Gene SgK110 (Human)
SgK110
Sequence
Protein domains of SgK110.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SgK110.AA | NKF1 | 43-304 | 45 | 1.6e-159 | 536.24 | In-house | 1-269 (269) | Show / Hide |
Range on Protein: 43-304 Range on HMM: 1-269/269 Sequence Identity: 45% (124 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPR--YFAFAQEYAPCGDLSGMLQ---ERGLPE |..||.||.|.||..||....|.|...|||...........|.||||.|.|.|.|.....|.....||.. |..|||||||||||..|.| .||||| YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE LLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDP-VCSRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLP-PDTLPLRPAVDSWGLGVLLFCA . .||.|||||.||||.|||.|||.|.||.||||||| |.||.|.|.|.|||.|....... ..|...||.|. || ....|..|..|.|..|||.||. NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC ATACFPWDVALAP-NPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLDFL |.||||. |... .|..|.|. | ..| |||..|.||..|.|.|......||...||.|.|. .. ... LTGCFPWQKADWMCDPCYEWFMWWQRRK-QPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM |
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| Kinase | SgK110.AA | S_TKc | 43-304 | 19 | 9.7e-40 | 139.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 43-304 Range on HMM: 1-231/231 Sequence Identity: 19% (56 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPC--GDLSGMLQERG------ |...||.|.|..|.| ... . | ||.| .. ...|| . . || . . . .. . ||.. ||| ....|| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRP-AVDSWGLGVLL .|| ......|.. ||...||.| .| |.||.|.|. . .. ..| || | . . .||.. . . ..| | .|..| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL FCAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLD---------FL . .. . |.. ... | . |.|. .....|. ||| | .| .. YEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | SgK110.AA | Pkinase | 43-304 | 19 | 4.2e-30 | 107.52 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 43-304
Range on HMM: 1-293/293
Sequence Identity: 19% (58 aa)
YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRST---FLR--EFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPCG----DLSGMLQ--
||..||.||||.|.| ... . | ||.| .... . .| | .. . .. || .... ... . .||...| ||. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW
-ERGL--PELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVF-DPVC-SRVALGDLGLT----RPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRPA
.... .| .|... |.. .|...||.| .| |.||.|.|. .... ..| ..| || .| . . . .. ..||... . . |.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPK
VDSWGLGVLLFCAATACFPWDVAL----APNPEFEAFAGWVTTKPQPPQPPPPWDQFA-----------------PPALALLQGLLDLDPETRSPPLAVL
|| |..|..|.. .. .|.. . . . .. . .|... . | |. .... .. ..|..||. | . .|
VDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICR--IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL
DF--L
.
QHPWF
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| Kinase | SgK110.AA | CAMK | 48-171 | 16 | 8.3e-20 | 59.85 | In-house | 1-212 (425) | Show / Hide |
Range on Protein: 48-171 Range on HMM: 1-212/425 Sequence Identity: 16% (35 aa) KLGSGSYGRVLLAQPHQGG------------PAVALKLLRRD-----------------------------LVLRSTFLREFCVGRCVSA------HPGL .||.||.| | |.. . . || | . .. . | ..|| .. . ... || . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LQTLA--------------GPLQT-----PRYFAFAQ---EYAPCG----DLSGMLQERG----------------LPELLVKRVVAQLAGALDFLHSRG .. . .. .... . ||.. | || ...|.| ..| ..|.. |.. |....||.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN LVHADVKPDNVLV || | ||.|.|. IVHRDLKPENILL |
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| Kinase | SgK110.AA | CAMKL | 43-171 | 24 | 1e-18 | 56.19 | In-house | 1-160 (297) | Show / Hide |
Range on Protein: 43-171 Range on HMM: 1-160/297 Sequence Identity: 24% (39 aa) YHLIRKLGSGSYGRVLLAQP-HQGGPAVALKLLRRDLVLRSTFLR----------------EFCVGRCVS--AHP---GLLQTLAGPLQ---TPRYFAFA | ... || ||.| | ||. | || | . .. .. . | . . .. || |.... | | .. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV QEYAPCGD--LSGMLQERG-----LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV ||.. |. | .....| .|| .| |. |....||.| || | ||.|.|. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL |
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| Kinase | SgK110.AA | AGC | 109-170 | 24 | 3e-15 | 34.4 | In-house | 101-187 (395) | Show / Hide |
Range on Protein: 109-170 Range on HMM: 101-187/395 Sequence Identity: 24% (21 aa) QTPRY--FAFAQEYAP--------CGD-LSGMLQE-R----GLPELLVKRVVAQ-------LAGALDFLHS-RGLVHAD-VKPDNVL |.... | ||.| .|. . . . | ..| .. |. .. ||..||| .| .| | .||.|.| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL |
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| Kinase | SgK110.AA | Iota | 43-171 | 33 | 3.4e-14 | 43.25 | In-house | 1-133 (271) | Show / Hide |
Range on Protein: 43-171 Range on HMM: 1-133/271 Sequence Identity: 33% (45 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFL----REFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPCGDLS-GMLQERGLPE ..||| .| ||| .||... .. |.|......| . | | | || | | ||. | |. . ||| | . | ||| FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHP-FLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPE LLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV . | .. ||.|||.||.. |.| ||||. EHARFYSAEICLALNFLHERGIIYRDLKLDNVLL |
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| Kinase | SgK110.AA | ROCK | 43-171 | 29 | 4.8e-14 | 43.91 | In-house | 1-131 (263) | Show / Hide |
Range on Protein: 43-171 Range on HMM: 1-131/263 Sequence Identity: 29% (39 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAH--PGLLQTLAGPLQTPRYFAFAQEYAPCGDLSGMLQERGLPELLV .|.|. .| | .| | | .. |.|.| .. ... . | | . || . | | .|| .| | ||| .. . .|| FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA KRVVAQLAGALDFLHSRGLVHADVKPDNVLV . . . ||| .|| |..| ||||||.|. RFYTMEVVLALDAIHSMGFIHRDVKPDNMLL |
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| Kinase | SgK110.AA | NuaK | 43-77 | 40 | 1.9e-11 | 25.8 | In-house | 1-35 (252) | Show / Hide |
Range on Protein: 43-77 Range on HMM: 1-35/252 Sequence Identity: 40% (14 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRD | ....||.| ||.| || |. | || |. ... YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKC |
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| Kinase | SgK110.AA | CDK4 | 134-171 | 44 | 1.3e-10 | 32.42 | In-house | 106-143 (290) | Show / Hide |
Range on Protein: 134-171 Range on HMM: 106-143/290 Sequence Identity: 44% (17 aa) GLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV |.|. .|.. .|| ..||||| .| | ||.|.|| GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV |
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| Kinase | SgK110.AA | CMGC | 125-193 | 16 | 5.1e-10 | 28.15 | In-house | 140-257 (513) | Show / Hide |
Range on Protein: 125-193 Range on HMM: 140-257/513 Sequence Identity: 16% (20 aa) DLSGMLQERG----------LPELL------------VKRVV------AQLAGALD--FLHSRG--LVHADVKPDNVLVFDP------------------ || ..... |.| .| . |. .|. ..||.. .| | || |.|. . DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ VCSRVALGDLGLTRPEGSP . |. ..| || | .... KNGRLKICDFGLARWYHPH |
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| Kinase | SgK110.AA | TyrKc | 43-304 | 20 | 1.8e-09 | -69.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 43-304 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCV-SAHPGLLQTLAGPLQTP------RYFAFAQEYAPCGDLSGMLQERG- .|..|||.| .|.| ... || | |. | | |.|| . . . || ... .. .| ||.| ||| |.... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSP----------TP----APP--VPLPTAPPELCLLLPPDTL |. | | ..|||....| | |.|| .. .| .| ||.| .. .. .|. .|| |. .. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE-CI----NYG PLRPAVDSWGLGVLLF--CAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQF----APPAL-ALLQGLLDLDPETRSPPLAVLDFL .. | | ||... . . ...... . . .| . .|||| . .|... . . . ||| | .. ... KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | SgK110.AA | MARK | 119-171 | 33 | 4.3e-08 | 22.74 | In-house | 82-137 (262) | Show / Hide |
Range on Protein: 119-171 Range on HMM: 82-137/262 Sequence Identity: 33% (19 aa) EYAPCGDLSGMLQER---GLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV |||. |.| . .... |.| . .| |. |. ..||.. || | ||.|.|. EYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI |
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| Kinase | SgK110.AA | AGC | 43-61 | 31 | 6.2e-08 | 15.06 | In-house | 1-19 (395) | Show / Hide |
Range on Protein: 43-61 Range on HMM: 1-19/395 Sequence Identity: 31% (6 aa) YHLIRKLGSGSYGRVLLAQ ..... .| ||.|.| |.. FEFLKVIGKGSFGKVYLVR |
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| Kinase | SgK110.AA | CMGC | 43-77 | 24 | 1e-06 | 16.82 | In-house | 1-49 (513) | Show / Hide |
Range on Protein: 43-77 Range on HMM: 1-49/513 Sequence Identity: 24% (12 aa) YHLIRKLGSGSYGRVLLAQP--------------HQGGPAVALKLLRRD |. |.|.|.|.|| | .. |... ||.| .... YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNP |
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| Kinase | SgK110.AA | NuaK | 119-170 | 32 | 4e-06 | 11.44 | In-house | 79-131 (252) | Show / Hide |
Range on Protein: 119-170 Range on HMM: 79-131/252 Sequence Identity: 32% (17 aa) EYAPCGDLSGMLQE-RGLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVL ||| |.| . | . ||| .... | . |. . | . .| | | |.| EYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL |
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| Kinase | SgK110.AA | MARK | 221-243 | 47 | 0.000118 | 11.33 | In-house | 185-207 (262) | Show / Hide |
Range on Protein: 221-243 Range on HMM: 185-207/262 Sequence Identity: 47% (11 aa) PAVDSWGLGVLLFCAATACFPWD |.|| | |||.|. . .||.| PKVDIWSLGVVLYFMVCGYFPFD |
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| Kinase | SgK110.AA | CDK4 | 43-75 | 39 | 0.000212 | 10.77 | In-house | 1-33 (290) | Show / Hide |
Range on Protein: 43-75 Range on HMM: 1-33/290 Sequence Identity: 39% (13 aa) YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLR | .. .|.| || | | . | |||| | YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR |
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| Kinase | SgK110.AA | MARK | 43-61 | 42 | 0.000403 | 9.56 | In-house | 1-19 (262) | Show / Hide |
Range on Protein: 43-61 Range on HMM: 1-19/262 Sequence Identity: 42% (8 aa) YHLIRKLGSGSYGRVLLAQ | ... .| |||. | ||. YKMLKTIGHGSYAKVKLAC |
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| Kinase | SgK110.AA | NuaK | 221-233 | 69 | 0.001408 | 4.68 | In-house | 178-190 (252) | Show / Hide |
Range on Protein: 221-233 Range on HMM: 178-190/252 Sequence Identity: 69% (9 aa) PAVDSWGLGVLLF | ||.| |||||. PEVDCWSLGVLLY |
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| Kinase | SgK110.AA | AGC | 261-294 | 29 | 0.005478 | 1.97 | In-house | 333-373 (395) | Show / Hide |
Range on Protein: 261-294 Range on HMM: 333-373/395 Sequence Identity: 29% (12 aa) TKPQPPQPP-------PPWDQFAPPALALLQGLLDLDPETR ....... | |....| | | |...|| ||| | FINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR |
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| Kinase | SgK110.AA | CAMKL | 221-245 | 36 | 0.014048 | 3.88 | In-house | 215-239 (297) | Show / Hide |
Range on Protein: 221-245 Range on HMM: 215-239/297 Sequence Identity: 36% (9 aa) PAVDSWGLGVLLFCAATACFPWDVA |.|| | .||.|. . .|.| . PKVDIWSCGVILYAMVCGYLPFDDD |
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| Kinase | SgK110.AA | CAMK | 221-243 | 30 | 0.018155 | 2.96 | In-house | 313-335 (425) | Show / Hide |
Range on Protein: 221-243 Range on HMM: 313-335/425 Sequence Identity: 30% (7 aa) PAVDSWGLGVLLFCAATACFPWD |..| | .||.|. . ..|.. PKCDMWSCGVILYIMLCGYPPFY |
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