Gene RYK (Human)

RYK

Species: Human
Alias: JTK5A, RYK1, RYK, JTK5, D3S3195
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q22,

Classification

Group: TK
Family: Ryk

Sequence

Name Sequence Type Origin Length Description Download
RYK.NA RNA Sugen Kinome 2942 None Fasta, JSON
RYK.AA Protein Sugen Kinome 610 None Fasta, JSON
RYK.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of RYK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
WIF RYK.AA WIF 63-196 44 4e-80 273.43 SMART 1-146 (146) Show / Hide 
Range on Protein: 63-196
Range on HMM: 1-146/146
Sequence Identity: 44% (65 aa)

SVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSF------SLLVPSETNFLHFTWHAKS---KVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVF
.|.......|.|||||.||||||||...|.|||..|       ..||......||||.|..   .|.|....|.|.  .| ||.|||. ||.||.||.|.
HVNMWINKHEMRRLIGVDAELYYVREGHINHYAHNFRKAQQRMYPVPANIHYMHFTWQAVGQAHYVHYFINVQSDDQEVMPMPIVNIPHQGTVPHTLQVW

RVELSCTGKVD--SEVMILMQLNLTVN-SSKNFTVLNFKRRKMCYK
.||..|.|..|  .|.|..|......| |.||||.|||.|.|.||.
QVEYKCSGHRDGVAEFMVTMYVMVKYNRSTKNFTHLNFRRKKICYQ
WIF RYK.AA WIF 66-194 33 1.2e-65 225.74 Pfam 1-145 (145) Show / Hide 
Range on Protein: 66-194
Range on HMM: 1-145/145
Sequence Identity: 33% (49 aa)

LYLSEDEVRRLIGLDAELYYVRNDLISHYALS-----F------SLLVPSETNFLHFTWHAKSKVEYKLGFQV---DNVLAMDMPQVNISVQGEVPRTLS
....| .|..|||..||.||..|. ..|||..     |       ..|||... ..|||....|..|...|||   ..  .|..|..|||.||.||.. .
MWINEHQVMMLIGVSAEIYYIHNGHVNHYAHDPNFSHFRKAQQRMPPVPSNVHYVNFTWQSLGKHKYHYNFQVLYSSDQQIMKRPTLNISHQGRVPHEAK

VFRVELSCTGKVDSEVMILMQLNLTVNSSK--NFTVLNFKRRKMC
.|...| |.|......   ..|... ..||  |.|.|.|||.|.|
EFSIDLPCSGNRSGQATFTVNLEVMHRRSKPNNNTPLRFKRKKIC
Kinase RYK.AA Ryk 333-599 59 1.2e-232 743.35 In-house 1-292 (292) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-292/292
Sequence Identity: 59% (174 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPN------------KEKQAFVKTVKDQASEIQVTMMLTESCKLRGLH-HRNLLPITHVC--------IEEGEKPM
|......||||||||.|||.....|.|            .....|||||||.||..||..||.|||.|.|.. |.|.||..|||        ||....|.
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VILPYMN-WGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDT---LQVKITDNALSRDLFPMDYHCLGDNENR
|..|.|| |||||.||..|........||||...||||||||..||..|......|||.|.||||||..   |||||.|.||||||||||||||||||||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRDLFPMDYHCLGDNENR

PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
||.||.||||.....|.|||||.||||.||||||||.||..||||||..|||||||..||.|||||||.||||||...|||||.||||||||
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTFQQLVQCL
Kinase RYK.AA Pkinase_Tyr 333-599 36 6e-119 403.48 Pfam 1-270 (270) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-270/270
Sequence Identity: 36% (99 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQ--VTMMLTESCKLRGL-HHRNLLPITHVCIEEGEK--PMVILPYMNWGNLKLFLR
||.  .| || ||....|.. . .. |.. .  ||..|..|.. |    ... |   .. | || |..    ||...||   ......||  |.|. .||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH-CLGDNENRPVRWMALESLVNNEFSSAS
. .    ...|... .||..|..|||.||.||...  || ||||||| ......|||.|  |.||... ||    ...   |..|||.|.. ...|...|
KHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVWAFGVTLWELMTLGQTP-YVDIDPFEMAAYL-KDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|||.|||..||..|.|..| | .....|. .|. .|||| ..| |||||.  .|  ||. |||.|| |......|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RYK.AA TyrKc 333-599 34 3.9e-117 396.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-280/280
Sequence Identity: 34% (104 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL--HHRNLLPITHVCIEEG------EKPMVILPYMNWGNLKL
|||...| || ||....|...         |  ||..|. |    . ... |   .. |  || |.. .  ||...|      | .|... || .|.|| 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPM-------DYHCL--GDNEN--RPVRWMA
.|| ..         .. .||.....||||||.||... .|| ||||||| ... ..|||.|  ||||.          ||     .....   |.||||
YLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

LESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVD-----IDPFEMAAYLKDGYRIAQPIN--------CPDELFAVMACCWALDPEERPKFQQLVQCL
.|..  ..|...||||.|||..||..|.||.|| .     ....|. .|.|.|||  || |        ||||.. .| .||. |||.|| |.....|.
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RYK.AA TK 333-599 20 6.8e-96 321.95 In-house 1-486 (486) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-486/486
Sequence Identity: 20% (99 aa)

ITLKDVLQEGTFG---RIFHGILIDEKDPNKEKQAF--------------------VKTVK--DQASEIQVTM--------------MLTESCKLRG--L
||| ..| || ||   ... |....... | .. .                     ||..|  | .|. .  .               . | ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRNLLPITHVCIEEGEK-----------PMVILPYMNWGN----LKLFLRQCKLVEAN-----------------------------------------
|| |.. .  || ....|           .|... ||. |.    |. .||.|.  . .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------NPQAISQQDLVH-------------------MAIQIACGMSYLARR------EVIHKDLAARNCVIDDTLQ-----------VKITDNA----
        |......||..                   |. ||||||.||...       ..| ||||||| ... ..           .||.|      
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRDLFPMDYHCLGD------------------------NENRPVRWMALESLVNNE---------FSSASDVWAFGVTLWELMTLG-QTPYVDID
    |.||. . |. .  .                        .   |.|||| |.|  ..         |...||||.|||..||..|.| ...| ...
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

P---------FEMAAYLKDG--------------YRIAQPINCP--------------DELFAVMACCWALDPEERPKFQQLVQCL
           |.  ||..|              .| .|| .||              .|.. .| .||..|||.|| |.||...|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RYK.AA TK-Unique 333-599 33 3.1e-81 276.17 In-house 1-294 (294) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-294/294
Sequence Identity: 33% (98 aa)

ITLKDVLQEGTFGRIFHGILIDEK-DPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLH-HRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCK
....||..|| || ...| .   . . .| |.. ||..|| |.. .. ..| |   .. |  | |.. .  .|.. .| .| |..|.  |||  .||.|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

LV-----------------EANNPQA-ISQQDLVHMAIQIACGMSYLAR--REVIHKDLAARNCVIDDTLQVKITDNALSRDLF-PMDYHCLGDNENRPV
 .                 .. .. . || .||.| |.||||||.|||.  ....|.||.|||. . . ...||.|  ..||.  . .|   .  .  |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMALESLV--NNEF-SSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINC-PDELFAVMACCWALDPEERPKFQQLVQCL
||||.|||    . . .. ||||.|||..||..|||..|| .... ..   ..||||  || .| ..|.. .| .|| ..||||| | |... |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RYK.AA Met 334-593 35 3.9e-79 259.05 In-house 1-271 (271) Show / Hide 
Range on Protein: 334-593
Range on HMM: 1-271/271
Sequence Identity: 35% (99 aa)

TLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK--DQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIE-EGEKPMVILPYMNWGNLKLFLRQCK
 . ||.  | || ..|| ..|..   .| .  .|. .   .  . ..   |.|    ....|.| |    .|.. ||. |.|.||||  | || | |   
HFDDVIGQGHFGCVYHGMYHDNDG--NEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRN--

LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDL-FPMDYHCLGDNEN---RPVRWMALESLV--------
  . ||| .    ||.  . |.|.||.|.| .  .| |||.||| .|  . ||. |  |.||.     |    .       ||.|||.|.|         
--PQNNPCV---RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

NNE-FSSASDVWAFGVTLWELMTLGQTPYVDIDP-FEMAAYLKDG--YRIAQPINCPDELF-AVMACCWALDPEERPKFQ
 .  |...|||| ||| .||||| | .|| ..|. |    .|. |   |  ||  ||| |   || |||  .||.|| | 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase RYK.AA Axl 333-597 41 4.9e-75 255.61 In-house 1-267 (267) Show / Hide 
Range on Protein: 333-597
Range on HMM: 1-267/267
Sequence Identity: 41% (112 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE-----KPMVILPYMNWGNLKLFL
..|  .| || || .  | |  | |    | | ||..| |  .. ..   | |   ..   | | . .  |||.  |     |||||||.| .| |  ||
FVLGKMLGEGEFGSVMEGQLKQE-DGSFVKVA-VKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

RQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSAS
   .| .  .|  .  | ||.  . ||||| ||. |. ||.|||||||.. . . | . |  ||. ..  ||   |     ||.|.|.|||  . . | |
LYSRLGD--QPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKS

DVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ
||||||||.||.|| |||||  ..  ||  || .| |. || .| |||...|  || .||..|| | .| .
DVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RYK.AA UTK 333-599 28 2.8e-68 232.66 In-house 1-296 (296) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-296/296
Sequence Identity: 28% (86 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEIQVT---MMLTESC---KLRGLH-HRNLLPITHVCIEEGEKPMVILPYMNWGNLKL
. | . | .| || .... . ..... .| .  ||. . . ... . .     . |.     .  .| |.|.|   .||  |.  .|... ||  |.|  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

FLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDT-------LQVKITDNA---LSRDLFP--------MDYHCLGDNEN
.|| ..     .| . .  ....|| .||.||.||... ..| ||||||| ...        ...|| |     .||..           .| .  .. .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

R-PVRWMALESLVNN-EFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG--YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
| |.|||| |.|...  |...||||.|||..||..| |..|| ..   . .. . .|  || ..|  ||.... .|  ||. ||.||| |..||| .
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RYK.AA EGFR 333-600 33 6.3e-65 214.46 In-house 1-258 (258) Show / Hide 
Range on Protein: 333-600
Range on HMM: 1-258/258
Sequence Identity: 33% (90 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLV
. .  ||  | ||... || | | .  |   | .| ...| .. .   || |   . .. | .|. .  ||...    ...  || .|.|  ..|| |  
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVA-IKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHK--

EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFG
      .|  |.|.  ..||| ||.||  ....| ||||||  .    .|||||  |.. | . .     .    |..|||||.. .  . ..||||..|
-----DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYG

VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
||.||||| || ||  |   |    |..| | .|| .|   .. ||  || .|.. ||.|..|.. . 
VTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase RYK.AA Musk 432-599 39 6.3e-61 199.99 In-house 115-282 (282) Show / Hide 
Range on Protein: 432-599
Range on HMM: 115-282/282
Sequence Identity: 39% (66 aa)

VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAF
| .  |   .  ..  || |||||| ||  .  .| ||| ||| | ..  ||| |  |||     ||    .|.  |.|||..||.  | |. .|||||.
VSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAY

GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|| |||.   .  ||  .   |   | ..|.. . | ||| .....|  ||   | .|| |.|. .|.
GVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase RYK.AA RTKB 333-599 32 8.7e-60 200.23 In-house 1-264 (264) Show / Hide 
Range on Protein: 333-599
Range on HMM: 1-264/264
Sequence Identity: 32% (87 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL
. |   | .| ||  | . .. ..  |.|.   .|. | .||. .    ..|   .  |  | |.. |   |  . | ...   . . |||  .||.|  
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQD-EPYILLVELCELGNLRDYLRMCRA

VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSAS-DVWA
 .  ||| ..|. ||  . ||||||..| ...||| ||.||| ..|  |. || | ...| .   .|    .    |..||| ||.    ... | |||.
SQ-HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWS

FGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|||| ||  .|| |||.    ...  .| .|.|  .|   | . ...|  ||......|| |. ||. .
FGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RYK.AA FGFR 440-599 45 9.7e-58 195.36 In-house 133-293 (293) Show / Hide 
Range on Protein: 440-599
Range on HMM: 133-293/293
Sequence Identity: 45% (73 aa)

ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELM
..| ||| .| |.| || ||| | .|| ||||||  . |    || |  |.||   .||     |   |. |||.|.|  . . . |||| .|| ||| |
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIM

TLGQTPYVDID-PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|.|..||  |    |. .||| |.|.  | ||. |.. .|  ||   |..|| | |||  |
TYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RYK.AA S_TKc 333-606 18 7.3e-17 63.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 333-606
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNW--GNLKLFLRQCK
 .. ... .|.||. . .. ..       ..  .| .|         ... |   |.  || |.  .  |. .  ..  ... |..   |.|. ......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSS-ASDVW
    .  . ..  .  ... ||.|.. |. .. .|| ||   |  .|.  ..||.|  |.| |    ... |        .|| | |    ..  ..|.|
RHGLR--FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCG-----TPWYMAPEVL---GYGKCKCDWW

AFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ--CLTEFHAAL
..|..|.|... |..|.   ....|   ..           ..|.   .  |.  |||.||   .. |   .   |  .
SCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RYK.AA Pkinase 510-599 18 1.4e-10 38.48 Pfam 176-293 (293) Show / Hide 
Range on Protein: 510-599
Range on HMM: 176-293/293
Sequence Identity: 18% (22 aa)

RWMALESLV-NNEFSSASDVWAFGVTLWELMTLGQTPYVDI------DPFEMAAYLKD-GYRIAQPINCP-------------------DELFAVMACCW
..|| | .  ... ....|.|..|..|.|... |..|. .       |. .| .  ..  ..   |  |.                   .|.  .. .|.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

ALDPEERPKFQQLVQC--L
..||..|| ..|..|   .
CKDPKKRPTAEQILQHPWF
Kinase RYK.AA Pkinase 333-486 16 1e-07 28.4 Pfam 1-155 (293) Show / Hide 
Range on Protein: 333-486
Range on HMM: 1-155/293
Sequence Identity: 16% (28 aa)

ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLT---ESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG----NLKLF
.... .. .|.||. .... ... .     .  ||..| .  . .. . ..   | . .. |.| | . . ... . . .. ....|.. |     |. .
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LRQCKLVEANNPQAI--SQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQV----KITD
..        .  ..  | ... ... ||..|. |. .. .|| ||   |. ||.. ..    ||.|
IST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD
Kinase RYK.AA FGFR 333-375 31 0.001478 7.93 In-house 1-45 (293) Show / Hide 
Range on Protein: 333-375
Range on HMM: 1-45/293
Sequence Identity: 31% (14 aa)

ITLKDVLQEGTFGRIFHGILI--DEKDPNKEKQAFVKTVKDQASE
 ||  .| || ||..  .  .  |.. |.||    || .|. ...
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTD