Gene CDK11a (Human)

CDK11a

Species: Human
Alias: PITSLRE, p58CLK-1, p58CDC2L1, MGC131975, Hs.169204, CDC2L3, CDK11a, CDK11-p46, PK58, p58GTA, p58, CDC2L1, CDC2L2, CLK-1, CDK11-p110, CDK11-p58
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p36.3,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK11

Sequence

Name Sequence Type Origin Length Description Download
CDK11a.NA RNA Sugen Kinome 2913 None Fasta, JSON
CDK11a.AA Protein Sugen Kinome 795 None Fasta, JSON
CDK11a.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of CDK11a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK11a.AA PITSLRE 438-723 75 1e-243 815.95 In-house 1-295 (295) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-295/295
Sequence Identity: 75% (224 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME--KEKEGFPITSLREINTILKA-QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---
|||||||.|||||||||||||.|||||||||||||  |||||||||||||||.||.| ||||||.|.|||.||||||||.||.|||||||||||.||   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGEL
|||.|||.|.||.||||||.|.|||||.||||||||||.||.||||..|||||||||||.|.|||.||||||||||||||.|.|||.||||||||||.|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT-FSEHPYNNLRKRFG--ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
.|.||||.|||||||||..||..|||.||||||..|||..|.|. |...|||||||||.  ...||.||||.|..|||.| .||.|.|.|||..|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK11a.AA CDK 438-723 45 6.7e-174 560.91 In-house 1-284 (284) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-284/284
Sequence Identity: 45% (147 aa)

FQCLNRIEEGTYGVVYRAKDKKTD-----EIVALKRLKMEK-----EKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMD---------KIYIVMNY
...|..| ||||||||.|.||.|.     .|||||...||.     ||||||||..|||..  .  |||||.........|||         |.|.|. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGI-----LKVGDFGLAREYGS------PLKAYTPVVVTLWYRAPE
..||||..|.          .|..| |||||. ..|.|||.|||||..|.|... |.     ||..||||||..|.      |...||..||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGAKEYS--TAVDMWSVGCIFGELLT---QKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNK
||||.|.||  |..|||||||||.|..|    ||||||.|||||. |.|. .|||.|..||| ..||                            ||.||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

FLTYFPGRRISAEDGLKHEYF
.|.| | .|||||. |.|.||
MLCYDPKKRISAEQALQHPYF
Kinase CDK11a.AA CDK10 438-723 55 3.8e-144 485.19 In-house 1-285 (285) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-285/285
Sequence Identity: 55% (160 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
|  |||. |||||.||||.| ..|||||||. .|.|||.| || .||||  ... .|.||| ..|.|||  .| |..||.| | || ||.. | |||   
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
.|| .|.|.|||.| ||||...||||| ||||..  | .|| |||||| || | |  || .|||||||||||||...  ||.||| |||| |||| .|||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

FPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
.|| ||| ||. . . ||||||.||||.|.||.|.. | .. |||||...|  .||. |  |.|  . | | .|  ||. |. .||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF-HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK11a.AA CDC2 438-723 45 1.2e-143 444.69 In-house 1-301 (301) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-301/301
Sequence Identity: 45% (139 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG--FPITSLREINTILKAQ-HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLME-TMK--
.|....| ||||||||..||..|..|||||. . | | ||  .| |..||| .. . . |||||. .....     |.|.|  |...||| .|.   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV--VVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
... |  || .|.|.|.|| ..| . |.||||| .|.|.. .| .|..||||||  | |...||.   ||||||||||.|||.| |||.|||||.|||| 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGA--------LLSDQGFDLMNKFLTYFPGRRISAEDGL
|.    | ||||.|.|||||. |.|. ||||.|..||| ..||   |.|| . . ..|.| .           | ..|.|| .. | | | .||||.. |
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHEYF
.| ||
QHPYF
Kinase CDK11a.AA CMGC 438-723 27 1.5e-139 461.68 In-house 1-513 (513) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

FQCLNRIEEGTYGVVYRAKD--------------KKTDEIVALKRLK---MEK------EKEGFPITSLREINTILKAQ-----------------HPNI
......| ||||||||...|              ..|.||||.|..|   .|       ||.||||..||||    . .                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTVREIVVGSNMD---------------KIYIVMNYVEHDLKSLMETMK--------QPFLPGE------------VKTLM------IQLLRGVK--HLH
|. ..|.. .|.|               ..|.|. |..|||. ... ..        .|. . .            .| .|       |.|||.|  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--ILHRDLKTSNLLLSHA--------------------GILKVGDFGLAREYGSP---------------------LKAYTPVVVTLWYRAPELLLG
 .|  |.||||| .|.|..|                     |.||..|||||| |...                     ...||. |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKEYS---------TAVDMWSVGCIFGELLTQ--------KPLFPGKSE-----------IDQINKVFKDLGTPS---------------EKIWPGYSEL
.|.|.         |..|||||||||.|..|         ||||||.||           |||..| || ||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PAVKK-------------MT------------FSEHPYNNLRKRFGA----------------------------------LLSDQGFDLMNKFLTYFPG
|  .|             ..            | ..|...... |                                    ....|..||..| |.| | 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

RRISAEDGLKHEYF
.||.||. |.|.||
KRITAEQALQHPYF
Kinase CDK11a.AA CDK7 438-723 40 9.40000000001e-139 372.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-288/288
Sequence Identity: 40% (120 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK----MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQP
.. .  | ||....||.| |..|..||| |. |     .  | |   | .|||      ||.|..  . |      . |. |. . . ||    .  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLT
. | ..|  |...|.|. ..| |||||||||  |||..  |.||..|||||| |||| ..||. ||| |||||||| ||. | |.|||||||||| ||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

QKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPY---NNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
  | .|| |.|||. ..|. ||||.|. ||. ....    ..| ..|      ||..| |  ||   ||| . .|  | .|... . ||..||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTA-ASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK11a.AA CDK5 438-723 41 1.4e-119 379.68 In-house 1-287 (287) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-287/287
Sequence Identity: 41% (121 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
.. ...| |||||.||.|..|.| ||||||| ... | || | | .|||  .   .|.|||    ..   .  |. .|  ..  |||  |. ..    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELL-TQKP
 .| .| |||.|.   |.. .||||||  ||| .  |.|| .|||||| .| | . |.  |||||||.|  |.|.| ||| .||||.|||| |.  . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK--KMTFSEHPYNN-LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|||| .. ||  ..|| .|||.|  ||. ..||  |     .  .| .  . .     |. .| ||..| | . |  ||||...|.| ||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK11a.AA CRK7 438-723 36 3e-109 369.27 In-house 1-343 (343) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-343/343
Sequence Identity: 36% (126 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE---KEGFPITSLREINTILKAQHPNIVTVREIVVG------SNMDK--IYIVMNYVEHDLKSL
.. .. | ||||| || ||.|.| |.||||...|. |   |||||||. |||      .|.|||. .|||.       .. .|  .| |  |. |||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

METM-KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPL--KAYTPVVVTLWYRAPELLLGAKEY--------
.|    . | ....| .| ||| |.  .|.. .||||.| ||.|.   |..|  |||||| | |    . ||  |.|||||.||||||...|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLR
                               ...||||.|||.|||.|.||.|.|. |..|. |..|  |.|    ||   .||  . |         ||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

KRFGA-----LLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
. |       ... . .||. | |.. |  |..||. | |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK11a.AA S_TKc 438-723 27 4.7e-95 323.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEH---DLKSLMETMKQP-
.. |. | .|..|.||....|||..|||.|..|         .. .|||.   | .|||||.  .. .    |..|.|| |...   ||..... .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST-AVDMWSVGCIF
    | . ... .| |........|...|.||||| .|.||..   .|..||||||..       | ...|.||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLK-------HE
 |.|. .|.||      |....|| .|                                     |... |...| |.. | .|..| . |.       |.
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase CDK11a.AA CDK4 438-723 41 3.8e-92 312.43 In-house 1-290 (290) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-290/290
Sequence Identity: 41% (124 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE--GFPITSLREINTILK----AQHPNIVTVREIVVGSNMDK----IYIVMNYVEHDLKSLM
.||.. | || || |||| | .|  .||||. .   . |  | |.  .||| ....      |||||   ..   .  |     | .|.  .. ||. ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREI-SVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

ETMKQPFLPGE-VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGC
. . .| .| . .| .| ||||||  || . | |||||  |.|..  | .|  ||||||.|..   | ||||||||||||| || .  | | ||||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|| |.   .|||.|.|| ||  |.|.  |.| |. ||  . ||      |      .... |   .. || ||..| |.| . .|.||. .|.| ||
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKD-FCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK11a.AA PFTAIRE 438-723 40 1.3e-88 300.68 In-house 1-287 (287) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-287/287
Sequence Identity: 40% (116 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
.. |..  ||.|  ||... . .  .||||  ....| || | |  ||       .| |||.   |.         .|  ||. ||.  |.       | 
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKET--LTFVFEYVHTDLCQYMDKHPGGMHPN

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
 |.  . |||||    |   .||||||  |||.||.| ||  ||||||    | . |   ||||||| |  |||. |||| .||| ||||| |... .|.
NVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPA

FPGK-SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS--EHPYNNLRKRFGALL-SDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|||     || .|.|| |||| |  ||| ..||  |.  |    .   .|.. .  ..   ...|||.|.| ..|  |.||.. ..|.||
FPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK11a.AA Pkinase 438-723 31 5.9e-88 303.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR--EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM-----
.... .| .|..|.||....|.| .|||.|..| ..||.....| .|  ||   .. .|||||. ....     |.||.|| |.|..|. .|. .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--KQPF--LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL----KVGDFGLAREY-GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDM
  . .|   . |.|  | |.|||....|...|.||||| .|.|... | .    |..|||||. .   .   .| ...|.||.|||...|...|...|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCIFGELLTQKPLFPGK----SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG
||.|||. |.|. .|.|||.    . .||. ......|.| .  ||  .. .  .  .. . .    ...|  ..|. . |.... |.. | .|..||. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHEYF
|.|..|
LQHPWF
Kinase CDK11a.AA Pkinase_Tyr 446-623 30 2.3e-15 52.69 Pfam 9-199 (270) Show / Hide 
Range on Protein: 446-623
Range on HMM: 9-199/270
Sequence Identity: 30% (61 aa)

EGTYGVVYRAKDK----KTDEIVALKRL---KMEKE--KEGFPITSLREINTILKA-QHPNIVTVREIVV--GS-NMDKIYIVMNYVEH-DLKSLMETM-
|| .|.||... |    .|.  || | |    |...  .| |    .||...  .  .|||||    ...  |  |  .||||| |..| ||..   .  
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR

--KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTL-------WYRAPELLLGAKEYSTAVDM
  |||. . .     .|  .|  .|... . |||| . | |... .. |..||||||      . |  ....        |. ||| .   | ..|. | 
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDV

WS
||
WS
Kinase CDK11a.AA TyrKc 438-723 22 2.3e-13 -6.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 438-723
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKA--QHPNIVTVREIVVGS-----NMDKIYIVMNYVEH-DLKSLMET
 . .  . || .|.||... |   . || | || .. .| |    .||..   |   .|||||    ... .       . ..||| |..| |||.    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP------LKAYTP-----VV--VTLWYRAPELLLGAKEYS
 .  . . .    ..|  .|  .||.. . |||| . | |... .. |..||||.|. ..        . |..         . .   ||| .   ....
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TAVDMWSVGCIFGELLTQ-KPLFPG-----KSEIDQINKVFKDLGTPSEKI----WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTY
|. | || |    |..|  ..  ||     .| .. |..| .    |  .                               |    .|  ...| .   .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQIMKQCWHE

FPGRRISAEDGLKHEYF
 |  | . ..   ||.|
DPEDRPTFSEI--HECF