Gene PAK6 (Human)

PAK6

Species: Human
Alias: PAK5, PAK6
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 15q13.3-q15,

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK6.NA RNA Sugen Kinome 3961 None Fasta, JSON
PAK6.AA Protein Sugen Kinome 681 None Fasta, JSON
PAK6.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of PAK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK6.AA PBD 11-67 31 1e-19 71.4 Pfam 1-60 (60) Show / Hide 
Range on Protein: 11-67
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

EISAP-QNFQHRVHTSFDPKEGKFVGLPPQWQNILDTL--RRPKPVVDPSRITRVQLQPM
.||.|  ||.|..|  .|...|.|.|.||.||..|..   ..|.. ..|.... |.  ..
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK6.AA PBD 12-47 47 1.8e-13 51.99 SMART 1-38 (38) Show / Hide 
Range on Protein: 12-47
Range on HMM: 1-38/38
Sequence Identity: 47% (18 aa)

ISAPQ-NFQHRVHTS-FDPKEGKFVGLPPQWQNILDTL
||.|  ||.|.||   .|...|.|.|||.|||..| . 
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK6.AA PAKB 407-658 84 2.6e-223 748.18 In-house 1-252 (252) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-252/252
Sequence Identity: 84% (212 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATV
||.|||||||||||||.|.|||.|||||||.|||||||||||||||||||||||| |.||||.|||||.||||.|||..||||||||...|.||||||||
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSP
|..|||||||||||||||||||||||||| ||||||||||||||.||.|||||||||||||||||||||..|.|||||||||||||||||||||||...|
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

VQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
.|||||.||..||.|||.|||||.||.||.|||||||..|.||||||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK6.AA STE20 407-658 45 4.4e-148 498.25 In-house 1-288 (288) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-288/288
Sequence Identity: 45% (131 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQ----VAVKMMDLRKQ----QRRELLFNEVVIMRDYQHFNVVEMYKSYLVG----EELWVLMEFLQGGALTDIVS
 . . |||.||.| |..|..|..|..    ||.|.|.|.|.    ...|....|..||....| |.|..| |||..    .|||..||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

QV----------RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISK-----DVPKRKSLVGTPYWMAPEVISR----
..          ..||||||..|  |||.|.|||....||||||.| |||| ||.|||.|||.|||..|     . .||...||||||||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLR--DSPPPKLKN--SHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
 . | . .|||||||. |||..||||||  .|..|| .    . |||.||.  .|| || ..||....|..||..|.||..|| |||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK6.AA PAKA 408-658 47 1.6e-128 433.26 In-house 2-260 (260) Show / Hide 
Range on Protein: 408-658
Range on HMM: 2-260/260
Sequence Identity: 47% (124 aa)

DSYVKIGEGSTGIVCLAREKHSGRQ--VAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR------LN
. . |||.|..| | .| ... . .  ||.| |.. .| . ||. ||  .|....| |.|  ..|||| .|||| ||...|| |||...|..      ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEP
|.||| ||. .||.| ..|....|||||||| |||  ||.||. |||||||...   ||.. ||||||||||||.|  |   |||||||||.|||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
|| .. |. ||  .     |..|. .|.|. ..|||.. |  |...||.||||| ||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK6.AA STE 407-658 29 1.1e-115 390.66 In-house 1-359 (359) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

LDSYVKIGEGSTGIVCLAREK------HSGRQ---------VAVKMMDLRKQ-----------------QRRELLFNEVVIMRDYQ--HFNVVEMYKSYL
..   |||.|..| |..|. .      ..|..         .|.| |.|...                 . .. . .|. ||....  | |.|. | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------EELWVLMEFLQGGALTDIVSQV---------------RLNEEQIATVCEAVLQA-LAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCA
..       .|||. ||.. || |.||. ..               |..|.|||..| ..|.. |.||| ...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QISKDVP----------------KRKSLVGTPYWMAPEVISR------SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS-----------
|......                ||...|||| |||||||..      . | | .||||||...|||..|.||..  .| .|| .  ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPKLKN-----------------SHKVSPVLRDFLERMLVRDPQERATAQELLD--HPFL
    |||.|..                 .||.|| ..||... |..||..|.||..||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK6.AA S_TKc 407-658 29 4.2e-92 313.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQG--GALTDIVSQVR-------
 .   |||.|. | |...|.|..||.||.|...       | . .|. |..  .| |.| .| ..   ..|.. ||.. |  | | |.  . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT-EVDIWSLGIMVIEMVD
..| ... ..  ...||.|.| .|.||||.| . |||.   ..|..|||...|.       ....|||..|||||.    | . ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLD-------HPFL
|.||.    . . .|...             || ..||....|..||..| || |.|        ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK6.AA Pkinase 407-658 27 4.9e-82 283.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL--LFN--EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGG----ALTDIVS---Q
.    |||.|| | |.....| .|..|||| ...|..   ..  ...  |. ||.  .| |.|..| ..  . .... ||...||     | |..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VRL--NEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV----KLSDFGFCAQI-SKDVPKRKSLVGTPYWMAPEVIS-RSLYATEVDIWSL
 ..   |...  ..  .|..|.|.|..|.||||.|.. ||.  .| .    |..|||...|.     .  ....|||..||||||  .. | ..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMVDGEPPYFSD----SPVQAMKRLRDSPPPKLKNSHKVS---------------------PVLRDFLERMLVRDPQERATAQELLDHPFL
|....||. |.||. ..    . .  |....   .|.|. .   .                     . ..||....| .||..| ||...| ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK6.AA YSK 410-658 38 7.3e-81 243.13 In-house 1-257 (257) Show / Hide 
Range on Protein: 410-658
Range on HMM: 1-257/257
Sequence Identity: 38% (101 aa)

YVK---IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQ---VRLNEEQ
..|   || || | |  . ... .| ||.|  || .     |..  |. .  .    ..   | ||| .  ||. ||.. || . |   .     . |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISR--SLYATEVDIWSLGIMVIEMVDGEPP
||..   .|..| ||| . .||||||.  .||. .| ||| |||  .||   . ||   ||||||||||||    | | . .|||||||  .||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YFSDSPVQAMKRLRDSPPPKLKN-SHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
|    |  .| ..  ..||||.  |.  |  . .| |  |. ||..| .|.||| | | 
YCDYHPMRVMFLIPKNNPPKLEGRSY--SKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK6.AA MST 412-658 41 2.2e-78 248.74 In-house 6-254 (254) Show / Hide 
Range on Protein: 412-658
Range on HMM: 6-254/254
Sequence Identity: 41% (103 aa)

KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL--VGEELWVLMEFLQGGALTDIV--SQVRLNEEQIATVC
|.|.|| | |  |  | .|  ||.||.        . . .|  || . .  ..|  | ||.    ...|  ||.  .| . ||.   |  |||.|||...
KLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACIL

EAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPV
  .|| |.|||    ||||||.  |||  .|  ||.|||  .| .    || ...|||||||||||  . | . .|||||||  |||  |.|||.   |.
YDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPM

QAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
 ||.    .|||..|. .. |. . ||. . |...|..|.|| .|| ||| 
RAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK6.AA KHS 408-658 42 5.8e-77 258.38 In-house 2-258 (258) Show / Hide 
Range on Protein: 408-658
Range on HMM: 2-258/258
Sequence Identity: 42% (108 aa)

DSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATV
.   ..| |  | |  ||...|.  .|||.. .  ..  ...  |...|.| .| |.|  . |||  . ||. ||.  ||.| ||      |.| ||| |
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS---RSLYATEVDIWSLGIMVIEMVDGEPPYFS
|  .||.|.|||..| .|||||   |||| .| ||| |||  |||.  . |||| .|||||||||| .   .  |    |||..||  ||. .  || | 
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

DSPVQAMKRLRDSP--PPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
  |..|.  .  |   |||||. || |.   .|.   |...|. | ||. || |||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK6.AA SLK 408-658 37 8.9e-73 244.83 In-house 2-259 (259) Show / Hide 
Range on Protein: 408-658
Range on HMM: 2-259/259
Sequence Identity: 37% (96 aa)

DSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR--LNEEQIAT
.    .|.|  | |  |..|  ..  | ||......   |  . |. |. . .| |.|..|..| . ..||...|| .|||.  |.  .   | |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-----SRSLYATEVDIWSLGIMVIEMVDGEPP
||. ...|| .|| . |||||.|   ||.|.|| |.| |||  |.  ... || . .||||||||||.         |   .||||||| .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
.   .|.  . ... | ||.|..  . |   .|||.. ||.||| | |...|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK6.AA CAMK 412-658 18 3.5e-71 228.39 In-house 1-425 (425) Show / Hide 
Range on Protein: 412-658
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

KIGEGSTGIVCLAREKHSG------------RQVAVKMMDLRKQQR----------------------------RELLFNEVVIMRD-------YQHFNV
..|.|| |.| |...|...            ..||.|..| .| .                             |. ...|. ||.         .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEMYKSYL------------VGEE--------LWVLM---EFLQGG----A-LTDIVSQ---------------VRLNEEQIATVCEAVLQALAYLHAQG
. .|  |               .         ..  |   |. .||      .  ||..                |..|.. ...   ...|..|.| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKSDSILLTLD-----------------GRVKLSDFGFCAQISKDV-----------------------PKRKSLVGTPYWMA-PEVISRSL---
..|||.| . |||. .                 . .|..|||| ... ..                        .| |  .|||. || |||....    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMK----------------RLRDS-PPPKLKN------------------SHKVSPVL
           |  ..|.||.|..   |. |.||. .|.  . ..                . . . |||....                  . .||.  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

RDFLERMLVRDPQERATAQELLDHPFL
.|.. .||..||..|.|... |.||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK6.AA PAKL 463-658 40 1.9e-64 220.4 In-house 57-256 (256) Show / Hide 
Range on Protein: 463-658
Range on HMM: 57-256/256
Sequence Identity: 40% (80 aa)

NVVEMYKSYLVG-EELWVLMEFLQGGALTDIVSQVR--LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVP-KR
|.|  . |   .  ..|.||..   |   |.   .   |||.||. .   .|  | ||| ...||||||.  |||. |. ||. |||   |.        
NIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQA

KSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
....|||||||||.| .  |   .||||||| .||| ||.||     |  ||.     |||...| .. || . ||| . .| || .|. . .||.|||.
NQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase PAK6.AA Pkinase_Tyr 407-615 28 1.5e-23 80.39 Pfam 1-231 (270) Show / Hide 
Range on Protein: 407-615
Range on HMM: 1-231/270
Sequence Identity: 28% (65 aa)

LDSYVKIGEGSTGIVCLAREK----HSGRQVAVKMM--DLRKQQ--RRELLFNEVVIMRDY-QHFNVVEMYKSYL-VGEE--LWVLMEFLQGGALTDIVS
.    |.|||. | |.... |      . .|||||.  .  ..|  |....  |. ||. . .| |.| .|   .  ||   ... ||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QV-----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQI-SKDVP--KRKSLVGTPYWMAPEVISRSLYATEVDIWS
.      .|. ...   |  . ....||.... ||||.    .|.| .. || .||| .  | ..|    ||..      |||||.|. . . |. |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGIMVIEMVD-GEPP-YFSDSPVQAMKRL-RD
 |.   |..  || | |   |. . .... .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PAK6.AA TyrKc 407-658 25 1.6e-22 82.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 407-658
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDY--QHFNVVEMYKSYLVG-------EELWVLMEFLQGGALTDIVSQVR
.    |.|||  |.|.... |   .||||||.   .   || . .|  ||. .  .| |.| .|   . .       | |...||.  .|.| |     |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD-------VPKRKSL-VGTP-----YWMAPEVISRSLYATEV
  |. ..    |  . .  .||| ...||||.    .|.. ...|| |||| .  |  |         .||.   |.       |||||.|  . . |. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVIEMV-DGEPPYFS-----DSPVQAMKRLRDS---PPPKL-----KNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
|.|| |..  |.  .|..||        |. ........    |.|.            .. . .  ..   .|| .| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF