Gene RIPK3 (Human)

RIPK3

Species: Human
Alias: RIP3, RIPK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q11,

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
RIPK3.NA RNA Sugen Kinome 1940 None Fasta, JSON
RIPK3.AA Protein Sugen Kinome 518 None Fasta, JSON
RIPK3.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of RIPK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIPK3.AA RIPK 27-283 38 1.5e-149 503.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-290/290
Sequence Identity: 38% (112 aa)

VGKGGFGTVFRAQHRKWGYDVAVKIVN------------SKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPK-PALVTKFMENGSLSGLLQSQC---
||.||||.||.|.||.||..||.|...            ......|.|.|..|..|......|......||.|.| ...|...||||||...|....   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

--PRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGT-------GSG----EPGGTLGYLAPELFVNVNRK
  |.||||.||...|...||.|||..||...||||||.|.|.|...|||.|||||.|....|.|..       ...    ...||| |..||.|...|.|
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

A----STASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKT
.    ....|||||.|.||.||..................|....||.|...|.. ||.|..|...||||.||...|.|||.|||| ..|
PIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase RIPK3.AA TKL 27-283 23 1.7e-86 293.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

VGKGGFGTVFRAQHRKWG--------YDVAVKIVNS---------------------------------KAISREVKAMASLDNEFVLRLEGVIEKVNW-
.|.||||.|.....| ||        .|||||. .|                                 . . .|.. | .|. . .... |.    .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------DQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQN------PVLLHRDLKPSNVLLDPELH--------------VK
       ........|. ....|||  .|.      |...||. ... .|| ||| .|      | ..|||||..|.|.|  ..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LADFGLSTFQGGSQSGTG-----------------SGEPGGTLGYLAPELFVNV--------------NRKASTASDVYSFGILMWAVLAGREVE--LPT
..|||||.|  .|.. .                  .. ..||....|||.. .               ....|...|||||||..| .|......  .| 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

EPSLVY-------EAVCNRQNRPSLAELPQA----GPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKT
.| ..        . ||....|| . . .|      |... ....|.||| ||...|..||||||.| . 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc RIPK3.AA S_TKc 21-287 21 6e-52 179.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMEN--GSLSGLLQSQCP------R
 |  ...|||.||.|....|.| |  ||.||.. . | ||.. . . . ... .| .|..        .  .|. ....  |.|  ..... .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKAST-ASDVYSFGILM
|    ........... |.|...   .||||||.|.|||   |.|..||||...              ||. |.|||..     . .. ..|..|.|...
PE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL

WAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLP-----KTDEVF
.  |.|.      .. .... ..                     . .|.... |.  .|..||.  |.|      | .. |
YEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase RIPK3.AA Pkinase 21-280 19 2.2e-48 171.87 Pfam 1-288 (293) Show / Hide 
Range on Protein: 21-280
Range on HMM: 1-288/293
Sequence Identity: 19% (61 aa)

LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISR----------EVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENG----SLSGLL
..  . .|.|.||.|....|.. |  |||||.. . ..           |.. |..|. ....|| .. |      .... .|. ..|.|    .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

Q--SQCPR--PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHV----KLADFGLST-FQGGSQSGTGSGEPGGTLGYLAPELFVNVNRK
.  ....   ..  ... ..... |. |.|..    .||||||.|.|.| . |.    |..||||.  |.    ...    . ||..|.|||. .. ...
STWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEV-IRGGQY

ASTASDVYSFGILMWAVLAGREVELPTEPSLVYEA---------VCNRQNRPSLAELPQAGPETPGL----------------EGLKELMQLCWSSEPKD
 ....|..|.|.... .| ||         . ...         .. .....   . .   . .. .                | .|...  |.   ||.
YGPKVDMWSCGCILYEMLCGR--------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPSFQECL
||.....|
RPTAEQIL
Kinase RIPK3.AA Dicty4 88-285 31 3.1e-40 131.99 In-house 75-277 (277) Show / Hide 
Range on Protein: 88-285
Range on HMM: 75-277/277
Sequence Identity: 31% (68 aa)

PKPALVTKFMENGSLSGLLQS-------QCPRPWPLLCR---LLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLST-FQGGSQSGTGS
.|.  || .|  |.|  || .         . .|||  |   . . ...|| .||  ||| .|||||..| | |  . || .|||||. .. ... ... 
GKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQ

GEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVEL--PTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRP
  . || .. |||    ...    ..|||||||. |  | . |  .    ..  ...|||| ..||   ..|. .|       .|.|.| ||. .|. ||
MTACGTPCWMAPEVM--MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP---PIPDWCPPS-----WKHLIQWCWDHDPQHRP

SFQECLPK--TDE
||.|....   ..
SFEEIIQRRILEH
Kinase RIPK3.AA TK 21-283 14 5.3e-37 121.05 In-house 1-486 (486) Show / Hide 
Range on Protein: 21-283
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

LENQELVGKGGFG---TVFRAQHR---KWGY----------------------DVAVKIVNSK--AISR------------------EVKAMASLD----
..  .  |.| ||   .|.... |   .|.                       .||||.. ..  . ..                  |. .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NEFVLRLEG-VIEKVNW------DQDPKPALVTKFMENGS----LSGLLQSQCP---------------------------------------------
  . ..|| | . ....       . .. . .|. .|..|.    |   |..  |                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------RPWPLLCRLLKEVVLGMFYLHDQNP----VLLHRDLKPSNVLLDPELH-----------VKLADFG---
                                . . |.     .  || |||..|      . ||||   |.|.. ...           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSTFQGGSQSGTGSGEPGGTLG------------------------YLAPELFV-NV------NRKASTASDVYSFGILMWAVLA-GREVELPTE
     |.   . ..  . ....|....                        ..||| .  .|      ..| .|.|||.|||.||| ..  |.|   .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

P----------SLVYEAVCNRQNRPS-------LAELPQAGPETPGL-------------EGLKELMQLCWSSEPKDRPSFQECLPKT
.            |.| ... .   .          .... |.                 | . .||| ||. .|.|||.|.... . 
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RIPK3.AA MLK 21-219 24 3.3e-34 116.09 In-house 1-234 (291) Show / Hide 
Range on Protein: 21-219
Range on HMM: 1-234/291
Sequence Identity: 24% (59 aa)

LENQELVGKGGFGTVFRAQHRKWGYD-----VAVKIVN------------SKAISREVKAMASLDNEF----VLRLEGVIEKVNWDQDPK-PALVTKFME
....| .|.|.|| |.... |  . |     ||||.|.            .... .|..  . |. .     . .. ||.      |.|.  ..|. ..|
IQFHEWIGSGSFGKVWKGRWR--NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCL-----QPPCHFCIVMEYCE

NGSLSGLLQSQ--------------CPRPWPLLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDP------ELHVKLADFGLSTFQGGSQSGTGSG
.|||. .| ..                 .  .. .  . .  || ||| . |. . |||||..|.|.|       ....| .|||.|..   .|..|   
GGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW--HQMCTNMM

EPGGTLGYLAPELFVN-VNRKASTASDVYSFGILMWAVLAGRE
   ||. . ||| .    . | | ..||.|.|...| .|....
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase RIPK3.AA TKL-Unique 25-212 27 5.8e-33 113.64 In-house 3-219 (290) Show / Hide 
Range on Protein: 25-212
Range on HMM: 3-219/290
Sequence Identity: 27% (61 aa)

ELVGKGGFGTVFRAQHRKWGYDVAVKIVN----SKAISRE-----VKAMASLD-NEFVLRLEGVIEKVNWDQDPKPA---LVTKFMENGSLSGLLQ----
...| ||.|.|... .|  ||.||.|. .    |  ....     |. |  |.  ...... |.      |. ..|.   .|. ... |||  .|.    
NKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYC----MDHQVYPPNMCIVMEYCPGGSLYDVLHQNNN

------SQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPE-----LHVKLADFGLSTFQGGSQSGTGSG-------EPGGTLGYLAPE
      . |. .. .  .. . ...|| |||  .|  .|||||.||.|.| .     . .|..|||||.|.  .  .| ..       .. |.. ..|||
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

LFVNVNRKASTASDVYSFGILMW
.. ... . |. |||||||| .|
VLRMNFCQYSEKSDVYSFGIVLW
Kinase RIPK3.AA STE 21-212 20 1.8e-32 112.05 In-house 1-259 (359) Show / Hide 
Range on Protein: 21-212
Range on HMM: 1-259/359
Sequence Identity: 20% (56 aa)

LENQELVGKGGFGTVFRAQHRK---------------WGYDVAVKIVN-----------------------SKAISREVKAMASLD--NEFVLRLEGVIE
.|..| .|||.||||..| ..|                |  .|.|..|                        . | .|.| |  ..   ... .  |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KVN--WDQDPKPALVTKFMENGSLSGLLQS--QCPRP------------WPLLCRLLKEVVLG-MFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGL
| .   ..| .  ..  .|..|||. ....   |..|             ..... ..... | . |||...    |||.||.|.||     |||.|||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

STFQGGS--------------QSGTGSGEPGGTLGYLAPELFVN--VN--RKASTASDVYSFGILMW
..    |               ..  .    ||  . |||   .   .   . .| .|..|.|....
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII
Kinase RIPK3.AA Ciliate-E2-Unclassified 22-218 18 2.5e-29 98.89 In-house 2-267 (352) Show / Hide 
Range on Protein: 22-218
Range on HMM: 2-267/352
Sequence Identity: 18% (50 aa)

ENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLR---LEG------------------------VIEKVNWDQDP-KPALV
. ..  |.||||.|...||.| .  ....  ..|.... .| . . | |...    ..                         .. .. ..||  .. .|
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TKFMENGSLSGLLQSQ-----------------CPRPWPLLC-----RLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPEL---HVKLADFGLSTFQG
. ..|.|.|.  ....                 .  .    .     ........|  ||| .|   .|||.||.|.|.| .    ..|..|||.| ...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

---GSQSGTG-----------SGEPGGTLGYL----APELFVNVNRKAS--TASDVYSFGILMWAVLAGR
   ... ...           .    ||..|.    |||.. . |   |   ..|..|.|... . | |.
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase RIPK3.AA Shk 125-288 35 9.3e-27 92.91 In-house 111-269 (269) Show / Hide 
Range on Protein: 125-288
Range on HMM: 111-269/269
Sequence Identity: 35% (63 aa)

VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLST-FQGGS-----QSGTGSGEPGGTLGYLAPELFVNV--NRKASTASDVYSFGILMWAVLA
.|||  ||  |.. .|||||..| | |  . || .|||.|   . ..     |.|     . ||  . |||  .|   | ||    |||||||. |  | 
ALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKG-----AKGTPLWMAPEVMMNHPYNEKA----DVYSFGIILWEILT

GREVELP---TEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPK--TDEVFQ
 ..   |    |    |||.|| ..||.    |   |       ||.| | ||  .|. ||||.| . .   ...  
-CQEPYPKHHSEYDKFYEAICNKKERPP---IPDDCPKS-----LKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase RIPK3.AA TyrKc 21-286 24 6.9e-25 89.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-286
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN---SKAISREVKAMASL--DNEFVLRLEGVIEKV--NWDQDPKPALVTKFMENGSLSGLLQSQCP-R
..  .  | | ||.|.... .   ..|||| ..    ... || . | .|  ... ..|| ||. .   |.  .. . .|. .|..|.|   |..  |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGS-------QSGTGS---GEPG-GTLGYLAPELFVNVNRKASTA
... |.     .  || |||..|  . ||||   |.|.. ...|| .||||| . .         .  . .   |. .   .  .||| .    .| .|.
CMKDLLSFCWQIACGMEYLHSKN--CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTK

SDVYSFGILMW------AVLAGREVELPTEPSLVYEAV--CNRQNRPSLAELPQAGPETP-----GLEGLKELMQLCWSSEPKDRPSFQECLPKTDEV
|||.|||..||      .     ... . ... |.| |   .|  .|  ..        |       . . ..|. ||  .|.|||.|.|.    .. 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase RIPK3.AA LRRK 90-212 26 1.6e-24 83.67 In-house 130-273 (351) Show / Hide 
Range on Protein: 90-212
Range on HMM: 130-273/351
Sequence Identity: 26% (39 aa)

PALVTKFMENGSLSGLLQ----SQC----PR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLL---D---------PELHVKLADFGLST-FQ
...|. .. .|.|. .|.    ..     .. .| |. ..  ..  || |||..|| ..|||||. |.||   .         .. ..|.||||.|. | 
LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-

GGSQSGTGSGEPGGTLGYLAPELFVNV-NRKASTASDVYSFGILMW
  .   ..    .|. |..|||   .  .   .. .|.||||...|
-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILW
Kinase RIPK3.AA Pkinase_Tyr 21-164 26 3.4e-18 62.25 Pfam 1-158 (270) Show / Hide 
Range on Protein: 21-164
Range on HMM: 1-158/270
Sequence Identity: 26% (44 aa)

LENQELVGKGGFGTVFRAQHR----KWGYDVAVKIVNSKAISR---------EVKAMASL-DNEFVLRLEGVIEKVNWDQDPK--PALVTKFMENGSLSG
..  .  |.| ||.|...  .    . ...||||... .| ..         |.| | .| ... ..|| ||.     ||.    . .|. .|..|.|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLD

LLQS----QCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLS
 |..    . | . . |.    ..  || ||...|  . ||||   |.|.. ...|| .||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLA
Kinase RIPK3.AA MLK 256-283 39 7.1e-10 30.58 In-house 264-291 (291) Show / Hide 
Range on Protein: 256-283
Range on HMM: 264-291/291
Sequence Identity: 39% (11 aa)

EGLKELMQLCWSSEPKDRPSFQECLPKT
|..|.||. ||...|..||||...... 
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase RIPK3.AA TKL-Unique 256-283 35 1.4e-07 23.02 In-house 263-290 (290) Show / Hide 
Range on Protein: 256-283
Range on HMM: 263-290/290
Sequence Identity: 35% (10 aa)

EGLKELMQLCWSSEPKDRPSFQECLPKT
. ...|.| || ..| .||||.| . . 
KEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase RIPK3.AA LRRK 21-53 25 2.8e-07 21.77 In-house 1-60 (351) Show / Hide 
Range on Protein: 21-53
Range on HMM: 1-60/351
Sequence Identity: 25% (15 aa)

LENQELVGKGGFG-TVFRAQHRK--------------------------WGYDVAVKIVN
|. .|..|.|||| .|.||  |.                           ...||.|. |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN
Kinase RIPK3.AA LRRK 258-285 32 1e-06 19.53 In-house 324-351 (351) Show / Hide 
Range on Protein: 258-285
Range on HMM: 324-351/351
Sequence Identity: 32% (9 aa)

LKELMQLCWSSEPKDRPSFQECLPKTDE
...|.|.||. .||.||.|.. . .  .
YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase RIPK3.AA Pkinase_Tyr 258-283 38 3e-06 21.92 Pfam 245-270 (270) Show / Hide 
Range on Protein: 258-283
Range on HMM: 245-270/270
Sequence Identity: 38% (10 aa)

LKELMQLCWSSEPKDRPSFQECLPKT
. .||..||  .|.|||.|.|.. . 
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RIPK3.AA Dicty4 21-55 37 2.3e-05 14.07 In-house 1-33 (277) Show / Hide 
Range on Protein: 21-55
Range on HMM: 1-33/277
Sequence Identity: 37% (13 aa)

LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSK
.  ... |||.||.|...  |  | .||||. |..
INIEQRIGKGSFGEVYKGTWR--GKEVAVKKLNNH
Kinase RIPK3.AA Pkinase_Tyr 199-212 71 0.000307 14.98 Pfam 192-205 (270) Show / Hide 
Range on Protein: 199-212
Range on HMM: 192-205/270
Sequence Identity: 71% (10 aa)

STASDVYSFGILMW
.|.|||.|||.|||
TTKSDVWSFGVLMW
Kinase RIPK3.AA Shk 21-51 35 0.0147 5.43 In-house 1-29 (269) Show / Hide 
Range on Protein: 21-51
Range on HMM: 1-29/269
Sequence Identity: 35% (11 aa)

LENQELVGKGGFGTVFRAQHRKWGYDVAVKI
    .. | | ||.|  .  |  | .||||.
INREDFLGQGSFGKVYKGRCR--GKEVAVKV
Kinase RIPK3.AA STE 258-280 26 0.194603 0.99 In-house 330-352 (359) Show / Hide 
Range on Protein: 258-280
Range on HMM: 330-352/359
Sequence Identity: 26% (6 aa)

LKELMQLCWSSEPKDRPSFQECL
.|. ...|   .|..||. .. |
FKDFINKCLQKDPNKRPTASQLL
RHIM RIPK3.AA RHIM 450-468 52 6.3e-10 32.33 In-house 1-19 (19) Show / Hide 
Range on Protein: 450-468
Range on HMM: 1-19/19
Sequence Identity: 52% (10 aa)

VNIYNCSGVQVGDNNYLTM
..||||||.|.|..||...
IHIYNCSGIQIGNHNYMWI