Gene SCYL1 (Human)

SCYL1

Species: Human
Alias: NTKL, TEIF, P105, NKTL, SCYL1, MGC78454, GKLP, TAPK, HT019, TRAP
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 11q12-q13,

Classification

Group: Other
Family: SCY1

Sequence

Name Sequence Type Origin Length Description Download
SCYL1.NA RNA Sugen Kinome 2667 None Fasta, JSON
SCYL1.AA Protein Sugen Kinome 808 None Fasta, JSON
SCYL1.kin_dom Protein Kinase Domain Sugen Kinome 231 None Fasta, JSON

Protein domain

Protein domains of SCYL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SCYL1.AA SCY1 29-263 29 1.3e-105 357.13 In-house 1-337 (337) Show / Hide 
Range on Protein: 29-263
Range on HMM: 1-337/337
Sequence Identity: 29% (101 aa)

WALHRGRKKATGSPVSIFVYDVK--------PGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKC--LHVVTEAVTPLGIYLKARVEAGG-------
|..|.|.||.||. .|.||.|.|        ...||.....|...|| |.||||||| ||..||..|.  .....|...||. .||.. ....       
WKIHNGTKKYTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKTQ

--------------------LKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGG---------LDYMYSAQ-GNGGGPPRKGIPE-
                    |.|||..||..||..|||||.|||...|||.|....||...|.||.||         .|.....| ||...|. .  .. 
DVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWR

------------LEQYDPPELADSSGRVVREK-------------------WSADMWRLGCLIWEVFNGPLPRAAALRNP-------------------G
            ...|.||...... . ....                   |..||..||||||.|.||  |.. ...||                   .
EMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWD

KIPKTLVPH----YCELVGANPKVRPNPARFLQNCRA
.||| |  |    ||.|....|..||.|..||| |. 
HIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
Kinase SCYL1.AA S_TKc 32-294 17 7.4e-05 -105.7 SMART 16-231 (231) Show / Hide 
Range on Protein: 32-294
Range on HMM: 16-231/231
Sequence Identity: 17% (50 aa)

HRGRKKATGSPV---SIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVT----PLGIYLKARVEAGG---LKELEISWGL
...|.| ||  |    |          |...   .  |.    .||||  ..|  .. ..|..|.| .      |  |.| |   |.   . | ..   .
YKCRHKKTGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

HQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG--GLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSA---DMWRLGCLIWEVF
.||..|| .. .    ||  .  . ...|.  . |..  ||   .            | |.   | .||.          ...    |.| .||...| .
YQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPW---YMAPEVL---------GYGKCKCDWWSCGCILYEML

NGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPA-------EK-------QKFF
 |  |               .    ...|                            |   |.. .  |.|.        .         .|
CGYPPFP------------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase SCYL1.AA Fused 69-94 42 0.000274 10.4 In-house 53-78 (251) Show / Hide 
Range on Protein: 69-94
Range on HMM: 53-78/251
Sequence Identity: 42% (11 aa)

KTLRHPNILAYIDGLETEKCLHVVTE
. ..||.|   ||  ||.| . |||.
RRMHHPHIIHMIDSFETDKEVVVVTD
Kinase SCYL1.AA Jak 122-155 38 0.000508 10.29 In-house 125-157 (299) Show / Hide 
Range on Protein: 122-155
Range on HMM: 125-157/299
Sequence Identity: 38% (13 aa)

HQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEW
.||......| .|...||..||.  . ||| | |
KQICWGMHYL-EDKRYIHGDVCARNILVDREGHW
Kinase SCYL1.AA Fused 203-218 56 0.008444 5.21 In-house 178-193 (251) Show / Hide 
Range on Protein: 203-218
Range on HMM: 178-193/251
Sequence Identity: 56% (9 aa)

ADMWRLGCLIWEVFNG
|||| ||| ..| . |
ADMWSLGCILYELMVG
HEAT SCYL1.AA HEAT 350-380 19 0.228053 8.6 Pfam 1-31 (31) Show / Hide 
Range on Protein: 350-380
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

IIPVVVKMFSSTDRAMRIRLLQQMEQFIQYL
|.|...|.....|   |   .. . |.....
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT SCYL1.AA HEAT 389-419 22 0.000613 17.5 Pfam 1-31 (31) Show / Hide 
Range on Protein: 389-419
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

IFPHVVHGFLDTNPAIREQTVKSMLLLAPKL
|.||..... |... .||......  |....
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT SCYL1.AA HEAT 428-459 18 7.190055 3.41 Pfam 1-31 (31) Show / Hide 
Range on Protein: 428-459
Range on HMM: 1-31/31
Sequence Identity: 18% (6 aa)

LMKHFARLQAKDEQGPIRCNTTVCLGKIGSYL
.. |. ..   |.   .|...  |||.. ...
ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC
HEAT SCYL1.AA HEAT 507-537 29 7e-06 24.23 Pfam 1-31 (31) Show / Hide 
Range on Protein: 507-537
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ILPVLCGLTVDPEKSVRDQAFKAIRSFLSKL
|||.|. .  ||. .||..|.... ......
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC