Gene SIK (Human)

SIK

Species: Human
Alias: SIK, SNF1LK, MSK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 21q22.3,

Classification

Group: CAMK
Family: CAMKL
Subfamily: QIK

Sequence

Name Sequence Type Origin Length Description Download
SIK.NA RNA Sugen Kinome 4706 None Fasta, JSON
SIK.AA Protein Sugen Kinome 783 None Fasta, JSON
SIK.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of SIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SIK.AA QIK 27-278 70 6.2e-206 690.42 In-house 1-272 (272) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-272/272
Sequence Identity: 70% (191 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH------
||||||.||||||||||||||.|||.||||||||..||..||.|.|||||.||.|.|||||||||||||.||.|||||...||||||||...|.      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLD
              ..|||||..||||.|||.|||...|||||||.||.||| ||.||.|||||.|..|.|..|.||||||||||||.||||||.||..|
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
|||.||||||||||.|||||..|..||||||.|.||||||||||||.|||.||||||..|.||.||.|||||
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase SIK.AA CAMKL 27-278 46 2.3e-164 528.56 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-297/297
Sequence Identity: 46% (138 aa)

YDIERTLGKGNFAVVKLARH-RVTKTQVAIKIID--KTRLDSSNLEK-----------IYREVQLMKLLN---HPHIIKLYQVMETKDM------LYIVT
|.|..|||||.|..||||.| | |...|||||||  |...|  .. .           |.||.|.||.||   ||.|||||.|.||...      .|.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFAKNGE--MFDYLTSNGH----LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMD--IKLADFGFGNFYKS-----GEPLSTWCGSPPYA
| . .||  .|||. ..||    ..|.|||. |.||.|||.|||.|.|||||.| ||.||| |..  ||..||||.|.|.      |. |.|.||||||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVFEG--KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLP---------TLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
|||.|.|  |.|.||. ||||.||.||..||| ||||.....          ...... ....|....| ||..|||.||.|.| .|.|| ||..|.||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase SIK.AA AMPK 27-278 51 2.9e-151 452.3 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 51% (132 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPHIIKLYQVM-ETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| |. |.|.| |  ||.. |  |...|||||..|... |..  |.| ||....||..|||||.||.|  ||.. ...|.|.. .|| ||| ...| |.| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF
||.. | ||.|.|||||.| ||||||| |||||| |. ||..|||  | .| || |.| |||| |||||. .|| |.||. |||| ||.||...|| |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
| .| ||| .....|.. || |.|.....||..|| |||  |||| .||.| | 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase SIK.AA MARK 27-278 47 4.1e-149 490.43 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-262/262
Sequence Identity: 47% (124 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDS-SNLEKIYREVQLMKLLNHPHIIKLYQVME--TKDM-LYIVTEFAKNGEMFDYLTSN--GH
| . .|.|.|..|.||||.|. |...|||||..|..|.   ......||...||.|.||.||||..|.|  |.   .|.. | | .||..||. .   |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNM--DIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV
|.|.|||. | ||.|||.|||...|||||.| ||.|.| |.  .||..||||..  ..|. |.| ||.|||.|||.|..|.|.||  ||||||||||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

CGSLPFDGPN--LPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
||..|||| .  . .|....| |...||...| .|..||.|.|.|.| .|.|| .| .|.||
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase SIK.AA CAMK 32-278 29 9.20000000001e-142 459.96 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-278
Range on HMM: 1-425/425
Sequence Identity: 29% (126 aa)

TLGKGNFAVVKLARHRVTK------------TQVAIKIIDKTRLD--------------------------SSNLEKIYREVQLMKL-------LNHPHI
|||.|.|..|||..|. |.            ..||||||||..|.                           .......||...||.       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYQVME------------TKDM--------LYIVT---EFAKNGEM----FDYLTSNGH---------------LSENEARKKFWQILSAVEYCHDHH
||||.|.|            | ..        .|.|.   |.. .||.    |||....|.               ..| |||. |.||.|||.|||.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKTENLLLDGNM-----------------DIKLADFGFGNFYKS------------------------GEPLSTWCGSPPYAA-PEVFEG-----
||||||| ||.||| |.                 .||..|||| |....                        |....|.||.|.|.| |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KEYEGPQLDIWSLGVVLYVLVCGSLPFDGP-------------NLPTLRQRVLEGRFR-IPFFMS-----------------------QDCE
        |.| ||. |.||.||.||...|| .||.|.             |.. | .....|... .|...|                       |.| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLIRRMLVVDPARRITIAQIRQHRWM
.|||.||.||| .|.||.|. .| ||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SIK.AA NuaK 27-278 48 5.3e-135 357.56 In-house 1-252 (252) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-252/252
Sequence Identity: 48% (123 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENE
|....||||| .  ||||. . |  .|||| | | .  |   . .| ||...|  |||||||. | | | || . || |.|  ||..||. . . |.|.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFD
||. | || ||| ||| | |.||||| || ||| | ..| ||||  |.|. .. | | |||| || ||. .|. |.||  | |||||.||..| |..|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
| .  .| . . .|... |   |. |. ||| || |.| || || .| .| |.
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase SIK.AA NIM1 27-278 41 6.9e-109 321.0 In-house 1-258 (258) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-258/258
Sequence Identity: 41% (106 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIID--KTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| .   .| |||  |||. |  ||  |||||.|  || .|   .    ||.| |  ..|| |..|| | ||   .. |.|.|  || . . .  | |.| 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKS----GEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCG
..   | ||.|||   |   |||||.| || ..  |  .|..||||    |     .. | | |||||||||| |    | |.  |.| ||. ||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

SLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
  ||  .  | .   .|.| . || . |  |  |||.||  .|. | || |. .| ||
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase SIK.AA BRSK 27-278 49 1.8e-107 363.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 49% (126 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLD--SSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| .|.|||||    |||  | ||   |||||| | .|    | | |. ||. .||| .|||..|.| | |.|  || . |.   ||.||||   | |   
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF
|||| | || ||...|| | | ||||| ||||||.   || |||| .     .  | | |||| || |||  | .| | . |.|| ||.|| |  | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
|  ||  |  .|  | | .| |  .|| .| | |. |||..||....|..| | 
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase SIK.AA S_TKc 27-278 36 1.7e-105 357.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKN--GEMFDYLTSNGH----
|.| |..||| |..|...||. |. .||||||.         |.|.||.|..|  .||.|.||| |... | ||.|.|.. .  |..|||. ..|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV
  ..| .||. ..||..|.||||.|.|.||||| ||.|||    ||..|||.  ..      .| ||.| | ||||.    | ..  |.||.|..|| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQ-------HRWM
||  ||.  .. .. ....          |... ..||..|..||..|.|. .. |       | |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SIK.AA TSSK 27-278 37 8.10000000001e-105 344.94 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-289/289
Sequence Identity: 37% (109 aa)

YDIERTLGKGNFAVVKLARHRVTKTQ----------------VAIKIIDKTRLDSSNLEK-IYREVQLMKL-LNHPHIIKLYQVMETKD-MLYIVTEFAK
|. ....|.|..| |..|... .|                  |||||||...  . .|.| . || | |.  |.||.||..|.  || . . |.| |.| 
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

NGEMFDYLTSN------GHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEP------LSTWCGSPPYAAPEVF
.| ...|   .      | |.| .||| |.|. |||.|||.|..|||||| ||.||| .  |||.||||..  ....|      ..| |||  |||||..
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

EGKEYEGPQLDIWSLGVVLYVLVCGSLPFDG--PNLPTLRQRVL--EGRFRI--PFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
 |..| . . |.||.||.||..|||..|||    |.... ...   .  |..    . ||.| .|||.||  .| .|..| .|  | ||
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase SIK.AA Pkinase 27-278 35 4.1e-103 353.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR--EVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNG----EMFDYLT--SN
| |.|..|.|.|..|....|. |  .||.|||.| . .|. ..   |  |.|.|| ||||.|..|| ..|.|| .|.|.|.. .|    . |||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHL--SENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDI----KLADFGFGNF--YKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSL
| .  ||.|... ..|||...||||.. |.||||| ||.|.| |..|    |..|||.  .  | ... ..| ||.|.|.||||  | .| ||  |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYVLVCGSLPFDGP------NLPTLRQRVLEGRFRIPFF---------------------MSQDCESLIRRMLVVDPARRITIAQIRQHRWM
|..|| ..|| .||.|       .   . .|....... ...                     .|..| ..|...| .||..|.|..|| || |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SIK.AA SNRK 27-278 45 4.7e-97 318.35 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 45% (115 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH-LSENE
||.|.|||.| |||||||||  |  .||.|.||||..|     ....||. |||  || |..|| |..|.  ||.. |    ..|.||.    . |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMD-IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPF
||| | ||. |..|||  |.|||||| || .    .  .|| |||| | .. || | | |||  |.|||.  | .|. | .|||||||.||.|||| .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM
.  |      .... .. .|  .|..|  || .||| || .| .. .|  | |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase SIK.AA Pkinase_Tyr 27-169 30 4.3e-28 95.77 Pfam 1-156 (270) Show / Hide 
Range on Protein: 27-169
Range on HMM: 1-156/270
Sequence Identity: 30% (48 aa)

YDIERTLGKGNFAVVKLARHR----VTKTQVAIKIIDKTRLDSSN--LEKIYREVQLMKLL-NHPHIIKLYQVME-TKDM--LYIVTEFAKNGEMFDYLT
  . ..||.|.| .|.... .     ||..||.|.. |   ....  .|.  ||...|| | .||.|..|| |    ..   .|||.|....| . ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----NGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFG
.    ...|.  .  .  ||| .. || ......|||| . | |.. |. .| .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase SIK.AA TyrKc 27-278 23 7.1e-21 76.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLL--NHPHIIKLYQVMETK-------DMLYIVTEFAKNGEMFDYLTS
   ...|| |.| .| ... .   .|||.| . .       .| ..|| ..|. |  .||.|..|| |  ..       . |.||.|....|   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NGH-LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSG-------EPLSTW---CGS--PPYA--APEVFEGKEYEG
... |.  .  .  ||| .  || |.....|||| . | |.. |  .| .|||   . ...       .  ..    .|    |.   |||..  ...  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-T

PQLDIWSLGVVLY-VLVCGSLPFDG-----PNLPTLRQRVLEG-RFRIPFF--------MSQDCESLIRRMLVVDPARRITIAQIRQHRWM
.. |.|| ||... ..  |  |  |      .   ....| .| | ..|          ....  .....    ||. | | ..|  |. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SIK.AA Pkinase_Tyr 206-244 26 2.442795 1.77 Pfam 196-236 (270) Show / Hide 
Range on Protein: 206-244
Range on HMM: 196-236/270
Sequence Identity: 26% (11 aa)

DIWSLGVVLYVLVC-GSLP-FDGPNLPTLRQRVLEGRFRIP
|.|| ||... ..  |  | . |     . ... | . | |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
UBA_CAMKL SIK.AA UBA_CAMKL 305-342 46 2.1e-14 49.74 In-house 1-41 (41) Show / Hide 
Range on Protein: 305-342
Range on HMM: 1-41/41
Sequence Identity: 46% (19 aa)

DEQALGIMQTL--GVDRQRTVESLQNSSY-NHFAAIYYLLL
||... .|...  |.||. ..|||.| .| ||  |.|||||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA SIK.AA UBA 305-342 23 0.000216 21.84 SMART 1-38 (38) Show / Hide 
Range on Protein: 305-342
Range on HMM: 1-38/38
Sequence Identity: 23% (9 aa)

DEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLL
.|...  .  .| ||.. |..|... .|  .|...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS