Gene SgK396 (Human)

SgK396

Species: Human
Alias: STK31, TDRD8, SgK396, FLJ16102
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 7p15.3-p21,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
SgK396.NA RNA Sugen Kinome 3283 None Fasta, JSON
SgK396.AA Protein Sugen Kinome 1019 None Fasta, JSON
SgK396.kin_dom Protein Kinase Domain Sugen Kinome 240 None Fasta, JSON

Protein domain

Protein domains of SgK396.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TUDOR SgK396.AA TUDOR 28-147 28 9.2e-31 113.32 Pfam 1-128 (128) Show / Hide 
Range on Protein: 28-147
Range on HMM: 1-128/128
Sequence Identity: 28% (36 aa)

THYDKVEDVVGSHIEDAVTFWA--QSINRNKDIMKIGCSLSEVCPQASS--VLGNLDPNKIYGGLFSEDQCWYRCKV--LKIISVEKCLVRYIDYGNTEI
 ....  .|. .|||.. .||.  |..   ... |. ....|.. ..    .. .. | ...  .||.|.||||...  ..... ... |.||||||||.
IPEGEYMCVYVTHIESPCHFWIHQQPHEDDHKLEKMMEEMQEYYNCKPPDYECYPPKPGDGCCCVFSCDGCWYRAMIVVTCCVDDQCVEVFYIDYGNTEY

LNRSDIVEIP-LELQF-SSVAKKYKLWG
...||| .|| .|...    |.|..|.|
VPFSDIRQIPPPEFMHLPFQAFKCCLAG
TUDOR SgK396.AA TUDOR 77-135 31 5e-12 47.21 SMART 1-60 (60) Show / Hide 
Range on Protein: 77-135
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

GNLDPNKIYGGLFSEDQCWYRCKVLKIISV-EKCLVRYIDYGNTEILNRSDIVEIPLELQ
. .  . ..   .|||.|||||.. |. .  ... |..|||||.| ....|| ..|... 
PKWKVGQMCCARWSEDGCWYRCRIIKVDPDNQWYEVFFIDYGNCEWVPWWDIRQMPCKHM
Kinase SgK396.AA Other-Unique 739-973 15 8.9e-35 115.46 In-house 1-249 (249) Show / Hide 
Range on Protein: 739-973
Range on HMM: 1-249/249
Sequence Identity: 15% (39 aa)

LSSKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAEGDSGLLP-------------LIFLFLCKSDPMAYLMVPYYPRANLNAVQANMP
. .    . ..|..|.  .|.......|  ..| ... ... .|| .. ... .             |.|......... |.|.|.|.  ... .|... 
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEHW

LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNRE----------QGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYG
.| .. ....... .. |....   ..  ..|||.... ..          .  ....|| .. . . ......  .. .|||  .. |    .|.|..|
MNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFG

CLLLWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSSMTAEQVLNAECFL
|.......|...|. ..  . . ......|.  .|.| ..|....| ...  | .||.
CYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase SgK396.AA S_TKc 740-972 12 9.3e-07 -77.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 740-972
Range on HMM: 1-231/231
Sequence Identity: 12% (34 aa)

SSKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRAWREAE----GDSGLLPLIFLFLCKSDPMAYLMVPYYPR--ANLNA-VQANMP------L
  .  .. .   |.  . .  . .     |.|       ...|| .    .   .  |.  |        |.   | .    .|    . . .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELKMGKPASP-GSDLYAYGCLL-------
.  .. ..|. ....|  .|.  |||  |   |..  .  .  ..|| . . .      . ..| .  |.||.    . ..  .| .. ||.|       
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

-LWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSS--MTAEQVLN-------AECF
 ..   ... |.. .           .. .|.... . ..  .  .|| ..|.        . |
PPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SgK396.AA RAF 830-918 24 1e-06 17.2 In-house 104-211 (282) Show / Hide 
Range on Protein: 830-918
Range on HMM: 104-211/282
Sequence Identity: 24% (27 aa)

ETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRAS------VNMMVGDLSLMSPELKM--------------GKPASPGS
... . . |.||.  ||.  |||  |  ||.|  .  .  .|||   . | .| |      ..   .    |.||                   | |. |
WLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMT-VKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQS

DLYAYGCLL
| |..|  .
DVYSFGIVM
Kinase SgK396.AA TKL 831-918 16 1e-06 20.07 In-house 134-279 (364) Show / Hide 
Range on Protein: 831-918
Range on HMM: 134-279/364
Sequence Identity: 16% (24 aa)

TLKVMKGVAQGLHTLHKAD--------IIHGSLHQNNVFALNREQ--------------GIVGDFDFTKSVSQRASVNMM--------------------
... ....|.|.. ||  .        |||  |  .|..  .  .                ..|| . ...||. . |..                    
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGDLSLMSPELKMGK----------------PASPGSDLYAYGCLL
.| .  |.||. .|.                ..|. .| |..| .|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase SgK396.AA C8 841-918 25 1e-05 16.04 In-house 135-226 (226) Show / Hide 
Range on Protein: 841-918
Range on HMM: 135-226/226
Sequence Identity: 25% (23 aa)

GLHTLHKADIIHGSLHQNNVF-ALNREQG---IVGDFDFTKSVSQRAS---VNMM--VGDLSLMSPELKMG-----KPASPGSDLYAYGCLL
|. ..|   |.|  .  .|    |. ..|      ||.|   ||.  |      |  .| .  . ||   .     |  .  |||.  | .|
GVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase SgK396.AA Worm5 832-860 37 2.9e-05 11.88 In-house 109-137 (260) Show / Hide 
Range on Protein: 832-860
Range on HMM: 109-137/260
Sequence Identity: 37% (11 aa)

LKVMKGVAQGLHTLHKADIIHGSLHQNNV
||.|  .. .| |||.   ||  .| .|.
LKIMCCMSHSLQTLHSIGFIHRDCHWQNI
Kinase SgK396.AA PDK1 896-918 43 6.8e-05 10.36 In-house 207-229 (307) Show / Hide 
Range on Protein: 896-918
Range on HMM: 207-229/307
Sequence Identity: 43% (10 aa)

SPELKMGKPASPGSDLYAYGCLL
||||  .|...|..|. |.||..
SPELLTDKECTPSCDIWALGCII
Kinase SgK396.AA RAF 826-918 22 8.7e-05 12.35 In-house 97-207 (275) Show / Hide 
Range on Protein: 826-918
Range on HMM: 97-207/275
Sequence Identity: 22% (25 aa)

LNSEETLKVMKGVAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSV-SQRA-----SVNMMVGDLSLMSPELKMGK------------PASP
..   |... . ..||   ||.  |||. |  .|.|  |    ...||.  ..  ....     ...   | .  |.||. .              | |.
FDMNWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSF

GSDLYAYGCLL
 || ||.|. .
QSDVYAFGTVW
Kinase SgK396.AA Jak 832-853 31 0.000922 9.37 In-house 121-142 (299) Show / Hide 
Range on Protein: 832-853
Range on HMM: 121-142/299
Sequence Identity: 31% (7 aa)

LKVMKGVAQGLHTLHKADIIHG
....|....|.|.|.  ..|||
MQFAKQICWGMHYLEDKRYIHG
Kinase SgK396.AA NEK4 838-916 27 0.000964 9.53 In-house 111-190 (257) Show / Hide 
Range on Protein: 838-916
Range on HMM: 111-190/257
Sequence Identity: 27% (22 aa)

VAQGLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVS-QRASVNMMVGDLSLMSPELKMGKPASPGSDLYAYGC
.| .|  .|.  |.|  |   |.|   .    .|||   .           |.|    ||||.   .|    ||... ||
IAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGC
Kinase SgK396.AA TKL-Unique 816-855 33 0.001 9.23 In-house 94-138 (290) Show / Hide 
Range on Protein: 816-855
Range on HMM: 94-138/290
Sequence Identity: 33% (15 aa)

NLNAV---QANMPLNSEETLKVMKGVAQGLHTLHKAD--IIHGSL
|.|       |..|| .  .|  . .|||...||  .  |||. |
NNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDL