Gene PKCb (Human)

PKCb

Species: Human
Alias: PKCB, MGC41878, PKC-beta, PRKCB, PKCb, PKCbeta, PRKCB1, PRKCB2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 16p12.1-p13.1,

Classification

Group: AGC
Family: PKC
Subfamily: PKCa

Sequence

Name Sequence Type Origin Length Description Download
PKCb.NA RNA Sugen Kinome 8014 None Fasta, JSON
PKCb.AA Protein Sugen Kinome 673 None Fasta, JSON
PKCb.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of PKCb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 PKCb.AA C1_1 37-89 45 2.8e-20 78.1 Pfam 1-55 (55) Show / Hide 
Range on Protein: 37-89
Range on HMM: 1-55/55
Sequence Identity: 45% (25 aa)

HKFTAR-FFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHEFVTFSCPGA
|.. .. .|||||||.|| .|.|| .|.||..||.| ...|.|||..|.  |.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCb.AA C1 37-86 33 3.6e-18 67.59 SMART 1-61 (61) Show / Hide 
Range on Protein: 37-86
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HKFTARFFKQPTFCSHCTDFIWGFGKQ-----GFQCQVCCFVVHKRCHEFVTF-------SC
|.. .. | .||.|.|| ..|||. ||     |..|..|....||.||..|.        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCb.AA C1_3 67-79 38 4.532068 1.68 Pfam 18-30 (30) Show / Hide 
Range on Protein: 67-79
Range on HMM: 18-30/30
Sequence Identity: 38% (5 aa)

CQVCCFVVHKRCH
|  | |..|..| 
CMQCDFMLHEDCA
C1_1 PKCb.AA C1_1 102-154 47 2.4e-25 95.32 Pfam 1-55 (55) Show / Hide 
Range on Protein: 102-154
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HKFKIH-TYSSPTFCDHCGSLLYG-LIHQGMKCDTCMMNVHKRCVMNVPSLCGTD
|... | .. .||||.|||....| |.|||.||..| .|.|.||.|.||..|| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCb.AA C1 102-151 27 7.5e-18 66.54 SMART 1-61 (61) Show / Hide 
Range on Protein: 102-151
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFKIHTYSSPTFCDHCGSLLYGLIHQ-----GMKCDTCMMNVHKRCVMNVPS-------LC
|....... .||.|.||.....|. .|     |..|  | ...||.|. .||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCb.AA C1_3 113-144 25 0.000165 12.97 Pfam 1-30 (30) Show / Hide 
Range on Protein: 113-144
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCV
 .|. ||  .|.  . . .| .|  ..|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C2 PKCb.AA C2 173-260 49 7.5e-36 124.76 Pfam 1-90 (90) Show / Hide 
Range on Protein: 173-260
Range on HMM: 1-90/90
Sequence Identity: 49% (45 aa)

LIVLVRDAKNLVPMD--PNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ-LKESDKDRRLSVEIWDWDLTSRNDFMGSLS
| | |  |.|| |||  .||.||||||..| .||| ..|.|||.|| .|||.||||| |.   ..  . .| ...||||  .|.||.|  .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQH-TLRFTVWDWDRFGRDDFIGQCC
C2 PKCb.AA C2 172-275 25 1.7e-25 91.95 SMART 1-92 (92) Show / Hide 
Range on Protein: 172-275
Range on HMM: 1-92/92
Sequence Identity: 25% (32 aa)

VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSL---NPEWNE---TFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFG---
.| | .  |.||         |||||..           |||..|..|   ||.|||   || | . .    . | .|.||.      ||.| ....   
TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN

-----------ISELQKASVDGWF
           .|...    . | 
PHWHQWDGCIHLSDIL-GYRH-WW
Kinase PKCb.AA Alpha 342-600 89 2.6e-239 801.29 In-house 1-259 (259) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-259/259
Sequence Identity: 89% (232 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP
|||||||||||||||||.||||||||||.|||||||.|||||||||||||||||||||||||.|.||||||||||||||||||||||||||||||.||||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
||||||||||||||||..||||||||||||||||.|||||||||||||||.|...||.|||||||||||||||||||||||||||||||||||.|||.||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
.|||||||||.||||||.||||||||||.||||..||||.|||||||.||.||.||.||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCb.AA PKC 342-600 78 8e-224 732.65 In-house 1-262 (262) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-262/262
Sequence Identity: 78% (205 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP
||||.||||||||||||.|||||||.||.|.|||||.||||||||||.|||||||..|.||||.||.||||||||.||||||||||||.||||..||||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
||.||||||...|.|| .|||||||||||||.||.|||||||||||||||.|.|.||.|||||||||||||..||.|||||||||||||.|||.|||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEG---ERDIKEHAFF
.||||||||||||..|. ||...|||||.||||.|||.|.|||||.|..   |.||.||.||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCb.AA AGC 342-600 34 2.2e-192 503.04 In-house 1-395 (395) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-395/395
Sequence Identity: 34% (137 aa)

FNFLMVLGKGSFGKVMLSERK------GTDELYAVKILKKDV-VIQDD--DVECTMVE------------KRVLALPGK---------PPFLTQ-LHSCF
|.|| |.||||||||.| ..|      .|...||.|.|||.. .....  .||.||.|            ...|..  .          ||... ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTMDR--LYFVME----YVN-----GG-DLMYHIQ---QVGRFKEPHAVFYAAE-------IAIGLFFLQS-KGIIYRD-LKLDNVMLDSEGHIKIADFG
|. |.  ||||||    |||     || .|..|.|   . ||| |..| |||||       |. .| .| | .|||.|| ||..|..||..||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENIWDG--------------------------------------------------VTTKTFCG--TPDYIAPEIIAYQPYGKSVDWWA--FGVLLY
.|||.. ||                                                  ..|.||||  ||.|.||||.    |||..|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGQAPFEGE----------DEDELFQSIM------EHNVAYP----------KSMSKEAVAICKGLMTKHPGKRLGCGPE-----GERDIKEHAFF
|||.|. || |.          ...|.||.||      ...| .|          ...|.||. ..|.|..|.| ||||||..     |  .||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCb.AA Eta 342-600 67 2.8e-164 552.05 In-house 1-261 (261) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-261/261
Sequence Identity: 67% (176 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP
|||. |||||||||||| |||||||.||.|.|||||.|||||||||| |||.|.|  | |||||||.|||| |||.||||||||||||..||.  .| ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
 | |||||. . | ||  .|.|||||||||..|| ||| |.|||||||| | .|.|| |||||||||||||.  . || ||||||.|||.|||..||.||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIKEHAFF
| . ||.||.||.. .| ||  ..||||.| |. ||| | |||||     ||..|..|.||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCb.AA Delta 342-600 64 6.9e-146 490.95 In-house 1-259 (259) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-259/259
Sequence Identity: 64% (169 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP
|.|. ||||||||||||.| ||... ||.| ||||||..||||||||||.|||||  . |||..|   ||| . |.|||||.|||||||||||..||.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
 | |||.|| .|| || .|||||||||||||.|| .||||||||||||||.    ...||||||||||||||  | | .|||||.||||.|||| ||.||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GPEGERDIKEHAFF
.||||||||.||.. .  ||. ..|||  . |.|. ..| ||||    |.|  ||..| ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF
Kinase PKCb.AA SGK 342-600 41 1.6e-126 392.89 In-house 1-283 (283) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-283/283
Sequence Identity: 41% (119 aa)

FNFLMVLGKGSFGKVMLSERKGT------------------DELYAVKILKKDVVI-------QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL
| || |.||||||||.. ..|..                  | .||.|.|.|. .|       .   .  .| |. |.    | ||. .||  ||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ
||||.|||||.. ||.|  ..|.|. | ||||||.  |  | |. ||||||| .|..||..||... ||| |||.| .  ||.|||||| | |||... |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
|....||||  | .||||. |  ||.  .  .... |.      |..|| .|  . .|| .| | ||||   .. ..||.| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase PKCb.AA Akt 342-600 49 5.9e-125 401.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-264/264
Sequence Identity: 49% (130 aa)

FNFLMVLGKGSFGKVMLSERKGTDELY-AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE
|.|| ||||||||||.| . | |...| | |.||||. || . || |. |...|      ||...||  ||| |.|||||.|.|||.| ||.|. .||.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PHAVFYAAEIAIGLFFLQSKGIIYRD-LKLDNVMLDSEGHIKIADFGMCKEN-IWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA-FGVLLYEMLAG
. | ||.|||  .. .| ||.||||| ||. |...|..|||...|||.|||| | |. .|||||||| |.||||.  . ..|.||||. .|...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
. ||  .| ...|. |.. .| .|  .  |.|.  . .|| .| | |||| ||.. ..||.| .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCb.AA Iota 342-600 52 3.2e-121 405.69 In-house 1-271 (271) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-271/271
Sequence Identity: 52% (142 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP
|. . |.|.||. ||.. | | |. .||.|..||..| .|.|..    || |       |||  |||||||  ||.||.|.|||||||.|.|.  .  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
|| ||.|||.. | || ..||||||||||||.||.|||||. |.|||||.| .| || |||||| ||||||.  . || |||||| |||..||.|| .||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

E--G-------EDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEG---ERDIKEHAFF
.  |         || ||| |.|...  |.|.|  |  . || . | |  |||| |.     .|||||.||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCb.AA PKN 342-600 50 7.4e-112 377.92 In-house 1-260 (260) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-260/260
Sequence Identity: 50% (133 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK
| .. |||.| ||||.||. |.|.|.||.|.|||  ..  |.||  |.|||...  .  . ||| .|..|||| .  .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA
||.|.|||| . .|| .|  . ||||||||||..|| ||..||||||.|||..  |  | ||||||...|||... . | . ||||  |||.|||| | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
|| |.||.|.|..|....| ||. .| ||.|| . |. | | .||| |     ||| ..||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCb.AA AktR 342-600 39 1e-107 364.17 In-house 1-268 (268) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-268/268
Sequence Identity: 39% (106 aa)

FNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE
| .. .|||| ||||.| ..|  ....|| |..||   |.    . |  |. ...   . ||. .|| |||| . |.|.|||. ||.| .|... ..|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PHAVFYAAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCK-ENIW-DGVTTKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLA
  | ||.|.| ..| .| ..  ||||||| .| .||..||.||.|||. | ...  .  ....||||| |.|||.|   ....|||||||||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQAPFEGEDEDELFQSIMEHN---VAYPKSMSKEAVAICK-GLMTKHPGKRLGCGPEGERDIKEHAFF
|. ||. ..  ..||.| ...   . ||.  |...  ... .|. |.| |||| . .|  .||.| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCb.AA S_TKc 342-600 37 2.7e-99 337.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-231/231
Sequence Identity: 37% (100 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNG--GDLMYHIQQVGR--
. .| ..|||.||||..   |.|....|.||.|          | .. | ..|    . |.. .|. .||. |.||.||||..|  |||. .|.. ||  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK-SVDWWAFGVLLY
    | | || ||...|. .| .. |.|||.|||| .|..||.  ||||.|||....        .||||||.|.|||..   .||| ..|||..|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGE--RDIKEHAFF
|||.|. ||.  .....|. |.          |.||  . .....| | ||...    .  .||| | .|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCb.AA Pkinase 342-600 32 1.2e-74 259.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 342-600
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGG----DLMYHIQ--Q
. .. ..|.||||.| .  .||| ...||||.||.    . |.. .   | ....   . |.  .|. .|.. |..|.||||..||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI----KIADFGMCKEN-IWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWA
 |.|   | .. ||. .|. || .. |.|||.||||..|...|..|||    ||.||| .|   .  .. ..||||||.|.|||.|  .|.||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLLYEMLAGQAPFEGE------DEDELFQSIME----HNVAYPKSMS-----------------KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF
.|..||||| |. || |.      |...... ||.     .  .. |.|                 .|.  ..|.. .| | ||..      ..|..| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase PKCb.AA S_TK_X 601-663 37 3.3e-22 81.03 SMART 1-79 (79) Show / Hide 
Range on Protein: 601-663
Range on HMM: 1-79/79
Sequence Identity: 37% (30 aa)

RYIDWEKLER--KEIQPPYKPKAC----G-RNAENFDRFFTRHPPVLTPPDQEVIRNIDQSE---------FEGFSFVN
| |||.||..  |||.||.||| .    . . ..|||  ||. .|.|||.|. ......|.|         |.||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCb.AA TyrKc 342-576 21 7.8e-14 0.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 342-576
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQLHSCFQTM-------DRLYFVMEYVNGGDLMYHIQ
  .. .|| | ||.|.. . |   .  ||| ||.|       .|  | | |..   | . | . .|. .  .        . |. ||||. .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QVGR-FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-------GVTTKTFCGTPD------YIAPEIIAYQPYG
  .. .. .. . ..  || |  .| ||..| |||   |.........||.|||....   |        . .|.  .  .        ||| | |  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDWWAFGVLLYEMLA-GQAPFEG-----EDEDELFQSIMEHNVAYPKSM--------SKEAV------------------AICKGLM
   | |.|||...|..  || | .|      . .|... ... .   .             ...                  . .. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKCb.AA Pkinase_C 626-665 45 9.9e-14 51.57 Pfam 8-46 (46) Show / Hide 
Range on Protein: 626-665
Range on HMM: 8-46/46
Sequence Identity: 45% (18 aa)

AENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSE
..||| .||. ||..||||.. ....||..|.||..||..
TSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCb.AA Pkinase_Tyr 415-489 30 3.1e-10 35.31 Pfam 81-159 (270) Show / Hide 
Range on Protein: 415-489
Range on HMM: 81-159/270
Sequence Identity: 30% (24 aa)

RLYFVMEYVNGGDLMYHIQQ----VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK
..| ||||. .|||  . ..     .... .. . ....|| |. .| ||..| |||   |.........||.|||...
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCb.AA Pkinase_Tyr 525-555 32 0.006244 10.55 Pfam 198-231 (270) Show / Hide 
Range on Protein: 525-555
Range on HMM: 198-231/270
Sequence Identity: 32% (11 aa)

WAFGVLLYEMLA-GQAP-FEGEDEDELFQSI-ME
|.||||..|..  |. | ..| .  |... |  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PKCb.AA Pkinase_Tyr 342-376 35 0.016509 9.12 Pfam 1-39 (270) Show / Hide 
Range on Protein: 342-376
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKD
  |. .||.|.||.|.. . |    .|.   |||.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG