Gene RIPK1 (Human)

RIPK1

Species: Human
Alias: RIPK1, FLJ39204, RIP
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p25.2,

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
RIPK1.NA RNA Sugen Kinome 3864 None Fasta, JSON
RIPK1.AA Protein Sugen Kinome 671 None Fasta, JSON
RIPK1.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of RIPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIPK1.AA RIPK 24-285 41 8.20000000001e-156 523.93 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-285
Range on HMM: 1-290/290
Sequence Identity: 41% (121 aa)

DS-GGFGKVSLCFHRTQGLMIMKTVYKGPNCIEH-----NEALLEEAKMMNRLRHSRVVKLLGVIIEE-----GK-YSLVMEYMEKGNLMHVLKAEMS--
.. ||||.|....||..| ...|.......|..|     .....||||.|..||....|...|....|     .| |..||||||.|.|.|.|.....  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---TPLSVKGRIILEIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN-GGTLYYMAPEHLNDVNA
   .|.....|.| ||..||||||...  .||.|||||||||||.||.||||.|||...|||.......| .|||.....|| .|||.||.|||....|.
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCN-QREVYSMKSKNRWGTLSYMPPEHFRTDNK

KP----TEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP-----REIISLMKLCWEANPEARPTFPGIEEKF
||    |.|.||||||.|.|.....|.|||...|.....||.|.|.||......||.|     ...|.||..||...|..||.|...||..
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase RIPK1.AA TKL 23-285 25 2.7e-88 299.65 In-house 1-364 (364) Show / Hide 
Range on Protein: 23-285
Range on HMM: 1-364/364
Sequence Identity: 25% (94 aa)

LDSGGFGKVSLCFHRTQG--------LMIMKTVYKGPNCIEHN--------------------------EALLEEAKMMNRLRHSRVVKLLGVIIEEGK-
. |||||.|    .| .|          .   ..|  |. |..                          . . ||..||.||||  .|...|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHG--------KGVIHKDLKPENILVDNDFH--------------IK
            . .||||...|.| |.|       .... |..|.|  ||.|||         ...|| |||..|||||....              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADLGLASFKMWSKLNNEEHNELREVDG--------TAKKNGGTLYYMAPEHLNDVNA--------------KPTEKSDVYSFAVVLWAIFANKEPYENA
|.|.||. |. .|. .|   .  .|  .        |  . .||...|||| |.. .               . .||.|||||..||| |.. ..||.. 
ICDFGLSRFMSQSGNMNDTMTTMME--SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

ICEQQL---------IMCIKSGNRPDVDDITEY---------CPREIISLMKLCWEANPEARPTFPGIEEKF
 .....         .|... |.|| ...| ..         ||.....||. ||...||.||.|  | ...
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc RIPK1.AA S_TKc 17-289 23 1.7e-56 194.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-289
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

FLESAELDSGGFGKVSLCFHRT-QGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEK--GNLMHVLKAEMS----
.    .. .|.|||| .| |.  . .. .| .          | .. | ... . .|  .|||..|. . ... .||||..   |.|....|   .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--TPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTE
   |  .  ... .|.... |.| .|.|| ||||||||.|.  ||||.| ||| .                     .   ||..||||| |     . . 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL-----GYGK

-KSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEE-----KFRPFY
 |.|..|. ..|.  .. . |..    ..|... .               ..| ..... |.. .|| |||   . .     |  |. 
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase RIPK1.AA Pkinase 17-285 23 7e-51 180.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-285
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

FLESAELDSGGFGKVSLCFHRTQGL-MIMKTV-YKGPNCIEHNEALL-EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKG----NLMHVLKAEMS
.     . ||.||.| .| |.  |    .|.. ... .. .. ....  |...|.||.|  .|.|...  ..... .||||.|.|     |.........
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPL----SVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHI----KIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDV
...     .  .....|..|. |.| .|.|| ||||||||.||. ||    ||.| ||| ..                .. ..   ||..||||| ..  
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPEVIR-G

NAKPTEKSDVYSFAVVLWAIFANKEPYENA----ICEQQLIMCIKSGNRPDVDDITEYCP-------------------REIISLMKLCWEANPEARPTF
. . . |.|..|. ..|.  .  . |. ..        |. |  . . .|   |. . |.                   .| ....| |.. .|. |||.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

PGIEEK--F
. | .   |
EQILQHPWF
Kinase RIPK1.AA TKL-Unique 62-285 30 3e-48 166.62 In-house 44-290 (290) Show / Hide 
Range on Protein: 62-285
Range on HMM: 44-290/290
Sequence Identity: 30% (79 aa)

EEAKMMNRLR-HSRVVKLLGVII----EEGKYSLVMEYMEKGNLMHVLK----------AEMSTPLSVKGRIILEIIEGMCYLHGKG--VIHKDLKPENI
.| . |..|. |  .|.. |. .     ......||||.. |.|. ||            ..  ..... .... |  ||.||| ..  .|| |||. |.
NEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNF

LVDND-----FHIKIADLGLASFKMWSKLNNEEHNEL---REVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKE------PYEN
||||.     . |||.| ||. |.  || |..  ||.   |        . |.. .|||| |...... .||||||||..||| |. .|       ||. 
LVDNNSNIAEWNIKICDFGLSKFN--SKINKMTNNEHKGTR-----NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQ-

AICEQQLIMCIKS---GNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF
..  .|..  ...   . ||    | . || |.  |.. ||  .|. ||.|  | .. 
GMDQEQWCEMVHYMEENYRP---PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase RIPK1.AA TK 59-285 19 6.7e-47 154.8 In-house 87-486 (486) Show / Hide 
Range on Protein: 59-285
Range on HMM: 87-486/486
Sequence Identity: 19% (80 aa)

ALLEEAKMMN--RLRHSRVVKLLGVIIEE------------GKYSLVMEYMEKGN----LMHVLK--AEMSTPLSVKGR---------------------
...||.|||.   ..|  .|.|.||. ..            . . .|||||..|.    | . |.   .  .. . ..                      
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

----------------------------------------------------IILEIIEGMCYLHGK------GVIHKDLKPENILVDNDFH--------
                                                    . . | .|| ||| |      ...| ||   |.||... .        
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGC

---IKIADLGLASFKMWSKLNNEEHNELREV----DGTAKKNGGTLY-------------------------YMAPEHLNDV-------NAKPTEKSDVY
   .|||| ||.  ..            |..    | ..|...||                           .|||| |||        . | |.||||.
GPVCKIADFGLSRQGS-G-------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVW

SFAVVLWAIFA-NKEPYENAICE---------QQLIMCIKSGNRPDVD------------DITEYCPR-------------EIISL-MKLCWEANPEARP
|| |..| ||   .|||   .           |... ....| |.                  ..||              |.. . |. ||...|| ||
SFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRP

TFPGIEEKF
||  . |..
TFSQLHEQL
Kinase RIPK1.AA Dicty4 58-295 27 1.3e-40 133.31 In-house 43-277 (277) Show / Hide 
Range on Protein: 58-295
Range on HMM: 43-277/277
Sequence Identity: 27% (72 aa)

EALLEEAKMMNRLRHSRVVKLLGVII----EEGKYSLVMEYMEKGNLMHVLKA-------EMSTPLSVKGR---IILEIIEGMCYLHGKG--VIHKDLKP
.... |.. |  .||  .....|  .    . || . |.||| ||||  .| .       . . ...   |   . . .  || .||.    .|| |||.
NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKS

ENILVDNDFHIKIADLGLAS-FKMWSKLNNEEHNELRE-VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYE-NAICEQQLI
 |.||| .. .|..|.||.  .|        .| ..    ....    ||  .|||| .  ..   .||.|||||. ||| |.  .|||    .   |..
HNLLVDKNWRVKVCDFGLSQYMK--------KHEDHKDNQMTAC----GTPCWMAPEVM--MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFV

MCIKS-GNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQ--LEE
  . . ..||    |  .||  ...|.. ||. .|. ||.|..|        ...  ||.
RAVCNKKLRP---PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEI--------IQRRILEH
TyrKc RIPK1.AA TyrKc 17-285 28 3.5e-40 140.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-285
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRL--RHSRVVKLLGVIIEE-------GKYSLVMEYMEKGNLMHVLKAE
     .| .| ||.| ..  .       |.. ..       |....||..| .|  .|  .|.|.||....       . . .|||||..|.| . |.. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

MS-TPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEE-HNELREVDGTAKK--NG---GTLYYMAPEHLND
    ... .  . . | .|| ||| |..|| ||   |.||......||.| ||.      .   .. ..  ..   ..|.  .|     .  |||| .  
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS------RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

VNAKPTEKSDVYSFAVVLWAIFAN-KEPYENA----ICEQQLIMCIKSGNRPDVDDITEY--------CPREIISLMKLCWEANPEARPTFPGIEEKF
   | |.||||.|| |..| || . ..||..     .  |..| ..|.|.|.   .. ..        || |. ..|| ||...|| ||||  | |.|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RIPK1.AA CAMK 22-277 17 3.1e-37 117.01 In-house 1-415 (425) Show / Hide 
Range on Protein: 22-277
Range on HMM: 1-415/425
Sequence Identity: 17% (75 aa)

ELDSGGFGKVSLCFHR-TQGL------------MIMKTVYKGPNC-------------------------IEHNEA-LLEEAKMMNR-------LRHSRV
.| .|.|||| ||.|. |.|.              .| . |                              ..... .. | ..|..       |.|  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLLGVIIE-------------------EGKYSLVM---EYMEKG----NLMHVLKAE---------------MSTPLSVKGRIILEIIEGMCYLHGKGV
.||. |.                     . .. .||   ||.. |     |   ...                   . .   |..  |.... |.| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHKDLKPENILVDND-----------------FHIKIADLGLASFKMWSKLN-----NEEHNELREV-------DGTAKKNGGTLYYMA-PEHLNDVN--
.| ||||||||.|..                 . |||.| |.| ... .. |     ... . . .        .   |   ||..||| || ||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------AKP-TEKSDVYSFAVVLWAIFANKEPYENA------------ICEQQLIMCIKSGNRP-D---------------VDDITEY----CPREI
          .. ..|.|. |  |.| .    . |..               ....|   |..|.   .                |||..     .  | 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

ISLMKLCWEANPEARPT
..| . . . .|| |.|
KDLIRKMLQVDPEKRMT
Kinase RIPK1.AA LRRK 63-287 27 9.7e-35 120.31 In-house 107-351 (351) Show / Hide 
Range on Protein: 63-287
Range on HMM: 107-351/351
Sequence Identity: 27% (72 aa)

EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL-----S----VKGRIILEIIEGMCYLHGKG--VIHKDLKPENILV---D-
|. .|..|.|. .|.|.|. |.   . .||||.  |.| |.|... ....     .    .| .| |.| .|| ||| .   .|| |||..|||.   . 
EVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQ

--------NDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT-AKKNGGTLYYMAPEHLNDV-NAKPTEKSDVYSFAVVLWAIFANK-EPYEN----AI
        .. ..|||| |. .  |. .           .  . ||. .|.  .|||| ...  .   |||.|.|||...|| .   .  |...    . 
NHSPNYPNAHVCAKIADFGISR--MF-QC----------FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDH

C--EQQLIMCIKSGNRPDVDDITEYCPR-----EIISLMKLCWEANPEARPTFPGIEEKFRP
   . |.  .|..| || .     |||.     .  .|...||...|. ||.|  | ..   
MQWMEQIEDKIIEGLRPTIPQH--YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase RIPK1.AA Ciliate-E2 17-283 19 3e-34 114.95 In-house 1-358 (365) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-358/365
Sequence Identity: 19% (74 aa)

FLESAELDSGGFGKVSLCFHRTQGLMI------------------------MKTV-YKGPNCIEHNEALL----------EEAKMMNRLRHSRVVKLLGV
.     . .|.||.| .| .. .. ..                        ||..  .. . |.  . ..          .| ... .| |  ..|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

II--EEGKYSLVMEYMEKGNLMHVLK--AEMSTPL---------SVKGRIILEIIE---------------GMCYLHGKG-VIHKDLKPENILVDNDFHI
 .   . .. ||||| . |.|.. .|     ..              ..|. .|..               .. ||| |. .|| |.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADLGLASF--------------KMWSKLNNEEHNELREVDGTAKKNG-----------GTLYYMAPEHLNDVN-------AKPTEKSDVYSFAVVLWA
||.|.||. .              |..   .|...   .  |                  ||..||||| ||  .          ..|.|..|. |.|  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

IFANKEPYENAICEQQLIM-------CIKSGNRPDVDDI------TEYCPREIISLMKL----CWEANPEARPTFPGIEE
   .| |.      || |.       | ..... .  .|      ..... | . |.|     . . .|| |.|  |.|.
MLFGKPPF------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQ
Kinase RIPK1.AA Pkinase_Tyr 17-160 28 4.8e-24 82.07 Pfam 1-158 (270) Show / Hide 
Range on Protein: 17-160
Range on HMM: 1-158/270
Sequence Identity: 28% (46 aa)

FLESAELDSGGFGKVSLCFHR-----TQGLMIMKTVYKGPNCIEHN---EALLEEAKMMNRL-RHSRVVKLLGVII-EEGK--YSLVMEYMEKGNLMHVL
     .| .| ||.| ..  .     |.     |.. | ... ...   |....|||.|  | .|  .|.|.||.. ...   . .|||||..|.| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KA----EMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA
..    . . ... .  . ..| .|| ||. |. || ||   |.||......||.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase RIPK1.AA MLK 17-160 22 7.9e-23 76.11 In-house 1-180 (291) Show / Hide 
Range on Protein: 17-160
Range on HMM: 1-180/291
Sequence Identity: 22% (41 aa)

FLESAELDSGGFGKVSLCFHRTQG-----LMIMKTVYKGPNCIEH----NEALLEEAKMMNRLRHSR----VVKLLGVIIEEGK-YSLVMEYMEKGNLMH
....  . ||.|||| .   | .      . . .       ..       ... .|..  ..|.|      .....||...... . .||||.|.| | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLKAEMS--------------TPLSVKGRIILEIIEGMCYLHGKG---VIHKDLKPENILVDN------DFHIKIADLGLA
||... |               ..... .. | . .|| ||| .    .|| |||. |||.|.      . . ||.| |..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS
Kinase RIPK1.AA MLK 185-285 33 4.1e-22 73.59 In-house 192-291 (291) Show / Hide 
Range on Protein: 185-285
Range on HMM: 192-291/291
Sequence Identity: 33% (34 aa)

KNGGTLYYMAPEHLND-VNAKPTEKSDVYSFAVVLWAIFANKEPYE-NAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIE
.| ||. .|||| .    . | .||.||.|..|||| ... ..||.    . . ... .  |.|| .      ||. . .||| ||...|. ||.|  | 
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIV

EKF
...
QHL
Kinase RIPK1.AA UTK 60-160 30 2.6e-20 66.17 In-house 53-175 (296) Show / Hide 
Range on Protein: 60-160
Range on HMM: 53-175/296
Sequence Identity: 30% (38 aa)

LLEEAK---MMNRLR-HSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLK----AEMSTPLSVKGR----IILEIIEGMCYLHGKGVIHKDLKPENILVD
..|||.   || ... |  |..|.||   |.   .|.||||.|.| ..|     . .  |.... .      . | .|| |||..|..| ||   |.||.
FMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH

ND-------FHIKIADLG---LA
 .         .||||.|   ..
MHRMMWHCMMVCKIADFGRGGMS
Kinase RIPK1.AA Pkinase_Tyr 206-285 42 6.1e-15 51.22 Pfam 192-270 (270) Show / Hide 
Range on Protein: 206-285
Range on HMM: 192-270/270
Sequence Identity: 42% (35 aa)

TEKSDVYSFAVVLWAIFA-NKEP-YENAICEQQLIMCI-KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF
|.||||.|| |..| ||   ..| |..   |. ..  | ..|.|    .. |.|| || .|||.||...|| ||||  | |..
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYRM---PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RIPK1.AA UTK 193-285 32 7.9e-15 47.17 In-house 206-296 (296) Show / Hide 
Range on Protein: 193-285
Range on HMM: 206-296/296
Sequence Identity: 32% (32 aa)

MAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN-KEPYENAICEQQLIMCIKSG---NRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF
|||| |..   ..|.||||.|| ||.| |... . ||.. . ..|..  .  |    .|. .|    ||...  ||. ||...|. ||.|. .....
MAPEALTHHT-RFTTKSDVWSFGVVCWEIWTWGRLPYPG-MSNMQVWHQVCNGGRYRMPCPWD----CPHPVYRLMHRCWHYDPQERPDFEDLVQQM
RHIM RIPK1.AA RHIM 531-549 63 3.2e-11 36.61 In-house 1-19 (19) Show / Hide 
Range on Protein: 531-549
Range on HMM: 1-19/19
Sequence Identity: 63% (12 aa)

YTIYNSTGIQIGAYNYMEI
..|||..||||| .|||.|
IHIYNCSGIQIGNHNYMWI
Death RIPK1.AA Death 584-669 34 2.4e-24 83.95 Pfam 1-87 (87) Show / Hide 
Range on Protein: 584-669
Range on HMM: 1-87/87
Sequence Identity: 34% (31 aa)

DKHLDPI--RENLGKHWKNCARKLGFTQSQIDEIDHDYERDG-LKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVS
.| .. .  ....||.|. .|||||.....||.| || .. . |....||||.|| .|   |.|||..|..||... |.|.....   .
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQR-HGKNATVDHLIEALRKMGRRDCAEKIQSWL