Gene PHKg2 (Human)

PHKg2

Species: Human
Alias: PHKg2, PHKG2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 22q13/16p11.2 (conflict),

Classification

Group: CAMK
Family: PHK

Sequence

Name Sequence Type Origin Length Description Download
PHKg2.NA RNA Sugen Kinome 1571 None Fasta, JSON
PHKg2.AA Protein Sugen Kinome 406 None Fasta, JSON
PHKg2.kin_dom Protein Kinase Domain Sugen Kinome 268 None Fasta, JSON

Protein domain

Protein domains of PHKg2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PHKg2.AA PHK 24-291 70 2.1e-238 798.27 In-house 1-273 (273) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-273/273
Sequence Identity: 70% (193 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVT-AERLSPEQLEEVREATRRETHILRQVA---GHPHIITLIDSYESSSFMFLVFDLMRKGELFDYL
|.||...||||||.||||.|..||.||||||...| .|..|....|..|||||.|.||||||.   |||.||.|.|.||..||||||||.|..|||||||
YEPKEILGRGVSSTVRRCIHKNTGQEFAVKIIDITGTEHQSENEAEHMREATRQEIHILRQVMEGEGHPNIIQLHDFYETNSFMFLVFDMMPRGELFDYL

TEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMD-ETHPGYGKEVDLWA
||||.||||.||.|||.|.|.|...||.|||||||||||||.||||.|..|||||.|.|..|||||||||||||||||..||||. |.|||||.|||.||
TEKVTLSEKKTRRIMRQLFEGVCYMHAHNIVHRDLKPENILCDDNMNIKISDFGFACQLQEGEKLRELCGTPGYLAPEMIKCSMYLENHPGYGQEVDMWA

CGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFF
||||..|||||.||||||.|..||||||||.|||.||||||.|.|.|||||..|||||..|.|||..||||||
CGVIMYTLLAGCPPFWHRKQMMMLRMIMEGKYQFGSPEWDDISDTPKDLISKCLQVDPQQRITAEECLQHPFF
Kinase PHKg2.AA CAMK 29-291 28 1.4e-124 403.57 In-house 1-425 (425) Show / Hide 
Range on Protein: 29-291
Range on HMM: 1-425/425
Sequence Identity: 28% (119 aa)

VIGRGVSSVVRRCVHRATG------------HEFAVKIMEVTAERLSP--------------------EQLEEVREATRRETHILRQVAG------HPHI
..|||  ..|..|.|. |.            ...|.||.. .  . .                     .. .. |.  ||| .|.... |      ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLIDSYESSSF-------------------MFLVF---DLMRKGEL----FDYLTEK---------------VALSEKETRSIMRSLLEAVSFLHANNI
| |.. ||....                   |..|.   ...  |||    |||..|.                 ..|.|.| ..| ...|| ..| .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILLDDNM-----------------QIRLSDFGFSCHLEP------------------------GEKLRELCGTPGYLA-PEIL----KCSM
|||||||||||||||.                 .| ..||||.....|                        |.|... ||||.| | ||.|    .|.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----DETHPGYGKEVDLWACGVILFTLLAGSPPFWHR-------------RQILMLRMIMEGQYQFSSPE------------WDDRSST--------VKD
    ||..|.||...| |.|||||...| | |||..               .  ....||.|.|.| .|.            ||| |          .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRLLQVDPEARLTAEQALQHPFF
||...|||||| |.|.||.|.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PHKg2.AA CAMK1 24-291 38 1.5e-119 349.21 In-house 1-276 (276) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-276/276
Sequence Identity: 38% (109 aa)

YDPKDVIGRGVSSVVRRCVHRAT---GHEFAVKIME-VTAERLSPEQLEEVREATRRETHILRQV--AGHPHIITLIDSYESSSFMFLVFDLMRKGELFD
|  ...||||  |.|..|.|. |   |...|.|...  ..   . .|  . .|| ..|  |...|    ||.|| ... ||| ..  || .|.  |||||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ--K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

YLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDN---MQIR--LSDFGFSCHLEPGE-KLRELCGTPGYLAPEILKC-SMDETHPGY
   ||   .||. | ||. .|.|| ..|...||||||||||.|. |.   ..|.  ..||| |  ....| ..   |||||| |||.|.| .      .|
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK----DKPY

GKEVDLWACGVILFTLLAGSPPFWHRR-QILMLRMIMEGQYQFSSPEWDDRSST-VKDLISRLLQVDPEARLTAEQALQHPFF
.|..|.| .|||...|| | |||.  . .  ....|....| | ||.||. |.  .||.|. .| |||. |.|.||.|.||..
DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PHKg2.AA Pkinase 24-291 31 2.3e-111 381.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKG----ELFDYL
|  . .||.| ...|..|.|. ||...||||...   . ....... | .  .| .|.. . .||.|..|.|..|... . .|......|    .||||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

T--EKVAL--SEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQI----RLSDFGFSCH--LEPGEKLRELCGTPGYLAPEILKCSMDETHPG
.  .. ..  ||.| ...|. .|... ..|...|.||||||||||.|.|..|    ...|||....  . ... .  .||||.|.|||...     ....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQY

YGKEVDLWACGVILFTLLAGSPPFWHR------RQILMLRMIMEGQYQFSSPEWDDRS-----------------STVKDLISRLLQVDPEARLTAEQAL
||..|| |.||.||. .| | |||...      .|. |...||.... |..|.|...|                 .. ||.|...|..||. |.||||.|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

QHPFF
|||.|
QHPWF
Kinase PHKg2.AA S_TKc 24-291 33 6e-107 362.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-231/231
Sequence Identity: 33% (96 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRK--GELFDYLTE
|.  ..||.|  ..|..|.|. ||...|.||.                | .|||  ||..  .||.|..|.|.... .....|....    |.||||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

KVA------LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGK-EV
.        ..| ..|..|. ...|. ..| ..|.||||||||||||.  .| ..|||....|      . .|||| |.|||.|         |||| ..
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---------GYGKCKC

DLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQ-------HPFF
| |.||.||. .|.| |||.   . .|...|.              |. .||.|...||.||| |.|| .|||       ||.|
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PHKg2.AA CAMKL 24-291 33 6.8e-90 287.06 In-house 1-297 (297) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-297/297
Sequence Identity: 33% (104 aa)

YDPKDVIGRGVSSVVRRCVH-RATGHEFAVKIMEVTAERLSPEQL--------EEVREATRRETHILRQV-AG-HPHIITLIDSYESSSF------MFLV
|.  ...|.|  ..|. ..| | ||.. |.||..    .. |  .        | .    ||| .|....  | ||.|| | . .| ...      ..||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FDLMRKGE--LFDYLTEK----VALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNM--QIRLSDFGFSCHLEP-----GEKLRELCGTPGY
  .   ||  ||||. ..      ..|.|.| . | ...||...| ..|||||.||||||||.|.  .| ..||||| . .|     |.||.. ||.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LAPEILKCSMDET-HPGYGKEVDLWACGVILFTLLAGSPPFWHR--------RQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQ
 ||||..     .  | .|..|| |.|||||.... |  ||            . .....||.| |..  | | . |  ..|||...|||.|| | |..|
MAPEIFQG----NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYP--PIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

ALQHPFF
 ..||..
IMNHPWM
Kinase PHKg2.AA Ciliate-E2a 24-291 34 7.1e-88 258.75 In-house 1-275 (275) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-275/275
Sequence Identity: 34% (99 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV
|. ...|| |   .|.   |. || .||.|. .  . . . .. |..     .|  |.||.  ||.|| |.. ||. .  .||...   |||.|.. .. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYF----MNEINIMRQL-DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCK

ALSEK--ETRSIMRSLL-EAVSFLHANNIVHRDLKPENILLD---DN----MQIRLSDFGFSCHL--EPGEKLRELCGTPGYLAPEILKCSMDE-THPGY
 . |.  | ..||. || .... .| .||.||||||||||..    |     .| ..|||..       ....   ||||||.|||.|. . .. .|. |
RFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLN-NKEVLKHKQY

GKEVDLWACGVILFTLLAGSPPFWH--RRQILMLRMIMEGQYQFSSPE-WDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFF
.. .|.| ||||...|| |.|||     ..|  | .. . ...|..|| | . |.  |||....|..||. |.||.|||.||.|
DTKCDMWSCGVIFYILLCGKPPFKGKTYNEI--LQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase PHKg2.AA RSK 26-291 32 1.5e-83 283.85 In-house 1-278 (278) Show / Hide 
Range on Protein: 26-291
Range on HMM: 1-278/278
Sequence Identity: 32% (92 aa)

PKDV--IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV
 |.   .| |  ...|.|.|..||...|.|. .    . .        . |..|  ||  . .|| |.|| ....  .  .|. ...| ||||. | ...
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD----TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEK

A---LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDD---NMQIRLSDFGFSCH--LEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVD
    .||.| . .|. .  ||..||   |.||||||||||.||   .  |.|.||||..   .. ....   |.|  |.|||.||        |..| .|
HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACD

LWACGVILFTLLAGSPPFWH---RRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----AEQALQHPFF
.|  ||.....|.| ||| .     .   .. |..|.. ...|.|.  | . ||||...|..||. ||.     ||. .|||.|
WWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PHKg2.AA CAMK-Unique 24-291 25 8.7e-81 266.39 In-house 1-363 (363) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-363/363
Sequence Identity: 25% (94 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEV-TAERLSPEQ-----------LEEVREATRRETHILRQVAGHPHIITLIDS----YESSS------
|.   .|| |  ..|..|  |.|| ..|.|. .  |... .  |           .      ..||  |.. | .||.|| | |     .. .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMV-DHPNIIKLYDWNNPIFCDRKYPLCDL

---------FMFLVFDLMRKGELFDYLTE--------------------KVALSE--KETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQ----
          |..| ..  .|.|||.. .                    .  .||   .|..||..||.||...| ..|||||||.|||..  . .    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

------------IRLSDFGFSCHLEPGEKLR---ELCGTPGYLAPEILKC------SMDET--HPGYGKEV----DLWACGVILFTLLAGSPPFWHRRQI
            | |.||| .||..  ..     . |||| |.|||| .|      . ||.   ..|.  .    |.|..|||....| |.||| .    
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------LMLRMIMEGQY-QFSSPEWDD---RSSTVKDLISRLLQVDPEARLTAEQALQHPFF
          .. |. |.|  |... |..    |   ||.. ....|||  |..|...|.|...
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase PHKg2.AA CDPK 87-291 42 7e-79 241.6 In-house 60-271 (271) Show / Hide 
Range on Protein: 87-291
Range on HMM: 60-271/271
Sequence Identity: 42% (92 aa)

HPHIITLIDSYESSSFMFLVFD--LMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD---DNM----QIRLSDFGFSCH
||.|| .   |. . . ..|.   .   |||||| .||  ..|||...||| .| ||.  | ||||||||||||||.|   |.     .| . |.| |. 
HPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKK

LEP-----GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLL
 ..     ..|... |||| |.|||.|. . .|       ..|.| |||||..|| |.|||. . .   . ....|.|.|  ||||. |.  ||||...|
FDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNE-------KCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKML

QVDPEARLTAEQALQHPFF
..||. |..|.|||||| |
CYDPKKRMSAQQALQHPWF
Kinase PHKg2.AA Ciliate-E2 24-291 26 1.3e-78 267.45 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFA----------------VKIMEVTAERLSPEQLEEVREATRRETHILR---------------QVAGHPHIIT
|.   .||.|  ..|..| .. ....||                |||...  ..... |.|..     .| ||.|               .   ||.|| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIK----QEIHIMREINCFYKKINEKNILEQLNHPNIIK

LIDSYE--SSSFMFLVFDLMRKGELFDYLTEK-----------VALSEKETRSIMRSLLE---------------AVSFLHANN-IVHRDLKPENILLDD
......  . . ..||...   |.||||. ..             ..||| . ||. .|.               |. .|| .| |.|||.||||||.  
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

NMQIRLSDFGF--SCHLEPGEKL----RE--------------------------LCGTPGYLAPEILK-CSMD--ETHPGYGKEVDLWACGVILFTLLA
   | ..|||.   .. .  ...    ..                          .||||||.|||||.  . |  ... ||....|.|..||||. .| 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GSPPFWHRRQILMLRMIMEGQYQFSSPE--------------WDDRSSTVKDLISR----LLQVDPEARLT-AEQALQHPFF
| |||        .. |......|..||              |.. |  .||||..    .||.||| |.| .||.|.||.|
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PHKg2.AA RSK 24-291 32 2.2e-74 253.45 In-house 1-271 (271) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-271/271
Sequence Identity: 32% (93 aa)

YDPKDVIGRGVSS---VVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
|. . .||.|  |   |...|.|..|....|.|| .  .   .          .  |  ||| .  || |..| .....    ... |.|| |.||| | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR------VCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLL

EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDN----MQIRLSDFGFSCHLEPGEK-LRELCGTPGYLAPEILKCSMDETHPGYGKEVD
 .. .||.| . .|. .. |. .||   ||||||||||||.||       |.. ||||.  |   .. |   |.|  |.|||.||        |... .|
KQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLK------RQGHDQACD

LWACGVILFTLLAGSPPFWHR---RQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTA-----EQALQHPFF
 |  ||.... |.| .|| ..   .   ..  | .|.. .... ||  | . |||....| .||. ||.|     ||..|||.|
WWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase PHKg2.AA TyrKc 24-291 20 2.7e-13 -7.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-291
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQV-AGHPHIITLIDSYESS-------SFMFLVFDLMRKGEL
   ....|.|   .|.... .    . ||| .   |           ||. .||  |....   ||.|. |.    ..         ...|. .| .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

FDYLTEKVA-LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPG-------EKLRELC--GTPG-----YLAPEILK
 ||| ..   |. |.  |..    .  ..|| .|..||||   |.|...| ... |||| |  .. .       .  |     |. .      .||| . 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

CSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWH-----RRQILMLRMIMEGQYQFSSPE------WDDRSSTVKDLISRLLQVDPEARLTAEQALQH
      .  .  . | |. || .. ..  | .| .         . ... ...| .    |.          .   . ....  . ||| | | ..   |
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--H

PFF
 .|
ECF
Kinase PHKg2.AA Pkinase_Tyr 76-173 28 1.5e-07 26.19 Pfam 52-156 (270) Show / Hide 
Range on Protein: 76-173
Range on HMM: 52-156/270
Sequence Identity: 28% (30 aa)

RETHILRQVAGHPHIITLIDSYE-SSSF--MFLVFDLMRKGELFDYLTE----KVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIR
||  |..|   ||.|. |.      .    ...|. .| .| | ||| .    | .|. |.  .. .   .. ..|...|..||||   |.|...|....
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LSDFG
 .|||
ICDFG
Kinase PHKg2.AA CDPK 24-54 39 1e-06 16.88 In-house 1-33 (271) Show / Hide 
Range on Protein: 24-54
Range on HMM: 1-33/271
Sequence Identity: 39% (13 aa)

YDPKDVIGRGVSSVVRRCVHR-ATGHEF-AVKI
|. |.|.|.|  ..||...|. .|. |  |.||
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKI