Gene SCYL3 (Human)
SCYL3
Sequence
Protein domains of SCYL3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SCYL3.AA | SCY1 | 18-245 | 21 | 4.3e-82 | 279.04 | In-house | 1-337 (337) | Show / Hide |
Range on Protein: 18-245
Range on HMM: 1-337/337
Sequence Identity: 21% (71 aa)
FTLPSGLAVYPAVLQDGKFASVF--------VYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADG--IHLVTERVQPLEVALETLSS----------
.. .| ..|... .. ...... ....|......|.||.||.||||..|.......| . .....|..|||| .|.....
WKIHNGTKKYTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKTQ
-----------------------AEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGG---------METVCKVSQATPEFLRSIQSIR-
.|||.||..|| ||.|||...|..|||.| .|.|| ..|.||.|| |..||......|.... ... .
DVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWR
------------DPASIPPEEMSPEFTTLPECHG-----------------HARDAFSFGTLVESLLTILN----EQVSA-------------------D
|....||....|... ...|. .|.| ||.|.|......... .. .. |
EMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWD
VLSSFQQTL----HSTLLNPIPKCRPALCTLLSHDFF
. .. |.. ...||.. |.||| ....|.|..|
HIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
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| Kinase | SCYL3.AA | S_TKc | 25-245 | 14 | 5e-06 | -88.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-245
Range on HMM: 1-231/231
Sequence Identity: 14% (38 aa)
AVYPAVLQDGKFASVFVYKRENEDKVNKAAK-----------HLKTLRHPCLLRFLSCTVEADGIHLVTERVQ----PLEVALET---------LSSAEV
.. | |..|. . . .. | | || .|| . ... . .. | ...|.| . | .. .. ..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA
CAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTTLPECHGH-ARDAFSFGTLVE
. .| |..|| ..|.. . | . . ....| | |.. ... . |. |.|| .|. . | |.| ..
RFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY
SLLT----------ILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLLS-------HDFF
.|. ... . ... . . . .|. |. || .| | .|
EMLCGYPPFPQMQMMFKKIG----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | SCYL3.AA | PLK | 225-245 | 42 | 3e-05 | 13.17 | In-house | 238-258 (258) | Show / Hide |
Range on Protein: 225-245 Range on HMM: 238-258/258 Sequence Identity: 42% (9 aa) LLNPIPKCRPALCTLLSHDFF .||. | || . .|.|.|| MLNWNPDERPTIDQILQHPFF |
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| Kinase | SCYL3.AA | PLK2 | 223-245 | 43 | 6.5e-05 | 11.45 | In-house | 235-257 (257) | Show / Hide |
Range on Protein: 223-245 Range on HMM: 235-257/257 Sequence Identity: 43% (10 aa) STLLNPIPKCRPALCTLLSHDFF . .| | |. || | .. |||| ARMLSPDPEDRPSLDHIIRHDFF |
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| HEAT | SCYL3.AA | HEAT | 338-368 | 22 | 0.067091 | 10.44 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 338-368 Range on HMM: 1-31/31 Sequence Identity: 22% (7 aa) VIPVLLQLFEVHEEHVRMVLLSHIEAYVEHF ..|.||.... ...||. .. . . .||. ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | SCYL3.AA | HEAT | 377-407 | 25 | 0.005506 | 14.2 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 377-407 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) ILPQVLLGLRDTSDSIVAITLHSLAVLVSLL ||| .| .|.|..... . .. .|..|.. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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