Gene PDK1 (Human)

PDK1

Species: Human
Alias: MGC35290, PRO0461, PkB-like, PDK1, PkB-like 1, PDPK1, MGC20087
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 16p13.3,

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
PDK1.NA RNA Sugen Kinome 7254 None Fasta, JSON
PDK1.AA Protein Sugen Kinome 556 None Fasta, JSON
PDK1.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of PDK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PDK1.AA PDK1 82-342 55 9.5e-217 671.25 In-house 1-307 (307) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-307/307
Sequence Identity: 55% (171 aa)

FKFGKILGEGSFSTVVLARELAT----SREYAIKILEKRHIIKENKVPYVTRERDVMSRLD-----HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR
|.|||..||||.|||.|||| .|    ...|||||.|||.||.|.||.||.||...|..|.     ||..|||||||||...|||.|.|..||.||.|..
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

K--IGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTA---KVLSP---------------ESK---------QARANSFV
|  .||||..|.|||.|||..|||.||..||||||||||||||..||||.|||||||   |.|..               ..|         |.|..|||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG-----NEYLIFQKIIKLEYDFPEK--FFPKARDLVEKLLVLDATKRLG-CEEMEGYGP
|||.||||||||.|....|.|.|||||||||.|||.||||.      |||..||||.|..||||..  |.|.|.|||.||||.|...||. |.|..|| .
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQ

LKAHPFF
.||||||
IKAHPFF
Kinase PDK1.AA AGC 82-342 31 1.7e-161 421.28 In-house 1-395 (395) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-395/395
Sequence Identity: 31% (127 aa)

FKFGKILGEGSFSTVVLAREL------ATSREYAIKILEKRH---IIKENKVPYVTRE------------RDVMSRLD----------HPFFVK-LYFTF
|.| |..|.|||..| |.|.       .| . ||.|.|.|.|   |.|.|.| .. .|            |.......          ||| || |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDEK--LYFGLSYAK---------NG-ELLKYIR---KIGSFDETCTRFYTAE-------IVSALEYLHG-KGIIHRD-LKPENILLNEDMHIQITDFG
||...  ||| . |..          | ||. ...   | |.||| ..|||.||       ||.||||||  .|||||| ||||||||.|| || .||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKVLSPES------------------------------------------------KQARANSFVG--TAQYVSPELLTEKSACKSSDLWA--LGCIIY
 .|..  .                                                 |..|...|.|  |..|..|| |      |. | |.  |||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QLVAGLPPFRAGN----------EYLIFQKII--------KLEYDFP--------EKFFPKARDLVEKLLVLDATKRLGC--EEME--GYGPLKAHPFF
....|.|||.. |          .. .||||.        |....||        ..| | |.||..|||. | .|||||  . ..  |.  .|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PDK1.AA S_TKc 82-342 36 2.1e-99 337.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-231/231
Sequence Identity: 36% (99 aa)

FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKN--GELLKYIRKIGS---
.......|.|.|..| ..|.  | |..||||.             . ||...... .||. |||| .||| ..||. . |. .  |.|..||.| |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACK-SSDLWALGCII
   |.|  .|||...|..||||.| .||||||||||||||.|  || |.||| |..|         ..|.||  |..||.|   .  | ..| |..|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEG-YGPLKAHPFF
| ...| |||.  .....|.||            | |.|...|.|. | .||... |        |.||.|
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDK1.AA AktR 82-342 42 1.8e-95 323.51 In-house 1-268 (268) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-268/268
Sequence Identity: 42% (114 aa)

FKFGKILGEGSFSTVVLAREL-ATSREYAIKILEKRHIIKENKVPYVTRERDVMS-RLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDE
|.. |.||.| |..|.|....  . . ||.|.. | .||..|.  .. .||..|    .|||.|||...||..|||.| ..| ..|||. ...|.. |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

TCTRFYTAEIVSALEYLHGK-GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE-KSACKSSDLWALGCIIYQLVA
  .||| |.|. |||||| .  || |||||||||| || |. ||||| .| .  ...  .|.||.|| .|..|| .|. |   ||.|.||.|. || .|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GLPPFRAGNEYLIFQKIIKLE---YDFPEKFFPKARDLVE-KLLVLDATKRLG--CEEMEGYGPLKAHPFF
|.||| ..|   .||||.. .    ..|..| ....||.. |||  . .||||  |.  |    .| ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEE---IKSHPWF
Kinase PDK1.AA PKA 82-342 41 2.8e-91 309.57 In-house 1-263 (263) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-263/263
Sequence Identity: 41% (112 aa)

FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFV-KLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
|.. . || ||| .| |.|.  . . ||.|.| |. |.... |  |  |. ... ..||| | |.|.||||| .||. . |.  ||. .|.|| |.|.. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

CTRFYTA-EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK-SACKSSDLWALGCIIYQLVAG
 ..|| | .||.|||||| . ||.|||||||||.... ||.||||| || .    .  |  .  || .|  || .. |    || | ||||..|| ..||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKV----DD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAG

LPPFRAG--NEYLIFQKIIKLEYDFPEKFFPKA---RDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFF
 |||..   .   |..||.. ...||. | ..|   .||..|||. | |||.|. .  |    | |..|
YPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKN-GVNDIKNHKWF
Kinase PDK1.AA Akt 82-342 39 1.2e-85 273.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-264/264
Sequence Identity: 39% (107 aa)

FKFGKILGEGSFSTVVLARELATSREY-AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
| | |.|| |||  |.|... .| . | |.|.| |..||. |.| ..  || .  . .||| |.|.. ||. .|||| . |.. |||  .... . |.| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

CTRFYTAEIVSALEYLHGKGIIHRD-LKPENILLNEDMHIQITDFGTAK--VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA-LGCIIYQLV
 .||| |||..|.|.|| |.|| || |||||||. .| || .|||| .|  ...    . ....| ||. | .|| |  . . |..| |. |||..| . 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKD---HDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

AGLPPFRAGNEYLIFQKIIKLEYDFP--EKFFPKARDLVEKLLVLDATKRLG-----CEEMEGYGPLKAHPFF
 |.||| . .    |.||   .. ||  ... |...||...||  | .||||      .|      .|.||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQE------IKRHPWF
Kinase PDK1.AA CAMK 87-342 23 2e-85 275.16 In-house 1-425 (425) Show / Hide 
Range on Protein: 87-342
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

ILGEGSFSTVVLARELATS------------REYAIKILEKRHIIK-------------------------ENKVPYVTRERDVMSR-------LDHPFF
.||.|||..| |...  |             ...||||..|. . .                         ...   | || ..|..       ||||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYFTFQD-------------------DEKLYFGL---SYAKNGEL----LKYIRKIGS---------------FDETCTRFYTAEIVSALEYLHGKGI
.||| ...|                   |...|. .    |. .|||    . ||.. |.               |.|  .|.|   |.||..|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENILLNEDM-----------------HIQITDFGTAKVLSPESKQA---------------------RANSFVGTAQYVS-PELLTEKS----
.|||||||||||....                  | |.||| |... | ...                        . |.||  |.. ||.|  |.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------ACKSSDLWALGCIIYQLVAGLPPFRAG-------------NEYLIFQKIIKLEYDFPEKFFPK------------------------ARD
            ...| |..|.| | .. | |||..              |.| .|.||.| .||||...|..                        ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVEKLLVLDATKRLGCEEMEGYGPLKAHPFF
|. |.|. | .||. .|.       ..||..
LIRKMLQVDPEKRMTIEQ------CLNHPWM
Kinase PDK1.AA SGK 82-342 35 2.8e-85 263.26 In-house 1-283 (283) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

FKFGKILGEGSFSTVVLARELAT------------------SREYAIKILEKRHII-------KENKVPYVTRER-DVMSRLDHPFFVKLYFTFQDDEKL
|.| |..|.|||  | ...  ..                     ||.|.| | |||       | ... ... || .... . ||| |.| . || ..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT
|| . |.  ||.  .... ..| |   |||.||||.|||||| . ||.||||||||||  . |. .|||| .|    ...     .| ||  |  || | 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTF--TFCGTPEYLAPEVLR

EKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFF
 .   .. | | |||. | .  |||||   |  . ...||. .  .|  . ..|.|| . ||  | .||||    .. .  | ||||
KQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK--RDFMEIKNHPFF
Kinase PDK1.AA Pkinase 82-342 29 5e-84 290.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT-RERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNG----ELLKYIR--KI
...|...|.|||..| ....  |....|.||..|||. .. ..  .  .|  .| ||.||. |.|| .|.|. ..|. . |. .|    .|  ||.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWA
|.|  .|   .||  .|...|||.| .|||||||||||||.....||     |.||| ||... . ..  ...|.||  |..||..   .   ...| |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCIIYQLVAGLPPFRAG------NEYLIFQKIIKLEYDFPEKFF---------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHP
.|||.|... | |||.        ... ....| . ...|..                        . ..|.....| .| .||...|.      .. ||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ------ILQHP

FF
.|
WF
Kinase PDK1.AA RSK 84-342 34 9.4e-81 274.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 84-342
Range on HMM: 1-278/278
Sequence Identity: 34% (97 aa)

FGKI--LGEGSFSTVVLARELATSREYAIKILEKRHIIKENK-VPYVTRERDVMSRLD-HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGS---
      .| |.....   .  .| ..|| |.|.|. |.. .| . .. .||....|   ||| |.|. .||...|||  . | . |||.. ..| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT--EKSAC---KSSDLWAL
|.|.  .|| ||||.|.|.|| .|||||||||||||...   . || .|||| .| .... .| ....|..|..|. ||.|.  .   .   |. |.| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQ-WTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GCIIYQLVAGLPPFRA---GNEYLIFQKIIKLE--YDFP--EKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFF
|...| . .| |||..    |   |...| | .   ..|  ..  . |.||. |.|  |  |||||  . .   .|.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ-DAEEIKQHPWF
Kinase PDK1.AA RSK-Unclassified 82-342 35 5.3e-80 250.89 In-house 1-283 (283) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-283/283
Sequence Identity: 35% (101 aa)

FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR--KIGSFDE
|   . .| |.|  | | |.  | . ||.|.|.|  .|. ||. ||  |...|.  .||| |.||. ||   .||  . |   |.. .     |   | |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

TCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL----SPESK---------------QARANSFVGTAQYVSPELLTEKSAC
   ||| .|.. |||||| ...| |||||.||.|  . |.  |||.  .       |  |                 |.|||.||  |. ||..      
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFP--EKFFPKARDLVEKLLVLDATKRLGCEEMEG-YGPLKAHPFF
|  | | || ..| .  |.||... |.  .|. | | .  ||  .    ..|||. |||     |||||    |     |.||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCK--MGDADDIKRHPFF
Kinase PDK1.AA Ciliate-E2 82-342 24 1.6e-76 260.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

FKFGKILGEGSFSTVVLARELATSR-----------------------EYAIKILEKRHIIKENKVPYVTRERD----------VMSRLDHPFFVKLYFT
.|| |..|.|.|..| ...   . .                       .||.||..|. |.  ... .. || .          ....|.||. .|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DDEKLYFGLSYAKNGELLKYIR-------------------KIGSFDETCTR-------FYTAEIVSALEYLHGKG-IIHRDLKPENILLNEDMHI
||  ||...|. . |.. |.|..||.                   .|. . .  ..       || |.|..|||||| |. |||||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

QITDFGTAK---------------VLSPESK---------------QARANSFVGTAQYVSPELLTEKSAC---------KSSDLWALGCIIYQLVAGLP
 |.|||..|                . .. |               |  .|...||. |..|| |  |.           ...|.|.||.|.|... | |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFRAGNEYLIFQKIIKLEYDFPEKFF------------------PKARDLVEK----LLVLDATKRLGCEEMEGYGPLKAHPFF
||        .|.|.. ..|||....                  ... ||  |    .|. |  ||..     |.  .. ||.|
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-----GWEQILNHPWF
Kinase PDK1.AA Pkinase_Tyr 82-225 31 2.3e-13 45.87 Pfam 1-156 (270) Show / Hide 
Range on Protein: 82-225
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FKFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRHIIKEN-KVPYVTRERDVMSRL-DHPFFVKLYFTFQ-DDEK--LYFGLSYAKNGELLKYIR
 .||| ||||.| .|....       |  . |.|.| | .  .|. .     ||  .|. | .||  |.||     ..|   .|  . |...| ||.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----IGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG
|     ....      . ..| ...|||. |..|||||   |.|..|.... |.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PDK1.AA TyrKc 82-342 20 2.3e-13 -6.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 82-342
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--DHPFFVKLYFTFQDD-------EKLYFGLSYAKNGELLKYIR
 ..||.|||| | .|....     .. |.| | . .      .    ||  .|..|  .||  |.||    ..       | |.  . |...| |..|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KIGS-FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPE------SKQARA----NS-FVGTAQYVSPELLTEKSAC
| .  .       .   | .  |||| |..|||||   |.|..|. .. |.||| .. .  .      ..  |.    .. ..      .|| . ..   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSSDLWALGCIIYQLV--AGLPPFR-----AGNEYLIFQKIIKLEYDFPEK--------FFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFF
  || |. |  .. .    . |.         |. .| .       . |.           ..  .. ..    |. .|   .|         | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------HECF
PDK1_PH PDK1.AA PDK1_PH 446-545 57 7.7e-65 221.72 In-house 1-112 (112) Show / Hide 
Range on Protein: 446-545
Range on HMM: 1-112/112
Sequence Identity: 57% (64 aa)

NPWHQFV--ENNLILKMGPVDKRKGLFA----RRRQLLLTEGPHLYYVDPVNKVLKGEIPWS-QELRPEAK-----NFKTFFVHTPNRTYYLMDPSGNAH
.|||||.  |...|||.| |.|||||||    .||||.||.||.|.||||...|.||||||| ..|..|.|     |||.||.||||||||..|| |.|.
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

KWCRKIQEVWRQ
|||..|..|...
KWCEAIEKVCKR