Gene ROCK2 (Human)

ROCK2

Species: Human
Alias: KIAA0619, ROCK2, ROCK_II
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p25.1,

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
ROCK2.NA RNA Sugen Kinome 6401 None Fasta, JSON
ROCK2.AA Protein Sugen Kinome 1388 None Fasta, JSON
ROCK2.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of ROCK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ROCK2.AA DMPK 92-354 65 5.9e-288 723.06 In-house 1-270 (270) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-270/270
Sequence Identity: 65% (176 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
....||||||.|||||.||||....|||||...|.||.||...|.||||||||...||.|..||.|||||..||||||||||||||..|||.|.  .||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD--GFYGRECDWWSVGVFLYEM
.|.||.||.|||...||.|| .|||.||||||||.|||.||||||.||||.. |||....|||||||||||||.....|  | ||.|||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LVGDTPFYADSLVGTYSKIMDH-KNSLCFPEDAE--ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF
|.|.|||||||||.||.|||.| ||.|.||.| .  .|..||.|||..|.|||.||||||.|....||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase ROCK2.AA ROCK 92-354 87 5.3e-215 720.55 In-house 1-263 (263) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-263/263
Sequence Identity: 87% (229 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWA
....|||||||||||||||||.|.||||||.|||||||||||||||||||||||.|||.|.|||.|||||||||||||.|||||||||||||||||||||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

KFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGD
.|||.|||||||||||||.||||||||||||||.||||||||||||||...|||.||||||||||||||||||||.|| |||||||||||||.|||||||
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF
||||||||||||||||||||||.||.|.||||.||.|||.||||||.|||||||..|.||.||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase ROCK2.AA AGC 92-354 31 8.99999999999e-176 459.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-395/395
Sequence Identity: 31% (125 aa)

YDVVKVIGRGAFGEVQLVRHK------ASQKVYAMKLLSKFE--------MIKRSDSAF-------FWEERDIMAFAN----------SPWVVQ-LFYAF
....||||.|.||.| |||.|      ...|.|||| |.| .        |...  ...       .||||.|.. .|          .|..|. |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDRY--LYMVMEYMP--------GGDLVNLMSNY------DVPEKWAKFYTAE-------VVLALDAIHS-MGLIHRD-VKPDNMLLDKHGHLKLADFG
||...  ||.||||||        ||..  .....        .|..|.||.||       .||||. .|| || |||| .||.|.|||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCMK--------------------------------------MDETG-----------MVHCDTAVG--TPDYISPEVLKSQGGDGFYGRECDWWS--VG
 | .                                      .....           .. . | .|  ||.|..||.|        ||..|||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

VFLYEMLVGDTPFYADSLV----------GTYSKIMDH----KNSLCFP--------EDAEISKHAKNLICAFLT-DREVRLGRN-------GVEEIRQH
...||||.| .|||.|. .           .. |||..    .. . ||        || ..|. ||.||  .|. |.| ||| .       |.|||..|
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PFF
|.|
PWF
Kinase ROCK2.AA GEK 92-354 53 3.5e-135 455.38 In-house 1-269 (269) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-269/269
Sequence Identity: 53% (144 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
....|||||||||||  |. | ...|||||.| |.||.||.. | | ||||.. .  . |. .| |||||..|||.||.|  ||||. |.| ..  .||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEML
 |.|| ||.|.|.|..| .. .|||.||||.|||..||..||||| |..|.. |||.   |||||||||||.|.  ..| | ||.||||||.||..||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

VGDTPFYADSLVGTYSKIMDHKNSLCFPEDAE---ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF
 |.|||||.||| ||.|||.||. . ||.. .   .|..|| ||.  .  .|.||||||... ..||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase ROCK2.AA CRIK 92-354 45 5.2e-124 397.36 In-house 1-272 (272) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-272/272
Sequence Identity: 45% (125 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEK
. |  .||.| ||.||.|| |.   .|||| . | ..  . . .|| ||||||. .||||. || |||||.  || .|||.|||||  ||. .|    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD----GFYGRECDWWSVGVFLY
 |.|| || ..|.  .| || .|||.||.| |.|  || ||||||   ||.. ..|     ||||||. |||| .  |.    | || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLVGDTPFYADSLVGTYSKIMD------HKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF
|| .| |||  |. . |||.||.       .  | || |  .|  . .||   |...  ||   . | .  ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase ROCK2.AA S_TKc 92-354 34 2.8e-97 330.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-231/231
Sequence Identity: 34% (96 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPG--GDLVNLMSNYD----
|.....||.||||.| ..||| .....|.| ..            .. |..|.   . |..|.|...|||  .|||||||..|  |||  .. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGR-ECDWWSVG
    || .|.||......||. .||.| ||||.||.| |||.  |.|..||| . ..        .| .|||.|..||||        ||. .|||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLT-DREVRLGRNGVEE----IRQHPFF
. |||||.| .||.   .  .. ||.              |. ||..|.  |. | | |..   . .    |..||.|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROCK2.AA RSK 95-354 38 3.4e-89 302.65 In-house 1-278 (278) Show / Hide 
Range on Protein: 95-354
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

VKVIGRGAFGEVQLVRHK---ASQKVYAMKLLSKFEMIKRS-DSAFFWEERDIMAFAN-SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV---
.|| |.|..|.| |.| .   .....|||| |.| ....|  | .  ..||.|..  . .| .|.|.||||.. .||..|||..||.|    ..      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDK---HGHLKLADFGTCMKM--DETGMVHCDTAVGTPDYISPEVLK---SQGGDGFYGRECDW
  |. |.|| ||.|||.. .|. | |||| ||.|.|.|    .||.|| ||| | ..  |.... .  | ..| .|. ||.||    |||   ... |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTM--TFCYTIEYMAPEMLKRANQQGG---HDKACDW

WSVGVFLYEMLVGDTPFYA---DSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLT-DREVRLG--RNGVEEIRQHPFF
|| || .||||.| .||..   ..   .  .|.  | || .|.....|. ||.|| . |. | . |||  ....|||.|||.|
WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase ROCK2.AA NDR 92-234 53 5.7e-85 261.92 In-house 1-149 (350) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-149/350
Sequence Identity: 53% (80 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN--SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN---LMSNYDV
....|.||.|||||| |||.| ....|||| . | ||...   |    |||||| |.  .|||| |.|.|||. ||| ||||.||||.     | ...|.
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG
 .| ||.|| || |.|....|.|| ||||.|||| |.||.||.|| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase ROCK2.AA AktR 92-354 37 1.1e-83 284.29 In-house 1-268 (268) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-268/268
Sequence Identity: 37% (102 aa)

YDVVKVIGRGAFGEVQLVRHK-ASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPE
..| |..|.||||.| ||..|  .||.||||...| ..|.|        ||.||.  .| |  |.|.|.||....|. .|||.|||.| .  . .    |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

KWAKFYTAEVVLALDAIHSM-GLIHRDVKPDNMLLDKHGHLKLADFGTCM-KMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLY
. |.|| |...|||.  |.    | || ||.| |||..||.|..|||      ..    . .. .||| |..||...  .|    ... .|||..|.|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKG----HNKSVDWWAFGIFIY

EMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLIC-AFLTDREV-RLG--RNGVEEIRQHPFF
||..| .|||...    . ||  .   . ||. ...|...|.||.   | ..   |||  .|| |||. ||.|
EMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase ROCK2.AA MAST 92-234 46 3.2e-75 229.06 In-house 1-147 (337) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-147/337
Sequence Identity: 46% (69 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAFANSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYD--
.. .|.|..||.| | ||.|| . . .||| . .  .|..   |..|   ||.| ...  |.|| .||.||   ..||.|||||| |||   |...|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG
 ||  ||.|.|| ||.|. .||.| .|||.||||||.|. ||.||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK2.AA MAST 92-234 47 1.2e-71 230.14 In-house 1-144 (334) Show / Hide 
Range on Protein: 92-234
Range on HMM: 1-144/334
Sequence Identity: 47% (70 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPE
.. .|.|..||.| | ||.|| . . .||| . | .||..   |. .   ||.| |.. .|.|| .||.|| ..||.|||||| |||.  |...|   .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG
  ||.|.||.||.|. .||.| .|||.||||||.|. || ||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK2.AA Pkinase 92-354 32 5.8e-70 243.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 92-354
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW-EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG----DLVNLMS---N
| ....||.|.||.| . .|| ..|..|.| ..| .  .  | . ..  |  ||.  |.| .|.|...|.|....||||||..||    ||  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YDV--PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL----KLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDW
  .  .|. .|||  ... .|. .|||| ||||.||.| |.|..||.    |..||| . ..|.   . ..| .|||.|..|||..   |.  ||...|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDM

WSVGVFLYEMLVGDTPFYAD------SLVGTYSKIMDHKNSLCFPEDAEIS-----------------KHAKNLICAFLT-DREVRLGRNGVEEIRQHPF
||.|. ||||| | .||. .      .    . .||. ...  .|.. .||                 . .| .|.  |. | . |..    |.| |||.
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

F
|
F
Kinase ROCK2.AA NDR 250-354 44 3.4e-54 165.22 In-house 241-350 (350) Show / Hide 
Range on Protein: 250-354
Range on HMM: 241-350/350
Sequence Identity: 44% (50 aa)

AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL-----CFPEDAEISKHAKNLICAFLT-DREVRLGRN
.||||||. |||.. ..|   |. .|||||.|. .|||||| .||..|.   |. |||. |. .      ||..|..|. |..||  ... |.. |||..
TVGTPDYMAPEVFQQKTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

G--VEEIRQHPFF
|  |.||..||||
GKGVDEIKSHPFF
Kinase ROCK2.AA MAST 251-354 41 3.3e-36 107.64 In-house 229-337 (337) Show / Hide 
Range on Protein: 251-354
Range on HMM: 229-337/337
Sequence Identity: 41% (47 aa)

VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVG-TYSKIMDHKNSLCFPED------AEISKHAKNLICAFLT-DREVRLGR
.||||||.|||.  ||    ||   ||||.|. .|| ||| .|| .|.    . ..|  |.. . .||.       ..|. |. ||  .|. .  .||| 
CGTPDYIAPEVILGQGT---YGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

NGVEEIRQHPFF
||..|| |||||
NGADEIKQHPFF
Kinase ROCK2.AA MAST 251-354 39 1e-33 105.85 In-house 225-334 (334) Show / Hide 
Range on Protein: 251-354
Range on HMM: 225-334/334
Sequence Identity: 39% (45 aa)

VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK-NSLCFPED------AEISKHAKNLICAFLTD-REVRLGR
.||||||.|||.. ||    .|   ||||.|. .|| ||| .||  |.   ....|  .. |   .||.       ..|. |. ||  .|.   ..||| 
CGTPDYIAPEVILGQGT---HGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

N-GVEEIRQHPFF
| |..|. |||||
NNGADEVKQHPFF
Kinase ROCK2.AA TyrKc 92-348 19 5.6e-12 -29.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 92-348
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA--NSPWVVQLFYAFQDD-------RYLYMVMEYMPGGDLVNLMS
    |..|.|||||| . . |  ..| | | | .         . | .|  ||     . | .|.|. .  ..         |..||||||.||| .   
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDET-------GMVHCDTAVGTPD-----YISPEVLKSQGGD
..   .. |    .   .    . .||...||||    | |... .. | .||| . . ..         . .  .  |. .       .||..     .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

GFYGRECDWWSVGVFLYEML-VGDTPFYA-----DSLVGTYSKIMDHKNSLCFPEDAE------ISKHAKNLICAFLTD--------REVRLGRNGVEEI
| .  . | || || ..|..  |..| .       |    . ... . . .  |....       ..   ...              .|.      .|..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase ROCK2.AA Pkinase_Tyr 92-179 29 1.6e-05 19.37 Pfam 1-96 (270) Show / Hide 
Range on Protein: 92-179
Range on HMM: 1-96/270
Sequence Identity: 29% (29 aa)

YDVVKVIGRGAFGEVQLVRHK-----ASQKVYAMKLLSKFEMIKRS--DSAFFWEERDIMAFANSPWVVQLFYAFQ-DDRY--LYMVMEYMPGGDLVN
    |..|.|||||| . . |       ..| | | | |    ..     .|. | .  . . . | .|.|  .   ...   .|.||||||.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase ROCK2.AA Pkinase_Tyr 206-234 37 0.277377 4.97 Pfam 128-156 (270) Show / Hide 
Range on Protein: 206-234
Range on HMM: 128-156/270
Sequence Identity: 37% (11 aa)

HSMGLIHRDVKPDNMLLDKHGHLKLADFG
.|...||||.   | |... .. | .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
S_TK_X ROCK2.AA S_TK_X 357-417 22 5.9e-15 56.93 SMART 1-79 (79) Show / Hide 
Range on Protein: 357-417
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

DQWHWDNIR----ETAAPVVPELS----SDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLP----------FIGFTYYR
... ||...    |. .| .|...    |..| ||||. .... ...| . | .. ... .          |.|||| .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Pkinase_C ROCK2.AA Pkinase_C 374-419 34 1.8e-10 40.13 Pfam 1-46 (46) Show / Hide 
Range on Protein: 374-419
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

ELSSDIDSSNFDDIEDDKGDVET-FPIPKAFVGNQLPFIGFTYYREN
...|..| ||||. ..|  ...|  . .  . |.|.||.|||| ...
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
HR1 ROCK2.AA HR1 475-554 20 1e-06 27.01 Pfam 1-74 (74) Show / Hide 
Range on Protein: 475-554
Range on HMM: 1-74/74
Sequence Identity: 20% (16 aa)

TRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIST
 ||..  |..| |  ...  |  .|.......  .|     .... . . ..|. .. ...|..|||.|..|.|. ....
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-----RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
Rho_Binding ROCK2.AA Rho_Binding 978-1046 73 1.5e-42 147.25 Pfam 1-72 (72) Show / Hide 
Range on Protein: 978-1046
Range on HMM: 1-72/72
Sequence Identity: 73% (53 aa)

LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ---LLTERTLKTQAVNKLAEIMNRKE
||.|||||||||||||||.|. ||.|..||.||.....|||||||.   |.||||||||||||||||||||.
LTKDVANLANEKEELNNKMKKQQEELQKLKEEEQQMNQIKAQFEKCRAKLQTERTLKTQAVNKLAEIMNRKD
HR1 ROCK2.AA HR1 1116-1137 31 11.956029 1.87 Pfam 54-74 (74) Show / Hide 
Range on Protein: 1116-1137
Range on HMM: 54-74/74
Sequence Identity: 31% (7 aa)

IEQLRSQLQALHIGLDSSSIGS
||.||.||. |.  .   ....
IEYLRMQLEKLQQRHQD-HPPN
C1 ROCK2.AA C1 1261-1315 30 1.2e-14 55.88 SMART 1-61 (61) Show / Hide 
Range on Protein: 1261-1315
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HEFIPTLYHFPTNCEACMKPLWHMFKP---PPALECRRCHIKCHKDHMDKKEEI----IAPC
| .. . .  ||.|. |.|..|.|||.   .....|..|. ||||...||  ..    ...|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH ROCK2.AA PH 1151-1351 9 4.3e-08 34.12 SMART 1-82 (82) Show / Hide 
Range on Protein: 1151-1351
Range on HMM: 1-82/82
Sequence Identity: 9% (19 aa)

SRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVG
  .||||.        | .| |..... .. ...|...       | ........  ||. .                                      
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK------KPKGSIPLSDC-TVRE-P--------------------------------------

EKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAK-NLLLLANSTEEQQKWVSRLVKKIP
                                                                   .  |.. .  ... ..| ||.|.|.. . | | 
-------------------------------------------------------------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIH

KK
. 
NN
PH ROCK2.AA PH 1151-1235 17 2.8e-07 28.87 Pfam 1-67 (92) Show / Hide 
Range on Protein: 1151-1235
Range on HMM: 1-67/92
Sequence Identity: 17% (15 aa)

SRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANE
 ..||||.. .    |. .| | .... ......|....    ..| ........  |..|.          . | .||| . ..
VIKEGWLHKKG----KRKSWKKRWFVLFNNCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQIRT-DR
C1_1 ROCK2.AA C1_1 1261-1303 24 1.8e-05 23.73 Pfam 1-43 (55) Show / Hide 
Range on Protein: 1261-1303
Range on HMM: 1-43/55
Sequence Identity: 24% (11 aa)

HEFIPT-LYHFPTNCEACMKPLWH-MFKPPPALECRRCHIKCHKD
| ....  .  || |. |....|.  ..  ... |. || .||..
HHWVHHWNFKQPTFCCHCGEFCWGWLGH--QGWKCQWCHYNCHHR
PH ROCK2.AA PH 1327-1349 21 5.83013 2.51 Pfam 70-92 (92) Show / Hide 
Range on Protein: 1327-1349
Range on HMM: 70-92/92
Sequence Identity: 21% (5 aa)

LLLLANSTEEQQKWVSRLVKKIP
... |.| || . |.. . . . 
YYFQAESEEEMNDWMQAIQSACR