Gene PKN1 (Human)

PKN1

Species: Human
Alias: DBK, PKN1, PRK1, MGC46204, PRKCL1, PKN, PAK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.13-p13.2,

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
PKN1.NA RNA Sugen Kinome 2964 None Fasta, JSON
PKN1.AA Protein Sugen Kinome 948 None Fasta, JSON
PKN1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of PKN1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 PKN1.AA HR1 43-111 32 2e-20 76.41 Pfam 1-74 (74) Show / Hide 
Range on Protein: 43-111
Range on HMM: 1-74/74
Sequence Identity: 32% (25 aa)

LERERLRREIRKELKLKEGAENLRRA---TTDLGRS----LGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAA
. ...||..|..|.|.||||||.|||   |||  ..    .  ..  || |......|..||..|.....  .|..
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTD-NKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN1.AA HR1 132-204 37 2.8e-20 75.85 Pfam 1-74 (74) Show / Hide 
Range on Protein: 132-204
Range on HMM: 1-74/74
Sequence Identity: 37% (28 aa)

SRVAGLEKQLAIELKVKQGAENMIQTY--SNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAA
.| . |.|....|.|.|.|||||.. |  ...  |.||..  .||||..|..||. .||||..  |  |    ..
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN1.AA HR1 219-291 32 1.2e-20 77.14 Pfam 1-74 (74) Show / Hide 
Range on Protein: 219-291
Range on HMM: 1-74/74
Sequence Identity: 32% (25 aa)

LRIEELRHHFRVEHAVAEGAKNVLRLL---SAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKG
.|...||.....| .. |||.|..|..   .. |.. ||. ...| .| |||||. .||..||..  ...  || .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2 PKN1.AA C2 331-467 11 0.000161 22.26 SMART 1-92 (92) Show / Hide 
Range on Protein: 331-467
Range on HMM: 1-92/92
Sequence Identity: 11% (18 aa)

TLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGP---NA-WDQ---
||.|... .|.||                                                          |.      .|.....     |  |..   
TLTVHIIEARNLP------------------------------------------------------DPYVKVY-----KTKVVKNTLSGFNPVWNEWME

SFTLELERARELELAVFWRDQRGLCALKFLK--------------LEDFLDNERHEVQ
.|.... . . |.. |. .    .     .               |.| | ..|| . 
TFYFDVHP-Q-LRFEVWDH---DFIGHCCIPPNNPHWHQWDGCIHLSDIL-GYRH-WW
Kinase PKN1.AA PKN 621-880 85 6.1e-205 687.13 In-house 1-260 (260) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-260/260
Sequence Identity: 85% (221 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSE
|...||||||||||||||.....||..|||||||.|||||||||||||||||...|....||||||||.|||| |||||||||..|||||.|||.|||||
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

PRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESP
|||.||.||||||||.||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||.|
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
|||||||||||.||||.||||||||.||| |||||||.|||||||..||||||.|.||||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKN1.AA AGC 621-880 32 5.3e-180 470.26 In-house 1-395 (395) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-395/395
Sequence Identity: 32% (130 aa)

FKFLAVLGRGHFGKVLLSEFR------PSGELFAIKALKKGD-IVARD--EVESLMCE------------KRILAAVTSAG-------HPFLVN-LFGCF
|.|| |.|.|.|||| | . .       .|...|.| ||| . || ..  .||  | |            ..||. . . .       |||.|. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPEH--VCFVMEYSA---------GG-DLMLHIHSD----VFSEPRAIFYSAC-------VVLGLQFLHE-HKIVYRD-LKLDNLLLDTEGYVKIADFG
|...|  ..|||||           || .|.||.. .    .|.|.|| || |.       .||.|..||. ..|..|| ||..|.||| .|..|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGMGYG--------------------------------------------------DRTSTFCG--TPEFLAPEVLTDTSYTRAVDWWG--LGVLLY
||||||..|                                                  |||.||||  |||..|||.|    |..|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGESPFPGD----------DEEEVFDSIV------NDEVRYP----------RFLSAEAIGIMRRLLRRNPERRLGSSERD-----AEDVKKQPFF
|||.| .|| ||          ...|.|..|       |..|..|          |..| ||  ....|| ..||.|||. ..|     ||..|. |.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKN1.AA PKC 621-880 53 4.8e-152 496.24 In-house 1-262 (262) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-262/262
Sequence Identity: 53% (142 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFS
|.|| |||.| ||||.|.| . . |..|||.|||  |.  | ||. |.|||.||  .   ||||..|. ||||...  |||||  ||||| || .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGES
|..|.||.| ....||||||. |.|||||||| ||| || .||||||.|||.| .||.||||||||...|||.|    |. .|||| .|||.|||..| |
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERD---AEDVKKQPFF
|| |.||.|.|.|| .|...||| || || .|.  .. .|||.|||. ...   ..|... |||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKN1.AA Alpha 621-880 51 9.20000000001e-121 407.49 In-house 1-259 (259) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-259/259
Sequence Identity: 51% (134 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFS
| || |||.| ||||.|.| . . ||.||| |||  |.  | ||  | |||.||       |||| .  ||||.    |||||  ||||| ||     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGK--PPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGES
|| |.|| | .  || ||||  |.|||||||| .|| || .||||||.|||.|  .. | ||||||...|||.     | ..||||  |||||||..|  
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
|| |.||.|.| .| . .| ||. .| ||. | . .| ..| .|||.   . .|... |||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKN1.AA Akt 621-880 43 2.9e-120 386.17 In-house 1-264 (264) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-264/264
Sequence Identity: 43% (116 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELF-AIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VF
| || |||.| ||||.| .   ..... |.|.|||  |.....||  . |..||  .    |||.|||   |||... .|||.|  ||.|  |.. . .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

SEPRAIFYSACVVLGLQFLHEHKIVYRD-LKLDNLLLDTEGYVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWG-LGVLLYEML
||.|| || | ..|....||.. |.||| ||. |.|.| .|.....|||||||. . ..|.| ||||||| ||||.| .. .|.|||||| ||...|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGESPFPGDDEEEVFDSIVNDEVRYP--RFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
 |  ||  .| .. |. | | .|..|  ...| |.  . ..|| ..|..|||. . ||...|  |.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKN1.AA Eta 621-880 50 6e-120 404.78 In-house 1-261 (261) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-261/261
Sequence Identity: 50% (132 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFS
|.|. |||.| ||||.| | .  .|..||| |||  |.  |.||  |.|||||.    . |||| .|. ||||.. . |||||  ||||| .| ..  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLA--RKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGES
|||| || | |.. |.|||.| ..||||||||.||| ||  |.||||.||||.  |  |.||||||...|||.| .  |  .|||| .|||.|||. |..
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSE--RDAEDVKKQPFF
||  | |...|.||..|.| || .|. ||..|..  . .||..|||. .   . ..... |||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKN1.AA Delta 621-880 51 1.3e-118 400.39 In-house 1-259 (259) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-259/259
Sequence Identity: 51% (134 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFS
|.|..|||.| ||||.|.|..   . .|||.|||  ..  |.||. | |.|.||  .   ||||  ||  ||| ||. |||||  ||||| || ..  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWE--HPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGES
| || ||.. ...||||||.. |.||||||||.||| .| .||||||.||| |    ..|||||||...|||..    |...||||  |||.||||.| |
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
|| |.||.|.|.||.||.  |||....|| .....|. |.||.|||. .  . |... .||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKN1.AA SGK 621-880 39 3.4e-106 328.99 In-house 1-283 (283) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

FKFLAVLGRGHFGKVLLSEFRPS------------------GELFAIKALKKGDIV-------ARDEVESLMCEK-RILAAVTSAGHPFLVNLFGCFQTP
|.|| |.| | ||||.. .                      . ..|.| |.|  |.       .. |.   | |.  ||  .    |||.|||   |||.
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK---HPFIVNLHYAFQTK

EHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL
.   |||.|  ||..  |.     |.|.|| || | .|. |  ||. .|.||||| .|.||| .|.... ||||||||.   | |.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
    . |.|||| || .||||..|  ||   . .. .| | | . . |.. |..|  ..  || ..|. ||| . ||....|. |||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase PKN1.AA S_TKc 621-880 34 1.7e-98 334.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAG--GDLMLHIHSDV-
...| ..|.| |||| .   . .|...||| .|          |... | .||      .||..|.|...||. .|...||||  |  |||. .|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTR-AVDWWGLGVL
      |.| .| || . ....|...|.|.|..|||| .|.|||.   .||.||||...        .||||||...|||||   .|.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDA--EDVKKQPFF
|||||.|. |||  .....|. |.          | ||. ..|..|...||.|..  |  .  .|.|. |.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKN1.AA AktR 621-880 38 2.7e-97 329.56 In-house 1-268 (268) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-268/268
Sequence Identity: 38% (105 aa)

FKFLAVLGRGHFGKVLLSEFR-PSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVF
|.....||.| |||| | . .  .....|.| .|| .|. |   . .  |. |...   . |||.|.|. |||| |.  |.|||..||.|  |.  .  |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEM--CCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

SEPRAIFYSACVVLGLQFLHEH-KIVYRDLKLDNLLLDTEGYVKIADFGLCK-EGMG-YGDRTSTFCGTPEFLAPEVLTD-TSYTRAVDWWGLGVLLYEM
|| .| ||.| ..|.|..||.| .|.||||| .|.||| .|.|||.|||| | ..|  | ... .|||||| .|||..|    ....|||| .|...|||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGESPFPGDDEEEVFDSIVNDE---VRYPRFLSAEAIGIMR-RLLRRNPERRLGSSERDAEDVKKQPFF
..|  ||  .. .. |..| . .   . ||  .| ..  .   .|| .||. |||..  ..|..|. |.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKN1.AA RSK 624-880 38 8.4e-93 314.62 In-house 1-278 (278) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

LAVLGRGHFGKVLLSEFR---PSGELFAIKALKKGDIVARDE-VESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVF-
| |||.| .||| |  .     .| ..| | |||  ||.|.  ..  | | .||....  .|||.|.|.  |||....  .|||  ||.|  |.   .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---SEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDT---EGYVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----DTSYTRAVDWWGL
   || .| || | .|| ...||...|..||||..| |.|    || .|. |||.||..   .. .| |||.| |..|||.|.    .  ...|.||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLLYEMLVGESPFPG---DDEEEVFDSIVNDE--VRYP--RFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
|||.||||.| .|| |   .. .|... | . .  .. |   .||.||  . |..| |.|..|||.  .|||..|. |.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKN1.AA Pkinase 621-880 28 1e-82 285.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLM-CEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGG----DLMLHIH-
.... ..|.| ||.| .   . .|...|.| .|| ..    ... .   | .|.. . .  ||. | |...|... |...||||  ||    ||. .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--SDVF--SEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV----KIADFGLCKE--GMGYGDRTSTFCGTPEFLAPEVLT-DTSYTRAVD
  . .|  ||  ..||   .. ||...|...|..||||..|.|.| .|..    ||.||||.|      ..  ..||||||...||||.  .. |...||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

WWGLGVLLYEMLVGESPFPGD------DEEEVFDSIVNDEVRYPRFLS---------------------AEAIGIMRRLLRRNPERRLGSSERDAEDVKK
.|..|..||||| |. ||||.      |. .... |   ....... .                      |.. .....|...|..|..     ||....
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQ

QPFF
 |.|
HPWF
Kinase PKN1.AA Pkinase_Tyr 621-823 27 1.6e-20 70.17 Pfam 1-218 (270) Show / Hide 
Range on Protein: 621-823
Range on HMM: 1-218/270
Sequence Identity: 27% (61 aa)

FKFLAVLGRGHFGKVLLSEFR----PSGELFAIKALKKGDIVARDE--VESLMCEKRILAAVTSAGHPFLVNLFGCFQ-TPEH--VCFVMEYSAGGDL--
 .|. .||.|.||.| . . .      .   |.| ||       ..   |..| | .|.       || .|.| |.     |.  .. |||| ..|||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQL--GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

MLHIH---SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMG---Y-GDRTSTFCGTPEFLAPEVLTDTSYTRAV
 |. |    . .. .. . ... .  |...|...... |||   | |.. .. |||.||||..  .    |   |...       .|||.. .  .| . 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKS

DWWGLGVLLYEMLV-GESP-FPG
| |  |||..|..  ||.| .||
DVWSFGVLMWEIFTYGEQPTYPG
Kinase PKN1.AA S_TK_X 881-945 29 1.9e-20 75.2 SMART 1-79 (79) Show / Hide 
Range on Protein: 881-945
Range on HMM: 1-79/79
Sequence Identity: 29% (23 aa)

RTLGWEALLA--RRLPPPFVPTLS----GRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQA--------AFLDFDFVA
| . |..|..  ....|||.|...    . ||.||||.||| |.|.|.|. ..   .. ...         |..|..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKN1.AA TyrKc 621-874 23 1.5e-17 61.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 621-874
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV-TSAGHPFLVNLFGCFQTP-------EHVCFVMEYSAGGDL--M
 ... .||.|.||.| . . .   .  |.| ||..       .| .| | ||.  .     || .|.|.|.  ..       | .. |||| ..|||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY---GDRTSTFCG----TPEF------LAPEVLTDTS
|. | . .. .  . ..  .  | ..||..... |||   | |.. .. |||.||||....  .   | ....          .      .|||.. .  
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTRAVDWWGLGVLLYEML-VGESPFPG-----DDEEEVFDSIVNDEVRYPRFL---------SAEAIGIMRRLLRRNPERRLGSSERDAEDV
.| . | |  ||...|..  |..| ||      . .||.  . . . . .            ..|   ||..  ...|| |   ||   |. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKN1.AA Pkinase_C 900-947 37 5.7e-15 55.92 Pfam 1-46 (46) Show / Hide 
Range on Protein: 900-947
Range on HMM: 1-46/46
Sequence Identity: 37% (18 aa)

TLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGG
.....||.||||.||| |.|...|  | | .....|..| .| .|.  
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD