Gene SgK269 (Human)

SgK269

Species: Human
Alias: SgK269, FLJ21140, FLJ34483, KIAA2002
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 15q24-q25,

Classification

Group: Other
Family: NKF3

Sequence

Name Sequence Type Origin Length Description Download
SgK269.NA RNA Sugen Kinome 11576 None Fasta, JSON
SgK269.AA Protein Sugen Kinome 1746 None Fasta, JSON
SgK269.kin_dom Protein Kinase Domain Sugen Kinome 338 None Fasta, JSON

Protein domain

Protein domains of SgK269.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK269.AA NKF3 1330-1666 66 0.0 890.77 In-house 1-360 (360) Show / Hide 
Range on Protein: 1330-1666
Range on HMM: 1-360/360
Sequence Identity: 66% (238 aa)

TSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSK--AKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKG
|.|||||..||||||.|...|||..|||||||...  ||.||||.|...|.||..||||||||||||.||||.|.|.|||||.|||||||||.||||||.
TCDKPCCRSGDAVYYCATHPKDPGSNYAVKICCDPNKAKQSQQYCHMTKVMQSHPVHFNIQQDCGHFIAEVPSRMLQWEDPDAPEKDEDDMEDTEEDAKA

ETDGKNPKPCSEAASSQKENQGVMSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHY
|||||||.||.|....|.|||.||..||...|||||||||..|||||||||.|.|...|..||||||..|||||.||.|||..|..||||.||||||||.
ETDGKNPSPCLETHPPQQENQRVMNRKQQDCVVVITREVPHQTVADFVRDSMAHHEHEPEVYERQVCFMLLQLCQGLCHLKEHHMCHCDLCLENLLLVHC

QP-GGTAQGFGPAEP-----------SPTSSYP--------TRLIVSNFSQAKQKS-HLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLP
|| ||..||..||.|           .||...|        .|||.|||.|||||| |.|.|...|||.||||||.||.||.||.|||||||||||||.|
QPQGGPHQGPTPADPTTTARCPSAAPCPTTACPEGPREKQLPRLIISNFMQAKQKSGHTVNPQQKRDQARLAPEIVTAKQYQKCHEFQTGILIYEMLHQP

NPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCL
||||..|.|.||.|||.||||||.|||||.||||||.||||.||..||....||.|||||
NPFDTRPQLRERDYTRDDLPRIPVRSPYSWGLQQLAHCLLNKNPQDRIRCNQAKRILQCL
Kinase SgK269.AA S_TKc 1344-1666 13 4.4e-09 -43.66 SMART 16-231 (231) Show / Hide 
Range on Protein: 1344-1666
Range on HMM: 16-231/231
Sequence Identity: 13% (48 aa)

YTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASS
| .   |     .|.|| |                                                                               . 
YKCRHKK-TGRIVAIKIIK------------------------------------------------------------------------------EHI

QKENQGVMSKKQRSHVVVITREVPC----LTVADFVRD---SLAQHGKSPD-------LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQP
..| | ...|  .   .|   .|        | ...     .| .. |.         . | ... .. |.|..||..   .. |.||  ||.|| .   
RREIQ-ILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---

GGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR--LAPEIITATQYK--KCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADL
                    .. .. |  |.|             ..  .|||..   .|   |||    |...||||    ||.   . .  .  .   
--------------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---

PRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKG------ILQCL
         |. . .. . .|. .|..|. . .|        . . .
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SgK269.AA NKF2 1587-1653 29 6e-06 17.03 In-house 279-355 (365) Show / Hide 
Range on Protein: 1587-1653
Range on HMM: 279-355/365
Sequence Identity: 29% (23 aa)

YKKCDEFQTGILIYEMLHLPNPFDE----------NPELKERE--YTRADLPRIPFRSPYSRGLQQLASCLLNPNPSER
| | |    | ..|| . . |||            .  |  .   |  ..||  | . |   .|.||   ||...||.|
YEKADTWACGAIAYEIFGQKNPFYSSSGGMAREQGEMHLDSCNSDYQEDQLPQMPQSCPP--VLRQLVYNLLQRDPSKR
Kinase SgK269.AA AMPK 1488-1524 43 1.5e-05 12.5 In-house 97-133 (254) Show / Hide 
Range on Protein: 1488-1524
Range on HMM: 97-133/254
Sequence Identity: 43% (16 aa)

LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLL
| ||. | .. |  ||.| .    . | || .|||||
LQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLL
Kinase SgK269.AA CAMKL 1484-1524 22 1.8e-05 13.29 In-house 116-160 (297) Show / Hide 
Range on Protein: 1484-1524
Range on HMM: 116-160/297
Sequence Identity: 22% (10 aa)

KSPD----LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLL
| ..    . |.. . .  |..|.....   .. | |. .||.||
KHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL
Kinase SgK269.AA DCAMKL 1490-1530 31 4.8e-05 11.03 In-house 114-154 (279) Show / Hide 
Range on Protein: 1490-1530
Range on HMM: 114-154/279
Sequence Identity: 31% (13 aa)

ERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPG
||.  .....||. |..|    . | |. .||||.. .. |
ERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG
Kinase SgK269.AA ULK 1578-1654 22 5.7e-05 13.65 In-house 215-313 (324) Show / Hide 
Range on Protein: 1578-1654
Range on HMM: 215-313/324
Sequence Identity: 22% (23 aa)

APEIITAT-----QY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADL-------------PRIPFR-----SPYSRGLQQLASCLLNPNPSER
||.|.        .| .||| .  |...||||    || ..   .. .|  ..|               |.|.      . |  ...| ...|  ....|
APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR

I
|
I
Kinase SgK269.AA Ciliate-E2a 1490-1556 20 0.000108 9.77 In-house 100-153 (275) Show / Hide 
Range on Protein: 1490-1556
Range on HMM: 100-153/275
Sequence Identity: 20% (14 aa)

ERQVCLLLLQLCS-GLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNF
. ..| .. || . ||.... ... | ||..||.|.                 |..|.... .....|
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKN--------------CSKNSIQNSDIKIIDF
Kinase SgK269.AA TyrKc 1383-1663 11 0.000183 -150.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 1383-1663
Range on HMM: 1-280/280
Sequence Identity: 11% (39 aa)

VHFNIQQDCGHF----LAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKK--QRSHVV----VITR--------
.... .  .|.|    ...                              .   |  |...  .   .| . .|.|   .  ..|    |.|         
ITLGKKLGEGAFGEVYKGTWK---------------------------IQVAVKMLKEDA-REDFMREAR-IMCKLGGHHPNIVRLYGVCTQQGRNFMYI

EVPCLTVA--------DFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNF
| ... .         |. |..  .      |  .. .   .| ..| |.|   .. | ||   | |. . .                     .  .| |
EPLMIVMEYMPHGDLKDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------TVKISDF

SQAKQKSHL----VDPEILRD----QSR-------LAPEIITATQYKKCDEFQT-----GILIYEMLHLPNPFDENPEL--KEREYTRADLPRI--PFRS
  ..   .     .  .  |     ...       .||| |   .|.|.  ...     |....|.. .  .  .....  .. .  .... .   . . 
GLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQP

PY---------SRGLQQLASCLLNPNPSERILISDAKGIL
|.         .  . |. ..  . .|..|   |. . ..
PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK269.AA NAK 1626-1663 31 0.000307 9.96 In-house 262-299 (299) Show / Hide 
Range on Protein: 1626-1663
Range on HMM: 262-299/299
Sequence Identity: 31% (12 aa)

PRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGIL
. ||  | ||.....| . .|.|.|..|. | .   .|
YSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase SgK269.AA ULK 1578-1654 20 0.000488 10.09 In-house 219-318 (329) Show / Hide 
Range on Protein: 1578-1654
Range on HMM: 219-318/329
Sequence Identity: 20% (21 aa)

APEIITAT-----QY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADL-------------PRIPFR-----SPYSRGLQQLASCLLNPNPSER
||.|.        .| .||| .  |...||||    || ..   .. ..   .|               . |.      . |  ...| ...|  ....|
APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR

I
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Kinase SgK269.AA Kin4 1488-1524 45 0.000646 7.22 In-house 107-143 (273) Show / Hide 
Range on Protein: 1488-1524
Range on HMM: 107-143/273
Sequence Identity: 45% (17 aa)

LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLL
| | . | |  || || . .    . | ||.||||||
LKEMNACRLFAQLISGVHYMHYKGLVHRDLKLENLLL