Gene PKR (Human)

PKR

Species: Human
Alias: PKR, EIF2AK1, p68, EIF2AK2, PRKR, MGC126524
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p22.2,

Classification

Group: Other
Family: PEK
Subfamily: PKR

Sequence

Name Sequence Type Origin Length Description Download
PKR.NA RNA Sugen Kinome 2696 None Fasta, JSON
PKR.AA Protein Sugen Kinome 551 None Fasta, JSON
PKR.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON

Protein domain

Protein domains of PKR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Dsrm PKR.AA dsrm 10-75 35 2.7e-19 72.87 Pfam 1-67 (67) Show / Hide 
Range on Protein: 10-75
Range on HMM: 1-67/67
Sequence Identity: 35% (24 aa)

FMEELNT-YRQKQGVVLKYQELPNSGPPHD-RRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEIL
.. .|.  | ||.|  . |...   ||||. ..|| .....|... .|.|..|||||..||..|...|
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCPTFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL
Dsrm PKR.AA dsrm 101-165 26 6.6e-15 57.05 Pfam 1-67 (67) Show / Hide 
Range on Protein: 101-165
Range on HMM: 1-67/67
Sequence Identity: 26% (18 aa)

YIGLINR-IAQKKRLTVNYEQCASGVHGPE--GFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQI
....... ..||......|. . . .   .   |.  |... |.| .|.||.|.||||.||..|. ..
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCPTFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL
Kinase PKR.AA PKR 267-536 84 6.2e-222 743.59 In-house 1-272 (272) Show / Hide 
Range on Protein: 267-536
Range on HMM: 1-272/272
Sequence Identity: 84% (229 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQM
||.||.|||||||||||||||||||.||||||||||||||.||.|||||||||||||..||||||||||.||||||||||||||.|..||.||.||||||
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNNEKAEHEVQALAKLDHVNIVHYHSCWDGFDYDPEHSDDSLESSDYDPENMKDTSRYKTRCLFIQM

EFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK-RTRSKGTLRYMSPEQISSQDY
|||||||||||...||.||.||||.|.|.|||.|||||||||||||||||||||||||....|||||||||.|||||| |||.||||.|||||||.||.|
EFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALKNDGKSRTRRKGTLQYMSPEQIFSQHY

GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIIS-DIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL
|||||.||||||||||||||.|.||..|||.|||||..| ||||.||||||||||||||.||||||||||||
GKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNKEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PKR.AA PEK 267-538 19 1e-121 410.65 In-house 1-655 (655) Show / Hide 
Range on Protein: 267-538
Range on HMM: 1-655/655
Sequence Identity: 19% (125 aa)

FKEIELIGSGGF-GQVFKAKHRIDGKTYVIKRVKYNN---------------------EKAEREVKALAKLDHVNIVHYNGCWDGFD-------------
|.||...|.||| |||.|.....||. | |||.|.|.                     ||..||||.||.|.| |||.|  .|.. .             
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

----------------------------------------------------------------------------------------------------
                                                                                                    
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

-------------------------------------------------------------------------YDPETSDDSLESSDYDP----------
                                                                         |.....||. |..|..           
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

-------------------------------ENSKNSSRSKTK-------------CLFIQMEFCDKGTLEQWIEKR-----------------------
                               |.  |....|.|             .|.||||.|.|.||..||. .                       
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

-------------------RGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ-----VKIGDFGLVTSLK-----------------
                   . ...||......|.|| .|..||||. .|||||||||||| .  |     ||||||||.|...                 
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYW

---NDGK----RTRSK----------------------------------GTLRYMSPEQISSQ-----DYGKEVDLYALGLILAELLH-VCDTAFETSK
   ....    .|...                                  ||..||||||.| |      |.. ||.|.||.|..|...  ..| .| .|
KYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVK

FFTDLRD------GIIS-DIFDKK---EKTLLQKLLSKKPEDRPNTSEILRTLTV
..|||||      |... ..||.|   .....|..||..|..||....|| ....
TLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase PKR.AA S_TKc 267-540 29 4.6e-64 220.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 267-540
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQM
.. ...||.|.||.|.|..|. .|. . ||..|   |...||.. | | .| |||.. ....                               ..|.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------------------------------DHLYMVM

EFCDK--GTLEQWIEKRRGEK----LDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI
|.||   |.| . |.||....    ..   |  .. || ....|.||.. |||||||.||.| .  ..||.|||| . |      |   ||. ||.|| .
EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL

SSQDYGK-EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR-----TLTVWK
    ||| ..| ...| ||.|.|    . |.       . . |     ..  | ...|.| | ||.||   |.|.      .  | 
---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKR.AA Pkinase 267-482 29 3.2e-58 204.54 Pfam 1-206 (293) Show / Hide 
Range on Protein: 267-482
Range on HMM: 1-206/293
Sequence Identity: 29% (70 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER--------EVKALAKLDHVNIVHYNGCW-DGFDYDPETSDDSLESSDYDPENSKNSSRS
.. .. ||||.||.|.|..|. .||....|..|. .|| .         |.. ...|.| ||| . ... |                             
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----------------------------

KTKCLFIQMEFCDKG----TLEQWIEKRRGEKL--DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV----KIGDFGLVTS--LKNDGKR
|...  . ||.|..|     |  .|. .|. ..  .   .   . || .|..|.||.. |||||||.||..... ..    ||.||||     . |..  
KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M

TRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELL
|   ||..||.|| |  .|.||..|| ...|.||.|.|
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase PKR.AA STE 267-482 24 2.1e-46 160.46 In-house 1-262 (359) Show / Hide 
Range on Protein: 267-482
Range on HMM: 1-262/359
Sequence Identity: 24% (70 aa)

FKEIELIGSGGFGQVFKAKHRI---------------DGKTYVIKRVK---------------------YNNEKAEREVKALAKLD--HVNIVHYNGCWD
.. || ||.|.||.|.||...                 |. . ||...                      . .. ..|.| . |..  | |||.| ||  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GFDYDPETSDDSLESSDYDPENSKNSSRSKT-KCLFIQMEFCDKGTLEQWIE-K-RRGEKLD----------KVLALELFEQITKG-VDYIHSKKLIHRD
  . .                       .|    |.| ||..| |.|.. |. |  .|. |.            .      || ||  .|.||.. ||||
KEGHN-----------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRD

LKPSNIFLVDTKQVKIGDFGLVTSLKN-----------------DGKRTRSKGTLRYMSPEQISS------QDYGKEVDLYALGLILAELL
.||.||.|     ||. |||. ..| .                 ..||.   ||  .|.|| |.       ..|.  .| . ||. . |..
IKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase PKR.AA CAMK 272-478 17 2.3e-46 146.96 In-house 1-324 (425) Show / Hide 
Range on Protein: 272-478
Range on HMM: 1-324/425
Sequence Identity: 17% (62 aa)

LIGSGGFGQVFKAKHRIDG------------KTYVIKRVKY--------------------------------NNEKAEREVKALAK-------LDHVNI
 .|.|.||.|....|. ..            . . || ..                                 . .. .||.. . |       ||| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHYNGCWD------GFDYDPETSDDSLESSDYDPENSKNS--SRSK-----TKCLFIQM---EFCDKG----TLEQWIEKRRG-------------EKLD
..    ..      ..                      |.  . ||     .|.... |   |.|. |     | ..| ....              ...
IKLYEVYEDPHYFKNT----------------------NDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT

KVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK-----------------QVKIGDFGLVTSLKN------------------------DGKRT
   |  .| ||  .|.|.||.. .|||||| || |.| .                 ..|| |||. . ..                         . | .
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK

RSKGTLRYMS-PEQISSQD--------------YGKEVDLYALGLIL
 . ||. ||. || ....               ||...|  ..| ||
TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase PKR.AA TKL 273-536 19 5.5e-46 159.1 In-house 1-364 (364) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-364/364
Sequence Identity: 19% (78 aa)

IGSGGFGQVFKAKHRI--------DGKTYVIKRVKYNN-------------------------------EKAEREVKALAKLDHVNIVHYNG-CWDG---
|||||||.|.|.|.|         .||. ..|. | .|                               .. |.|.. . .|.| |||.. | | ..   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHS--------KKLIHRDLKPSNI
 . ..|                      . .. |.| ||.|..|.|.  .           . . .  .| .|..| ||        ...||||||..||
CVCMHPV---------------------GPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

FLVDTKQ--------------VKIGDFGLVTSLKNDG--------------------KRTRSKGTLRYMSPEQISSQ----------------DYGKEVD
.. .  .              .||.|||| ......|                    .. .  ||.|.|.|| .  |                .| . .|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

LYALGLILAELLHVCDTAFETSKFFTDLR-------DGIISDIFDKKEK--------------------TLLQKLLSKKPEDRPNTSEILRTL
 |. |..| |.|  |   ..   .  ...        .....      .                     |.|.  . .||.||. .||| .|
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase PKR.AA Ciliate-E2-Unclassified 267-478 20 7.9e-46 156.95 In-house 1-260 (352) Show / Hide 
Range on Protein: 267-478
Range on HMM: 1-260/352
Sequence Identity: 20% (59 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKA----------LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPE-------
.| |. ||.||||.|.|..|. ... |..|  | ..... . ..           . .. . ...                        |  .       
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K---------------------Y--NKIMQQIL

--------NSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG---------------EKLDKVLAL-----ELFEQITKGVDYIHSKK-LIHRDLKPSNI
          .     ......| ||.|. |.|.|.|.|| .               ....   |.      .| || .| .|.|.|.  ||||.||.||
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENI

FLVDTK---QVKIGDFGLVTSLKND---------------GKRTRSK-GTLRYM----SPEQISSQDYG----KEVDLYALGLIL
.. . .   ..|| |||.   ....                ... .. ||..||    .|| . .| |.    ...| ..|| ||
LFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase PKR.AA GCN2 330-538 24 2.6e-40 138.7 In-house 221-511 (511) Show / Hide 
Range on Protein: 330-538
Range on HMM: 221-511/511
Sequence Identity: 24% (73 aa)

FDYDPETSD-------------------DSLESSDYDPENSKNSSRSKTKC----------LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITK
| .. |...                     ....| . .|..... ...            |.||||.|...|| | |.   |  .|.. . ..| ||  
FQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNH-GWCMDHDELWRYFRQILE

GVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS--------------------------------LKNDGKRTR--SK------------GTLRY
|..||||.  ||||||||||||  . .||||||||.|.                                ..|. .     ..            ||  |
GLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFY

MSPEQISSQDYGKEVDLYAL-GLILAELLHV-CDTAFETSKFFTDLRDGIISDIFD-------KKEKTLLQKLLSKKPEDRPNTSEILRTLTV
|.|||  .  |.. ||.|.| |.|. |...   .|. | ..  ..||.  . . ||       |.........|. .|  ||.....| . . 
MCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase PKR.AA Ciliate-E2 358-478 21 2.8e-38 128.98 In-house 105-286 (365) Show / Hide 
Range on Protein: 358-478
Range on HMM: 105-286/365
Sequence Identity: 21% (41 aa)

KTKCLFIQMEFCDKGTLEQWIEKR---RGEK------LDKVLALELFEQITK---------------GVDYIHSKK-LIHRDLKPSNIFLVDTKQVKIGD
....... ||.|. |.|...|...   |...      ..   ......||..               .. |.|||.  ||||.||.||..     .|| |
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIID

FGLVTSLKND----------GKRTRSK-----------------------GTLRYMSPEQISSQD---------YGKEVDLYALGLIL
||| . ...|          .. .  |                       ||. ||.|| .....         |....|...|| ||
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase PKR.AA PEK 362-437 41 3.9e-31 100.32 In-house 414-514 (758) Show / Hide 
Range on Protein: 362-437
Range on HMM: 414-514/758
Sequence Identity: 41% (42 aa)

LFIQMEFCDKGTLEQWIEKR-RGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ------------------------VKIGDFGLV
..|||. | | ||..|.. |   |  .. . | .| ||  ||.||||| .|||||||||||..   |                        .||||||||
MYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLV

T
|
T
Kinase PKR.AA NEK 361-466 34 2.8e-27 93.34 In-house 80-202 (286) Show / Hide 
Range on Protein: 361-466
Range on HMM: 80-202/286
Sequence Identity: 34% (42 aa)

CLFIQMEFCD-KGTLEQW---IEKRR--GEKLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLVDTKQ----VKIGDFGLVTSLKNDGKR
||.| ||.|. .|.|.|    |.|..  |. ..    .. | |. ....|.|..     | .|||.||.|||| .       |||||||.   |... . 
CLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDM

TRS-K-GTLRYMSPEQISSQDYG
 ..   ||  |||||..... |.
AYTTQVGTPYYMSPEVCQNKPYN
Kinase PKR.AA PEK 450-538 31 1.2e-26 85.0 In-house 650-758 (758) Show / Hide 
Range on Protein: 450-538
Range on HMM: 650-758/758
Sequence Identity: 31% (34 aa)

GTLRYMSPEQISSQ----------------DYGKEVDLYALGLILAELLHV-CDTAFETSKFFTDLRDGIISDIFDK---KEKTLLQKLLSKKPEDRPNT
||. ||||||.. |                 |   || |.||||..||.|    |..|  . ..|||.|..  .|..   .|  ..| ..|  |. || .
GTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTA

SEILRTLTV
..|.  . .
DQISMHDFF
Kinase PKR.AA PEK 267-323 44 1.2e-20 64.65 In-house 1-70 (758) Show / Hide 
Range on Protein: 267-323
Range on HMM: 1-70/758
Sequence Identity: 44% (31 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN---------EKAE----REVKALAKLDHVNIVHY
|..|. .|.|||| ||.||   |.  | |||.   |         |.|     |||..||.||| ||| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRY
Kinase PKR.AA NEK 267-323 36 1e-18 62.83 In-house 1-69 (286) Show / Hide 
Range on Protein: 267-323
Range on HMM: 1-69/286
Sequence Identity: 36% (25 aa)

FKEIELIGSGGFGQVFKAKHRIDGKT-----YVIKRVKYNN------EKAE-REVKALAKLDHVNIVHY
...|. ||.| ||.|.|.....|||      ||.|.....|      ..|   ||. |..|.| ||| |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKY
Kinase PKR.AA TyrKc 267-536 21 2.6e-15 24.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 267-536
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE--REVKALAKL--DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKT---
 . .. .|.| ||.|.|.. .    .  .| .| .  ...  || . . ||  .| |||   |.              ....                  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGV-------------CTQQGRN------------FMYI

KCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKND--------GKRT----R
. |.| ||....| | . . |.|.. |     |.   || .| .|.|||..|||||   |. . . ..|||.||||   ...|         .|.     
EPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

SK--GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFET--------SKFFTDLRDGIISDIFDK-----------KEKTLLQKLLSKKPEDR
.|    .| |.|| |    .  . | .. |  . |..  ...  .         .  . ....|   .. .            .  .. ..    .||||
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PNTSEILRTL
|. ||| . .
PTFSEIHECF
Kinase PKR.AA GCN2 267-323 39 1.4e-13 43.53 In-house 1-66 (511) Show / Hide 
Range on Protein: 267-323
Range on HMM: 1-66/511
Sequence Identity: 39% (26 aa)

FKEIELIGSGGFGQVFK-AKHRIDGKTYVIKRVKYN-NEK-------AEREVKALAKLDHVNIVHY
|.||...| |||||| | .. . ||. | ||. . | ...        .|||| |..| | ..| |
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRY
Kinase PKR.AA Ciliate-E2 267-321 20 1.2e-10 32.75 In-house 1-95 (365) Show / Hide 
Range on Protein: 267-321
Range on HMM: 1-95/365
Sequence Identity: 20% (19 aa)

FKEIELIGSGGFGQVFKAKHRIDG-----------------------KTYVIKRVKYNNEKAEREVKALA-----------------KLDHVNIV
.| |..||.|.||.|.|.|.. ..                       | | .|..| |. ..   .. .                  .|.| ||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII
Kinase PKR.AA Pkinase_Tyr 366-435 37 1.5e-09 32.96 Pfam 86-157 (270) Show / Hide 
Range on Protein: 366-435
Range on HMM: 86-157/270
Sequence Identity: 37% (27 aa)

MEFCDKGTLEQWIEKR--RGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGL
||.. .| |     |.   ...|.    |.   || || .| .||..|||||   |. . ....|||.||||
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase PKR.AA NEK 512-538 33 0.000231 11.72 In-house 260-286 (286) Show / Hide 
Range on Protein: 512-538
Range on HMM: 260-286/286
Sequence Identity: 33% (9 aa)

KTLLQKLLSKKPEDRPNTSEILRTLTV
. |....| | ||.||....|| .  .
QNLISQMLQKDPEQRPSCNQILEMPFI
Kinase PKR.AA CAMK 512-538 29 0.00074 7.52 In-house 399-425 (425) Show / Hide 
Range on Protein: 512-538
Range on HMM: 399-425/425
Sequence Identity: 29% (8 aa)

KTLLQKLLSKKPEDRPNTSEILRTLTV
| |..|.| . ||.|.. ...|.   .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKR.AA Pkinase_Tyr 267-321 25 0.00095 13.32 Pfam 1-67 (270) Show / Hide 
Range on Protein: 267-321
Range on HMM: 1-67/270
Sequence Identity: 25% (17 aa)

FKEIELIGSGGFGQVFKAKHR-IDGKTYV---IKRVKYNNEKAE-------REVKALAKL-DHVNIV
 . .. .|.| ||.|.|.. .  ...| .   .| .| .  . .       ||.| . .| .| |||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV
Kinase PKR.AA Ciliate-E2-Unclassified 514-538 40 0.012333 4.99 In-house 328-352 (352) Show / Hide 
Range on Protein: 514-538
Range on HMM: 328-352/352
Sequence Identity: 40% (10 aa)

LLQKLLSKKPEDRPNTSEILRTLTV
||||.| |.|. |.. ..||     
LLQKMLKKNPNKRITFEQILNHPWF
Kinase PKR.AA Ciliate-E2 512-533 37 0.017482 4.32 In-house 334-360 (365) Show / Hide 
Range on Protein: 512-533
Range on HMM: 334-360/365
Sequence Identity: 37% (10 aa)

KTLLQK----LLSKKPEDRPN-TSEIL
| |..|    .| |.|| |..  ..||
KDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase PKR.AA Pkinase 514-536 28 0.137239 6.7 Pfam 269-293 (293) Show / Hide 
Range on Protein: 514-536
Range on HMM: 269-293/293
Sequence Identity: 28% (7 aa)

LLQKLLSKKPEDRPNTSEILRT--L
.. ..| |.|..||.  .||    .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase PKR.AA Pkinase_Tyr 521-536 56 3.05713 1.44 Pfam 255-270 (270) Show / Hide 
Range on Protein: 521-536
Range on HMM: 255-270/270
Sequence Identity: 56% (9 aa)

KKPEDRPNTSEILRTL
..|||||  |||.. |
YDPEDRPTFSEIHEQL