Gene PKCg (Human)

PKCg

Species: Human
Alias: SCA14, PKC-gamma, PRKCG, PKCC, PKCg, MGC57564, PKCG
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19q13.42,

Classification

Group: AGC
Family: PKC
Subfamily: PKCa

Sequence

Name Sequence Type Origin Length Description Download
PKCg.NA RNA Sugen Kinome 3156 None Fasta, JSON
PKCg.AA Protein Sugen Kinome 697 None Fasta, JSON
PKCg.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON

Protein domain

Protein domains of PKCg.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 PKCg.AA C1_1 36-88 47 2.7e-22 85.19 Pfam 1-55 (55) Show / Hide 
Range on Protein: 36-88
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HKFTAR-FFKQPTFCSHCTDFIWG-IGKQGLQCQVCSFVVHRRCHEFVTFECPGA
|.. .. .|||||||.|| .|.|| .|.||..||.| ...| |||..|. ||.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCg.AA C1 36-85 32 1.6e-18 68.81 SMART 1-61 (61) Show / Hide 
Range on Protein: 36-85
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HKFTARFFKQPTFCSHCTDFIWGIGKQ-----GLQCQVCSFVVHRRCHEFVTF-------EC
|.. .. | .||.|.|| ..|||. ||     |..|..| ...| .||..|.         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCg.AA C1_3 66-78 38 0.107689 5.81 Pfam 18-30 (30) Show / Hide 
Range on Protein: 66-78
Range on HMM: 18-30/30
Sequence Identity: 38% (5 aa)

CQVCSFVVHRRCH
|  | |..|..| 
CMQCDFMLHEDCA
C1_1 PKCg.AA C1_1 101-153 45 7.3e-23 87.07 Pfam 1-55 (55) Show / Hide 
Range on Protein: 101-153
Range on HMM: 1-55/55
Sequence Identity: 45% (25 aa)

HKFRLH-SYSSPTFCDHCGSLLYG-LVHQGMKCSCCEMNVHRRCVRSVPSLCGVD
|... | .. .||||.|||....| | |||.||..| .|.| ||.. ||..|| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCg.AA C1 101-150 27 1.2e-16 62.52 SMART 1-61 (61) Show / Hide 
Range on Protein: 101-150
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFRLHSYSSPTFCDHCGSLLYGLVHQ-----GMKCSCCEMNVHRRCVRSVPS-------LC
|... ... .||.|.||.....|. .|     |..||.| ...| .|.. ||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCg.AA C1_3 112-143 25 0.002931 9.79 Pfam 1-30 (30) Show / Hide 
Range on Protein: 112-143
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCV
 .|. ||  .|.  . . .|. |. ..|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C2 PKCg.AA C2 173-260 54 6.5e-40 138.61 Pfam 1-90 (90) Show / Hide 
Range on Protein: 173-260
Range on HMM: 1-90/90
Sequence Identity: 54% (49 aa)

IHVTVGEARNLIPMD--PNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMS
..|.| ||||| |||  .||.||||||..| .||.. .|.||...| ||||||||||.|.. | |....| ..|||||| .|.||.|  .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 PKCg.AA C2 172-275 30 6.6e-29 103.27 SMART 1-92 (92) Show / Hide 
Range on Protein: 172-275
Range on HMM: 1-92/92
Sequence Identity: 30% (38 aa)

EIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL---NPVWNE---TFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFG---
 ..|.. |||||.        |||||..           ||..|| ||   ||||||   ||.|.. |    . | .||||.      ||.|  ...   
TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN

-----------VSELLKAPVDGWY
           .|..|  . . |.
PHWHQWDGCIHLSDIL-GYRH-WW
Kinase PKCg.AA Alpha 351-614 83 3e-230 771.21 In-house 1-259 (259) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-259/259
Sequence Identity: 83% (220 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
|.||||||||||||||||||.|.||||||||||||||.|||||.||.||||||||.|.     |.||.|.||.|||.||||||||||.||||||||||.|
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGK-----PPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
|||||||.||||||||||||||..||||||||||||||||||||||.||||||||.....|||||||||||||||||||||||||||||.||||||||.|
KFKEPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMA

GQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF
||||||||||.||||||||..|.||||.|.|||.||||||||||.||||.|||||..||.|.||
GQPPFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCg.AA PKC 351-614 70 1.4e-213 698.91 In-house 1-262 (262) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-262/262
Sequence Identity: 70% (188 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
| ||.|||||||||||||||.|.||.||||.||||||.|||||.||..|||||||...     ..|||.||..|||.|||.|||||| |||||.|||| .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK-----HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQR

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
.|||.||.||||||...|.|||..||||||||||||.||.||||||.||||||||...|.||.|||||||||||||..||.||||||||.||||.|||.|
RFKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMA

GQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDG---EPTIRAHGFF
||.||.||||.||||.||.... ||..||.|||.|||||.||.|.||||..|..   |  ||.| ||
GQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCg.AA AGC 351-614 32 3.9e-183 478.56 In-house 1-395 (395) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-395/395
Sequence Identity: 32% (131 aa)

FSFLMVLGKGSFGKVMLAERR------GSDELYAIKILKKDV-IVQDD--DVDCTLVE------------KRVLALGGRGPGGR-----PHFLTQ-LHST
| || |.||||||||.|....      .....||.|.|||.. ||...  .|..|..|            ...|..      .        |... ||..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTH-NHPIKSHHPFIVKILHYS

FQTPDR--LYFVMEYVT---------GG-DLMYHIQ---QLGKFKEPHAAFYAAE-------IAIGLFFLHN-QGIIYRD-LKLDNVMLDAEGHIKITDF
||..|.  |||||||.          || .|..|.|   . |.| |..| |||||       |. .| .||. .|||.|| ||..|..||..||||.|||
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GMCKENVFPG--------------------------------------------------TTTRTFCG--TPDYIAPEIIAYQPYGKSVDWWS--FGVLL
|.|||..  |                                                   .| ||||  ||.|.||||.    |||..||||  .|.|.
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEMLAGQPPFDGE----------DEEELFQAIM------EQTVTYP----------KSLSREAVAICKGFLTKHPGKRLGSGPD-----GEPTIRAHGFF
||||.|.||| |.          ...|.|| ||      .. |..|          ...| ||. ..|..|.|.| ||||.|..     |   |..| .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCg.AA Eta 351-614 62 8.49999999999e-155 520.55 In-house 1-261 (261) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-261/261
Sequence Identity: 62% (167 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
| |. |||||||||||||||.| ||.||||.||||||.|||||.||. |||.|.|  . |     ||||||..|||.|||.|||||| |||||..||.  
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHP-----FLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRAR

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
|| || |.|||||. . | |||..|.|||||||||..||.||| |. ||||||| .  | || |||||||||||||.  . || ||||| .|||.|||..
KFDEPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMC

GQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGP--DGEPTIRAHGFF
|||||. . |..||..|..  | ||  |..|||.| |.|.|| | ||||.    .||  ||.| ||
GQPPFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCg.AA Delta 351-614 60 5e-141 474.82 In-house 1-259 (259) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-259/259
Sequence Identity: 60% (162 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
| |. |||||||||||||| .| .. |||| |||||...||||.||.||.|||||. . |     ||..|  |||| . |.|||||. |||||||||| .
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHP-----FLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCH

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
.|.|  | |||.|| .|| |||..||||||||||||.|| .||||| ||||||||..  ... ||||||||||||||  | | .||||||||||.|||| 
RFDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLI

GQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS--GPDGEPTIRAHGFF
|| || ||||.|||..|....  ||. ...||  . |. . ..| ||||.   |.|.  ||.| ||
GQSPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGD--IRQHCFF
Kinase PKCg.AA Akt 351-614 45 1.9e-128 412.76 In-house 1-264 (264) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-264/264
Sequence Identity: 45% (123 aa)

FSFLMVLGKGSFGKVMLAERRGSDELY-AIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPH-FLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQ
| || ||||||||||.|..   ....| |.|.||||.|.| . |  |. |...|           | |...||  |||.|.|||||.|. ||.| ||.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-------HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR

LGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD-LKLDNVMLDAEGHIKITDFGMCKEN-VFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS-FGVLL
 ..|.|. | ||.|||  .. .||...||||| ||. |...|..|||..||||.|||| .  . .| |||||| |.||||.  . ..|.||||. .|...
KRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVM

YEMLAGQPPFDGEDEEELFQAIMEQTVTYP--KSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF
|||. |.|||  .| ...|. |..| | .|  . .| |.  . .| |.| | ||||.||..   |..| .|
YEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCg.AA SGK 351-614 40 8e-123 381.27 In-house 1-283 (283) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-283/283
Sequence Identity: 40% (117 aa)

FSFLMVLGKGSFGKVMLAERRGS------------------DELYAIKILKKDVIV-------QDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQ
| || |.||||||||..... .                   | .||.|.|.|. |.       .   .  .. |. |.    . |     |. .||  ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHP-----FIVNLHYAFQ

TPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE
|.. |||||.|| ||.. ||.|  ..|.|. | ||||||.  |  || | ||||||| .|..||..||...|||| |||.. . .|| |||||| | |||
TKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPE

IIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF
... ||....||||. | .||||. | |||   . ..... |. |    |.. | .|  . .| |.| | ||||.  |..  |. | ||
VLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFM-EIKNHPFF
Kinase PKCg.AA Iota 351-614 50 6.5e-116 387.69 In-house 1-271 (271) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-271/271
Sequence Identity: 50% (139 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
|  . |.|.||. ||...| .  . .||.|..||... .|.|.|    || |       |     ||  ||| |||. ||.||.|.| |||||.|.|.  
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHP-----FLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQR

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
|  | || ||.|||.. | |||..||||||||||||.||.|||||.||.|||||.. || || |||||| ||||||.  . || |||||  |||..||.|
KLPEEHARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA

GQPPFD--G-------EDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDG---EPTIRAHGFF
|  |||  |         |. ||| |.|...  |.|||  |  . |||| | |  |||  |.       |. | ||
GRSPFDIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCg.AA PKN 351-614 49 2.2e-108 366.37 In-house 1-260 (260) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-260/260
Sequence Identity: 49% (131 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
| .. |||.| ||||.|.. ....|.||||.|||  ||  |.|.  ..|||...  .|    |  || .|.. ||| .  .|||||. ||||| || .  
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNR---MRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-D

KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLA
 |.||.| |||| . .|| .||.. ||||||||||..||.||..|| |||.|||.. .|  | ||||||...|||... . | . ||||  |||.|||| 
VFSEPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLV

GQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF
| .|| |.||||.|..|... | ||. || ||.|| .  | | | .|||.|      |. . ||
GECPFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCg.AA AktR 351-614 38 7.89999999999e-104 351.25 In-house 1-268 (268) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-268/268
Sequence Identity: 38% (106 aa)

FSFLMVLGKGSFGKVMLAERR-GSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA-LGGRGPGGRPH-FLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQ
| .. .|||| ||||.|....  ....||.|..||  |..    . |. |. ... .         | |. .|| .||| . |.|.|||. ||.| .|..
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCN-------HPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLK

QLGKFKEPHAAFYAAEIAIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCK-ENVF-PGTTTRTFCGTPDYIAPEIIAY-QPYGKSVDWWSFGV
. .||.|  | ||.|.| ..| .||..  ||||||| .| .|| .||.||||||. | ...     ....||||| |.|||.|   ....||||||.||.
KKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGI

LLYEMLAGQPPFDGEDEEELFQAIMEQT---VTYPKSLSREAVAICK-GFLTKHPGKRLGSGPDGEPTIRAHGFF
..|||..|.|||. .. ...|| | ...   ..||. .| ..  ... . | |.| ||||..  |   |. | .|
FIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCg.AA S_TKc 351-614 35 9.4e-97 328.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTG--GDLMYHIQQ
. .| ..|||.||||...  .......||||.|          . .. | ..|         .  .. .|. .||. |.||.||||. |  |||. .|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

LGK------FKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGK-SVDWWSF
 |.      | | ||.||...|. .| ..|..|||.|||| .|..||   ||||.|||....        .||||||.|.|||..   .||| ..||||.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGE--PTIRAHGFF
|..|||||.|.|||.  .....|. |.          |.||  . .. |.| | ||..     .    |..| .|
GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCg.AA Pkinase 351-614 31 2.2e-78 271.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTL-VEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGG----DLMYH
. .. ..|.||||.| .. ..|. ...|.||.||. .  . |.  ..  | ....   . |     .  .|. .|...|..|.||||. ||    ||. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHP-----NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IQ--QLGKF--KEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHI----KITDFGMCKEN-VFPGTTTRTFCGTPDYIAPEIIA-YQPYGKS
|.  . |.|   | .. ||. .|. || ..|..|||.||||..|...| .|||    ||.||| .|     ... . ||||||.|.|||.|  .|.||..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDWWSFGVLLYEMLAGQPPFDGE------DEEELFQAIMEQTVTYPKSLS---------------------REAVAICKGFLTKHPGKRLGSGPDGEPTI
||.||.|..||||| |.|||.|.      |. .... ||.  . .. . .                     .|.  ..|. |.| | ||..      . |
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQI

RAHGFF
  | .|
LQHPWF
Kinase PKCg.AA S_TK_X 615-677 36 3.1e-22 81.11 SMART 1-79 (79) Show / Hide 
Range on Protein: 615-677
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

RWIDWERLER--LEIPPPFRPRPC----G-RSGENFDKFFTRAAPALTPPDRLVLASIDQAD---------FQGFTYVN
| |||..|..   ||.|||.|...    . .  .|||. ||...| |||.|. ...|..| .         | |||||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCg.AA Pkinase_C 641-679 56 5.5e-14 52.47 Pfam 9-46 (46) Show / Hide 
Range on Protein: 641-679
Range on HMM: 9-46/46
Sequence Identity: 56% (22 aa)

ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD
.|||..||...| .||||.  . |.||. |.||||||||
SNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCg.AA TyrKc 351-590 19 2.5e-13 -7.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 351-590
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTP------DRLYFVMEYVTGGDLMY
 ... .|| | ||.|.... .   .  |.| ||.|       .   . | |..   |   |  |. .  .    |        . |. ||||. .|||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLG---GHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HIQQLGK-FKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPG--------TTTRTFCGTPD------YIAPEIIAY
...  .. .. ..   ..  || |  .|| ...| |||   |.........||.|||.... .  .        . . .  .  .        ||| | |
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD-IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

QPYGKSVDWWSFGVLLYEMLA-GQPPFDG-----EDEEELFQAIMEQTVTYPKSL--------SREAV------------------AICKGFL
  .    | |||||...|..  ||.|  |      . .|... ...     .             ...                  . .. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKCg.AA Pkinase_Tyr 429-503 27 1.9e-09 32.59 Pfam 81-159 (270) Show / Hide 
Range on Protein: 429-503
Range on HMM: 81-159/270
Sequence Identity: 27% (22 aa)

RLYFVMEYVTGGDLMYHIQQ----LGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCK
..| ||||. .|||  . ..     .... ..   ....|| |. .|.....| |||   |.... ....||.|||...
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCg.AA Pkinase_Tyr 539-569 38 0.000165 15.89 Pfam 198-231 (270) Show / Hide 
Range on Protein: 539-569
Range on HMM: 198-231/270
Sequence Identity: 38% (13 aa)

WSFGVLLYEMLA-GQPP-FDGEDEEELFQAI-ME
||||||..|..  |. | . | . ||....|  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PKCg.AA Pkinase_Tyr 351-385 28 0.000918 13.37 Pfam 1-39 (270) Show / Hide 
Range on Protein: 351-385
Range on HMM: 1-39/270
Sequence Identity: 28% (11 aa)

FSFLMVLGKGSFGKVMLAERR----GSDELYAIKILKKD
 .|. .||.|.||.|.... .    . .   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG