Gene Dusty (Human)
Dusty
Sequence
Protein domains of Dusty.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Dusty.AA | SgK496 | 652-915 | 89 | 1e-227 | 762.82 | In-house | 1-265 (265) | Show / Hide |
Range on Protein: 652-915 Range on HMM: 1-265/265 Sequence Identity: 89% (236 aa) PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGG-GSSIAVLLIMERLHRDLYTGLKAGLT |||.||.|||||||||.||||||||.||.|||||||.|||||||.|||||||.|||.|.||.||||||||||| |.||||||||||.||||||..||... PKLEQEIGRGQYGVVYSCDNWGGHFHCAVKSVVPPDDKHWNDLAMEFHYMRSIPKHDRIVDVHGSVIDYNYGGMGCSIAVLLIMERMHRDLYTAIKANME LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPE ||.||.||||||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||| LEERLHIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKHNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHIKLPE AFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCK ||||||||||||||||||.|||||||||||||||||||||||||||||||||||||..||.|||| AFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCK |
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| Kinase | Dusty.AA | TKL | 658-897 | 20 | 2.6e-39 | 136.91 | In-house | 1-355 (364) | Show / Hide |
Range on Protein: 658-897 Range on HMM: 1-355/364 Sequence Identity: 20% (74 aa) LGRGQYGVVYLC--DNWGGHF------PCALKSVVPPD-------------------------EKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYG .|.| .|.|| .||| . . | | . | .|. .|. | . .|. .| . |.... ..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG G------GSSIAVLLIMERL-HRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQG--------LVHRDIKLKNVLLDKQNR--------------AKIT . |.. ..|| . .|. | .. |...|||. |. .|||.. ..|||.| ||.|.|. .. .||. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC DLGFCK-------PEAMM---------------SGSIVGTPIHMAPELFT-----------------GKYDNSVDVYAFGILFWYICSGSVKLPEAFERC |.|... ...| .....||| .||||.. ..|. ..|||.|||..| |... . .. DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDY ASKDHL---------WNNVRRGARPERL------------PVFDEECWQLMEACWDGDPLKRP . ... . .. .| ||.. | .... .||. ||| || ||| PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP |
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| Kinase | Dusty.AA | S_TKc | 652-906 | 19 | 4.6e-39 | 137.0 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 652-906
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)
PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR---DLYTGLKAG
......|.| .|.||.| . . . .|.| . ... | ... .|. .| |... | . ..|| . ||.. .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKR
--------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDN-SVDVYAFGILFW
.. . .. ..... ..||.| .|||.| |.|||. . ||.| |... ...||| ||||.. .|. ..|....|....
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILY
YICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQ--------PML
..| | . ...... ..|...... |.. || ||| . | | .
EMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | Dusty.AA | Pkinase | 652-897 | 21 | 1.2e-38 | 137.72 | Pfam | 1-282 (293) | Show / Hide |
Range on Protein: 652-897
Range on HMM: 1-282/293
Sequence Identity: 21% (64 aa)
PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWND--LAL--EFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERL-HR----DLY
..|. .|.| .|.||.| . | |.| . ..||.| | ... | ..|..| .|. | |.... | . . ..|| . . ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLF
----TGLKAGL--TLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRA----KITDLGFC----KPEAMMSGSIVGTPIHMAPEL--FTGKYD
| . .. . .. ... ...|. ..||.| .|||.|. |.|.|... ||.| |.. ...||| ||||. . .|.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG
NSVDVYAFGILFWYICSGSVKLPEA--FERCASKDHLWNNVRRGARPERLPVFD--------------------EECWQLMEACWDGDPLKRP
.||....|..... ..| |.. .. ...... ...... .. | . ||| .... |.. || |||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
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| Kinase | Dusty.AA | TK | 652-906 | 15 | 7.2e-31 | 100.11 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 652-906
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)
PKLGQELGRGQYG---VVYLC-------------------------DNWGGHFPCALKSVV---PPDEKHWND--------------LALEFHYMRS-LP
.||..||.||.| .||.. . ||. |.| | . . ... | .|.| |.. |
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
KHERLVDLHG--------------------SVIDYNYGGGS---SIAVLLIMERLHRDLYTGLKAG----------------------------------
.|. .| |.| .. . .|. | | | .. . ...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LTLETRLQIALDVVEGIRFLHSQ------GLVHRDIKLKNVLLDKQNR-----------AKITDLGFCK
||....| ..... .| ..|||. ..||||. |.|....|. .||.| | ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-------PEAMMSGSIVGTPIH------------------------------MAPELFT----------GKYDNSVDVYAFGILFWYICS-GSVKLP--E
. .. . . . |||| .. ||. ||..||.| | |.. | . .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
AFERCASK---DHLWNNVRRG--------------ARPERLPVFD--------------EECWQLMEACWDGDPLKRPLLGIVQPML
..... . . ...||| |... | || .|| ||. || .|| .. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Dusty.AA | Dicty5 | 753-839 | 37 | 6.8e-27 | 89.59 | In-house | 105-194 (260) | Show / Hide |
Range on Protein: 753-839 Range on HMM: 105-194/260 Sequence Identity: 37% (34 aa) TRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-PEAMMSGSI-VGTPIHMAPELFTGK-YDNSVDVYAFGILFW ..| .|.|. ..|.||| . .|||.| |.|. . .|| | | .. . |||. ||.|||.|. |.. .|||.||| | QQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW |
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| Kinase | Dusty.AA | Ciliate-E2-Unclassified | 749-844 | 24 | 4.1e-26 | 87.57 | In-house | 135-266 (352) | Show / Hide |
Range on Protein: 749-844 Range on HMM: 135-266/352 Sequence Identity: 24% (33 aa) LTLETRL-----QIALDVVEGIRFLHSQG-LVHRDIKLKNVLLDKQN---RAKITDLGFCK-------------------PEAMMSGSIVGTPIHM---- .| . . ... ...|. .||... .|||||. |.|.|... . ||.|.|..| .. ||. ...|||. | FTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMW-TFCGTPNYMPQYT APELFTG-KYDNS----VDVYAFGILFWYICSG |||.. | .||.| .|....|... ... | APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG |
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| Kinase | Dusty.AA | ULK | 755-838 | 27 | 1.1e-24 | 83.11 | In-house | 133-246 (329) | Show / Hide |
Range on Protein: 755-838 Range on HMM: 133-246/329 Sequence Identity: 27% (31 aa) LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y .|. . ..| ..||... .|||||. |.|... ....||.| ||.| |. | . | |||. |||... |. | IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY DNS-VDVYAFGILF ... .|.. .|..| YDYKCDIWSLGCIF |
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| Kinase | Dusty.AA | ULK | 755-838 | 27 | 1.4e-24 | 84.14 | In-house | 129-242 (324) | Show / Hide |
Range on Protein: 755-838 Range on HMM: 129-242/324 Sequence Identity: 27% (31 aa) LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y .|. . ..| ..||... .|||||. | |. . ....||.| ||.| |..| ..| |||. |||... |. | IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY DNS-VDVYAFGILF ... .|.. .|..| YDYKCDIWSLGCIF |
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| Kinase | Dusty.AA | Ciliate-E2 | 761-844 | 23 | 2.5e-24 | 80.38 | In-house | 169-292 (365) | Show / Hide |
Range on Protein: 761-844
Range on HMM: 169-292/365
Sequence Identity: 23% (31 aa)
VVEGIRFLHSQG-LVHRDIKLKNVLLDKQNRAKITDLGFCK--------------PEAMMSGS---------------------IVGTPIHMAPELFTGK
.......|||.. .|||||. |.|. ||.|.|..| . .| . |.||| |||| . ||
IILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGK
----------YDNSVDVYAFGILFWYICSG
|| ..|....|... . ..|
KYDNQQKQKGYDYKCDIWSLGVILYEMLFG
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| Kinase | Dusty.AA | CAMK | 761-837 | 21 | 2.5e-23 | 71.39 | In-house | 188-323 (425) | Show / Hide |
Range on Protein: 761-837 Range on HMM: 188-323/425 Sequence Identity: 21% (29 aa) VVEGIRFLHSQGLVHRDIKLKNVLLDKQ-----------------NRAKITDLGFC--KPE------------------------AMMSGSIVGTPIHMA ........||.. ||||.|. |.|||. | ||.| || ... . .||| || ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA -PELFTGK---------------YDNSVDVYAFGIL ||.. || |. ..|. . |.. APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI |
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| Kinase | Dusty.AA | LISK-DD1 | 749-837 | 35 | 3.5e-23 | 80.81 | In-house | 120-220 (290) | Show / Hide |
Range on Protein: 749-837 Range on HMM: 120-220/290 Sequence Identity: 35% (37 aa) LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQ----NRAKITDLGFCKPEAMMSGS----------IVGTPIHMAPELFTG-KYDNSVDVYA .. . |. ||||. .. ..||| ...||| | || |.|. .|.|. |.|| . |.... |.||.. ||||. .| .|| |.||. IPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFAR---MFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFS FGIL ||.. FGMV |
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| Kinase | Dusty.AA | Pkinase_Tyr | 653-906 | 25 | 3e-21 | 72.57 | Pfam | 2-270 (270) | Show / Hide |
Range on Protein: 653-906 Range on HMM: 2-270/270 Sequence Identity: 25% (70 aa) KLGQELGRGQYGVVYLCDNW----GGHFPCALKSVVPP--DEKH--WNDLALEFHYMRSLPKHERLVDLHGSVI-DYNYGGGSSIAVLLIMERLHR-DLY ..|..||.|..|.||.. ... |.| |.. .. .... . |. | |..|..|. .| |.| .. . . ....|| ||. TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL TGLKAG------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPE-------AMMSGSIVGTPIH-MAPE-LFTGKYDN . |.. ||... ||..... .| .|.|....|||. .|.|....| .||.| | .. . .|. || |||| ...||. DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTT SVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNV-RRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML ||..||.| | |.. | ... . | . . . ..| | .. . .| .|| ||. || .|| .. .| KSDVWSFGVLMWEIFTYGE-QP-TYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Dusty.AA | TyrKc | 652-906 | 22 | 4.3e-18 | 67.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 652-906
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)
PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYGG-------GSSIAVLLIMERLHRDLYT
.||..||.|..|.||.. ..| |.. . |. | |..| ..|. .| |.| ... . . |. |. . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQ----QGRNFMYIEPLMIVMEYMPHGDLKDYL
GLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMM------SGSIV------GT---PIH-MAPELF-TGKY
. . |.... |...... .| ..|||....|||. |.|.......||.| | .. . .. | || |||| . .||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF
DNSVDVYAFGILFWYICSGSVKLPEA--FERCASKDHLWNNVRRGARPERLPV--------FDEECWQLMEACWDGDPLKRPLLGIVQPML
||..||.. | |.. . .. .. | ... ..|..| |... | .| |.|. ||. || .|| . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | Dusty.AA | CAMK | 657-669 | 61 | 4.6e-05 | 11.47 | In-house | 1-13 (425) | Show / Hide |
Range on Protein: 657-669 Range on HMM: 1-13/425 Sequence Identity: 61% (8 aa) ELGRGQYGVVYLC .||||..|.|.|| TLGRGSFGKVKLC |
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| Kinase | Dusty.AA | Ciliate-E2 | 652-672 | 38 | 0.000625 | 9.36 | In-house | 1-21 (365) | Show / Hide |
Range on Protein: 652-672 Range on HMM: 1-21/365 Sequence Identity: 38% (8 aa) PKLGQELGRGQYGVVYLCDNW |. . .|.|..|.||.| .| YKFIKKIGQGNFGSVYKCKVW |
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| Kinase | Dusty.AA | Ciliate-E2-Unclassified | 653-669 | 41 | 0.004134 | 6.66 | In-house | 2-18 (352) | Show / Hide |
Range on Protein: 653-669 Range on HMM: 2-18/352 Sequence Identity: 41% (7 aa) KLGQELGRGQYGVVYLC |... .|.|..|.||.| KIIKQIGQGGFGKVYKC |
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| Kinase | Dusty.AA | LISK-DD1 | 657-668 | 50 | 0.106894 | 2.21 | In-house | 1-12 (290) | Show / Hide |
Range on Protein: 657-668 Range on HMM: 1-12/290 Sequence Identity: 50% (6 aa) ELGRGQYGVVYL | |.| .| ||. EIGKGSFGKVYK |
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