Gene NEK5 (Human)

NEK5

Species: Human
Alias: NEK5, MGC75495
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 13q14,

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
NEK5.NA RNA Sugen Kinome 2924 None Fasta, JSON
NEK5.AA Protein Sugen Kinome 857 None Fasta, JSON
NEK5.kin_dom Protein Kinase Domain Sugen Kinome 256 None Fasta, JSON

Protein domain

Protein domains of NEK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK5.AA NEK1 4-259 65 1.2e-205 689.43 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-276/276
Sequence Identity: 65% (182 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGR--LFIVMEYCDGGDLMKRINRQ--RGVL
|..||.||.|.||||.|.| |.|..|.||||||..||...|.|.|..||..|.||||||||....||.|||.  |.||||||||||||..||||  .|.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLS--KNGM--------------VAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNN
||||||. ||.||.|.|.|||||||||||||.|||||.  ||||              ..|||||||||.||..||.|.|||||||||||||||||||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFL
|.||||||||||||||||||||.||...|||||||....||.| .|.||.||.||.|...||.|||.|.||.|||.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK5.AA NEK 4-259 51 1.5e-171 576.19 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-286/286
Sequence Identity: 51% (146 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKH-----CVIKEINFEKMPIQEKEASK-KEVILLEKMKHPNIVAFFNSFQENG--RLFIVMEYCD-GGDLMKR---
|..|| ||||.|||.|... |||.||     .|.|.||...|  .||...  .||..|...||||||....||.|..  .|.||||||. ||||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

INRQR--GVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIFLSKNGM---VAKLGDFGIARVLNNSMELART-CIGTPYYLSPEICQNKP
|..|.  | .|.|.||. ||.|..|.||..|||     |||||||| |||||.||..   ..|.|||||..|||.....|.| ..|||||.|||.|||||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKTDIWSLGCVLYELCTL--KHPFEGN--NLQQLVLKICQA-HFAPISPG--FSRELHSLISQLFQVSPRDRPSINSILKRPFL
|||| |||||||||||.|||  |||||..  |. .|..||..  ...||..   .|..|..||||..|..| .|||.|.||..||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK5.AA NEK8 4-259 40 8.4e-135 387.34 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-278/278
Sequence Identity: 40% (112 aa)

YDVIKAIGQGAFGKAYLAKGKSDS--KHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFS
|  |  .|.|||| . |  .|.|.  .  ..|.|| . |   |  .   |. .| .  ||||.. ...| |.. |.|.|||.||| |   |..|.. ||.
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

ED-----------------QILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNS--MELARTCIGTPYYLSPEICQNKPYN
|                  .||  |.|..... |.|.  |||||.| ||||. .  || |.|||||. ..|    |  ..| .|||||.|||.|. ||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQA-HFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFL
.| |.|.|||||||.|.||  ||. ||  ||.|| |   ..||| . | |...|.... |. |  |||   |...| .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK5.AA NEK4 4-259 43 9.5e-115 387.52 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQ-ENG-RLFIVMEYCDGGDLMKRINRQRGVLFS
|. .| .|.| .|  .| . . | |  |.| ..  .   .|. |  .|. || ..|||||| ...|.. |||  |.||| .|.|||| ..  .|.. . .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLK
| |.. ||||| ..|  .|...||||| | ||||| |  .. |.|||||.|||||. ..|.| ||||||.|||.  |.||. | ||||||| .||. |||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNII-KIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

HPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFL
| |.  ..  |. .| | .  |..| .| .|  |. |. .  | .|||| .|.. |..
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK5.AA S_TKc 4-259 32 2e-96 327.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDG--GDLMKRINRQRG----
|.... ||.||||| |... |.. ... ||.|.         |  ..|. .|.| .||||| .. .||. ..|..|||||||  |||...| ....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

VLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNN-KTDIWSLGCVLYE
. |.| ..  .. || ..|...|...|.|||.| .||.|..   . |..|||.||.|       .|..|||.|..||..   .|.  | |.||.||.|||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILK-------RPFL
... . ||.  ..|..  ||.           |.|. ..|....|. |..||..  .|.        |..
MLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK5.AA NEK2 4-259 35 7.4e-82 275.42 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-319/319
Sequence Identity: 35% (112 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSF--QENGRLFIVMEYCDGGDLMKRINRQRG--VL
|.| ..||.| ||. .  . ||| |  | |||. ..|   |. .   |. .| . |||||| . .     .| .| |||||| ||||   | . |     
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FSEDQILGWFVQISLGLKHIHD---------------------RKILHRDIKAQNIFLSKNGM-------------------------------------
. |  |.. . |. . |. .|                      . |||||||  ||||. ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

-VAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF
 |.|||||| ||.|| .   | | .||||| |||  .  .|| | ||||.||..||.|.|. ||.. | .||  || | || .|    ||.|  .|.   
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

QVSPRDRPSINSILKRPFL
 | .. ||||. ||. |..
NVDHYHRPSIEEILQHPQI
Kinase NEK5.AA Pkinase 4-259 27 1.2e-81 282.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKK--EVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGG----DLMKRIN-RQR
| ... ||.|.||. |... |...|  ..|.|. ..   .....  .  |. .. ...||||| .. .|...... .|||||.||    ||. .|  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVL-FSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVA---KLGDFGIARVL-NNSMELARTCIGTPYYLSPEICQ-NKPYNNKTDIWSL
|.. |||...  .. ||  ||...|...|.|||.| .||....|| ..   |..|||.|... . . . . |  |||.|..||... ...|  | |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYELCTLKHPFEGN------NLQQLVLKICQAHFAPISPGFS--------------------RELHSLISQLFQVSPRDRPSINSILKRPFL
||.|||... . || |       . .|.. .| .. .   .|  .                    .|. ..|. .... | .||..  ||. |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK5.AA CAMK 9-259 19 2.5e-79 255.11 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-259
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

AIGQGAFGKAYLAKGKSDS------------KHCVIKEINFEKMP--------------------------IQEKEASKKEVILLEK-------MKHPNI
 .|.|.||| .|.. |..             ... || |. .|..                           . ..  ..|. .. |       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAFFNSFQENG-------------------RLFIVM---EYCDGG----DLMKRINRQRG-------------VLFSEDQILGWFVQISLGLKHIHDRKI
. ..  .. .                    ....||   |||.||    ||  .| ....               |.|..   .| ||  .....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKAQNIFLSKNG----------------MVAKLGDFGIARVLNNS-----------------------MELARTCIGTPYYLS-PEICQN------
 |||.|  || |..|.                   |. ||| |.... .                        .. .|. |||.| . ||. .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYNNKTDIWSLGCVLYELCTLKHPFEGN-------------NLQQLVLKICQAHFAPISPGFSR-----------------------ELHS
        ..|. |.|.||.|..|| . . . ||.|              |...|  ||... .  ..| ||                        |  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISQLFQVSPRDRPSINSILKRPFL
||... || | .|..|  .|. |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK5.AA NEK-Unclassified 4-259 37 1.5e-77 256.3 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-258/258
Sequence Identity: 37% (100 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGV--LFS
|| |  .|||  |  || . .  ||  ... |   |     |   .  .|.| ...|| || .  || || .||   .|||||.| .|| ..|.    | 
YDKITTLGQGGGGAVYLVRHQI-SKRHLVQQISKRK----KKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLK
|  |  |..|.   .  || |||.||| | ||||| .  .|  .|||||.|...   . ||||.||. ..|||.|| .||||. |.|||||..||.||  
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVS-MGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HPFEGNNLQQLVLKICQAHF------APISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFL
  |   |.  .  || |          |.|  .|  |  .|  . .  .  |||   |.  .. 
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK5.AA ULK 4-259 28 5.4e-77 262.11 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

YDVIKAIGQGAFGKAYLAK-GKSD---SKHCVIKEINFEKMPIQEKE--------ASKKEVILLEKMK--------HPNIVAFFNSFQENGR--LFIVME
| ... .|.|.||| | ..  |..    . ...| |  .|| ....|          |.|. .. |.|        ||||| ..  |..     ..|.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCDGGDLMKRINRQRG--------VLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNG-----------MVAKLGDFGIARVLNNS-M--E
||.||||.. |.....          .||....  | ||  |.|..|...| ||||| ||| ....            .|.|..||| |....|. |  .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LARTCI------GTPYYLSPEICQ----NKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAH-------------FAPISPG------FS
.. ||       |||.| .|.| |    .|||... .|||||||..||. . | ||...  ....|.|.|               . .  |       .|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

RELHSLISQLFQVSPRDRPSINSILKRPFL
 |...||....|. ..|| |.  ... |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK5.AA CAMKL 4-259 28 6.5e-76 241.71 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-297/297
Sequence Identity: 28% (85 aa)

YDVIKAIGQGAFGKAYLAKG-KSDSKHCVIKEINFEKMP-IQEKEAS------------KKEVILLEKMK---HPNIVAFFNSFQENGR------LFIVM
|...| .|.|.|||  ||.  .   ..  || |. .|.  .. ...             ..|. ......   ||||. ..  ..          ...||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCDGGD--LMKRINRQRGVL--FSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGM-VAKLGDFGIARV---L-NNSMELARTCIGTPYYL
|||.||.  |. .| .....   ..|..    | ||  .....|...| |||||. || |..||. ..|. ||| .       ... .. .|. |.| | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEICQN--KPYN-NKTDIWSLGCVLYELCTLKHPFEGN--------NLQQLVLKICQAHFAP-ISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFL
.|||.|   |||.  |.||||.| .|| . . . ||..         |   | .|| .  . | | .  | ....||... || | .||.|  |.. |..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase NEK5.AA ULK 4-259 28 5.3e-75 255.48 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

YDVIKAIGQGAFG-KAYLAK-GKSD--SKHCVIKEINFEKMPIQEKE--------ASKKEVILLEKMK---HPN--IVAFFNSFQENGR--LFIVMEYCD
| ... .|.|.|| | | ..  |..   ..  .| |.  || ....|          |.|. .. |.|   |||  || ..  |..     ..|.||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLMKRINRQRG-------VLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNG-----------MVAKLGDFGIARVLNNSM---ELART
|||| . |.....         .||..... | ||  |.|..|...| ||||| ||| ....             |.|..||| |....| .    .  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CI------GTPYYLSPEICQ----NKPYNNK-TDIWSLGCVLYELCTLKHPFEGNNLQQLVLK--------------ICQAHFAPIS----PGFSRELHS
|       |||.| .|.| |    .|||... .|||||||..||. . | ||...  ....|.              |..  . . .    | .| |...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LISQLFQVSPRDRPSINSILKRPFL
||....|. ..|| |.  |.. |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK5.AA TyrKc 4-259 22 2.8e-30 107.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKM--KHPNIVAFFNSFQEN-------GRLFIVMEYCDGGDLMKRINR
   .| .| ||||. |... |     . .| .. ..     .|.  .|  .. |   .|||||...    .        . |.|||||...||| ... .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNS------MELART-----CI--GTPYYLSPEICQNKPY
 |.  .. .. | . .||. |  ..|.... |||. | |. ...|. ..| .||| .| . .        .  |.     .        ..||  . . .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NNKTDIWSLGCVLYELCTL-KHPFEG-----NNLQQLVLKICQAHFAPISPG--------FSRELHSLISQLFQVSPRDRPSINSILKRPFL
. |.|.|| | ...|..|. . | .|      . |... .. | .  |. |          . |......|  .  | |||. . |  . ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK5.AA Pkinase_Tyr 4-200 25 2.2e-27 93.35 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-200
Range on HMM: 1-210/270
Sequence Identity: 25% (54 aa)

YDVIKAIGQGAFGKAYLAKGK----SDSKHCVIKEINFEKMPIQE--KEASKKEVILLEKM-KHPNIVAFFNSFQ-ENGR--LFIVMEYCDGGDLMKRIN
   .| .|.||||. |... |    ..  .. .| .. |.   ..  .|.  .|. .. .. .||||| .      . .   ..|||||. .||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RQ--RGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVL-NNSME-LARTCIGTPY-YLSPEICQNKPYNNKTDIW
..   .  ..  ..|.. .||. |. . ..... |||. | |. ...|. |.| .||| || . | .    .|.    |   ..||  ... .. |.|.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLGCVLYELCTL
| | ...|..|.
SFGVLMWEIFTY