Gene PDHK1 (Human)
PDHK1
Sequence
Protein domains of PDHK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| BCDHK_Adom3 | PDHK1.AA | BCDHK_Adom3 | 55-221 | 37 | 7.7e-85 | 292.95 | Pfam | 1-199 (199) | Show / Hide |
Range on Protein: 55-221 Range on HMM: 1-199/199 Sequence Identity: 37% (77 aa) SPLSMKQFLDFGSVNACEKT---SFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLD-F---------------KDKSAED---- .|||..|...||. |.|||| |..|...|||.|||....|. .||..|...|..|.|..||.||..||. | . |. || TPLSLRQMMQFGRPNPCEKTLFKSAQFCHEELPIRLAHRIRELQNLPYGLNKMPHIQQVYNWYYQSFEELRECFPKPISELKHLRYYEPPPKTLEDWLHD -AKAIYDFTDTVIRIRNRHN-DVIPTMAQGVIEYK-ESFGVDPVTSQ----NVQYFLDRFYMSRISI---RMLLNQHSLLFGGKGKGSPSH---RKHIGS . |.|....|..||. .|.|||||||.|.| ...|.|..... ..||||||||||||.| |||..|| .||. . .| | ...|. YNEK---FCDMLRDIKDRHDRNVVPTMAQGVLEWKCRYYGQDNQPDDLHWFQIQYFLDRFYMSRIGINFIRMLIGQHIALFE-FNYHNPHHFEHPDYVGI INP | . ICT |
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| Kinase | PDHK1.AA | PDHK | 268-392 | 87 | 4.5e-107 | 362.01 | In-house | 1-125 (125) | Show / Hide |
Range on Protein: 268-392 Range on HMM: 1-125/125 Sequence Identity: 87% (109 aa) YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQ |||||||||.|||||||||||.|||.||..||||.|.||||.||||.||||||||||||||||||||||||||||..|||||.|||||||||||.||||. YVPSHLYHMLFELFKNAMRATVEHHENRKIYPPIKVMVTLGKEDLTIKMSDRGGGVPLRKIDRLFNYMYSTAPRPQMETSRAAPLAGFGYGLPICRLYAK YFQGDLKLYSLEGYGTDAVIYIKAL ||||||||||.||||||||||.||| YFQGDLKLYSMEGYGTDAVIYLKAL |
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| Kinase | PDHK1.AA | PDHK | 268-392 | 74 | 4.8e-101 | 341.99 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 268-392 Range on HMM: 1-140/140 Sequence Identity: 74% (104 aa) YVPSHLYHMVFELFKNAMRATMEHHANRG-VYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPR----PRV----------ETSRAVPL |||.|||||.|||||||||||||||..|. .||||.|.|.||.||||.||||||||||.|||||||||||||||| ||. |||||.|. YVPMHLYHMLFELFKNAMRATMEHHEDRPYNYPPIKVMVALGDEDLTIKMSDRGGGVPHRKIDRLFNYMYSTAPRSTQDPRMSPLFGHLDMHETSRAAPM AGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKAL .||||||||.||||.||||||.|||.||||||||||.||| HGFGYGLPICRLYAKYFQGDLQLYSMEGYGTDAVIYLKAL |
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| Kinase | PDHK1.AA | HATPase_c | 268-392 | 25 | 3.3e-22 | 79.54 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 268-392 Range on HMM: 1-120/120 Sequence Identity: 25% (34 aa) YVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPL------RKIDRLFNYMYSTAPRPRVETSRAVPLAG--FGYGL .| .|...| .| ||...| | . | |.|. ...... .| | |.| .|.|.| |.| | || | .|.|| GDPDRLHQVVWNLVDNAIKHTPEG-------GHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD-----SR-RKYGGGLTGLGL PISRLYAQYFQGDLKLYSLEGYGTDAVIYIKAL |.| ... ..|.. . | .| || ..... YICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE |
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| Kinase | PDHK1.AA | HATPase_c | 268-393 | 21 | 2.4e-18 | 68.2 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 268-393 Range on HMM: 1-130/130 Sequence Identity: 21% (30 aa) YVPSHLYHMVFELFKNAMRATMEHHAN----RGVYPPIQVHVTLGNEDLTVKMSDRGGGVPL------RKIDRLFNYMYSTAPRP--RVETSRAVPLAG- | .|.... .| .|| ..| | ||. | . ...|.. .. .| | |.| .|.|.| .|.|.. | . . ||. | GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH----RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGG -FGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALS .|.||.|.. ... ..|.... | ..... LTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER |
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