Gene SgK085 (Human)
SgK085
Sequence
Protein domains of SgK085.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | SgK085.AA | MLCK | 106-361 | 64 | 5.1e-242 | 646.04 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-257/257 Sequence Identity: 64% (167 aa) VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTI .. .| ||.|.||.||.|.|..||...|||.||.| ||||.|||||..||||.| ||||..||||.||..|..|||..|||||.||.||...|||...| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI LFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK-LKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFL ..|.|||||..|||...|.|||||||||.|..| .|||||||||||.|.|.|| .||.||||||.||||||||.|.|.|||||||||.||||||||||. HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM GDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL ||||.||.||...|.|| .||.|.|||.||| |||.||.|.|..| .|.|.|.|||| GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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Kinase | SgK085.AA | DAPK | 108-361 | 45 | 1.6e-128 | 356.2 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 108-361 Range on HMM: 1-264/264 Sequence Identity: 45% (120 aa) KTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK------EEVKNEISVMNQLD-HANLIQLYDAFESKNDIVLVMEYVDGGELFDRIID-ESYNL | || |.| | || . ||.. ||| || | .. || . ||.. .. | |.| | ...| . |..|. ||| |||||| . | MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLL .| | . ||||| ||....|. | ||||||.||. .| | ||||||||.|. .. | .. .||||..|||.|||. | |||||.|||.|..| CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML SGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL || ||||||. ||. || ... | ..|.|. ||.|| || .|| |. | .| |.|.|||. SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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Kinase | SgK085.AA | CAMK | 111-361 | 24 | 1.4e-122 | 397.06 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 111-361 Range on HMM: 1-425/425 Sequence Identity: 24% (106 aa) ILGGGRFGQVHKCEETATG------------LKLAAKIIKTRGMK----------------------------DKEEVKNEISVMNQ-------LDHANL .|| |.||.|..|... |. | |.|||... .| |...|..||..|.. ||| |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IQLYDAFES-------------------KNDIVLVM---EYVDGGEL----FDRIIDESYN--------------LTELDTILFMKQICEGIRHMHQMYI |.||...|. ......|| ||..|||| ||.|.. ... .|| .. ...|||......|.. | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LHLDLKPENILCVNRDA---------------KQIKIIDFGLARRYKP------------------------REKLKVNFGTPEFLA-PEVVNY------ |.||||||||..... .|||||||.|....| .|.| .||||. | |||.|. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM --------DFVSFPTDMWSVGVIAYMLLSGLSPFLGD-------------NDAETLNNILACRWDLEDEEFQD------------ISEE--------AKE . .....||||.||| |..|.| .|| || || |.. .|.....| ....| . ||.| .| QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD FISKLLIKEKSWRISASEALKHPWL .|.|.| .. . |......|.|||. LIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | SgK085.AA | DAPK | 107-361 | 46 | 5.6e-114 | 330.15 | In-house | 2-264 (264) | Show / Hide |
Range on Protein: 107-361 Range on HMM: 2-264/264 Sequence Identity: 46% (123 aa) SKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMK------DKEEVKNEISVMNQLD-HANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL | .| | | | || | ||.. ||| || | .. |.. |.|. .. | | | | |..| | |.||. | | |||||| . .. | DMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKEC-L TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLL .| | ||| .|..||| | |.||||||| .| . . |||||||||.| .| . | |||||| |||.||| . |||||.||| | || NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL SGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL || ||||||. ||| || | . . ..| |.. || || || .||.|. |. |.|.||| SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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Kinase | SgK085.AA | Trio | 104-361 | 39 | 1.6e-111 | 287.1 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 104-361 Range on HMM: 1-258/258 Sequence Identity: 39% (103 aa) YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELD ||. ..|| | |||. |..| . |||. .|||.| | |.||| | | ... | | ...| |..|. .|. | |.||| ... . . ..| . YTF-QEEI-GRGRFSVVRRCWHKATGRTCAAKFIPYR-MMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWG-SYCESE TILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA--KQIKIIDFGLARRYKPR--EKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSG .. .| |. |... |. |||||.||||.. . . | ||||.||| | . | | . |.||| |||... . || || ||.||..| .||| VKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSG LSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL |||....| ||. ||. . ..... |. .|..||.|| |.| . | .|||.| |||. ISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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Kinase | SgK085.AA | CAMK1 | 104-361 | 37 | 1.7e-102 | 298.75 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 104-361 Range on HMM: 1-276/276 Sequence Identity: 37% (105 aa) YTVSKTEILGGGRFGQVHKCEETAT---GLKLAAKIIK-TRGMKDK-----EEVKNEISVMN---QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDR | . ....| | |..|..|.. | | . | |.|. . || | | ..|||..| ..|| | |..|. .||.|.. ||||.| ||||||| YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR IIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNR-DAKQIK--IIDFGLARRYKPRE-KLKVNFGTPEFLAPEVVNY---DFVSFPT |.. | || | . ||||.. . .||.. | | ||||||.|... . .|| |.||||...... | ..| .|||.. ||||... .. . . IVEKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKAC DMWSVGVIAYMLLSGLSPFLGDN-DAETLNNILACRWDLEDEEFQDISEE-AKEFISKLLIKEKSWRISASEALKHPWL ||||.||| | || | .|| ..| |.| . |. | .. .. .||.. ||.||...| .. . |......|.|||. DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | SgK085.AA | S_TKc | 106-361 | 34 | 1.9e-92 | 314.36 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-231/231 Sequence Identity: 34% (94 aa) VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDG--GELFDRIIDESYN----- . ...| | ||.|.|| .. || . | |||| | ...||... . .| |...|||.|.. ... .||||.|| |.|||.| . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSF-PTDMWSVGVIAYMLL ..| .. .|.|||... ..|.. |.| ||||||||. . .|||.||||||.. . |||...||||. .. . |.||.|.| | .| FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALK-------HPWL .| || ........|. |.|||.||.|.| |. . |..| |||. |||. CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | SgK085.AA | Ciliate-E2a | 104-361 | 38 | 6.2e-92 | 270.9 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 104-361 Range on HMM: 1-275/275 Sequence Identity: 38% (107 aa) YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKE----EVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL | . | ..| | ||.| . . || . |.|... | ... ...|||. | |||| |.|.||. .|..| . |||||..||||.|.|. . YKFIK--KIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFF TE-LDTILFMKQIC-EGIRHMHQMYILHLDLKPENILCV--NRDA---KQIKIIDFGLARRYKPREK--LKVNFGTPEFLAPEVVNYDFV------SFPT .| . .|.|. .|. .||| |.| |||||||| . . ..|||||||||..... || ... ||| ..|||| |. | . EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKC DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEE-FQDISEEAKEFISKLLIKEKSWRISASEALKHPWL ||||.||| | ||.| .|| | . .|.| .. .| |... | ....| |.| ...|.| | . ||.| .||.||| DMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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Kinase | SgK085.AA | Pkinase | 106-361 | 33 | 1.5e-87 | 302.0 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-293/293 Sequence Identity: 33% (100 aa) VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN----EISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGG----ELFDRII-DES . ...| | ||.| || . || . | |||| |. |..... . ||..|. |.| | ..|||.||.|..| .||||..|| .|||.| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH YNL--TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAK--QIKIIDFGLARR--YKPREKLKVNFGTPEFLAPEVVN-YDFVSFPTDMWSV .. .| . . .|.||..|. ..|.| |.| ||||||||..|.. .||.|||||. | . . ... |||...||||.. . . . ||||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVIAYMLLSGLSPFLGD------NDAETLNNILACRWDLEDEEFQDIS-----------------EEAKEFISKLLIKEKSWRISASEALKHPWL |.| | .|.| || |. .. . ...|. .... . .. .|| ||.|.||...| | . |..| ..|.|||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | SgK085.AA | CDPK | 106-361 | 37 | 6.3e-87 | 266.66 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-271/271 Sequence Identity: 37% (104 aa) VSKTEILGGGRFGQVHKCEET-ATGLKL-AAKIIKTRGMKDKEE---VKNEISVMNQLDHANLIQLYDAFESKNDIVLVME--YVDGGELFDRIIDESYN . ..|| | |||| |. . .|. . | |||. . ||||. ..||| .. |||| | |..| .. .. . .||| |. ||||||.||.... YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH- LTELDTILFMKQICEGIRHMHQMYILHLDLKPENIL-CVNRDAK----QIKIIDFGLARRYKPR-----EKLKVNFGTPEFLAPEVVN--YDFVSFPTDM .|| .. . |.|| . ..|. | | |||||||| . . | .||.||.|....... .|.. .||| .|||| . |. . | FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKC---DI WSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL || ||| | ||.| || |.|| |..... .. ..|..|...||.||| |.|.| .. |.||..||.||| WSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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Kinase | SgK085.AA | DRAK | 108-361 | 39 | 6.6e-87 | 270.05 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 108-361 Range on HMM: 1-259/259 Sequence Identity: 39% (103 aa) KTEILGGGRFGQVHKCEETATGLKLAAKIIKTR--GMKDKEEVKNEISV-MNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFD-RIIDESYNLTELD .| |.| | || . || ||| .| | | ..|.. || | |. | ..| | . .| . ...||.|| |||.|. . |. ..| | TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD TILFMKQICEGIRHMHQMYILHLDLKPENI-LCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSP . |.|| ||.. .|| | |||||| || | . |||.|||..| . | . |||...|||. ||| .. |||||.||..|..|...|| VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP FLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL |.|| || || | | .|.| .|..| || .|. .. |..| | |.|||| FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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Kinase | SgK085.AA | Ciliate-E2 | 106-361 | 24 | 7.8e-81 | 274.85 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 106-361 Range on HMM: 1-365/365 Sequence Identity: 24% (92 aa) VSKTEILGGGRFGQVHKCEETATG-----------------------LKLAAKIIKTRGMKDKEEVKNEISVMN-------------QLDHANLIQLYDA . ...| | ||.| ||. .. . | ||.| .. . .. ..... .| ||.| |.|..|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--SKNDIVLVMEYVDGGELFDRI------------IDESYNLTELDTILFMKQICE---------------GIRHMHQMY-ILHLDLKPENILCVNRD |. ..| | |||||..||.|||.| . . ..|| . .||||.. .....|. |.| |.|||||| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- AKQIKIIDFGLARRYKPR----------EKLKVNF-----------------------GTPEFLAPEVVNYDF---------VSFPTDMWSVGVIAYMLL ||||||||...|.. .... . |||...|||..|. .. |.||.||| |..| ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML SGLSPFLGDNDAETLNNILACRWDLEDEE--------------FQDISEEAKEFISK----LLIKEKSWRIS-ASEALKHPWL .| || ...|. | .|. .| ....|.|.| .|.| .| |. . ||. ....|.|||. FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | SgK085.AA | Pkinase_Tyr | 106-252 | 30 | 5.1e-18 | 61.65 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 106-252 Range on HMM: 1-159/270 Sequence Identity: 30% (49 aa) VSKTEILGGGRFGQVHKCEET----ATGLKLAAKIIKTRGMKD---KEEVKNEISVMNQL-DHANLIQLYDAFE-SKND--IVLVMEYVDGGELFDRIID ... . || | ||.|.|.. . |... | |..| |.. .|. .|...| || .| |...|| . . | .||||. .| | | . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK E---SYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLAR .|| | . . ||..| . ... . | || |.| |... ..|| |||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL-VTENN-VVKICDFGLAR |
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Kinase | SgK085.AA | TyrKc | 106-334 | 21 | 1.7e-15 | 27.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 106-334 Range on HMM: 1-280/280 Sequence Identity: 21% (63 aa) VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQL--DHANLIQLYDAFESK-------NDIVLVMEYVDGGELFDRIIDES ... ..|| | ||.|.|.. . .. | | .| .|. .|...| .| .| |...|| . .. . .||||...| | |.. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR YNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPR-------EKLKVNF--GTPE-----FLAPEVVNYDFVSF .|. | . |. ||..| .. |.. . | || |.| .. ..|| ||||.| . . .. |. .|||. || .. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT PTDMWSVGVIAY-MLLSGLSPFLG-----DNDAETLNNILAC-RWDLEDE-----------------------------EFQDISEEA .| || || . .. | .| | ...| .... . | . .. |..| |. KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |