Gene RIOK3 (Human)

RIOK3

Species: Human
Alias: SUDD, RIOK3, DKFZp779L1370
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 18q11.1-q11.2,

Classification

Group: Atypical
Family: RIO
Subfamily: RIO3

Sequence

Name Sequence Type Origin Length Description Download
RIOK3.NA RNA Sugen Kinome 4035 None Fasta, JSON
RIOK3.AA Protein Sugen Kinome 519 None Fasta, JSON
RIOK3.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of RIOK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIOK3.AA RIO3 226-479 98 3.3e-201 674.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 226-479
Range on HMM: 1-254/254
Sequence Identity: 98% (251 aa)

HSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKII
||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||| 
HSTAEKAVDPKTRLLMYKMVNSGMLETITGCIATGKESVVFHAYGGSMEDEKEDSKVIPTICAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIH

RMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVS

QSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA
||||||||||||||||||||||||||||||||||||||||||||||||||||||
QSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA
Kinase RIOK3.AA RIO 229-478 44 6.7e-175 587.33 In-house 1-276 (276) Show / Hide 
Range on Protein: 229-478
Range on HMM: 1-276/276
Sequence Identity: 44% (123 aa)

AEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMW
.|...||.||..||||||.||.|....||..||||...|......|||||||||||||||||...|....||.|.||....|.||.|..|.|.|...|.|
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW

AEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLN-SEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKV-------W
|||||.|..|....|.|||.....|.|.|||.||.|||.||||....... .|.||..|.|....||.||..|.|||.|..|.||.||.||.       .
AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY

LIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAV------------------SGLNITADNE
.||..|.||..|||.|....|||..|..||.|..|.|...|||.|..|                  ........|.
MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
RIO RIOK3.AA RIO 222-470 48 5.6e-148 498.82 SMART 1-253 (253) Show / Hide 
Range on Protein: 222-470
Range on HMM: 1-253/253
Sequence Identity: 48% (127 aa)

EKKEHSTAEKAVDPKTRLLMYKMVNSGMLETIT--GCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKL
.|....|.|...||.||...|||||.|..|.|.  ||||||||..|.||.||       |..  ..|||.|...|...|||....||..|||||......
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGG-------DFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHI

NPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMK---EAYYQTLHLMRQLYHECTLVHADLSEYNMLWH-
|.||..|.|||||..||.||..||.|||.......|.|||.|||.|..|||.||.|.....||.   |.|.|... ||..||||.||||||||||||.| 
NWRKMVRLWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHD

-----AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSG
     ..|||.||.|||||..||. ||||.||..|...||.. ||..  ..||.|. . |
LEDENDCKVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Kinase RIOK3.AA RIO1 264-464 47 3.2e-122 381.63 Pfam 1-200 (200) Show / Hide 
Range on Protein: 264-464
Range on HMM: 1-200/200
Sequence Identity: 47% (99 aa)

VVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIG
.|.|||.  |||.|.       |||.|...|....||....|...||||..|... |.|...|||||||..|| ||. ||.||| ......|.|||.|||
NVYHAYS--MEDGKD-------ECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIG

-HDQVPAPKLKEVKLNSE----EMKEAYYQTLH-LMRQLYHECTLVHADLSEYNMLWHAG-KVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVK
 .| .|||.||.| ...|    |..| |.....  || .|.|| |||.||||||.|.| . |.|.||..|.||. ||| |||| |||||...||.. ||.
DKDGWPAPRLKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVD

E-ALSEREL
| ....||.
ERVMDFREI
Kinase RIOK3.AA RIO1 231-464 45 3.9e-94 319.06 In-house 1-225 (225) Show / Hide 
Range on Protein: 231-464
Range on HMM: 1-225/225
Sequence Identity: 45% (108 aa)

KAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAE
  .||.||....||.  |..  | ||||||||  |.||   |  . |        | |||..||    || |.||.   |||    .| |||| | .|||
QVIDPRTRMILFKMLTRGIITEINGCISTGKETNVYHA---SETNGKR------AEYAIKIYKTSILVFKDREKYVDGEFRFRHGHCKHNPRKMIKIWAE

KEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKL-NSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVE
||| || |.  . ||||  . .| ..|.|.||| |  .||.||.. . ....  . | | .  || .|  | |||||||||||| | .|. .||||||||
KEMRNLKRIYQSEIPCPEPIMVKSNVLMMEFIGKDGMAAPRLKDYQYKERDQYFHYYHQMIQYMRRMYQDCRLVHADLSEYNMLYHNDKLYMIDVSQSVE

PTHPHGLEFLFRDCRNVSQFFQKGGVKEALSEREL
. ||| |||| .|| ||  .|.| .|   ...|..
HDHPHSLEFLRMDCKNVNMYFMKHNVI-IFPVRDI