Gene PKCz (Human)

PKCz

Species: Human
Alias: PKCz, PKC2, PKCzeta, Hs.199054, PRKCZ
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p36.33,

Classification

Group: AGC
Family: PKC
Subfamily: PKCi

Sequence

Name Sequence Type Origin Length Description Download
PKCz.NA RNA Sugen Kinome 2359 None Fasta, JSON
PKCz.AA Protein Sugen Kinome 592 None Fasta, JSON
PKCz.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of PKCz.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 PKCz.AA PB1 15-98 28 1.2e-26 95.76 SMART 1-95 (95) Show / Hide 
Range on Protein: 15-98
Range on HMM: 1-95/95
Sequence Identity: 28% (27 aa)

RVRLKAHY-GGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWV--DSEGD-PCTVSSQMELEEAFRLARQ-------CRDEGLIIHVFPS
 |..|..| |||....||.  ..|..|...|...|......| |||.   | .|| ..|......|.|......         ... | .||||.
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 PKCz.AA PB1 15-98 31 7e-26 94.42 Pfam 1-86 (86) Show / Hide 
Range on Protein: 15-98
Range on HMM: 1-86/86
Sequence Identity: 31% (28 aa)

RVRLKAHYGGDIFI--TSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEG-DPCTVSSQMELEEAFRLARQC-RDEGLIIHVFPS
 ||.|..|||||..   .|.. ..||.|...|...| ..  |...... | .| | .|......|.|... .| . .   | .|||||
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCD--HTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSMTLRLHVFPS
C1_1 PKCz.AA C1_1 131-183 34 2.9e-20 78.05 Pfam 1-55 (55) Show / Hide 
Range on Protein: 131-183
Range on HMM: 1-55/55
Sequence Identity: 34% (19 aa)

HLFQAK-RFNRRAYCGQCSERIWG-LARQGYRCINCKLLVHKRCHGLVPLTCRKH
| .... .|.. ..| .| |..|| |..||..| .|....|.||| .||  |. .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCz.AA C1 131-180 37 4.2e-19 70.7 SMART 1-61 (61) Show / Hide 
Range on Protein: 131-180
Range on HMM: 1-61/61
Sequence Identity: 37% (23 aa)

HLFQAKRFNRRAYCGQCSERIWGLARQ-----GYRCINCKLLVHKRCHGLVPL-------TC
| ....|| ...|| .| ..|||...|     ||||..||. .||.||  ||.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCz.AA Iota 252-518 86 9.69999999999e-224 749.58 In-house 1-271 (271) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-271/271
Sequence Identity: 86% (234 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEE
|.||||||||||||||.|..||...||||||.|||.|.|||||||||||||||||||..||||||||||||.||||.|||.|||||||||||||||||||
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
|||||.||||.|||||||||||||||||||||||..||||||||||||||. |||||||||||||||||||||||.||||||||||||||||||||||||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

DII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQT--GFSDIKSHAFF
||.  .||||.|||||||||||||.|||||.|||.|.|||||||||||||||||.|||  ||.|||.|.||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCz.AA PKC 252-518 59 2.2e-199 652.18 In-house 1-262 (262) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-262/262
Sequence Identity: 59% (159 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEE
|....|.|.||..||.|...|..|..||.||.||.....|.|.....|||.|...|. .|||..||.|||| .||| |.|||||||||||.|.||...||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
|||||||||..||.||||.|||||||||||||||..||||..|.|||||.. .|||||||||||.|||||||...|||.||||||.||||.|||||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQT--GFSDIKSHAFF
..        .||.|||.|... ...|| ||..|....|||..|.|..||||.||.  |. ||..|.||
HGE-------DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCz.AA AGC 252-518 32 2.9e-183 478.89 In-house 1-395 (395) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-395/395
Sequence Identity: 32% (128 aa)

FDLIRVIGRGSYAKVLLVRLK------KNDQIYAMKVVKKEL-VHDDE--DIDWVQTE------------KHVFEQASS---------NPFLVG-LHSCF
|....|||.||. || ||| |       ....|||||.||.  . ...  ... ..||            ....|....         .||.|  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTTSR--LFLVIE----YVN-----GG-DLMFHMQ---RQRKLPEEHARFYAAE-------ICIALNFLHE-RGIIYRD-LKLDNVLLDADGHIKLTDYG
|. ..  |..| |    |||     || .|..|.|   ......||.|||||||       |. || .||. .|||.|| ||..|.|||.|||||||| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGLGPG--------------------------------------------------DTTSTFCG--TPNYIAPEILRGEEYGFSVDWWA--LGVLMF
.|||| . |                                                  |.|.||||  ||.|.|||||    ||...|||.  ||.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMAGRSPFDIITD----NPDMNTEDYLFQVIL------EKPIRIP----------RFLSVKASHVLKGFLNKDPKERLGCRPQT----GFSDIKSHAFF
||..|..||   ..      ...... .|| |.      ......|          |..|. | . .|..|.|||..||||....    |...||.| .|
EMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCz.AA Eta 252-518 55 1.2e-130 440.34 In-house 1-261 (261) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-261/261
Sequence Identity: 55% (148 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEE
|. |.|.|.||. ||.| ..|  |..||.||.||. .  |.|..   ||| .   |   |||  ||.||||  ||| |.||||||||||..|| ||  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
 |||||||. .|| |||..|.|||||||||.|||..|| || |.||||||.  | ||.|||||| |||||||.  ||| ||||||.||||.|||.|..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRP-QTGFSDIKSHAFF
.   ||     || ||. ||.  .  | .|.  |  .||.|. | |..||||   | |  .|..|.||
E--ADN-----EDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCz.AA Alpha 252-518 53 3.4e-127 428.86 In-house 1-259 (259) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-259/259
Sequence Identity: 53% (144 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEE
|  . |.|.||. ||.|   |  |  || |. ||  .  | |..   .|| |    .  |||| .||||||  ||. | |||||||||.|.|.  |  | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
|| |||||| |.| ||||.||||||||||||.|||.||||..|.|||||.. ...|| ||||||.||||||   . || |||||| |||..|||||  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF
       | . || ||| | |.    |. .|. |  . |||| | |  |||| |.    ||. |.||
-------DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGE-QDIREHPFF
Kinase PKCz.AA SGK 252-518 41 1.5e-126 392.99 In-house 1-283 (283) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-283/283
Sequence Identity: 41% (122 aa)

FDLIRVIGRGSYAKVLLVRLKKN------------------DQIYAMKVVKKELVH-------DDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRL
||.. ||| ||. ||..|. |.                   |..||||| .|. .          .    ...|. |  .  . ||.|.||  |||.  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE
..| .|||||.. .|.|| ...||  ||||||||  ||  ||.  ||||||| .|.|||..||..||| | ||||  . |||.|||||| | |||.||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF
... .|||| || ...||| |  ||       . |..  ... |. .|..||.. |..|.. ..| |.||||.||| .   .| .||.| ||
PHDRTVDWWCLGCVLYEMMYGLPPFY------SRNKQ-QMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK--RDFMEIKNHPFF
Kinase PKCz.AA Akt 252-518 44 8.9e-121 387.84 In-house 1-264 (264) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-264/264
Sequence Identity: 44% (122 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIY-AMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPE
||...|.|.||..||.||. |.....| |||| ||.   .   .  ..||. . .    .||.|.||  |||  .|..| .|.|||.| .|.||.|. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

EHARFYAAEICIALNFLHERGIIYRD-LKLDNVLLDADGHIKLTDYGMCKEG-LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWA-LGVLMFEMMAG
. ||||.|||  |. .||...||||| ||. |.|.|.||||.||| |.|||. .  .|.| |||||| |.||||| |  .. .||||. ||..|.||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

RSPFDIITDNPDMNTEDYLFQVILEKPIRIP--RFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF
| ||    |.. |      |. |...|...|  ...| ..   ..| ||||||.|||  |. .  .||.| .|
RPPFYN-QDHHQM------FKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPN-DAQEIKRHPWF
Kinase PKCz.AA Delta 252-518 48 7.1e-112 377.98 In-house 1-259 (259) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-259/259
Sequence Identity: 48% (130 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEE
| . .|.|.||. ||.|. ||. .. ||.| .||. |  |.|..    |..|   |. .|||  |   ||| . || |.||.||||||.|.| ...  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
 |||||.|| ..| |||..||||||||||||||| |||||. |.||||| .    ..||||||| ||||||..|. | .|||||. ||||.||. | |||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGC-RPQTGFSDIKSHAFF
         . || ||. |..     ||...  | ..||. ...||..|||  .  .|  ||. | ||
-------HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF
Kinase PKCz.AA AktR 252-518 37 4.90000000001e-101 341.97 In-house 1-268 (268) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-268/268
Sequence Identity: 37% (103 aa)

FDLIRVIGRGSYAKVLLVRLK-KNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPE
|......|.| ..|| ||. | .|...||||..||.   . . .. ..||. . |  ...||.| || |||| . ||...||. ||.| .| ....|. |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EHARFYAAEICIALNFLHER-GIIYRDLKLDNVLLDADGHIKLTDYGMCK-EGLG-PGDTTSTFCGTPNYIAPEILRG-EEYGFSVDWWALGVLMFEMMA
| ||||.|.|..|| .||..  ||||||| .| ||| |||.|.||.|. | ..     ... .||||| |.|||...  . ...||||||.|.. .||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRSPFDIITDNPDMNTEDYLFQVILE-KPIRIPRFLSVKASHVLK-GFLNKDPKERLG-CRPQTGFSDIKSHAFF
|  ||     . . ........ | . ... .|  .| ..   .. . |.|.|..|||  ..  |...|||| .|
GCPPF-----YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN--GWEEIKSHPWF
Kinase PKCz.AA RSK 255-518 39 2.7e-99 336.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 255-518
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

IRVIGRGSYAKVLLVRLK---KNDQIYAMKVVKK-ELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK---
..| |.|.| || |.| .   ...|||||||.|| ..|  . |.  . ||  . |   . ||.| ||  ||| . |.|. ||..||.|  | |...    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDA---DGHIKLTDYGMCKEG-LGPGDTTSTFCGTPNYIAPEILR----GEEYGFSVDWWALGV
. |. |.||.|||  |. .||..|||.||||..|.|.|    .||||||| | ||.. .  .  | |||.| .|.|||.|.    .. .. ..||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP--IRIP--RFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF
||.|| .|..||    .    |. . ... |...    ..|   .||  | . ... | .||. |||| || . ..||.|..|
LMYEMLTGCPPFQG-PND---NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ-DAEEIKQHPWF
Kinase PKCz.AA S_TKc 252-518 32 3.5e-96 326.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG--GDLMFHMQRQRK--
....|.||.|...|| ..| || ..|.|.|..|          . .. |  . ..    |..| |. .||. ..|..| ||..|  |||. .......  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF-SVDWWALGVLMF
    .|| |||||...|| ||...|..|||.|||| .|.|||   |||..| |....        .||||||.|.|||.|    ||. ..|||..|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTG-FSDIKSHAFF
||..|. ||.         ... .|..|.          |  | . ... |.|||..|...       .|||.| .|
EMLCGYPPFP---------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCz.AA Pkinase 252-518 27 1.9e-81 281.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQ-TEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGG----DLMFHMQ--R
. ..|.||.||...| . . |.. .|.|.|..||.  ....|.  .  .| ..     . |. | |. .|.. ... .| ||..||    ||. ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRKL--PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI----KLTDYGMCKEG-LGPGDTTSTFCGTPNYIAPEILR-GEEYGFSVDWWA
....  .|....||. .|. .|...|..|||.||||..|.|.| .|||    |..| | .|   . ..  ..||||||.|.|||..| |..|| .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMFEMMAGRSPFD-IITDNPDMNTEDYLFQVILEKPIRIPRFLS---------------------VKASHVLKGFLNKDPKERLGCRPQTGFSDIKS
.|....||. || ||.  . . .. ........ |...|.. ... .                       . ...|. |.||||.|..      . .|. 
CGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQILQ

HAFF
| .|
HPWF
Kinase PKCz.AA S_TK_X 519-582 36 2.7e-23 84.62 SMART 1-79 (79) Show / Hide 
Range on Protein: 519-582
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

RSIDWDLLEK--KQALPPFQPQIT----DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSE---------FEGFEYIN
|.|||| |..  |.  |||.|.|.    ..  . |||. ||.|.. |||||. ......|.|         |.|| |..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCz.AA Pkinase_C 538-584 40 4.3e-14 52.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 538-584
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

QITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPL
|....    |||..||.||...||.|.. .  .||..|.|| | || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCz.AA TyrKc 252-518 19 5.1e-14 3.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 252-518
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA-SSNPFLVGLHSCFQTT-------SRLFLVIEYVNGGDLMFHMQ
  |....|.| . .| . ..|       ..|  | | .|   .     |  .  .   ..| .| |. .  .          |..| ||. .|||  . .
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RQRK-LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGP-------GDTTSTF--CGTP----NYIAPEILRGEEYG
. |. |. ..   ..  |.   ..||....| |||   |.|.......| .| |.....             ...   .|         ||| ..  .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FSVDWWALGVLMFEMMA-GRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF--------LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF
.  | |. ||.|.|..  | .|   .. . .|. .. . .|   .  ..|           . .   . |   . ||..|        ||.|  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP------TFSEI--HECF
Kinase PKCz.AA Pkinase_Tyr 252-451 20 2.2e-12 42.58 Pfam 1-216 (270) Show / Hide 
Range on Protein: 252-451
Range on HMM: 1-216/270
Sequence Identity: 20% (44 aa)

FDLIRVIGRGSYAKVLLVRLK----KNDQIYAMKVVKKELVHDDE--DIDWVQTEKHVFEQASSNPFLVGLHSCFQ-TTSR--LFLVIEYVNGGDLMFHM
  .....|.|.. .| . ..|    ....  | |.. ||  ....    |  . |  .  |  ..| .| |. .         ...| ||. .|||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QR----QRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEG-----LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVD
..    ...|. ..   ....|. ....|.....| |||   |.|.. ....| .| |...            ....        ||| ..  ..    |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGKFTTKSD

WWALGVLMFEMMA-GRSP-F
 |. ||||.|..  |..| .
VWSFGVLMWEIFTYGEQPTY