Gene SRPK2 (Human)

SRPK2

Species: Human
Alias: SFRSK2, FLJ36101, SRPK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 7q22.3,

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK2.NA RNA Sugen Kinome 3671 None Fasta, JSON
SRPK2.AA Protein Sugen Kinome 699 None Fasta, JSON
SRPK2.kin_dom Protein Kinase Domain Sugen Kinome 606 None Fasta, JSON

Protein domain

Protein domains of SRPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK2.AA SRPK 92-697 50 0.0 1185.56 In-house 1-554 (554) Show / Hide 
Range on Protein: 92-697
Range on HMM: 1-554/554
Sequence Identity: 50% (321 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPS---------------------DPNKDMVVQLIDDFKISGMNG
||||||||||||||||||||||..|.||||.||||.||||||.||||||.|||..||.                     |||...||||.|.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQ--
 |.|||||||||.|||||...||||.|..|||.|.||||.||||||.||.||||||||||.|.||...|..|||||.|||||.|...||.|.|.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

-QKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEK
 |....|.|||||||.|||||.|.|..||..|.....|......                         ...  |.. .....|.| ..|...|.|..||
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN-------------------------EDNNQEDNDNEQDNKNNQNQENNMENEQEEK

ENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTS
|| .|........ ...|....|..........                             ||.| ... .|..||......|..||  .......||.
ENTNKQKKNQKKKEQHKDKKEQECQNVQKQNND-----------------------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTK

LFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNAD---KIRVKIADLGNACWVHKHFTEDIQTRQYRSI
..... .. ..|.. || |..........                      |...||....|||||   ||..||||||||||||.|||||||||||||.
QQNKQ-DQQKEGQKQSEESECESEDMQEQ----------------------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSP

EVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPH
||.|||||.|||||||||||||||||||||||||||||||||.|||||||||.|.||.||||||||||||||..||||||.|||||.|..||.|||.|.|
EVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSH

EDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
|.|.||.|||.|||...|||||.|.|||.||||
EEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK2.AA CMGC 92-697 14 1e-127 422.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 92-697
Range on HMM: 1-513/513
Sequence Identity: 14% (117 aa)

YHVIRKLGWGHFSTVWLCWD--------------MQGKRFVAMKVVKSAQHYTE-------------TALDEIKLLKCVR----------ESDPSDPNKD
|..|.|.|.|....|. |.|              ......||.| .|... |.|             .||.|||.||...          . ||..... 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

MVVQLIDDFKISGMNGI-------------HVCMVFEVLGHHLLKWIIKSN--YQG------------------------LPVRCVKSIIRQVLQGLD--
 .|.|.| |. ....|              |...||| ..| |.. | . .  |||                        ... ... ...|.|.||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHSKCK-IIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKI
|.||... |||.|.||||||.. .  ...|| .    | |      .                                                     
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------

IEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDE
                                                                                                    
----------------------------------------------------------------------------------------------------

DDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL
                                                                                                    
----------------------------------------------------------------------------------------------------

PKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH------------------------FTEDIQTRQYRSIEVLIGAG----------YSTPADI
        | . ||.    ... |.||.| |.|.|.|.|                        .|....|| ||. |.|.|..          |.|| |.
--------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDM

WSTACMAFELATG--------DYLFEPHSGE-----DYSRDEDHIAHIIELLGSIPRHFALSGK-------YSREFFNRRGELRHITKLK----------
|| .|. .|. ||        ..|| .||..     ..... |....|...||... ... .||       ...|..|. . .......|          
WSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNH

---------------PWSLFDVLVEKYGWPHE--------------------------------DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
               ||  .  . ... | ..                                .  |. |.|  ||.. |.|| .| ..|.||..
WSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK2.AA S_TKc 92-697 12 1e-46 162.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 92-697
Range on HMM: 1-231/231
Sequence Identity: 12% (76 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH---HLLKWI
|...||.| | |..|..|..   .| ||.|..|      |... ||..||          . . .|.|.| |        |..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV------RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKN
 | ...|    .|   ......|....|.|.||. .||| |.||||||..     .      |..                                   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-----------------------------------

KKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVD
                                                                                                    
----------------------------------------------------------------------------------------------------

QELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVAC
                                                                                                    
----------------------------------------------------------------------------------------------------

GSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST-PAD
                                                                          |  . |. |.. |||   ||.. ..|
--------------------------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCD

IWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPM
.||  |. .|...|  .|.         ... . ..|                                                      .. ||.  .
WWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKC

LEMVPEKRASAGECLR-------HPWL
|.. |||| .| |.|.       |||.
LQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK2.AA CLK 92-234 30 3.6e-37 108.46 In-house 1-148 (350) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-148/350
Sequence Identity: 30% (48 aa)

YHVIRKLGWGHFSTVWLCWDMQG-KRFVAMKVVKSAQHYTETALDEIK-LLKCVRES-DPSDPNKDM--VVQLIDDFKI-SGMNGIHVCMVFEVLGHHLL
| .. .|| | |..|  |||..  |..|| |.....  |.| |  ||.  .| . |  ||   || .  .....| |.   |    |.|.||| .|  . 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPN--NKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIY

KWIIKSN------YQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
  . . |      |...| . .... .| .. .  || . |..||| |||||. .
DFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFV
Kinase SRPK2.AA DYRK 92-234 30 1.6e-32 114.36 In-house 1-138 (320) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-138/320
Sequence Identity: 30% (44 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| ..  .| | |. |  ||| ...  ||.|.... . .  .|..|||.|.. ..    . .|  .|.. | |.  .    |.|.||| |   |   . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYQGL-PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
. ||. ... |.....|.|..|..||.. .||| |.|||||...
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase SRPK2.AA DYRK2 92-232 34 9.5e-26 80.43 In-house 1-134 (318) Show / Hide 
Range on Protein: 92-232
Range on HMM: 1-134/318
Sequence Identity: 34% (48 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| .   .| | |  |  | |   | .|| |..   . . ..|. ||. |.  |. |.   |   .| . | |   .    |.|..|| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL
..||. .. |   ....||.|. || | .||| | ||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENIL
Kinase SRPK2.AA HIPK 92-236 31 2.3e-24 73.23 In-house 1-136 (329) Show / Hide 
Range on Protein: 92-236
Range on HMM: 1-136/329
Sequence Identity: 31% (45 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| |.  || | |  |  ||    .  ||.|. |    |      |...|.|... .. . .   .|   . |.    .  |.|.|||.|   |  .  . 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYH---FVRAYECFH----HKNHTCLVFEMLEQNLYDFQKQN

NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVD
..  ||.. .. |. |||  |  | .   .|| |.||||| | ||
KFMPLPLKHIRPILQQVLTALMKLKELG-LIHADLKPENI-MLVD
Kinase SRPK2.AA DYRK 530-697 26 2.2e-23 83.99 In-house 138-320 (320) Show / Hide 
Range on Protein: 530-697
Range on HMM: 138-320/320
Sequence Identity: 26% (50 aa)

RNA-DKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG
... .| ..|..| | .| .|....  || | ||. ||..|  |... |.||  |   || ||  ||   .||..    | .| |.|.|| .|...  .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--KYSREFFNR------------RG------ELRHITKLKPWSLFDVLVE--KYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
  .. ..||..            .       ... . ...  .      .  ...    |  ||.||.  .|.  |.|| .. . |.|||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK2.AA CDC2 92-232 33 5e-22 64.02 In-house 1-135 (301) Show / Hide 
Range on Protein: 92-232
Range on HMM: 1-135/301
Sequence Identity: 33% (50 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE-----TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLK
|  |.|.| | .  |  | ||| .. ||.| ..  |   .     ||. || .||  ..    .||   .|.| | ...       . |||| | ..| |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKD----HPN---IVKLHDVIHQ-----NKLYMVFEYLDMDLKK

WIIKSNY--QGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL
   .|.   . .|.  |||.. | |||....|.. .|.| |.|| |||
YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNIL
Kinase SRPK2.AA Pkinase 92-233 30 1.5e-20 73.7 Pfam 1-141 (293) Show / Hide 
Range on Protein: 92-233
Range on HMM: 1-141/293
Sequence Identity: 30% (47 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALD------EIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH---
||..||.| | |..|..| .    . ||.|..|   |  .  .       ||...| ..      ||   .|.|.| |      . |..||.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN-----HPN---IVRLYDWFED----KDHIYMVMEYCEGGLY

--HLLKWIIKSNYQGL--PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM
   |  .|  ... ..  . . .|....|.|.||.|.|| ..||| |.||||||.
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI
Kinase SRPK2.AA DYRK1 92-234 29 5.9e-20 66.36 In-house 1-138 (321) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-138/321
Sequence Identity: 29% (43 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| ..  .| | |  |   .| | . .||.|..|  . . . |. ||.||  . . |.   .|  .|.|   |    |   |.|.|||.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE--MKYYIVHLKRHF----MFRNHLCLVFELLSYNLYDLLRNT

NYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC
...|  .  .. . .|... | .. .   .||| |.||||||.|
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase SRPK2.AA CLK 537-641 30 8.4e-19 52.33 In-house 186-291 (350) Show / Hide 
Range on Protein: 537-641
Range on HMM: 186-291/350
Sequence Identity: 30% (34 aa)

VKIADLGNAC---WVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLG-SIPRHFALSG---K
... | |.|      | | .. ..||.||  ||  | |.|.| |.|| .|  ||| ||. ||  |.        .| | . ...|  || . . .    |
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFK

YSREFFNRRGEL
 ....|......
VKQKYFYHNRLD
Kinase SRPK2.AA YAK 92-234 31 7.6e-18 56.84 In-house 1-140 (347) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-140/347
Sequence Identity: 31% (46 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCV-RESDPSDPN-KDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWII
| |   || | |  |  |     .  .| ||.|. | |   |  ||..|.      || . | .  .. ..| |        | |.||| |   |   . 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFF----VHKNHFCLVFEMLSNNLYEYLK

KSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
  .. |. .  ..    |.| |.  | .| .||| | |||||. |
QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIMLC
Kinase SRPK2.AA DYRK2 537-639 33 9.2e-17 50.72 In-house 143-245 (318) Show / Hide 
Range on Protein: 537-639
Range on HMM: 143-245/318
Sequence Identity: 33% (36 aa)

VKIADLGNACWVHK-HFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG-----KY
.|..| |  | .|  ..  .||.| ||. || .|  |... |.||  | . || ||  ||    ||..    | .| ..|.||  |..|         ..
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGMPPKKFFDTWFYIHCFR

SREFFNRRG
 . |||...
RKYFFNSHC
Kinase SRPK2.AA Pkinase 536-697 22 1.1e-16 60.05 Pfam 150-293 (293) Show / Hide 
Range on Protein: 536-697
Range on HMM: 150-293/293
Sequence Identity: 22% (38 aa)

RVKIADLGNAC---WVHKHFTEDIQ-TRQYRSIEVLI-GAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKY
.|||.| | |.   . ... . ..  |. |.. ||.  | .|....|.||  |. .|...|  .|  ... .  .  |... | . .| ...        
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

SREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
 . || .|    |                    |.    . ||.  .|.. |.|| .| ..| |||.
ISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK2.AA DYRK1 530-637 34 8.1e-16 51.58 In-house 138-239 (321) Show / Hide 
Range on Protein: 530-637
Range on HMM: 138-239/321
Sequence Identity: 34% (37 aa)

RNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGK
.|. .  .|| | | .| . .   . || | ||| |||.|  |..  |.||  |.  |. ||. ||   ||   | . | . .|.| ||  |.|.  .. 
CNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLGMPPKHMIDQAP

YSREFFNR
 .. .|..
KAHKYFEK
Kinase SRPK2.AA DyrkP 534-595 45 1.1e-15 47.45 In-house 144-205 (323) Show / Hide 
Range on Protein: 534-595
Range on HMM: 144-205/323
Sequence Identity: 45% (28 aa)

KIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLF
| .||| | | .|..| |    .| | ||  ||.||  |    |.||  |.  || ||  ||
KCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase SRPK2.AA DyrkP 92-141 34 3.8e-09 25.55 In-house 1-50 (323) Show / Hide 
Range on Protein: 92-141
Range on HMM: 1-50/323
Sequence Identity: 34% (17 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLK
| ..  ||   ||    | | |  . . ||..   . | . ..||||||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase SRPK2.AA YAK 530-588 37 1.4e-08 24.83 In-house 140-198 (347) Show / Hide 
Range on Protein: 530-588
Range on HMM: 140-198/347
Sequence Identity: 37% (22 aa)

RNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFEL
.. .|  .|| | | .|   |  .  || | ||| |....  |.|  | ||  |   ||
CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase SRPK2.AA DyrkP 204-233 60 2.8e-08 22.64 In-house 111-139 (323) Show / Hide 
Range on Protein: 204-233
Range on HMM: 111-139/323
Sequence Identity: 60% (18 aa)

IIRQVLQGLDYLHSKCKIIHTDIKPENILM
|  |.| .|||.||  ..|| |.|||||||
ITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase SRPK2.AA CLK 664-697 32 3.6e-07 16.79 In-house 317-350 (350) Show / Hide 
Range on Protein: 664-697
Range on HMM: 317-350/350
Sequence Identity: 32% (11 aa)

HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
.... |. | .  |||  | || .... | ||. 
DPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase SRPK2.AA CDC2 672-697 50 7.8e-07 16.48 In-house 276-301 (301) Show / Hide 
Range on Protein: 672-697
Range on HMM: 276-301/301
Sequence Identity: 50% (13 aa)

DFLIPMLEMVPEKRASAGECLRHPWL
| |  ||   |.|| || | |.||..
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase SRPK2.AA CDC2 549-595 35 2e-06 15.53 In-house 157-209 (301) Show / Hide 
Range on Protein: 549-595
Range on HMM: 157-209/301
Sequence Identity: 35% (19 aa)

HKHFT--EDIQTRQYRSIEVLIGAG-YSTPADIWSTACMAFEL---ATGDYLF
..  |   .. |. ||. |.| |.  |||| |.||  |   |.   .|  .||
IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLF
Kinase SRPK2.AA TyrKc 92-308 16 1.4e-05 -132.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 92-308
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

YHVIRKLGWGHFSTVWLC-WDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCV--RESDPSDPNKDMVVQLIDDFKISG---MNGIHVCMVFEVLGHHLL
 . ..||| |.| .|... |.    . || |..|.     |  ..|..... .  .      ||   .|.|.     .|   |    ...|.|   |  |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGH-----HPN---IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

KWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD------------------------AYV------RR-------MAAEAT
|  ....   |...   |.  |. .| .||||| ..|| |.   |.|   .                          |.      ..       || |. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EWQKA---------------------GAPPPSG-----SAVSTAPQQKPIGKISKNKKKKLKK-----KQKRQAELLEKRLQE-------IEELEREA
  ..                      |..|..|        . . ..   |.  .  .  .         .   .. ..  .|        .|. .. 
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRPK2.AA DYRK2 670-697 35 1.6e-05 13.53 In-house 291-318 (318) Show / Hide 
Range on Protein: 670-697
Range on HMM: 291-318/318
Sequence Identity: 35% (10 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
|.||.   .|  |..| .. . |.|||.
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK2.AA DyrkP 670-697 39 4.6e-05 11.87 In-house 296-323 (323) Show / Hide 
Range on Protein: 670-697
Range on HMM: 296-323/323
Sequence Identity: 39% (11 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
| ||   .| .   .| .| | |.|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SRPK2.AA HIPK 536-588 37 9e-05 10.42 In-house 143-196 (329) Show / Hide 
Range on Protein: 536-588
Range on HMM: 143-196/329
Sequence Identity: 37% (20 aa)

RVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWSTACMAFEL
|||. | | |  | |  ..  .| | ||  |...|  .    |.||  |   ||
RVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAEL
Kinase SRPK2.AA DYRK1 661-697 29 0.000272 10.42 In-house 285-321 (321) Show / Hide 
Range on Protein: 661-697
Range on HMM: 285-321/321
Sequence Identity: 29% (11 aa)

GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
|   ||  .| | .  ||.  |..| .  . |.|...
GHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase SRPK2.AA YAK 670-697 28 0.001321 7.68 In-house 320-347 (347) Show / Hide 
Range on Protein: 670-697
Range on HMM: 320-347/347
Sequence Identity: 28% (8 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
|.||.  .|.  | .| ..     || .
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase SRPK2.AA HIPK 666-697 31 0.024167 2.63 In-house 298-329 (329) Show / Hide 
Range on Protein: 666-697
Range on HMM: 298-329/329
Sequence Identity: 31% (10 aa)

DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
|  .| . |  |. . ..|| .  | |.||. 
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV