Gene PKCa (Human)

PKCa

Species: Human
Alias: PKC-alpha, PKCA, PRKCA, AAG6, PKCalpha, PKCa, MGC129901, MGC129900, PRKACA
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q24.1,

Classification

Group: AGC
Family: PKC
Subfamily: PKCa

Sequence

Name Sequence Type Origin Length Description Download
PKCa.NA RNA Sugen Kinome 8787 None Fasta, JSON
PKCa.AA Protein Sugen Kinome 672 None Fasta, JSON
PKCa.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of PKCa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 PKCa.AA C1_1 37-89 45 3.9e-21 81.22 Pfam 1-55 (55) Show / Hide 
Range on Protein: 37-89
Range on HMM: 1-55/55
Sequence Identity: 45% (25 aa)

HKFIAR-FFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHEFVTFSCPGA
|..... .|||||||.|| .|.|| .|.||..||.| ...|.|||..|.  |.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCa.AA C1 37-86 33 1.6e-18 68.75 SMART 1-61 (61) Show / Hide 
Range on Protein: 37-86
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HKFIARFFKQPTFCSHCTDFIWGFGKQ-----GFQCQVCCFVVHKRCHEFVTF-------SC
|..... | .||.|.|| ..|||. ||     |..|..|....||.||..|.        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCa.AA C1_3 67-79 38 4.532068 1.68 Pfam 18-30 (30) Show / Hide 
Range on Protein: 67-79
Range on HMM: 18-30/30
Sequence Identity: 38% (5 aa)

CQVCCFVVHKRCH
|  | |..|..| 
CMQCDFMLHEDCA
C1_1 PKCa.AA C1_1 102-154 43 6.8e-24 90.51 Pfam 1-55 (55) Show / Hide 
Range on Protein: 102-154
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HKFKIH-TYGSPTFCDHCGSLLYG-LIHQGMKCDTCDMNVHKQCVINVPSLCGMD
|... | .. .||||.|||....| |.|||.||..| .|.|..|. .||..||..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCa.AA C1 102-151 27 6.8e-18 66.68 SMART 1-61 (61) Show / Hide 
Range on Protein: 102-151
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFKIHTYGSPTFCDHCGSLLYGLIHQ-----GMKCDTCDMNVHKQCVINVPS-------LC
|....... .||.|.||.....|. .|     |..|  |....||.|. .||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCa.AA C1_3 113-144 28 1e-06 18.31 Pfam 1-30 (30) Show / Hide 
Range on Protein: 113-144
Range on HMM: 1-30/30
Sequence Identity: 28% (9 aa)

TFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCV
 .|. ||  .|.  . . .| .|| ..|. |.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C2 PKCa.AA C2 173-260 51 3.9e-39 135.98 Pfam 1-90 (90) Show / Hide 
Range on Protein: 173-260
Range on HMM: 1-90/90
Sequence Identity: 51% (47 aa)

LHVTVRDAKNLIPMD--PNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFK-LKPSDKDRRLSVEIWDWDRTTRNDFMGSLS
|.|.|  |.|| |||  .||.||||||..| .|||...|.|||.|..||||.|||.|||    |.  . .| ...||||| .|.||.|  .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQH-TLRFTVWDWDRFGRDDFIGQCC
C2 PKCa.AA C2 172-275 25 3.3e-28 100.96 SMART 1-92 (92) Show / Hide 
Range on Protein: 172-275
Range on HMM: 1-92/92
Sequence Identity: 25% (32 aa)

KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTL---NPQWNE---SFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFG---
.|.|..  |.||.        |||||..           |||... ||   ||.|||   .|.|.. |    . | .|.||.      ||.| ....   
TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN

-----------VSELMKMPASGWY
           .|...  . . |.
PHWHQWDGCIHLSDIL-GYRH-WW
Kinase PKCa.AA Alpha 339-597 88 4.6e-238 797.15 In-house 1-259 (259) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-259/259
Sequence Identity: 88% (228 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP
||||||||||||||||||.||||.||||||||||||.|||||||||||||||||| .|||||.|.||||||.||||||||||||||||||||||||||||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
.||||||||.|||||||..|||||||||||||||.||||||||||||||.|....||||||||||||||||||||||||||||||.|||||||.||||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFF
||||||||||.|||||||||||.|||||..|||..||||.|||||||.||.|.|||.||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCa.AA PKC 339-597 76 4.3e-222 726.95 In-house 1-262 (262) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-262/262
Sequence Identity: 76% (201 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP
||||.|||||||||||||.||||.|.||||.|||||.||||||||||.|||||||  |.||||.||.|||| |||.||||||||||||.||||...|||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
.|.||||||...|.|||..||||||||||||.||.||||||||||||||.|..|.||.|||||||||||||..||.|||||||||.|||.|||.|||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEG---ERDVREHAFF
.||||||||||||..|..||..|||||||.|||.|||.|.|||||.|..   |.|.|||.||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCa.AA AGC 339-597 34 2.8e-193 505.38 In-house 1-395 (395) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-395/395
Sequence Identity: 34% (136 aa)

FNFLMVLGKGSFGKVMLADRK------GTEELYAIKILKKDV-VIQDD--DVECTMVE------------KRVLALLDK---------PPFLTQ-LHSCF
|.|| |.||||||||.|. .|      .|...||.|.|||.. .....  .||.||.|            ...|.....          ||... ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTVDR--LYFVME----YVN-----GG-DLMYHIQ---QVGKFKEPQAVFYAAE-------ISIGLFFLHK-RGIIYRD-LKLDNVMLDSEGHIKIADFG
|. |.  ||||||    |||     || .|..|.|   . |.| |..| |||||       |  .| .||. .|||.|| ||..|..||..||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEHMMDG--------------------------------------------------VTTRTFCG--TPDYIAPEIIAYQPYGKSVDWWA--YGVLLY
.||| |.||                                                  ..| ||||  ||.|.||||.    |||..|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGQPPFDGE----------DEDELFQSIM------EHNVSYP----------KSLSKEAVSVCKGLMTKHPAKRLGCGPE-----GERDVREHAFF
|||.|.||| |.          ...|.||.||      ...| .|          ...|.||.. .|.|..|.|.||||||..     |  ....| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCa.AA Eta 339-597 68 2e-164 552.51 In-house 1-261 (261) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-261/261
Sequence Identity: 68% (179 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP
|||. |||||||||||||.||||.|.||||.|||||.|||||||||| |||.|.|  | |||||||.|||| |||.||||||||||||..||.  || ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
 | |||||. . | |||..|.|||||||||..|| ||| |.|||||||| .|.|.|| |||||||||||||.  . || |||||| |||.|||..|||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGP--EGERDVREHAFF
. . ||.||.||.. .| ||  |.|||||. |. ||| | |||||     ||...|.|.||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCa.AA Delta 339-597 64 1.4e-145 489.91 In-house 1-259 (259) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-259/259
Sequence Identity: 64% (169 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP
|.|. |||||||||||||. ||... |||| ||||||..||||||||||.|||||  . |||..|   ||| . |.|||||.|||||||||||...|.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
 | |||.|| .|| ||||.||||||||||||.|| .|||||||||||||.|.   .. ||||||||||||||  | | .|||||..|||.|||| || ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGC--GPEGERDVREHAFF
 ||||||||.||.. .  ||. ..||| .. |.|. ..| ||||    |.|  |.|.| ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF
Kinase PKCa.AA Akt 339-597 46 4.3e-132 424.6 In-house 1-264 (264) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-264/264
Sequence Identity: 46% (124 aa)

FNFLMVLGKGSFGKVMLADRKGTEELY-AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKE
|.|| ||||||||||.|.  | |...| |.|.||||. || . || |. |...|   .  ||...||  ||| |.|||||.|.|||.| ||.|. ..|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PQAVFYAAEISIGLFFLHKRGIIYRD-LKLDNVMLDSEGHIKIADFGMCKEH-MMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWA-YGVLLYEMLAG
..| ||.|||. .. .||...||||| ||. |...|..|||...|||.|||. . |. .| |||||| |.||||.  . ..|.||||.  |...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFDGEDEDELFQSIMEHNVSYP--KSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFF
.|||  .| ...|. |.. .| .|  . .|.|. .  .|| .| | |||| ||.. .....| .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCa.AA SGK 339-597 40 1.9e-126 392.64 In-house 1-283 (283) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-283/283
Sequence Identity: 40% (115 aa)

FNFLMVLGKGSFGKVMLADRKGT------------------EELYAIKILKKDVVI-------QDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRL
| || |.||||||||... .|..                  . .||.|.|.|. .|       .   .  .| |. |.  . | ||. .||  ||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQ
||||.|||||.. ||.|  ..|.|..| ||||||   |  ||.  ||||||| .|..||..||... ||| ||| . .  || |||||| | |||... |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFF
|....||||  | .||||. | |||   .  .... |.      |.. | .| .  .|| .| | ||||   .. .....| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase PKCa.AA Iota 339-597 52 9.3e-122 407.49 In-house 1-271 (271) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-271/271
Sequence Identity: 52% (143 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP
|. . |.|.||. ||.... | |. .||.|..||..| .|.|..    || |       |||  |||||||. ||.||.|.|||||||.|.|.  |  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
 | ||.|||.. | |||.|||||||||||||.||.|||||. |.||||| . .| || |||||| ||||||.  . || |||||| |||..||.||  ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

D--G-------EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEG---ERDVREHAFF
|  |         || ||| |.|...  |.|||  | .| || . | |. |||| |.     .|..||.||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCa.AA PKN 339-597 50 1.4e-112 380.29 In-house 1-260 (260) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-260/260
Sequence Identity: 50% (132 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD--KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFK
| .. |||.| ||||.|.. |.|.|.||||.|||  ..  |.||  |.|||...     . ||| .|..|||| .  .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQP
||.|.|||| . .|| .||.. ||||||||||..|| ||..||||||.||| |  |  | ||||||...|||... . | . ||||  |||.|||| | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFF
|| |.||.|.|..|....| ||. || ||... . |. | | .||| |     |.. ..||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCa.AA AktR 339-597 40 2e-112 379.82 In-house 1-268 (268) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-268/268
Sequence Identity: 40% (109 aa)

FNFLMVLGKGSFGKVMLADRK-GTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKE
| .. .|||| ||||.|. .|  . ..||.|..||   |.    . |  |. ... . . ||. .|| |||| . |.|.|||. ||.| .|... .||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PQAVFYAAEISIGLFFLHKR-GIIYRDLKLDNVMLDSEGHIKIADFGMCK-EHMM-DGVTTRTFCGTPDYIAPEIIAY-QPYGKSVDWWAYGVLLYEMLA
 || ||.|.| ..| .||..  ||||||| .| .||..||.||.|||. | . || .  ....||||| |.|||.|   ....||||||| |...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFDGEDEDELFQSIMEHN---VSYPKSLSKEAVSVCK-GLMTKHPAKRLGCGPEGERDVREHAFF
|.|||. ..  ..||.| ...   . ||. .|... . .. .|. |.| |||| . .|  ....| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCa.AA S_TKc 339-597 36 8.2e-100 338.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNG--GDLMYHIQQVGK--
. .| ..|||.||||...  |.| ...||||.|          | .. | ..|    . |.. .|. .||. |.||.||||..|  |||. .|.. |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK-SVDWWAYGVLLY
    | | .| ||...|  .| ..|..|||.|||| .|..||.  ||||.|||....        .||||||.|.|||..   .||| ..|||. |..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGE--RDVREHAFF
|||.|.|||.  .....|. |.          |.|| .  .....| |.||...    .  .|.. | .|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCa.AA Pkinase 339-597 32 3e-83 287.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 339-597
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM-VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG----DLMYHIQ--Q
. .. ..|.||||.| .. .|||....|.||.||.    . |.. .   | .... | . |.  .|. .|.. |..|.||||..||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGKF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHI----KIADFGMCKEH-MMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWA
 |.|   | .. ||. .|  || ..|..|||.||||..|...|..|||    ||.||| .| .    .. . ||||||.|.|||.|  .|.||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

YGVLLYEMLAGQPPFDGE------DEDELFQSIMEHNVSYPKSLS---------------------KEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAF
.|..||||| |.|||.|.      |...... ||.  .... . .                     .|. ...|.. .| |.||..      ... .| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase PKCa.AA S_TK_X 598-660 39 8.5e-28 99.58 SMART 1-79 (79) Show / Hide 
Range on Protein: 598-660
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

RRIDWEKLEN--REIQPPFKPKVC----G-KGAENFDKFFTRGQPVLTPPDQLVIANIDQSD---------FEGFSYVN
| |||.||.|  .||.||||||..    .   ..|||. ||...|.|||.|. ......|..         |.||.||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCa.AA TyrKc 339-573 21 7.6e-15 17.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 339-573
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALL--DKPPFLTQLHSCFQT------VDRLYFVMEYVNGGDLMYHIQ
  .. .|| | ||.|...  |   .  |.| ||.|       .|  | | |..  |  . |  .  .  | |       .. |. ||||. .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QVGK-FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD---GVTTRTFC-----GTPD-----YIAPEIIAYQPYG
  .. .. .. . ..  |. |  .||....| |||   |.........||.|||.....  |   |. . .       |. .       ||| | |  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDWWAYGVLLYEMLA-GQPPFDG-----EDEDELFQSIMEHNVSYPKSL--------SKEAV------------------SVCKGLM
   | |..||...|..  ||.|  |      . .|... ... .   .             ...                  | .. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKCa.AA Pkinase_C 617-662 42 2.3e-14 53.77 Pfam 1-46 (46) Show / Hide 
Range on Protein: 617-662
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

KVCG-KGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQ
.|..   ..|||..||.  |..||||.  . ..||. |.||.|||| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCa.AA Pkinase_Tyr 412-497 24 1.1e-11 40.15 Pfam 81-171 (270) Show / Hide 
Range on Protein: 412-497
Range on HMM: 81-171/270
Sequence Identity: 24% (22 aa)

RLYFVMEYVNGGDLMYHIQQ----VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT-TRT
..| ||||. .|||  . ..     .... .. . ....|. |. .|. ...| |||   |.........||.|||... .. |.   . .
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKR
Kinase PKCa.AA Pkinase_Tyr 339-373 33 0.00138 12.77 Pfam 1-39 (270) Show / Hide 
Range on Protein: 339-373
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

FNFLMVLGKGSFGKVMLADRK----GTEELYAIKILKKD
  |. .||.|.||.|...  |    .|.   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase PKCa.AA Pkinase_Tyr 522-552 29 0.010257 9.82 Pfam 198-231 (270) Show / Hide 
Range on Protein: 522-552
Range on HMM: 198-231/270
Sequence Identity: 29% (10 aa)

WAYGVLLYEMLA-GQPP-FDGEDEDELFQSI-ME
|..|||..|..  |. | . | .  |... |  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED