Gene RSK2 (Human)

RSK2

Species: Human
Alias: RPS6KA3, RSK, HU-2, HU-3, ISPK-1, MRX19, p90-RSK2, pp90RSK2, MAPKAPK1B, RSK2, S6K-alpha3, CLS
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xp22.2, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK2.NA RNA Sugen Kinome 7723 None Fasta, JSON
RSK2.AA Protein Sugen Kinome 740 None Fasta, JSON
RSK2.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON
RSK2.kin_dom2 Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of RSK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK2.AA AGC 68-327 34 1.7e-192 503.34 In-house 1-395 (395) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-395/395
Sequence Identity: 34% (139 aa)

FELLKVLGQGSFGKVFLVKKISGS---DARQLYAMKVLKKAT---LKVR-DRVRTKME------------RDILVEVN----------HPFIVK-LHYAF
||.|||.|.||||||.||.| .|    |  ..||||||||..   .| . .  .|. |            |.||...|          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALALDHLHS-LGIIYRD-LKPENILLDEEGHIKLTDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..|||..||| .|||.|| ||||||||||.|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKESIDHE--------------------------------------------------KKAYSFCG--TVEYMAPEVVNRRGHTQSADWWS--FGVLMF
|.|| .. .                                                  .....|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGTLPFQGK----------DRKETMTMIL------KAKLGMP----------QFLSPEAQSLLRMLFKRNPANRLGAGPD-----GVEEIKRHSFF
|||||  ||.|.          ...|..  |.      . |. .|          ...||||..|...|....|..|||.|..     |.||||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK2.AA RSK 68-327 57 9.69999999999e-191 639.95 In-house 1-271 (271) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-271/271
Sequence Identity: 57% (155 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....|||||.||...||. ..|..|.||||..||||..|.|||....||.|| ...|||||||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE----GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT
..||||.||.|||...|||.||..|||||||||.|.|    ||||..|||..|...|.......||.|..||||||..|.||.|..|||||||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GTLPFQGKDRKETMTMILKAKLGM-------PQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
|..|||.|.|...|..|...||||       ..|.|.||..||||...|.|.|||||||.|||.||.|..|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK2.AA RSK 71-327 55 8.8e-174 583.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 71-327
Range on HMM: 1-278/278
Sequence Identity: 55% (154 aa)

LKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDR-VRTKM-ERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||..|||||..|. ..|..|.|||||||||....|.. .|..| ||.|| ... |||||.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKE-SIDHEKKAYSFCGTVEYMAPEVVN----RRGHTQSADWWSFGV
|.|....||.||..||..|||..|||.|||||||||.|.   ||||||||||..|. ..||......||.|.||||||...    ..||....||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGTLPFQG---KDRKETMTMILKAK--LGMP--QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
||.||||| .||||   ..|||.|. |.|.|  |.||  |.||.||..|.|....|.|..|||.||...||||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK2.AA Akt 68-327 50 2.2e-149 480.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-264/264
Sequence Identity: 50% (135 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLY-AMKVLKKATLKVRDRVR-TKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.|||||||||||    |  ..| |||||||  .  .. |. || || ||. .||||||.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALDHLHSLGIIYRD-LKPENILLDEEGHIKLTDFGLSKES-IDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWS-FGVLMFEML
.|.  .|| ||. ||..|||| .||||| |||||||.|..|||.||||||.||  | .  |...|||| ||.|||. |  |||...|||. .|..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGTLPFQGKDRKETMTMILKAKLGMP--QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
.| .||  .|... .  |. ... .|   ..|||...|.. | ...| .|||.||....||||| .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK2.AA p70 68-327 47 2.5e-142 479.14 In-house 1-299 (299) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-299/299
Sequence Identity: 47% (143 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKA--TLKVRDRVRTK-------------------------MERDILVEVNHPFIVKLHYAFQTE
||||||||.| .||||.|.|  |.|. ..||||||.||  .   .|   |.                          || || ||.||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK----------AYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  .|| |||..|||||||||||..|.. ||..||||||.||||   ..           ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAK--LGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
| ||||||.. | || .  |||| |.||. ||||  || |  ||.|.  |||.|  | .|  |..|.  |.. | ||.|. |.||||. ...|..| ||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK2.AA AktR 68-327 47 3.2e-123 415.65 In-house 1-268 (268) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-268/268
Sequence Identity: 47% (127 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKK-ATLKVRDRVRTKMERDILV-EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|...|.||.| ||||.||.|    |  ..||||..||    . . . .| .||.|.  ..||||||||||.|||. ||..|... .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSK-ESID-HEKKAYSFCGTVEYMAPEVVNR-RGHTQSADWWSFGVLMFEM
.||...|| |.  |||..||.   |||||||||||||||.||.|.||||||| . ..  . ||||||||.||||||....  ||. |.|||.||.. .||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGTLPFQGKDRKETMTMILKAK-LGMPQF--LSPEAQSLLR-MLFKRNPANRLGAGPDGVEEIKRHSFF
.||  ||. |....   .|..   .  |.   .|.....|.   |...|| .||| .  | ||||.| .|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK2.AA S_TKc 68-327 35 2.7e-108 367.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|.||||.......     ...|.|..|          ... |..|| . .||.||||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQ-SADWWSFGVLM
     |.| ...||......||...||.|||.||||||||||||  |||..||||...        ..|||| .||||||.   |..  ..||||.|...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGV--EEIKRHSFF
.|||.|  ||.      .| |..|  .      |||| ...| .....|..|..|       ..|| | .|
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK2.AA MSK 71-322 40 1.6e-107 363.55 In-house 1-277 (277) Show / Hide 
Range on Protein: 71-322
Range on HMM: 1-277/277
Sequence Identity: 40% (113 aa)

LKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK--MERDILVEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|. ||.|...|....|. .|||||.|.|||.  . ..      || .|  . .||.||.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKESIDH-EKKAYSFCGTVEYMAPEVVNR-----RGHTQSADWWSFGVLM
. . ....|| .|.||.|..|||.|||||||||.|.|   ||.||.|||....     |....|.|.| .|||||...|      |. .. |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGTLPFQ--GKDRK-------ETMTMILKAKLGMP----QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK
..||||  |||  ..||.       | |  |.|..   |    |  ||.|. |.. |  ..|. |||... ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK2.AA Pkinase 68-327 29 3.8e-97 333.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM--ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||||.|.. .... ..   ..|.|..|| . |   ...     |  |. ..|||.||.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKES-IDHEKKAYSFCGTVEYMAPEVVN-RRGHTQSADW
 ..  |  .|...|||. ... .|...|| |||.|||||||||.|..|||    |..||||.|   . .   ...|||| .||||||.. ........|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGVLMFEMLTGTLPFQGK------DRKETMTMILKAKLGMPQFLS---------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRH
||.|....|||.| .||.|.      | .. . .|....|  . . .                     .|...... .....|. |..      |.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

SFF
 .|
PWF
Kinase RSK2.AA Ciliate-E2 68-327 24 8.3e-90 304.66 In-house 1-365 (365) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

FELLKVLGQGSFGKVFLVKK-ISGS-------------------DARQLYAMKVLKKATLKVRDRVRTKM-----------ERDILVEVNHPFIVKLHYA
....|..|||.||.|...|.   .                    .. ..||||..||  ..   ..   |           |. || ..|||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALALDHLHSLG-IIYRDLKPENILLDEEGHI
||  .. ..||..... ||||| ..                   ||.  .... ..       ||.|.. ||| .||| . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKESIDHEK-------------------------------KAYSFCGTVEYMAPEVVNRRG---------HTQSADWWSFGVLMFEMLTGTLP
|..||||||.  | ..                                ....||| .|||||..|. .         .. ..|.||.||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRKETMTMILKAKLGMPQF------------------LSPEAQSLLRM----LFKRNPANRLGAGPDGVEEIKRHSFF
|        .  |.. |.  |..                  .|.|.. |..     .....| .|..    | |.|. | .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase RSK2.AA CAMK 73-327 22 1.2e-88 285.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 73-327
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

VLGQGSFGKVFLVKKI-SGSDAR--------QLYAMKVLKKATLK--------------------------VRDRVRTKMERDILVE-------VNHPFI
.||.||||||.|.. . .. . |        | .|.|...|  ||                           .|| . . | .|.         ..|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALALDHLHSLG
.||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. |....||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKPENILLDEE-----------------GHIKLTDFGLSKESIDHE-----------------------KKAYSFCGTVEYMA-PEVVNR-----
|. |||||||||||.                  . ||..|||.... .. |                       .| . |||| |||| |||.|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RGHTQSADWWSFGVLMFEMLTGTLPFQGK-------------DRKETMTMILKAKLG-MPQFLSP-----------------------EAQ
         .......| || ||... ||.|..||.|.             . .|.. .|.|.|    | ..||                       |..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
.|.| . ...| .|. .     |....| ..
DLIRKMLQVDPEKRMTI-----EQCLNHPWM
Kinase RSK2.AA CAMK1 68-311 29 1.4e-64 186.59 In-house 1-265 (276) Show / Hide 
Range on Protein: 68-311
Range on HMM: 1-265/276
Sequence Identity: 29% (80 aa)

FELLKVLGQGSFGKVFLVKKISG-SDARQLYAMKVLK-KATLKVRDR---VRTKMERDILVEV---NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRL
.|. |..| |.|..|.|.....      . ||.|... |  .|  |.    . ..| .|.  |   .||.|.|..  .... ..||... . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIK--LTDFGLSKESIDHEK-KAYSFCGTVEYMAPEVVNR---RGHTQSAD
 .   .||.|      ... |. ..||.||  |||||||.|.   ||.  ||  . ||||||  .||.  . .  ||| .|.||||...    .. .. |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

WWSFGVLMFEMLTGTLPFQGKD-RKETMTMILKAKLGMPQF----LSPE-AQSLLRMLFKRNPANRL
 || ||  . .|.|  ||....  .| . .|.|.....| .     | . |  ... . . .| .|.
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase RSK2.AA S_TK_X 328-389 41 8.7e-23 82.94 SMART 1-79 (79) Show / Hide 
Range on Protein: 328-389
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

STIDWNKLYR--REIHPPFKPATG----RPEDTFYFDPEFTAKTPKDSPGIPPSANAHQL-----------FRGFSFVA
. |||.|||.  .|| |||||        |.|| .|||||| .||...|  ||. |...            ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK2.AA Pkinase_Tyr 68-289 27 7.3e-22 74.66 Pfam 1-237 (270) Show / Hide 
Range on Protein: 68-289
Range on HMM: 1-237/270
Sequence Identity: 27% (67 aa)

FELLKVLGQGSFGKVFLVKKI-SGSDARQLYAMKVLKKATLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS
 ...|.||.|.||.|.. .   .... ..  | |.| | .   ..  |     |  |. .  .|| ||.|. .    ..   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAY-SFCG----TVEYMAPEVVNRRGHTQSADW
|    .  .| .|   . .. | ....|.| ..| |||   |.|..|....| .||||..    ...  |    |     .  ||||. | .  |   | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSFGVLMFEMLT-GTLP-FQGKDRKETMTMILKAKLGMPQ
|||||||.|..| |  | ..| .  | . .| .    ||.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK2.AA TyrKc 68-327 24 9.4e-18 64.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV--NHPFIVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | ||.|.. . .      .  | |.||. .     |     |  |. ..  .|| ||.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDH-----EKKAYSF----CGT----VEYMAPEVVNRRG
| |    .. .|   .    |   ..||| ..| |||   |.|..|....| .|||||..  |.     .|. |.     .|     .  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HTQSADWWSFGVLMFEMLT-GTLPFQG-----KDRKETMTMILKAKLGMPQFL---------SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
 |   | |||||.|.|..| |  |  |     .. .| .  . . .  ..            ..|  .. ..  ...|..|        .||  |..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF-----SEI--HECF
Kinase RSK2.AA Pkinase_C 351-391 41 5.9e-11 41.83 Pfam 5-46 (46) Show / Hide 
Range on Protein: 351-391
Range on HMM: 5-46/46
Sequence Identity: 41% (18 aa)

PEDTFYFDPEFTAKTPKDSP--GIPPSANAHQLFRGFSFVAIT
|.|| .||||||  .|.|.|  .   |.... .||||..|.  
PTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK2.AA RSK 422-679 57 2.4e-193 648.63 In-house 1-271 (271) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-271/271
Sequence Identity: 57% (155 aa)

YEVKEDIGVGSYS---VCKRCIHKATNMEFAVKIIDKSKRDPT-----EEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE
||..|.||.||.|   |||.|.||.||...|.|||.|..||..     ||..|.||||.||.|..|..|..|...|| ....|.||.|.|..|.||.|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLT
||.......|....|||| ||.|||||||.||||.||||||..|.|||||||||||.|||.|||.|||||..|||||||||.|.|||.||.|||.|.|||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTA-----ALVLRHPWI
|.|||.|.|.|||..|..||..|.||...|.|...||.||||...|||.|||.||.|     . ...|||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK2.AA RSK 424-679 43 2.8e-159 535.43 In-house 1-278 (278) Show / Hide 
Range on Protein: 424-679
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

VKED--IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT--------EEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF---
.|..  .|.|....|..|.|..|....|.|...|.|....        .|..||.|..|||.|.||..........| ..|...||||.......|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQGYDAACDIWSLG
|||.||.... .|...||.|| ||..||||||.|||| ||| |...|...||||.||.|.. |...||.|||....|||.||    . |.|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLLYTMLTGYTPFANGPDD-TPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLT-----AALVLRHPWI
||.|.||||..||.. |.| ...||..||..|||||... |...|..||||..||||.|||.||.     |. ...|||.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK2.AA CAMK1 422-679 38 7.2e-122 356.07 In-house 1-276 (276) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-276/276
Sequence Identity: 38% (108 aa)

YEVKEDIGVGSYSVCKRCIHKAT---NMEFAVKIID-KS---KRDP------TEEIEILLRYG--QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKIL
||... || |. |. ..|.|| |   . ..|.|.|| |.   | |         ||||. . .  .||||| ....|.. ...| |.||..||||.|.|.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIR--ICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---QGYDAACDI
  ....|..|. .   | . |||.|..|.||||||| |.||.|.. .   |.  |.||| .|..  ...|. |.| |  .||||||..   ..|| |||.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDED-SKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSLGVLLYTMLTGYTPFANGPDDT-PEEILARIGSGKFSLSGGYWNSVSDT-AKDLVSKMLHVDPHQRLTAALVLRHPWI
|| || .|..|.|| ||    |..  .|... | ....     .|...||  |||....|| ||| .|.|.. .|.||||
WSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK2.AA Pkinase 422-679 33 1.5e-109 375.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE--------EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG----ELLDKIL--R
|.... || ||......|.|| |. ..|||||.|..... .        ||.|..|  .||||..|.|.. |....|.|.|.. ||    .| | |   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKFF--SEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLK-RQGYDAACDIWS
.. |  ||.|.  ..  | . .||.|..|..||||||.|||....  ......|||||.|||.    |. ..|.| | ...||||.. .|.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLYTMLTGYTPFANG----PDDTPEEILARIGSGKFSLSGGYWNSVS-----------------DTAKDLVSKMLHVDPHQRLTAALVLRHPWI
.|..|| ||.|..|| .     . ... ....||...... .  .|.|.|                 ...||.....|..||..|.||. .| |||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK2.AA AGC 422-679 23 2.8e-105 272.58 In-house 1-395 (395) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YEVKEDIGVGSYSVCKRCIHK------ATNMEFAVKIIDKSK---------RDPT-------------EEIEILLRYGQ---------HPNIIT-LKDVY
.|..  || ||.. .  . .|      .|.  .|.|...|..          . |             || .|| .. .         ||.|.  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKY--VYVVTELMK---------GG-ELLDKIL-R-QKFFSEREASAVLFT--------ITKTVEYLHA-QGVVHRD-LKPSNILYVDESGNPESIRI
 | ..  .| | |.|.         || ||.  .  | ...  . |..   .         |.  .||||  .|..||| ||| |||  ..      |..
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

CDFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDAACDIWS--L
.|||..|... .                                                     .  .  || |....|||.|    |. |||.||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GVLLYTMLTGYTPFANGPDD-------TPEEILARIGSGKFSLSGG------------YWNSVSDTAKDLVSKMLHVDPHQRLT----------AALVLR
|.|.| |||||.|| . ...       .|.|.  .| .|.. .. .            .. ..|. ||||..|.|..|| .||.          |  . .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWI
||| 
HPWF
Kinase RSK2.AA CAMK 427-679 26 6.5e-105 339.06 In-house 1-425 (425) Show / Hide 
Range on Protein: 427-679
Range on HMM: 1-425/425
Sequence Identity: 26% (113 aa)

DIGVGSYSVCKRCIHKATN------------MEFAVKIIDKS--------------------------------KRDPTEEIEILLRYG------QHPNI
 .| ||... |.|||| |.             ..|.|||||.                                ..    ||||. .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVYDDGKY-------------------VYVVT---ELMKGGEL----LDKILRQKF---------------FSEREASAVLFTITKTVEYLHAQGV
| | .||.|..|                   .| |.   |.. ||||    .|.| ...                |.||||. .   |   |.|.| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYVDESGNPE-------------SIRICDFGFAKQLRA-----------------------ENGLLMTPCYTANFVA-PEVLKR------
||||||| |||..| ... .              | |.|||||....                        |. .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDIWSLGVLLYTMLTGYTPFANGPDD----------TPEEILARIGSGKFSLSGGY------------WNSVSDT--------AKD
        ..|. .||.||.||.||.||.|| ||    |.          ...|.. .| .||..    |            |...||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVSKMLHVDPHQRLTAALVLRHPWI
|..||| ||| .|.|.. .|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK2.AA S_TKc 422-679 36 1.1e-103 351.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-231/231
Sequence Identity: 36% (99 aa)

YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKG--GELLDKILRQKF------FSE
||. . || |.......|.|| |. ..|.|||.   ..   ||.|| .  .||||..|.||..| ...|.|.|.. |  |.|.| | ...       |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGVLLYTML
 .|  ..  | . .||.| .|..||||||.|||  .       | |||||.|.||       .| | | ...|||||   ||.  .||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLR-------HPWI
.||.||      ...... .||              |. |||...|.|..|| .|.||  .|.       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK2.AA MSK 422-679 35 6.4e-89 300.71 In-house 1-277 (277) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)

YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIID-----KSKRDPTE---EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSE
 .|.  .| |....|..| |. |. ..|.||.       ... . .   |. .|..  ||||| .|.... |    | | |. .||||. .| . . |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQG-YDAACDIWSLGVL
 |.. ..  .   |...|  |..|||||| |||. ||. |   ... |||||. . .. .  . .||.|  . |||.|.     .| ||.|||.|||||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYTMLTGYTPFA-NGPDDT-----PEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI
|||||||  ||. |..|         ||  ||  |.||. |  |...|  ||||....| .||  ||..   . | |.
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK2.AA Ciliate-E2 422-679 23 3.4e-76 259.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

YEVKEDIGVGSYSVCKRCIH-----------------------KATNMEFAVKIIDKSKRDPTEEIEILLR----------------YGQHPNIITLKDV
|.. . || |.... ..| .                       |......|.||. |..   .. .. ..|                  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGKYVYVVTELMKGGELLD--KILRQKF---------FSEREASAVLFTITK---------------TVEYLHAQG-VVHRDLKPSNILYVDESGN
.   | ...| |.|. .||.|.|  |. ..|.         |.|.|.. .   |..                .|||| .. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PESIRICDFGFAKQLRAENG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDAACDIWSLGVLLYTMLT
   | |.|||..|..  .|                                .  | |.|....|||.|....         || .||||||||.|| ||.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYTPFANGPDDTPEEILARIGSGKFSLSGG--------------YWNSVSDTAKDLVSK----MLHVDPHQRLT-AALVLRHPWI
|..||           .  |  .|....                 |...|. .||| .|    || .|| .|.| .  .| |||.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK2.AA p70 472-679 30 4.8e-31 109.46 In-house 86-299 (299) Show / Hide 
Range on Protein: 472-679
Range on HMM: 86-299/299
Sequence Identity: 30% (68 aa)

QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE
.||.|. |   . ..   | . | . ||||     |.  . |  |.  |  |.   |.|| .|.. ||||| |..  .. |    .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQGH---VVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGK--FSLSGGYWNSVSDTAKDLVSKM
             . | | |  . |||.| | |.. |.| ||||.|.| ||||  ||     ... ..   |  ||   .|        .  ..||. |.
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTG---ENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHVDPHQRLT-----AALVLRHPWI
|  .| ||..     || . .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK2.AA Akt 528-618 38 4.6e-29 89.99 In-house 114-203 (264) Show / Hide 
Range on Protein: 528-618
Range on HMM: 114-203/264
Sequence Identity: 38% (36 aa)

EYLHAQGVVHRD-LKPSNILYVDESGNPESIRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWS-LGVLLYTMLTGYTPF
|.|| .... || ||| ||| .|. |.   |...||| .|.    ..   .| | |.   |||.|. .|.. |.|.|. ||...| |..|  ||
EHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK2.AA AktR 496-618 34 2.4e-23 83.89 In-house 83-205 (268) Show / Hide 
Range on Protein: 496-618
Range on HMM: 83-205/268
Sequence Identity: 34% (45 aa)

MKGGELLDKILRQKFFSEREASAVLFTITK---TVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAK--QLRAENGLLMTPCYTANFVAPEV
..||||.. . ..|.||| .|   .| .      .|||| .  .. ||||| |||  || |.   ..| ||| .|    .... .  . | |   .|||.
CPGGELFQHLKKKKKFSEEQA---RFYFAQILLALEYLHQHMNIIYRDLKPENIL-LDEDGH---VKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEM

LKR-QGYDAACDIWSLGVLLYTMLTGYTPF
... .|.. ..|.|..|...| |.||..||
ITKKKGHNKSVDWWAFGIFIYEMVTGCPPF
Kinase RSK2.AA Pkinase_Tyr 422-636 24 1e-17 60.64 Pfam 1-232 (270) Show / Hide 
Range on Protein: 422-636
Range on HMM: 1-232/270
Sequence Identity: 24% (61 aa)

YEVKEDIGVGSYSVCKRCIHK----ATNMEFAVKIIDKSKRDPTE--------EIEILLRYGQHPNIITLKDVYD-DGKY--VYVVTELMKGGELLDKIL
 .  . .| |.. . .... |     |... |||.. | . .. .        |..|.  .|.||||. |  |   .|.   .|.|.|.|..| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----QKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL-------RAENGLLMTPCYTANFVAPEVLKRQGY
.    .. ..  .     . | |  |||.... .||||   |.|  .    .  ..||||| |. .       |.  |  .    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DAACDIWSLGVLLYTMLT-GYTPFANGPDD----TPEEILARI-GSG
  . |.|| |||.. ..| | .|      .    ..||....|  .|
TTKSDVWSFGVLMWEIFTYGEQP------TYPGMSNEEVYEYIYEDG
Kinase RSK2.AA TyrKc 422-679 19 3.4e-15 22.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 422-679
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE----EIEILLRYG-QHPNIITLKDVYDDG-------KYVYVVTELMKGGELLDKILRQK
 . .. .| | . .  ... |   .. ||| . ...    |    |..|. ..| .||||. |  |  ..       . ...|.|.|..| |.| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

-FFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-----NGLLMTPCY--TANFV------APEVLKRQGY
  .. ..     . | .  |||| ....||||   |.|. ..      ..|.||| .. .  .     ..   ..     ....      |||...   .
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DAACDIWSLGVLLYTMLT-GYTPFAN---GPDDTPEEILARIGSGKFSLSGGY------WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI
  . |.|| ||... ..| | .|  .     . ...|..... .|.      .          ..  . . ..  | ||..| | . .  |  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase RSK2.AA Akt 648-679 40 2.7e-07 19.28 In-house 228-264 (264) Show / Hide 
Range on Protein: 648-679
Range on HMM: 228-264/264
Sequence Identity: 40% (15 aa)

VSDTAKDLVSKMLHVDPHQRL-----TAALVLRHPWI
.|. .|||.|..|. ||..||     .|  . |||| 
ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK2.AA AktR 648-679 31 0.000111 14.42 In-house 231-268 (268) Show / Hide 
Range on Protein: 648-679
Range on HMM: 231-268/268
Sequence Identity: 31% (12 aa)

VSDTAKDLVS-KMLHVDPHQRLT-----AALVLRHPWI
.|...|||.  | |  .| .||.     .  . .||| 
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK2.AA AktR 422-457 24 0.019722 5.7 In-house 1-37 (268) Show / Hide 
Range on Protein: 422-457
Range on HMM: 1-37/268
Sequence Identity: 24% (9 aa)

YEVKEDIGVGSYSVCKRCIHK-ATNMEFAVKIIDKSK
..| . .| | ..    . .|  ..  .| |.|.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKK