Gene PKG1 (Human)

PKG1

Species: Human
Alias: FLJ36117, PRKGR1B, MGC71944, PKG1, PGK, cGKI, cGKI-BETA, PRKG1, PRKG1B, cGKI-alpha
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10q11.2-q21.1,

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
PKG1.NA RNA Sugen Kinome 3792 None Fasta, JSON
PKG1.AA Protein Sugen Kinome 686 None Fasta, JSON
PKG1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of PKG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP PKG1.AA cNMP 118-231 27 3.7e-29 104.12 SMART 1-123 (123) Show / Hide 
Range on Protein: 118-231
Range on HMM: 1-123/123
Sequence Identity: 27% (34 aa)

FMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------GVKLCTMGPGKVFGELAILYNCTRTATVKTL-VNVKLWAI
..|||. ....|..|.|.|..| . ..|...||.|. .|. ..|.|.|.|.         .. ....||| .|||||.| . .|||..... . ...| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRQCFQTIMMRTGLIKHTEYMEFL
|.| |. .... ...  ..  ...
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG1.AA cNMP_binding 136-221 33 2.2e-21 76.07 Pfam 1-91 (91) Show / Hide 
Range on Protein: 136-221
Range on HMM: 1-91/91
Sequence Identity: 33% (31 aa)

PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVK-----LCTMGPGKVFGELAILYNC-TRTATVKTLVNVKLWAIDRQCFQTIMMRTGL
...| |.. |...|| .. .|. ..|||.|.| . .     |...||| .|||.|...|. .|||||..|  ...|.|.|. |. .|..   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP PKG1.AA cNMP 236-358 35 9.3e-36 126.03 SMART 1-123 (123) Show / Hide 
Range on Protein: 236-358
Range on HMM: 1-123/123
Sequence Identity: 35% (45 aa)

TFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE---DSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAV-TCLVI
 |..|.|. |..|.|..|. ||. ||||.||| .||.|.||..|.| |...   . .. . .....||.|| ||| ||     |.....||.|. .|  |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

DRDSFKHLIGGLDDVSNKAYEDAEAKA
.|..|.|... | . ....|....  |
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG1.AA cNMP_binding 254-345 36 2.2e-23 82.95 Pfam 1-91 (91) Show / Hide 
Range on Protein: 254-345
Range on HMM: 1-91/91
Sequence Identity: 36% (34 aa)

ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGED-VRTANVIAAEAVTCLVIDRDSFKHLIGGLDD
. ||. ||.|..|| ..| |.|. .|.| |.. |.  .    |..||.||.||| || ...  |||.|.| . ..|..|.|..|. |.    .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ-ILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
Kinase PKG1.AA PKG 375-634 78 5.6e-227 760.33 In-house 1-260 (260) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-260/260
Sequence Identity: 78% (205 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDS
..||.||||||||||||||.....|.|||.|..||||||||||||||.|||.||. ...||||||||||.|.||.|||||||.||||||||||||.|.|.
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

TTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS
|||||.|||||||.|||.|.|||||||||||.||.|||.||||||||||||.|.|||||||||||||||||||||||.|.|||.|||||.|||||.||||
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

GPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
|.||||||||||.||||.|||.||...|.|.|||||||||.||||..|||..||.|||||
GSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKG1.AA AGC 375-634 30 4.1e-170 444.12 In-house 1-395 (395) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-395/395
Sequence Identity: 30% (121 aa)

FNIIDTLGVGGFGRVELVQLKS-----EESKTFAMKILKKRH-IVDTR--QQEHIRSE------------KQIMQGAH----------SDFIVR-LYRTF
|... ..| |.||.| ||. |.        | .|||.|||.| ||...  ..||. .|            ..|.. ..          ..|||. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDSKY--LYMLMEACL---------GG-ELWTILR---DRGSFEDSTTRFYTAC-------VVEAFAYLHS-KGIIYRD-LKPENLILDHRGYAKLVDFG
.| ..  ||..|| .          || ||...|.   ..|.|. ...|||.|.       .| |. |||| .|||.|| |||||. ||..|. ||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKIGFG---------------------------------------------------KKTWTFCG--TPEYVAPEIILNKGHDISADYWS--LGILMY
..|..  .                                                   ..||||||  ||||.||||.    .. ..|.||  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGSPPFSGP----------DPMKTYNIILRGI----DMIEFP----------KKIAKNAANLIKKLCRDNPSERLGNLKN-----GVKDIQKHKWF
|.||| |||.|           .||.... |. |.    . ..||          ... ..| .|||||.  .|..|||...|     |...|..|.||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKG1.AA PKA 375-634 50 1.5e-124 420.12 In-house 1-263 (263) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-263/263
Sequence Identity: 50% (136 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVR-LYRTFKDSKYLYMLMEACLGGELWTILRDRGSFED
|.||.||| | ||||.|.. |. . . .|||.|||. ||...|.||. .||.|.|  .. |||. .| ||.|..||||.|| . |||. . || .|.|  
FEIIQTLGTGSFGRVMLCRHKHSG-NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

STTRFYTA-CVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK-GHDISADYWSLGILMYELLTGSP
....|| |  .| |. ||||. ||||||||||. .| .|. |. |||||||.     ||| |||||| |||||..| ||  | | |.|||| ||.|.| |
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFSGP--DPMKTYNIILRGIDMIEFPKKIAKNA---ANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
||.    |||..|. |. |   |.||  . ..|     |||||   ....|.||.|||| || .||||
PFYDHNRDPMQIYEKICNGK--IKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKG1.AA Akt 375-634 41 7.4e-100 319.9 In-house 1-264 (264) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTF-AMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFED
|.... || | ||.| ||. |. . | . |||.|||..|.. .| ||.  |. | |   . ||| |.  | ....||. |. | |||| . |. .. |  
FDFLKVLGKGSFGKVFLVKKKDTQ-KWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

STTRFYTACVVEAFAYLHSKGIIYRD-LKPENLILDHRGYAKLVDFGFAK-K-IGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWS-LGILMYELLTG
...||| | .. |  .||||.||||| |||||. .|. |. .| ||| .|   |  . || |||||||| ||||....||. ..| |. ||..|||...|
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

SPPFSGPDPMKTYNIILRGIDMIEFP--KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
 |||   |  . .  |. .   ..||  ..| ... .||..|.  .|..|||. .|....|. | ||
RPPFYNQDHHQMFKKIKNQ--PVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKG1.AA AktR 375-634 40 1.4e-96 327.13 In-house 1-268 (268) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-268/268
Sequence Identity: 40% (109 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ-GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFED
| ..  || |.||.| ||| | .. | .|||..|| .|.. .|..|.. |..||.  .   |||.|. .|.. ..|. .|| | |||| ..|. .. |. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

STTRFYTACVVEAFAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGFAK---KIGFGKKTWTFCGTPEYVAPEIILN-KGHDISADYWSLGILMYELLT
...||| | .. |. |||..  ||||||||||. ||  |. |..||| .|   ..    |. .|||||||.|||.|.. |||. |.|.|..||. ||..|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GSPPFSG--PDPMKTYNIILRGIDMIEFPKKIAKNAANLIK-KLCRDNPSERLGNLKNGVKDIQKHKWF
| |||       |  . .| . .  ...|... ... .||. ||  .|| .|||  .|| ..| .|.||
GCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKG1.AA SGK 375-634 36 1e-95 296.04 In-house 1-283 (283) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

FNIIDTLGVGGFGRVELVQLKSE-----------------ESKTFAMKILKKRHIV-------DTRQQEHIRSEK-QIMQGAHSDFIVRLYRTFKDSKYL
| .. ..| |.||.| .|. |..                 | | .|||.|.| ||.          .| || .|.  |..   . ||| |   |   ..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK-KIGFGKKTWTFCGTPEYVAPEIILNK
|. |.   |||.   |. ...|  .  |||.| .| |  ||||. ||||||||||. ||| |...| ||| .| .|   ..| |||||||| |||... .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
.|| . | |.||...||...| |||   .    |  |...   . .|. .   |  ||. |   .|..|||  |..  .|..| .|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQ--PLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKG1.AA Pkinase 375-634 32 2e-95 328.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIR-SEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGG----ELWTILR--D
. |. ..| |.||.| . . |...  ..|.||.||||. .  .|.|.| || |||.  ....|||||..| |....|| || | ||    .|.....  .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGSF--EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYA----KLVDFGFAKK--IGFGKKTWTFCGTPEYVAPEIIL-NKGHDISADYWS
.|.|  .. . .||   .... .|.||.|||.|||||||. .|..|.     |. |||.||.  .  .  ..||||||.|.|||.|. ..... ..| ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILMYELLTGSPPFSGP------DPMKTYNIILRGIDMIEFPKKIA-------------------KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKW
.|...||.|.| |||.|       |.|. .. |.... . ..|...                    ...  .||.... .|..|..      ..| .|.|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase PKG1.AA S_TKc 375-634 34 3.2e-93 316.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLG--GELWTILRDRGS--
. |....| |.||.| ... |.   . .|.||.|          ||||.| ||..  | ..||.|| .| | ..||| || | |  |.| .....||.  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI-SADYWSLGILMYE
    |   ..|||.. ...| .|.||.|||.|||||||. ||.    |. |||.|...       ||||||.|.|||..   |..  ..| ||.|...||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGV--KDIQKHKWF
.|.| |||.  ........|.             . | ..|.|... .|..|..  .      || .| ||
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKG1.AA RSK 378-634 37 1.9e-91 310.13 In-house 1-278 (278) Show / Hide 
Range on Protein: 378-634
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

IDTLGVGGFGRVELVQLK--SEESKTFAMKILKKRHIVDTRQ-QEHIRSEKQIMQGAH-SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGS---
.  || ||.| | |.. .  .   . .|||.|||. || .   ..| . | .|..    . |||.|. .|.. ..||. || | |||| | |. ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDH---RGYAKLVDFGFAKK--IGFGKKTWTFCGTPEYVAPEIIL----NKGHDISADYWSLGI
|  .. .|| | .| |  .||..|||.||||||| ..|.   .|  ||.||||.|.  . ....| |||.| ||.|||..     ..||| ..|.||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYELLTGSPPFSG---PDPMKTYNIILRGIDMIEFP--KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
||||.||| ||| |    .. .. . |..|    ..|  ... ..| .||.|.   .|. |||  ......|..|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKG1.AA Ciliate-E2 375-634 24 6.3e-83 281.8 In-house 1-365 (365) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

FNIIDTLGVGGFGRVELVQLKSE----------------------ESKTFAMKILKKRHIVDTRQQEHIR----------SEKQIMQGAHSDFIVRLYRT
...|  .| |.|| | ... ...                       .| .||||.||. |  . | .||            ||.|..   ...|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DSKYLYMLMEACLGGELWTILRDR-----------GSFEDSTTR---------------FYTACVVEAFAYLHSKG-IIYRDLKPENLILDHRGYA
|.  | ...|. || | ||.|. .....           ..| .   .               || ||...|. |||||. ||.||.||||...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLVDFGFAKKIGFG--------------------------------KKTWTFCGTPEYVAPEIILNKG---------HDISADYWSLGILMYELLTGSPP
|..|||..||.                                     ..|.||||.|.||||. .|.         .| ..|.||||...||.|.| ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FSGPDPMKTYNIILRGIDMIEFP----------------KKIAKNAANLIKK----LCRDNPSERLGNLKNGVKDIQKHKWF
|        ...|. .   . .|                ||. ... .||||    .   .|..|..    | ..| .|.||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKG1.AA Ciliate-E2-Unclassified 375-634 26 5.1e-81 275.47 In-house 1-352 (352) Show / Hide 
Range on Protein: 375-634
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVD-----TRQQEHIRSEKQIMQG------------------AHSDFIVRLYRTFKDSKYLYM
..|| ..| |||| | ..| |..  . .|||..|| .|..     . . |.....|....                     . |||... .|.| ...|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

LMEACLGGELWTILRDRGS-----------------FEDSTTR-----FYTACVVEAFAYLHSKG-IIYRDLKPENLILDHRG---YAKLVDFGFAKKIG
 || | ||.|| ....|..                 |..  ..     ||.|...... |||.|. ||.||.||||...|  |   | |. |||..||..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

FG----------------KKTWTFCGTPEYV----APEIILNKGHD----ISADYWSLGILMYELLTGSPPFSGPDPMK----------------TYNII
                  ...|||||||.|     |||.. ....|    ...|.||||...||.|.| .||....  .                 |..|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LRG-IDMIEFPK-----KIAKNAANLIK----KLCRDNPSERLGNLKNGVKDIQKHKWF
. . |.  .||.     .. ..|...|.    |.   ||..|.     . ..| .| ||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-----TFEQILNHPWF
Kinase PKG1.AA MAST 375-523 34 2.4e-50 151.67 In-house 1-151 (337) Show / Hide 
Range on Protein: 375-523
Range on HMM: 1-151/337
Sequence Identity: 34% (53 aa)

FNIIDTLGVGGFGRVELVQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRG-S
|..|  ...|..|.| ||. | .   ..||||..... . |  |......|. |   .  .|.| .. .|     |||.| ||   ||   ..||. | .
FEFIKCISKGAYGAVYLVKHKKTN--DRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK
.. . ...|.|  | .  ||||.||. |||||.|...|  |  ||.|||..|.
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV
Kinase PKG1.AA MAST 534-634 40 4.7e-42 125.83 In-house 229-337 (337) Show / Hide 
Range on Protein: 534-634
Range on HMM: 229-337/337
Sequence Identity: 40% (45 aa)

CGTPEYVAPEIILNKG-HDISADYWSLGILMYELLTGSPPFSGPDPMK-TYNIILRGIDMIEFPKK--------IAKNAANLIKKLCRDNPSERLGNLKN
||||.| |||.|| .| .  ..|.||.|| |||.|.|.||| |  | . . . |.   ..||.|..        . . |  ||||| . ||..|||    
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN--

GVKDIQKHKWF
|...| .|. |
GADEIKQHPFF
Kinase PKG1.AA S_TK_X 635-686 30 2.9e-13 51.33 SMART 1-79 (79) Show / Hide 
Range on Protein: 635-686
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

EGFNWEGLRK--GTLTPPIIPSVA----SPTDTSNFD-SFPE-----DNDEP---------------PPDDNSGWDIDF
 |..|..|..  ....||..| .     |||||||||  |.|     ..|.|               |||.  |.. .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKG1.AA TyrKc 375-628 21 2.8e-12 -24.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 375-628
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA--HSDFIVRLYRTFKDS-------KYLYMLMEACLGGELWTIL
   ...|| | ||.| . ..|     . | | ||. .      .| ...| .||     | . |||||    ..       . |...|| . .| |   |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RDRGS-FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFG------KKTWTF----CGTP----EYVAPEIILNKGH
|...  .  ..   .   . .  .|||||..| |||   |  ..... .|  ||| ...|. .      |.. .     .|         ||| |  .  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DISADYWSLGILMYELLT-GSPPFSG-----PDPMKTYNIILRGIDMIEFPKK--------IAKNAANLIKKLCRDNPSERL--GNLKNGVKDI
 .  | || |..|.|..| | .| .|      ..   .. . .| .. . |.           .   ...|. .. .|..|    ..   ....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase PKG1.AA Pkinase_Tyr 375-500 26 0.005162 10.83 Pfam 1-137 (270) Show / Hide 
Range on Protein: 375-500
Range on HMM: 1-137/270
Sequence Identity: 26% (37 aa)

FNIIDTLGVGGFGRVELVQLK---SEESKTFAMKILKKRHIVDTRQ--QEHIRSEKQIMQGA-HSDFIVRLYRTFK-DSKY--LYMLMEACLGGELWTIL
  .. .|| | ||.| .  .|   ...  . | |.||     . .|  .|   .| .||    | . |||||     ...   .|. || . .| | . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RD----RGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDL
|.    ....  ..   . . . .. .||.||..| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase PKG1.AA Pkinase_Tyr 541-583 35 0.012578 9.52 Pfam 182-226 (270) Show / Hide 
Range on Protein: 541-583
Range on HMM: 182-226/270
Sequence Identity: 35% (16 aa)

APEIILNKGHDISADYWSLGILMYELLT-GSPP-FSGPDPMKTYN
||| | ..   .  | || |.||.|..| |  | . | ..   |.
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYE