  .. . |...||. ||  . ... |||.||..||||.| .....   |  . .||....||. .|. |||||.. . .... 
CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK
BROMO TAF1L.AA BROMO 1519-1628 33 7.2e-41 143.01 SMART 1-118 (118) Show / Hide 
Range on Protein: 1519-1628
Range on HMM: 1-118/118
Sequence Identity: 33% (40 aa)

DDDDQVAFSFILDNIVTQKMMA-------VPDSWPFHHPVNKKF--VPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYT
| . |  ....|. .. .|.         .|..|||..||..|   .||||..| ||.||.||.|.. .|.|||.|.|.||..|.. |  .||.|.|.. 
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQYQSMEEFVDDFMLMFNNCMTYNEPDSEVY

KTAQEIVNICYQTITEYDE
| |... . . ....|. .
KMAKKLQKFFEEKWREFPP
Bromodomain TAF1L.AA Bromodomain 1530-1614 35 4e-29 97.38 Pfam 1-89 (89) Show / Hide 
Range on Protein: 1530-1614
Range on HMM: 1-89/89
Sequence Identity: 35% (32 aa)

LDNIVT-QKMMAVPDSWPFHHPV--NKKFVPDYYKMIVNPVDLETIRKNISKHKYQ-SRESFLDDVNLILANSVKYNGPESQYTKTAQE
.|.|.. ...|  |...||.|||  ... .||||..| .|.||.||....  .||. . . |. |..|.. |...||||.|.. | |..
CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKLKNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK