Gene SgK196 (Human)

SgK196

Species: Human
Alias: MGC126597, SgK196, FLJ23356
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 8p11.1,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
SgK196.NA RNA Sugen Kinome 1615 None Fasta, JSON
SgK196.AA Protein Sugen Kinome 350 None Fasta, JSON
SgK196.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of SgK196.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK196.AA Other-Unique 84-329 11 1.3e-33 111.47 In-house 1-249 (249) Show / Hide 
Range on Protein: 84-329
Range on HMM: 1-249/249
Sequence Identity: 11% (30 aa)

LKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQN---VNTWQHRLE
.| .|.|. .||........|  ... |   .. . ... .. .. |. |.. . . |....| ....|............. . |..    ...|...|
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIH-CIFYWT-MNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCE

LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSI---------LANDLDALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDD
. |... .|..||| . .  ..||.|   . ..|  .  ....           ...   .. |. . |. .. .. .... . ... ... .. ..  .
HWMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYH

LMPSYDEKIDIWKIPDISSFLLG--HIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLE
.. .. .......| . ... ..  ..| ...  ..|. ... |...  ....  .....
FGCYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase SgK196.AA TKL-Unique 83-195 25 5.5e-11 35.15 In-house 1-129 (290) Show / Hide 
Range on Protein: 83-195
Range on HMM: 1-129/290
Sequence Identity: 25% (33 aa)

QLKRVGEGAVKRVFLSEWKEHKVALSQLT-----SLEMKDDFLHGLQMLKSLQ-GTHVVTLLGYCE----DDN--TMLTEYHPLGSLSNLEE-TLNLS--
 .. .|||.. .|.  .|.  .||. |.      |.||...|   .  .| |.    .|.. |||     . .   . .|| |.||| ..    .|..  
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KYQNVNTWQHRLELAMDYVSIINYLHHS
 .  . ...| |. .| | ..  .||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHC
Kinase SgK196.AA TKL 87-193 17 1.1e-08 27.39 In-house 1-149 (364) Show / Hide 
Range on Protein: 87-193
Range on HMM: 1-149/364
Sequence Identity: 17% (28 aa)

VGEGAVKRVFLSEWKEHK----------VALSQLTSLE-----------------------------MKDDFLHGLQMLKSLQGTHVVTLLGYCEDDN--
.|.|.   |.  .|. .           ||  .. | .                             ... .   . |...|.  ..| ..||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------TMLTEYHPLGS-LSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLH
              . .||.| || |..|              |..|. .|.|  . .||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLH
Kinase SgK196.AA Jak 98-157 22 6.6e-05 13.44 In-house 31-98 (299) Show / Hide 
Range on Protein: 98-157
Range on HMM: 31-98/299
Sequence Identity: 22% (15 aa)

SEWKE-HKVALSQLTSL---EMKDDFLHGLQMLKSLQGTHVVTLLG-Y---CEDDNTMLTEYHPLGSL
..|.|  .|.....      .  .||   ........  | | . | .   |.|...| .|| ..|.|
DQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPL
Kinase SgK196.AA TK 81-157 14 7.2e-05 11.42 In-house 1-146 (486) Show / Hide 
Range on Protein: 81-157
Range on HMM: 1-146/486
Sequence Identity: 14% (21 aa)

VRQLKRVGEGA---VKRVFLSEWKEH---------------------------KVALSQLT---SLEMKDDFL----------------HGLQMLKS--L
.. .|  |||.     .|.. ||...                           .||  .|.   . .... |.                . ..|...  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QGTHVVTLLGYCEDD--------------NTMLTEYHPLGS----L
.  ..| |.|.| ..                ...|| |.|.    |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSL
Kinase SgK196.AA TyrKc 81-331 14 8.5e-05 -145.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 81-331
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

VRQLKRVGEGAVKRVFLSEWKEHKVA--LSQLTSLEMKDDFLHGLQMLKSL--QGTHVVTLLGYCED--------DNTML-TEYHPLGSLSNLEETLNLS
.. .|  ||||  .|.. .||  .||    .  .   . ||.. ......|  .  ..| |.|.| .        .  |. .|| |.|.| .      | 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY-----LR

KYQNVNTWQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM----------LVKCGH----------R
|...  .... |. . .  .  .|||.                                            .           ||. .|          |
KHRPKLCMKDLLSFCWQIACGMEYLHSK-------------------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSR

ELHGD---------FVAPE--QLW----------------------------------------PYGEDVP--FHDDLMPSYDEKIDIWKIPDI----SS
... |          .. |  .                                          || ...     .. .  | .. .  ..|.     | 
DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-

FLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETY
        .      ...| | |    |..||| ... |  
--------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK196.AA S_TKc 81-335 13 9.2e-05 -107.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 81-335
Range on HMM: 1-231/231
Sequence Identity: 13% (40 aa)

VRQLKRVGEGAVKRVFLSEWKE--HKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCE-DDNTMLTEYHPL--GSLSNLEETLNLSKYQNVNTW
 . |. .|.||  .|..  .|.  ..||. ..      ....  .|.||. .  ..|.|..... |.  | .|| .   |.|  . .  .  ... . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QHRLELAMDYVSIINYLHHSPV---------------------GTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHRELHG--D
 |   ..   .. ..|.|   .                     |                                                . . |  .
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------------------------------TTFCGTPW

FVAPEQLWPYGE------------------DVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETY---
..||| | .||                     ||.      ... ... .                     . |. . |    |..|||| ..|.     
YMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--QKVL
     .
KCHPWF
Kinase SgK196.AA Frk 81-148 24 0.000431 9.68 In-house 1-70 (260) Show / Hide 
Range on Protein: 81-148
Range on HMM: 1-70/260
Sequence Identity: 24% (17 aa)

VRQLKRVGEGAVKRVFLSEWKEHK-VALSQLTSLEMK-DDFLHGLQMLKSLQGTHVVTLLGYCEDDNTML
.. ..|.| |    |.   |     ||. .| .  |  .|||   |..|.|. . .. |   |  .. ..
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIY
Kinase SgK196.AA EGFR 106-159 29 0.000798 8.38 In-house 35-89 (258) Show / Hide 
Range on Protein: 106-159
Range on HMM: 35-89/258
Sequence Identity: 29% (16 aa)

ALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTML-TEYHPLGSLSN
.| . |. . ....|    .. |..  |.| ||| |  .. .| | | |.|.| .
VLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLD
Kinase SgK196.AA TKL 311-331 28 0.024007 4.27 In-house 344-364 (364) Show / Hide 
Range on Protein: 311-331
Range on HMM: 344-364/364
Sequence Identity: 28% (6 aa)

KACKSQTPSERPTAQDVLETY
. | .. |..||..|..|.. 
QDCWDHDPEKRPSFQEILKRL
Kinase SgK196.AA TK 306-331 26 0.0522 1.66 In-house 461-486 (486) Show / Hide 
Range on Protein: 306-331
Range on HMM: 461-486/486
Sequence Identity: 26% (7 aa)

LFDIHKACKSQTPSERPTAQDVLETY
..|. . | .  |..||| ....|  
YYDLMQQCWHYDPEDRPTFSQLHEQL