Gene PKCi (Human)

PKCi

Species: Human
Alias: PRKCI, PKCI, MGC26534, nPKC-iota, PKCi, DXS1179E
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q26.2,

Classification

Group: AGC
Family: PKC
Subfamily: PKCi

Sequence

Name Sequence Type Origin Length Description Download
PKCi.NA RNA Sugen Kinome 4884 None Fasta, JSON
PKCi.AA Protein Sugen Kinome 596 None Fasta, JSON
PKCi.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of PKCi.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 PKCi.AA PB1 25-106 29 1.4e-27 98.85 SMART 1-95 (95) Show / Hide 
Range on Protein: 25-106
Range on HMM: 1-95/95
Sequence Identity: 29% (28 aa)

QVRVKAYY-RGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWI--DEEGD-PCTVSSQLELEEAFRLYEL---------NKDSELLIHVF
.|.||..| .||. ........||. |...|...|  ||.| || |..  ||.|| ..|.... .|.|....|.          .|   |....|
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 PKCi.AA PB1 25-108 35 3.7e-17 63.58 Pfam 1-86 (86) Show / Hide 
Range on Protein: 25-108
Range on HMM: 1-86/86
Sequence Identity: 35% (31 aa)

QVRVKAYYRGDIMI--THFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEG-DPCTVSSQLELEEAFRLYELN-KDSELLIHVFPC
.||.|..|.||| .   |. ..|||| |...|...|  |  . |. ...||.| | .|.... .|.|... |    |  .| .|||| 
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCD--HTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSMTLRLHVFPS
C1_1 PKCi.AA C1_1 141-193 36 1.7e-20 78.89 Pfam 1-55 (55) Show / Hide 
Range on Protein: 141-193
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HTFQAK-RFNRRAHCAICTDRIWG-LGRQGYKCINCKLLVHKKCHKLVTIECGRH
| .... .|.. ..|. | ...|| ||.||.|| .|....|..||..|..||| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCi.AA C1 141-190 33 2e-16 61.83 SMART 1-61 (61) Show / Hide 
Range on Protein: 141-190
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HTFQAKRFNRRAHCAICTDRIWGLGRQ-----GYKCINCKLLVHKKCHKLVTI-------EC
|.....|| ... |..| ..|||. .|     ||.|..||. .|||||. |.         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCi.AA Iota 254-522 91 5.6e-231 773.62 In-house 1-271 (271) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-271/271
Sequence Identity: 91% (248 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE
|.|.||||||||||||.|..|||.|||||||.|||.||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF
|||||||||.||||.|||||||||||||||||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQT--GFADIQGHPFF
||||..||||||||||||||||||||||||||||.||.|||.||||||||||||||||  ||.||..||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCi.AA PKC 254-522 60 4.5e-205 670.9 In-house 1-262 (262) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-262/262
Sequence Identity: 60% (163 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE
|..|.|.|.||..||.|...|.||..||.||.||.....|.|.....|||.|...|..||||..||.||||..|||||.|||||||||||.|.||...||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF
|||||.|||..||..|||.|||||||||||||||.|||||..|.|||||....|||||||||||.|||||||....||.||||||.||||.|||||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQT--GFADIQGHPFF
...         .||.|||.|.......||.||..|.|..|.|..|.|..|||||||.  |. ||. ||||
HGE---------DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCi.AA AGC 254-522 33 3e-187 489.43 In-house 1-395 (395) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-395/395
Sequence Identity: 33% (132 aa)

FDLLRVIGRGSYAKVLLVRLK------KTDRIYAMKVVKKEL-VNDDE--DIDWVQTE------------KHVFEQASN---------HPFLVG-LHSCF
|..|.|||.||. || ||| |       |...|||||.||.  . ...  ... ..||            ....|....         |||.|  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTESR--LFFVIE----YVN-----GG-DLMFHMQ---RQRKLPEEHARFYSAE-------ISLALNYLHE-RGIIYRD-LKLDNVLLDSEGHIKLTDYG
|....  |.|| |    |||     || .|..|.|   ......||.|||| ||       | ||| |||. .|||.|| ||..|.|||..||||||| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGLRPG--------------------------------------------------DTTSTFCG--TPNYIAPEILRGEDYGFSVDWWA--LGVLMF
.|||| . |                                                  |.|.||||  ||.|.|||||    ||...|||.  ||.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMAGRSPFDIVGSSDNP--DQNTEDYLFQVIL------EKQIRIP----------RSLSVKAASVLKSFLNKDPKERLGCHPQT----GFADIQGHPFF
||..|..||      . .  ...... .|| |.      ......|          |..|. | . .| .|.|||..||||....    |. .|. ||.|
EMLTGYPPFYGDNPQE-NRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCi.AA Eta 254-522 55 1.3e-133 450.19 In-house 1-261 (261) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-261/261
Sequence Identity: 55% (150 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE
|. ..|.|.||. ||.| ..| || .||.||.||. .  |.|..   ||| .   | .||||  ||.||||. |||||.||||||||||..|| ||  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF
 |||| ||. .|| .||..|.|||||||||.||| ||| || |.||||||.  | ||.|||||| |||||||.  .|| ||||||.||||.|||.|..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHP-QTGFADIQGHPFF
.     ||     || ||. ||. ..  |  |.  | |.||.|. | |..||||   | |  .|. ||||
EA----DN-----EDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCi.AA Akt 254-522 44 3.7e-132 424.81 In-house 1-264 (264) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-264/264
Sequence Identity: 44% (123 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIY-AMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPE
||.|.|.|.||..||.||. |.|...| |||| ||.   .   .  ..||. . .    |||.|.||  |||. .|.|| .|.|||.| .|.||.|. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

EHARFYSAEISLALNYLHERGIIYRD-LKLDNVLLDSEGHIKLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWA-LGVLMFEMMAG
. |||| |||.||. .||...||||| ||. |.|.|..|||.||| |.|||. .  .|.| |||||| |.||||| | ... .||||. ||..|.||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

RSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP--RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
| ||     ... .|     .|. |.......|  . .| .. . ... ||||||.||| .|. .  .|. ||.|
RPPF----YNQDHHQ-----MFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPN-DAQEIKRHPWF
Kinase PKCi.AA Alpha 254-522 53 8.99999999999e-130 437.43 In-house 1-259 (259) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-259/259
Sequence Identity: 53% (145 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE
|  | |.|.||. ||.|   | ||  || |. ||  .  | |..   .|| |    .  |||| .||||||  ||.|| |||||||||.|.|.  |  | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF
|| || |||. .| .|||.||||||||||||.||.|||||..|.|||||.. ...|| ||||||.||||||   . || |||||| |||..|||||  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
         | . || ||| | |..   |.|.|. | .. |.|| | |  |||| |.    ||. ||||
---------DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGE-QDIREHPFF
Kinase PKCi.AA SGK 254-522 41 4.3e-129 400.99 In-house 1-283 (283) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-283/283
Sequence Identity: 41% (123 aa)

FDLLRVIGRGSYAKVLLVRLKKT------------------DRIYAMKVVKKELVN-------DDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRL
||.| ||| ||. ||..|. |..                  | .||||| .|. .          .    ...|. |  .  .|||.|.||  |||.  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE
.|| .|||||.. .|.|| ...||  |||| ||| .|| |||.  ||||||| .|.|||..||..||| | ||||  . |||.|||||| | |||.||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
 .. .|||| || ...||| |  ||         ..|..  ... |. . ..||.. |..| . ..  |.||||.|||     .|..|. ||||
PHDRTVDWWCLGCVLYEMMYGLPPFY--------SRNKQ-QMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK--RDFMEIKNHPFF
Kinase PKCi.AA Delta 254-522 47 8.49999999999e-113 381.04 In-house 1-259 (259) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-259/259
Sequence Identity: 47% (128 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE
| ...|.|.||. ||.|. ||.... ||.| .||. |  |.|..    |..|   |..||||  |   |||.. ||||.||.||||||.|.| ...  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF
 ||||..|| ..| .||..||||||||||||||| .||||. |.||||| .    ..||||||| ||||||..|. | .|||||. ||||.||. | |||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
   .         || ||. |.. .   || ..  |...||  ...||..|||  ...   ||. |.||
HGED---------EDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGV-QYCPKGDIRQHCFF
Kinase PKCi.AA AktR 254-522 39 1.2e-104 354.02 In-house 1-268 (268) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-268/268
Sequence Identity: 39% (110 aa)

FDLLRVIGRGSYAKVLLVRLK-KTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPE
|......|.| ..|| ||. | .....||||..||.   . . .. ..||. . |  .||||.| || ||||.. |||..||. ||.| .| ....|. |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EHARFYSAEISLALNYLHER-GIIYRDLKLDNVLLDSEGHIKLTDYGMCK-EGLR-PGDTTSTFCGTPNYIAPEILRG-EDYGFSVDWWALGVLMFEMMA
| ||||.|.| ||| |||..  ||||||| .| |||..||.|.||.|. | .. .   ... .||||| |.|||...  . ...||||||.|.. .||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRSPFDIVGSSDNPDQNTEDYLFQVILEKQ-IRIPRS--LSVKAASVLK-SFLNKDPKERLG--CHPQTGFADIQGHPFF
|  ||         ...   ..|| |..|| ...| .  .| .. . ..   |.|.|..|||  |    |. .|  ||.|
GCPPF---------YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN---GWEEIKSHPWF
Kinase PKCi.AA RSK 257-522 40 1.1e-102 347.47 In-house 1-278 (278) Show / Hide 
Range on Protein: 257-522
Range on HMM: 1-278/278
Sequence Identity: 40% (115 aa)

LRVIGRGSYAKVLLVRLK---KTDRIYAMKVVKK-ELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK---
|.| |.|.| || |.| .   .|..||||||.|| ..|. . |.  . ||  . |   .|||.| ||  ||||. |. . ||..||.|  | |...    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDS---EGHIKLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILR----GEDYGFSVDWWALGV
. |. |.|| |||.||. .||..|||.||||..|.|.|.   |||||||| | ||.. .. .  | |||.| .|.|||.|.    .. .. ..||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQ--IRIP--RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
||.|| .|..||   . .     |. . ... |....   ..|   .||  | . ..  | .||. |||| || . ..|. ||.|
LMYEMLTGCPPFQG-PND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ-DAEEIKQHPWF
Kinase PKCi.AA S_TKc 254-522 34 2.7e-98 333.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG--GDLMFHMQRQRK--
...||.||.|...|| ..| |||.||.|.|..|          . .. |  . ..  .||..| |. .||. ..|..| ||..|  |||. .......  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGF-SVDWWALGVLMF
    .|| ||||| ..| .||.|.|..|||.|||| .|.|||.  |||..| |....        .||||||.|.|||.|    ||. ..|||..|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTG-FADIQGHPFF
||..|. ||.           ... .|..|.          |  | . ..  |.|||..|...        ||  ||.|
EMLCGYPPFP-----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCi.AA Pkinase 254-522 29 3.4e-87 300.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ-TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG----DLMFHMQ--R
. ..|.||.||...| . . |.| .|.|.|..||.  ....|.  .  .| ..     |||. | |. .|...... .| ||..||    ||. ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRKL--PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI----KLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILR-GEDYGFSVDWWA
....  .|....||  .|  .|.|.|..|||.||||..|.|.|..|||    |..| | .|   . ..  ..||||||.|.|||..| |..|| .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS---------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQ
.|....||. || ||.  .  . .. ........ |...... ... .                       . ...|. |.||||.|..      ...| 
CGCILYEMLCGRPPFPGHC--WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQIL

GHPFF
 ||.|
QHPWF
Kinase PKCi.AA S_TK_X 523-586 35 1.8e-22 81.86 SMART 1-79 (79) Show / Hide 
Range on Protein: 523-586
Range on HMM: 1-79/79
Sequence Identity: 35% (28 aa)

RNVDWDMMEQ--KQVVPPFKPNIS----GEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSE---------FEGFEYIN
|..|||  ..  |.. |||||.|.    ... . |||  ||.|.. |||||. ... ..|.|         |.|| |..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCi.AA TyrKc 254-522 19 1.3e-14 13.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 254-522
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQA-SNHPFLVGLHSCFQTE-------SRLFFVIEYVNGGDLMFHMQ
  |....|.| . .| . ..|       ..|  | | .|   .     |  .  .   .|| .| |. .  ..         |. | ||. .|||  . .
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RQRK-LPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP-------GDTTSTF--CGTP----NYIAPEILRGEDYG
. |. |. ..   ..  |.   .|||....| |||   |.|.......| .| |.....             ...   .|         ||| ..   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPD-----QNTEDYLFQVILEKQIRIPRS--------LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG
.  | |. ||.|.|..         | .  |.      . .. . .|   .  ..| .         . .  .. |.  . ||..|        |..|  
TKSDVWSFGVCMWEIFTY-------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP------TFSEI--

HPFF
| .|
HECF
Kinase PKCi.AA Pkinase_C 542-588 38 4.4e-14 52.79 Pfam 1-46 (46) Show / Hide 
Range on Protein: 542-588
Range on HMM: 1-46/46
Sequence Identity: 38% (18 aa)

NISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPL
.....    ||| .||.||...||.|..  ...||..|.|| | || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCi.AA Pkinase_Tyr 254-401 21 1.3e-11 39.97 Pfam 1-159 (270) Show / Hide 
Range on Protein: 254-401
Range on HMM: 1-159/270
Sequence Identity: 21% (35 aa)

FDLLRVIGRGSYAKVLLVRLK----KTDRIYAMKVVKKELVNDDE--DIDWVQTEKHVFEQASNHPFLVGLHSCFQ-TESR--LFFVIEYVNGGDLMFHM
  .....|.|.. .| . ..|    .|.   | |.. ||   ...    |  . |  .  |  .|| .| |. .    .    .. | ||. .|||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QR----QRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK
..    ...|. ..   ....|. ...||.....| |||   |.|.......| .| |...
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCi.AA Pkinase_Tyr 437-453 42 0.511455 4.07 Pfam 198-216 (270) Show / Hide 
Range on Protein: 437-453
Range on HMM: 198-216/270
Sequence Identity: 42% (8 aa)

WALGVLMFEMMA-GRSP-F
|. ||||.|..  |..| .
WSFGVLMWEIFTYGEQPTY