Gene SMG1 (Human)

SMG1

Species: Human
Alias: KIAA0421, LIP, 61E3.4, SMG1, ATX
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 16p12-p13,

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
SMG1.NA RNA Sugen Kinome 15353 None Fasta, JSON
SMG1.AA Protein Sugen Kinome 3661 None Fasta, JSON
SMG1.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT SMG1.AA HEAT 760-790 22 67.878978 0.03 Pfam 1-31 (31) Show / Hide 
Range on Protein: 760-790
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

FCKGLLANTLVEDVNICLQACSSLHALSSSL
..  ||     .| .. ..||..| .|.. .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FATC SMG1.AA FATC 1467-1477 45 5.137683 3.05 Pfam 1-11 (33) Show / Hide 
Range on Protein: 1467-1477
Range on HMM: 1-11/33
Sequence Identity: 45% (5 aa)

KKLSTQGQVDE
..||...|||.
EPLSVEQQVDR
HEAT SMG1.AA HEAT 1822-1852 32 2.6e-05 22.26 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1822-1852
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

IIPQLFSRLNHPEVYVRQSICNLLCRVAQDS
|.| |.. ||.|.  ||.. |. |..... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase SMG1.AA SMG1 2128-2369 98 6.6e-230 769.19 In-house 1-242 (242) Show / Hide 
Range on Protein: 2128-2369
Range on HMM: 1-242/242
Sequence Identity: 98% (238 aa)

ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA

LQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV

GYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPE
||||||||||||||||||||||||||||..||||||.|.|||
GYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase SMG1.AA PIKK 2120-2417 43 7.2e-166 557.33 In-house 1-290 (290) Show / Hide 
Range on Protein: 2120-2417
Range on HMM: 1-290/290
Sequence Identity: 43% (130 aa)

TIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK
 | .    .|....|.||||....|.|||.||||.||.|||..|.|.||.....||.............|.|.|||.|...|.|||.|||....|...||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

RWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYAR
.|.|.......|.||..|||..........|         ..|..... ......||||....|..|.|..|||....|..|.....|..||.....|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS---------YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTR

STAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE-KGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAF
|.|||.|||||.||||||..|..|||.|||.||||...||| ... |.||||||||.|.|...|.|..||||||| .||.|...||..||||.|..|.|
SYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase SMG1.AA PI3_PI4_kinase 2149-2427 21 2.3e-68 238.2 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2149-2427
Range on HMM: 1-300/300
Sequence Identity: 21% (75 aa)

SYPYLFKGLEDLH--LDERIMQFLSIVN-------------------TMFATINRQETPRFH----ARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW--
 ||..||| .||.   |.|.||.....                    ... .. ...   .     ...|.. |.|...|.|.||. .|.. .. . .  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

---------------QQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTT
               ... .....                                              .  .. | |. .  ||.. | ...|.. ..
KCKHKHFNKEHKMWMKMWPDWWHLM---------------------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPD

P-DEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLI--DMTTGEVVHIDYNVCFE--KGKSLRVPEKVPFRMTQ------NIETAL------GVTGVE
. .|||.. . ..|| |.|..|.||.|.||||.|| ..  |.|||...|||.. ||.  |.| . .||.|||| |.      ..  |.      ...| .
AYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDY

GVFRLSCEQVLHIMRRGRETLLTLL-------EAFVYDPLVDWTA
| || .|.... ..||  . ...||       |..|.|.|..|. 
GWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase SMG1.AA PI3Kc 2151-2482 22 6.3e-52 179.74 SMART 1-336 (336) Show / Hide 
Range on Protein: 2151-2482
Range on HMM: 1-336/336
Sequence Identity: 22% (80 aa)

PYLFKGLEDLHLDERIMQFLSIVNTMFATI----NRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK---RWQQREAALQAQKAQDSYQTPQNP
. .||. .||. |.|.||.....|.. ..     .|     .|.| |.. |.| ..|.|.||  ...|  . |    |.  . ...  .  |   .|.  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRR----DLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ

GIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPD-EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVL
    ..  .  .. .  ...    .. ..       .... |.   ...|. |.. .|. ...|. .|| .   ..||.|...||.|| |.||||.|| .
-K-NMY-MMIWHQQACHWMMMYQHMTHME-------WLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIM

IDMTTGEVVHIDYNVCFEKGKSLRVP-----EKVPFRMTQNIETALG----VTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPL-VDWTAGGEAG
.||.||...|||.. .|..|... ..     |.|||| |... .. |    ..|..| ||  |.... .||. ......|.|..||||.  .|...    
LDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----

FAGAVYGGGGQQAESK-QSKREMEREITR----SLFSSRVAEI--KVNWFKNRDEML
  .      .|. .   .|..|  . ...     | .. ...   ...|. ..  ..
--EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase SMG1.AA ATM 2307-2426 54 1.5e-50 159.52 In-house 130-249 (304) Show / Hide 
Range on Protein: 2307-2426
Range on HMM: 130-249/304
Sequence Identity: 54% (65 aa)

PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRG
|  |.     | || |  |.||||.||||||  |.||     |.||||  | ||.|| |  || ||||.|  |   .|.||||||||  ||. . .||  
PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNS

RETLLTLLEAFVYDPLVDWT
 |||||. |  .|||| |||
QETLLTIVEVLLYDPLFDWT
Kinase SMG1.AA ATR 2307-2417 46 3.7e-48 161.98 In-house 157-267 (267) Show / Hide 
Range on Protein: 2307-2417
Range on HMM: 157-267/267
Sequence Identity: 46% (52 aa)

PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRG
| .|.   . | ||.||..|||||||||||| ||.|||  .||.||.|||. | .|. . ||| ||||.|.|.. ..|  . .|.||  || .. .||  
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDH

RETLLTLLEAF
|. .. ....|
RDDIMSVWDCF
Kinase SMG1.AA FRAP 2283-2427 41 4.9e-42 145.97 In-house 106-251 (251) Show / Hide 
Range on Protein: 2283-2427
Range on HMM: 106-251/251
Sequence Identity: 41% (60 aa)

VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG-KSLRVPEKVPFRMTQNIET
. .  |. |  . |.| ||      . |      | || |.|||.|||.||||||. |....  || .||||.  |||   .  . |||.|||.|  .  
IFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVN

ALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTA
|. ..|.|| .|  || |. ..|  .| ..  |||||||||  |  
AMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase SMG1.AA DNAPK 2317-2427 29 1.4e-21 75.14 In-house 190-301 (301) Show / Hide 
Range on Protein: 2317-2427
Range on HMM: 190-301/301
Sequence Identity: 29% (33 aa)

YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE-KGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLE
..|. ||    ..| | |||||.| .. | .|... ||.   |   .  | |||  |||.|      .   .. |... .    .  .|. |  |.   .
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

AFVYDPLVDWTA
 |. ||..||  
VFINDPSFDWKN
Kinase SMG1.AA ATR 2119-2209 32 1e-13 42.66 In-house 1-91 (267) Show / Hide 
Range on Protein: 2119-2209
Range on HMM: 1-91/267
Sequence Identity: 32% (30 aa)

VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
  |      . || .  ||||. . ||||| |  . |  .||  | | |.| ...| .     ..    .| | |.| ||  ....| ||.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVN
Kinase SMG1.AA FRAP 2150-2208 35 6e-13 44.02 In-house 2-60 (251) Show / Hide 
Range on Protein: 2150-2208
Range on HMM: 2-60/251
Sequence Identity: 35% (21 aa)

YPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
| .| || ||.  |||.||   ..|.. .     .      . ||. || ...||| ||
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWV
Kinase SMG1.AA DNAPK 2119-2209 31 1.4e-11 38.18 In-house 2-92 (301) Show / Hide 
Range on Protein: 2119-2209
Range on HMM: 2-92/301
Sequence Identity: 31% (29 aa)

VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
| |      .|..    .||...  | | .  |...|| ||| .| || |   . |  |.            | |.. |.  | ||| |||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase SMG1.AA ATM 2152-2213 30 0.000463 8.42 In-house 2-63 (304) Show / Hide 
Range on Protein: 2152-2213
Range on HMM: 2-63/304
Sequence Identity: 30% (19 aa)

YLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATP
 | || .||  |  . |   . ||.          .     | | ||  ||| . |  |  |
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIP
FATC SMG1.AA FATC 3629-3661 48 1.4e-15 52.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3629-3661
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

RRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV
  .|| .|||  |.|||. .||.|.| || .|.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW