Gene PRKY (Human)

PRKY

Species: Human
Alias: PRKY
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Yp11.1-p11.2,

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PRKY.NA RNA Sugen Kinome 7192 None Fasta, JSON
PRKY.AA Protein Sugen Kinome 277 None Fasta, JSON
PRKY.kin_dom Protein Kinase Domain Sugen Kinome 217 None Fasta, JSON

Protein domain

Protein domains of PRKY.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRKY.AA PKA 49-272 58 2.5e-169 568.84 In-house 1-232 (263) Show / Hide 
Range on Protein: 49-272
Range on HMM: 1-232/263
Sequence Identity: 58% (135 aa)

CDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIR-LFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSST
.. . |.|||.||||.|...|. ....|.|........|.||..||||||..|....|||... . ||.. .|.|||.||||||||.|||||..|.||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TGLFYSA-EIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSK-GHGRAVDWWALGILIFEMLSGFPPFF
...|| | .|..|.|||||..|.||||||||||.|..||||.||||||||..||||||||||||||||.|||| |||..||||||||||.|||.|.|||.
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

DD--NPFGIYQKILAGKLYFPRHLDFHV---K
|.  .|..||.||..||. ||||.| ..   |
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFK
Kinase PRKY.AA AGC 49-268 30 1.9e-147 384.13 In-house 1-355 (395) Show / Hide 
Range on Protein: 49-268
Range on HMM: 1-355/395
Sequence Identity: 30% (108 aa)

CDALVTMGTGTFGRVHLVKEK------TAKHFFALKVMSIPD-VIRRK--QEQHVHNE------------KSVLKEVS----------HPFLIR-LFWTW
 . | . |.|.||.|.||..|      . ....|.||..  . ....|  ...|...|            . .|....          |||... |. ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HEERF--LYMLMEYVP---------GG-ELFSYLR---NRGHFSSTTGLFYSAE-------IICAIEYLHS-KEIVYRD-LKPENILLDRDGHIKLTDFG
. ..   ||..|||.|         || |||..|.   ..|.|.  .  || ||       |..|.||||| . |..|| |||||||||.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKLV-----------------------------------------------------DRTWTLCG--TPEYLAPEVIQSKGHGRAVDWWA--LGILIF
..|...                                                     |||||.||  ||||.|||..    .|.|.|||.  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLSGFPPFFDDN----------PFGIYQKILAG------KLYFP----------RHLD
|||.| |||..||          |. ..|||. |      |. ||          |...
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFS
Kinase PRKY.AA SGK 50-265 42 8.20000000001e-108 334.09 In-house 2-246 (283) Show / Hide 
Range on Protein: 50-265
Range on HMM: 2-246/283
Sequence Identity: 42% (103 aa)

DALVTMGTGTFGRVHLVKEKTA------------------KHFFALKVMSIPDVI-------RRKQEQHVHNEK-SVLKEVSHPFLIRLFWTWHEERFLY
| | . | | ||.| .|| |                    . |.|.|| .   .|       ..|.. |.  |.  .|| ..|||.. |      .  ||
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

MLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAK---KLVDRTWTLCGTPEYLAPEVIQSKG
. |.|| |||.|..|. ..||.     || |||.||.|||||. |.|||||||||||| .||..||||| .|   |  | | | |||||||||||.. ..
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

HGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKLYFPR
|.|.|||| ||.. .||..| |||.. |    |..|. ..| .|.
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP
Kinase PRKY.AA Akt 50-268 44 6.4e-99 316.86 In-house 2-229 (264) Show / Hide 
Range on Protein: 50-268
Range on HMM: 2-229/264
Sequence Identity: 44% (101 aa)

DALVTMGTGTFGRVHLVKEKTAKHFF-ALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTT
| |   | |.||.| |||.|  . .. |.|| .    | ..| .|.  |. .|. . |||.. |      .  ||. |.|..|||||..|. .. ||  .
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

GLFYSAEIICAIEYLHSKEIVYRD-LKPENILLDRDGHIKLTDFGFAKKL-VDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWA-LGILIFEMLSGFP
  || ||||.|||.|||| |.||| |||||||.|.||||.||||| .|.  . .   | |.||||||||||... .||..|||||. ||....||. |.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRP

PFFDDNPFGIYQKILAGKLYFP--RHLD
||....    ..||. ... ||  . ..
PFYNQDHHQMFKKIKNQPVKFPDKDWIS
Kinase PRKY.AA AktR 56-269 43 5.2e-95 321.96 In-house 8-231 (268) Show / Hide 
Range on Protein: 56-269
Range on HMM: 8-231/268
Sequence Identity: 43% (97 aa)

GTGTFGRVHLVKEK-TAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLK-EVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYS
| |.||.| ||..| . . ..|.|. .  . |.|.|..|. .|. ... ...|||...|. ..  .. |. .|||.||||||..|.....||  . .||.
GKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYF

AEIICAIEYLHSK-EIVYRDLKPENILLDRDGHIKLTDFGFAK---KLVD--RTWTLCGTPEYLAPEVIQS-KGHGRAVDWWALGILIFEMLSGFPPFFD
|.|. |.||||..  |.|||||||||||| |||.|.|||| .|   . ..  .. ..||||||.|||.|.  |||...|||||.||.|.||..| |||..
AQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYH

DNPFGIYQKILAGK-LYFPRHLDF
.|   ..|||.    ..|| . .|
KNQNQMFQKIKIKQQNKFPYPSYF
Kinase PRKY.AA PKG 50-266 48 2e-94 320.04 In-house 2-223 (260) Show / Hide 
Range on Protein: 50-266
Range on HMM: 2-223/260
Sequence Identity: 48% (108 aa)

DALVTMGTGTFGRVHLVKEKTAK-HFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTT
. . |.| | |||| ||. .  |   ||||.|    ..  .|..|. .|| .. | . .| .||. |. .....|||||   |||| . || ||||   |
KIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKT

GLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLV--DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFD
  || | .. | .|||.| |.||||||||..||..| .|| |||||||.    .||| |||||| |||.|  ||| |.||.||||||..| | | |||  
TRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFSG

DNPFGIYQKILAG--KLYFPRH
 .|  .|. || |  .. |||.
SDPMKTYNIILKGIDMWEFPRK
Kinase PRKY.AA Ciliate-E2b 49-267 36 7.8e-94 285.48 In-house 1-237 (272) Show / Hide 
Range on Protein: 49-267
Range on HMM: 1-237/272
Sequence Identity: 36% (87 aa)

CDALVTMGTGTFGRVHLVKE-KTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRG--HFS
 .     | | || | ||.. |. | ..|.|. |.  .| .  | |  .||.||. . |||..... .   ....|..||.. |.|||...|. |   .|
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

STTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD------RTWTLCGTPEYLAPEVIQ-----SKGHGRAVDWWALGILI
    .|| |.|. ..||||...|.|||.|||||..| .|..|| |.| || . .      || |..|||.|.|||.||      || . .|| |..||  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

FEMLSGFPPFFDD--NPFGIYQKILAG--KLYFPRHL
.|...| .|.  |  .|  |||.|. .  .. || ..
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYC
Kinase PRKY.AA RSK 52-265 40 7.9e-82 278.17 In-house 1-238 (278) Show / Hide 
Range on Protein: 52-265
Range on HMM: 1-238/278
Sequence Identity: 40% (96 aa)

LVTMGTGTFGRVHLVKEK---TAKHFFALKVMSIPDVIRRKQ-EQHVHNEKSVLKEVS-HPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGH---
|   |.| .| | |....    ... .| || .   ...|.    |.  | ..|...  |||...|. . ..|  ||. |||..|||||  |....|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDR---DGHIKLTDFGFAKK-LVD---RTWTLCGTPEYLAPEVIQ----SKGHGRAVDWWALGI
|| ..  || |||..|.|.||.. |..|||||||||.|    .||||||||||.|.   |   .| | |.| ||.|||..      .||..|.||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIFEMLSGFPPFFD---DNPFGIYQKILAGK--LYFPR
|..|||.|.|||     .|.  | ..|. ||  | .|.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN
Kinase PRKY.AA Pkinase 49-265 34 2.6e-78 271.3 Pfam 1-239 (293) Show / Hide 
Range on Protein: 49-265
Range on HMM: 1-239/293
Sequence Identity: 34% (82 aa)

CDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVH-NEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGG----ELFSYLR--NR
   . . | |.||.| . ..|   . .|.|... ..    |...|.. .| ...|...||. .||. ...... .|| |||..||    .||.|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHF--SSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHI----KLTDFGFAK---KLVDRTWTLCGTPEYLAPEVIQ-SKGHGRAVDWWALG
| |  |  .  ||  .|....||.||. |..|||||||||.|..|||    |..|||.||      ....|.||||.|.|||||. ....|..||.|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

ILIFEMLSGFPPFFDD------NPFGIYQKILAGKLYFPR
....|||.| ||| ..      ..  ....|. ..| |..
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDW
Kinase PRKY.AA p70 50-267 36 7e-77 261.72 In-house 2-263 (299) Show / Hide 
Range on Protein: 50-267
Range on HMM: 2-263/299
Sequence Identity: 36% (96 aa)

DALVTMGTGTFGRVHLVKEKT---AKHFFALKVMSIPDVIR-RKQEQHVH-------------------------NEKSVLKEVSHPFLIRLFWTWHEER
  |  .| | .| | .|.  |   .   .| ||.    ..|  |  .|                            | ..| || |||.. |.   . . 
ELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTNG

FLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR-------------TWTLCGT
 || . || .|||||  |   | .  .|  || .|||||.|.||.. |.||||||||..|.  ||..|||||  |. .               |.|.|||
KLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGT

PEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK--LYFPRHL
.|| |||..  .||..|||||.||.|.. || | |||  .|.  .  ||| ||  |  |  |
IEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYL
Kinase PRKY.AA S_TKc 49-277 31 2.2e-71 244.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-277
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

CDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPG--GELFSYLRNRGH---
 . | . | |.||.|.....|  .. .|.|...          .|. .| ..||.  ||....|. ....  .||| |||..|  |.||.|...||.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGR-AVDWWALGILIFEMLS
   |.  .  || ..|.||.||.||. |..|||||||||||.  |||..|||.|..|     |.||||.|.||||.   |.|. ..|||..|....|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GFPPFFDDNPFGIYQKILAGKLYFPRHLDFH------------------VKT-------GRMM
| |||   ... ...||.          ..                   . .          .
GYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase PRKY.AA MAST 56-201 40 7.9e-54 162.5 In-house 8-157 (337) Show / Hide 
Range on Protein: 56-201
Range on HMM: 8-157/337
Sequence Identity: 40% (61 aa)

GTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHE--ERFLYMLMEYVPGGELFSYLRNRG-HFSSTTGLFY
. | .|.| ||| |. . .||.||.   | |...| ..|  |. .|.... ||   .| .     .. |.| |||. ||  .| ||. |  .      .|
SKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMPEWMAKMY

SAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK-LVDRT
 ||.. ..|||||. || |||||.|.|.| .|||||||||..|. ..|.|
IAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKT
Kinase PRKY.AA MAST 205-264 46 9.6e-31 90.63 In-house 229-292 (337) Show / Hide 
Range on Protein: 205-264
Range on HMM: 229-292/337
Sequence Identity: 46% (30 aa)

CGTPEYLAPEVIQSKG-HGRAVDWWALGILIFEMLSGFPPFFDDNPFG-IYQKILA--GKLYFP
||||.|.|||||  .| .| .||||..|| ..| |.| |||..|.|   | |.|.    ....|
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWP
Kinase PRKY.AA TyrKc 49-276 19 2.7e-13 -7.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-276
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

CDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEV--SHPFLIRLFWTWHEE-------RFLYMLMEYVPGGELFSYLR
   . . | | ||.|.. . |      | |..          ..  ..| ......  .|| ..||.    ..         |...|||.|.| | .|||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NRGH-FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR-------TWTLC----GTPE-----YLAPEVIQSKGHG
.... ..  . | ..  | |  |||||| .. |||   |.|.......| .||| .... |                 |.        .|||.|. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RAVDWWALGILIFEMLS-GFPPFFD-----DNPFGIYQKILAG-KLYFPRH----------------------------LDFHVKTGRM
 . | |. |....|... | .|  .      ... ..... .|  .  | .                              |     ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PRKY.AA Pkinase_Tyr 122-244 28 8.4e-11 37.21 Pfam 82-216 (270) Show / Hide 
Range on Protein: 122-244
Range on HMM: 82-216/270
Sequence Identity: 28% (39 aa)

LYMLMEYVPGGELFSYLRN----RGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL-------VDRTWTLCGTPEY
.|. |||.|.| | .|||.    .....  . | ....| .. |||.|| .. |||   |.|.......| .||| |. .       . |. .       
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKW

LAPEVIQSKGHGRAVDWWALGILIFEMLS-GFPP-F
.|||.|. .    . | |. |.|..|... |  | .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY