Gene PDGFRa (Human)

PDGFRa

Species: Human
Alias: PDGFRa, CD140A, PDGFRA, PDGFR2, MGC74795, Rhe-PDGFRA
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q11-q12,

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
PDGFRa.NA RNA Sugen Kinome 6574 None Fasta, JSON
PDGFRa.AA Protein Sugen Kinome 1089 None Fasta, JSON
PDGFRa.kin_dom Protein Kinase Domain Sugen Kinome 358 None Fasta, JSON

Protein domain

Protein domains of PDGFRa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG PDGFRa.AA IG 34-122 9 1.5e-05 25.64 SMART 1-58 (58) Show / Hide 
Range on Protein: 34-122
Range on HMM: 1-58/58
Sequence Identity: 9% (9 aa)

ENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT---GLYTCYYNHTQTEENELEG-RHIYIYVP
    .|.. .. .|.|  . ...|                           |.. .......   | |.|  .       . ..   ....| 
PP-VTVKEGETVTLTC-VS-QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
IGc2 PDGFRa.AA IGc2 40-107 13 0.000464 13.81 SMART 1-56 (56) Show / Hide 
Range on Protein: 40-107
Range on HMM: 1-56/56
Sequence Identity: 13% (10 aa)

QLNSSFSLRCF----GESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT
.   |..|.|.     . ...| .   ... .                 |...... .. |.||||  .   
HEGQSVTLTCPATGNPDPNIHWYK---GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRa.AA IG 135-206 13 0.435916 0.4 SMART 1-58 (58) Show / Hide 
Range on Protein: 135-206
Range on HMM: 1-58/58
Sequence Identity: 13% (11 aa)

DYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTV----------GPYICEATVKGKKFQ--TIPFNVY
   | |   ... ..|  .     ....                   .|.          | | |.|| .|....  ..   |.
PP-VTVKEGETVTLTC-VS----QIWWY-------------------LTINVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IG PDGFRa.AA IG 220-310 18 2.6e-09 38.18 SMART 1-58 (58) Show / Hide 
Range on Protein: 220-310
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

ALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDS---GDYECAARQATREVKEM-KKVTISVH
   .. | |||.. || |       ..|.                          ||. .... ||   |.| |.|.     .... . .|..|.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
IGc2 PDGFRa.AA IGc2 226-297 23 2e-06 28.73 SMART 1-56 (56) Show / Hide 
Range on Protein: 226-297
Range on HMM: 1-56/56
Sequence Identity: 23% (17 aa)

KSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATR
..|.... || . .|.. . .|..     |. .               |||. ..|. ||| |.| || .  
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set PDGFRa.AA I-set 273-293 42 0.125151 8.04 Pfam 58-78 (92) Show / Hide 
Range on Protein: 273-293
Range on HMM: 58-78/92
Sequence Identity: 42% (9 aa)

YTLTVPEATVKDSGDYECAAR
||||. ...  |.| |.| |.
YTLTISNVQPDDEGKYTCVAT
I-set PDGFRa.AA I-set 337-399 26 4e-06 23.21 Pfam 22-80 (92) Show / Hide 
Range on Protein: 337-399
Range on HMM: 22-80/92
Sequence Identity: 26% (17 aa)

VEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIR-YRSKLKLIRAKEEDSGHYTIVAQNE
..|. .||| .||.|..  | .      .|  ....   ....|   ... .|.| ||.||.|.
CQVTGDPPPQVSWFKDGQPLRP-----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS
IG PDGFRa.AA IG 322-414 14 0.000782 19.98 SMART 1-58 (58) Show / Hide 
Range on Protein: 322-414
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

SQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDS---GHYTIVAQNEDAVKSYTF--ELLTQVP
..   |.. |   .   |      .|.|.                            | . ....|||   | |. .|.     ..|.   .   .| 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 PDGFRa.AA IGc2 330-401 21 0.000851 11.29 SMART 1-56 (56) Show / Hide 
Range on Protein: 330-401
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

HEVKHFVVE--VRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDA
||   .. .  ....| | |.|.|   . ..                ... |.. ....||||.|| .|.|.  
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set PDGFRa.AA I-set 435-447 38 0.274957 6.88 Pfam 22-34 (92) Show / Hide 
Range on Protein: 435-447
Range on HMM: 22-34/92
Sequence Identity: 38% (5 aa)

CTAEGTPLPDIEW
|...|.| |...|
CQVTGDPPPQVSW
Kinase PDGFRa.AA PDGFR 593-950 69 2.8e-300 975.69 In-house 1-358 (358) Show / Hide 
Range on Protein: 593-950
Range on HMM: 1-358/358
Sequence Identity: 69% (248 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDS
|..|..|||||||||||.||||||.||.|||||||||||||.||||.|||||||||.|||.|.||||||||||..||||||||||.||||.||||..|.|
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTL
|..|||||||||.......|...|....|....||.||||||......||||||..|.|.||.|.||..|..|.|....|.....|||.|..|.|..||.
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG
 |||.|.||||.||||||||||||||||||||||..||.|||||||||||||.|||||.||...|||||||||||||..|||.|||||||||||||||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
|.|||||.|||.||..||.|||||.|.||..|.||||.|||...|||||.|..|....
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase PDGFRa.AA Pkinase_Tyr 593-950 36 2.2e-157 533.65 Pfam 1-270 (270) Show / Hide 
Range on Protein: 593-950
Range on HMM: 1-270/270
Sequence Identity: 36% (132 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSE--KQALMSELKIMTHLGPHLNIVNLLGACT-KSGP--IYIITEYCFYGDLVNYLH
...|..||.||||.|..||..| . ... ..|||||||..| ...  ....|.|.|||..|| | |||.|.|.|| ...|  |||..||. .||| .||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS
|.|                                                                                              .. 
KHR----------------------------------------------------------------------------------------------EDK

EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY-VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLW
. ||. |||.. .|.|.|||.|.||||.||||||||.|.. ...||||||||||||..|..| ...|.. ||.||||||.|... .|| |||||.|.|.|
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW

EIFSLGGTP-YPGMMVDSTFYNKI-KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
|||..|..| ||||  .. .|..| ..||||..|.... |.|..| .||. .||.||.|  . |. 
EIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase PDGFRa.AA TyrKc 593-950 32 3.1e-143 483.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 593-950
Range on HMM: 1-280/280
Sequence Identity: 32% (128 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG-PHLNIVNLLGACTKS-------GPIYIITEYCFYGDLVN
..||..||.||||.|..||..        ..|||||||. |    ....|.|..||..||  | |||.|.|.||..       .|..|..||. .||| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSD
||.|.|.                                                                                             
YLRKHRPK--------------------------------------------------------------------------------------------

DNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD-------SNYVSK---GSTF-LPVKWMAPESIFDNLYT
     |.. ||||| .|.|.|||.|.||||.||||||||.|.. ...|||.||||.||| .|       . |..|   |. . ||..|||||.|... .|
-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

TLSDVWSYGILLWEIFSLGGTPYPGM----MVDSTFYNKIKSGYRMAKPDH--------ATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
| |||||.|...||||..|..|||||    | ..  ....|.|||| .|..        ...|.|.|| .||. .||.||.|  . |. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PDGFRa.AA TK 593-950 24 2.6e-127 429.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 593-950
Range on HMM: 1-486/486
Sequence Identity: 24% (133 aa)

LVLGRVLGSGAFG---KVVEGTAYGLS--------------------RSQPVMKVAVKMLKPTARSSEKQALM----------------SELKIMTH-LG
..||..||.|.||   .| .|...|..                     .. ...|||||||... .|... ..                .|.|.| | ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHLNIVNLLGACTKS------------GPIYIITEYCFYGD----LVNYLHKNRDSFLS-----------------HHPEKPKKELDIFGLNPADESTRS
 | |||.|.|.||..            .|..|..||. .||    | .||.|.|. |                   ||.                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------------

YVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLS-------------------FTY
                         |   |..     |   .| .. |   .   ...... |..| .. ||. |||.                   . .
-------------------------M---KGD-----I---TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCW

QVARGMEFLASK------NCVHRDLAARNVLLAQGKI-----------VKICDFG--------LARDIMHDSNYVSKG----------------------
|.|.|||.|.||      |.|||||||||.|......           .||.|||        ||||| .|..|..|.                      
QIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQ

--STFLPVKWMAPESIFDNL---------YTTLSDVWSYGILLWEIFSLGGTPYPGMMVD---------STFYNKIKSG--------------YRMAKPD
  .. ||..|||||...|.          .|| |||||.|.|.||||..| .||.|.| .           .......|              .||..|.
QSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPP

HAT--------------SEVYEIMVKCWNSEPEKRPSFYHLSEIV
|..               |.|..| .||. .||.||.|  | |  
HCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PDGFRa.AA TK-Unique 593-950 34 2.9e-115 389.22 In-house 1-294 (294) Show / Hide 
Range on Protein: 593-950
Range on HMM: 1-294/294
Sequence Identity: 34% (129 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVM-KVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSG-PIYIITEYCFYGDLVNYLHKNR
|..|.|.|.|||| |  |.. |.. ..    .|||||||  |.  .||....|...| .||.| |||..||.||||. | .|| ||| .|.| .||...|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

------------DSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEV
            .                                                                                      .
PAMRQHQTYGNLK------------------------------------------------------------------------------------FDF

KNLLSDDNSEGLTLLDLLSFTYQVARGMEFLAS--KNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGS-TFLPVKWMAPESIF--DNLY-
 .  .... | ... ||..| .|.|.|||.|||  |..|||||.||||||. .|..||||||.|||....  |....|   .|..||||||.   .. | 
HHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYH

TTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHA-TSEVYEIMVKCWNSEPEKRPSFYHLSEIV
|| |||||.|.|.||||.||..|||||  .. . ..|. |||| .|.|  . |.|..|  ||..|||.||||  .  . 
TTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase PDGFRa.AA VEGFR 790-950 62 2.6e-106 359.47 In-house 170-332 (332) Show / Hide 
Range on Protein: 790-950
Range on HMM: 170-332/332
Sequence Identity: 62% (102 aa)

LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD-IMHDSNYVSKGS-TFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE
||. ||... .|||||||||||..|.||||||||.||.  ..||||||||||. |  | .|| ||. . || ||||||||||. ||| |||||||..|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
|||||| ||||  .|  |.|..|.|||| .|| .| |.|.||  ||  ||| ||.|  | |. 
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase PDGFRa.AA FGFR 790-953 53 1.5e-85 290.55 In-house 133-293 (293) Show / Hide 
Range on Protein: 790-953
Range on HMM: 133-293/293
Sequence Identity: 53% (88 aa)

LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF
||  || |..||||||||.|||. |.||||||||||   . . ||||||||||| .   |  ..   ||.||||||. ||. ||. |||||||.|||||.
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIM

SLGGTPYPGMM-VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENL
 .||.|||. . |    |   |.|.|| || . ..|.| .|  ||  .|. ||.|    ..|| |
TYGGQPYPHIPSVE-ELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTF---KQLVEYL
Kinase PDGFRa.AA Src 782-950 43 3.9e-74 251.27 In-house 85-255 (255) Show / Hide 
Range on Protein: 782-950
Range on HMM: 85-255/255
Sequence Identity: 43% (75 aa)

LS-DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH--DSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDV
|  |.    | | .|.... |||.||..| |.| .||||||||||  .. ..|..|||||| ..   | .|...    .|.||.||| |  . .|. |||
LKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDV

WSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYE-IMVKCWNSEPEKRPSFYHLSEIV
||.||||.||.. | .|||||.   ..  ... |||| .|..   |.|| || .||...||.|| |  | .  
WSFGILLTEIVTYGRVPYPGMTNHEVL-QQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase PDGFRa.AA Ret 794-952 49 6.7e-73 248.33 In-house 136-293 (293) Show / Hide 
Range on Protein: 794-952
Range on HMM: 136-293/293
Sequence Identity: 49% (78 aa)

DLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGG
...||  |. .|| .|..   |||||||||||.| |.| || |||| ||.  |  || .    .||||||.|| .|. ||| |||||.|.|.|||  .|.
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

TPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN
 ||||   .   ..  | ||||  |.    |.| || .||  ||.|||.|  .|   | 
NPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase PDGFRa.AA UTK 790-950 36 1.5e-68 233.62 In-house 115-296 (296) Show / Hide 
Range on Protein: 790-950
Range on HMM: 115-296/296
Sequence Identity: 36% (66 aa)

LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG-------KIVKICDFG---LARDIMH--------DSNYVSK-GSTFLPVKWMAPESIFDN
||| ..|.. ...||||..|.|...|||||||||.|...         ..||.|||   ..|..          .|.|. . . . .|..|||||.. ..
LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSG-YRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
  .||.|||||.|...|||.. | .|||||  . .. .  . | |||..|..   .||..|..||...|..||.|  | . .
TRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase PDGFRa.AA Fer 786-951 35 2.9e-64 217.74 In-house 103-283 (283) Show / Hide 
Range on Protein: 786-951
Range on HMM: 103-283/283
Sequence Identity: 35% (64 aa)

NSEG-LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK---ICDFGLARDIMHDSNYVSKG--STFLPVKWMAPESIFDNLYTTLSDVW
|..  ... ... ..||.|.|||.| ||||.|||.||||.|. ..|..|   | |||..|.   . .  ...  .. .|..|.|||.. . .|.. .|||
NKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVW

SYGILLWEIFSLGGTPYPG----MMVDST----FYNKIKSGYRMAKPDHATSEVYEIMV-KCWNSEPEKRPSFYHLSEIVE
|.|...||||. | .||||    | .  .      ..||.||.|  |.|. .|...||  .||. .||.||.. .. ....
SFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase PDGFRa.AA Tie 787-950 48 3.2e-64 194.09 In-house 108-267 (267) Show / Hide 
Range on Protein: 787-950
Range on HMM: 108-267/267
Sequence Identity: 48% (80 aa)

SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLW
.  |.   .| |   |||||..|. |.|.||||||||.| ..  . || ||||.|    |  || |    |||.||| ||.    ||| |||||||.|||
ASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLW

EIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIV
|| ||||||| ||   . .|.|.  |||| .|     |||..| .||   | .||.|  .   .
EIVSLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase PDGFRa.AA VEGFR 593-719 44 8.9e-54 184.97 In-house 1-130 (332) Show / Hide 
Range on Protein: 593-719
Range on HMM: 1-130/332
Sequence Identity: 44% (58 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLHKN
| ||..|| ||||.|.|..| |. ....   |||||||..| .||. |||||||...|.| ||| ||.||.|||    ||  .| ||| .| | |||   
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDSFLSHHPEKPKKELDIFGLNPADESTRS
|. |       |. .. . .. |.|.. ..
RMYFVPYPDKSPHMRQRKECMGPQDHQDHK
Kinase PDGFRa.AA Pkinase 593-953 20 2e-41 147.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 593-953
Range on HMM: 1-293/293
Sequence Identity: 20% (84 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQ--ALM-SELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYG----DLVNY
...||..|||.||.| ...  | ..     .|||| .|   ..|.|.  ..  ||..|| .|  | ||| |..... .. ||...|||  |    ||  |
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDD
..                                                                                                 .
IST------------------------------------------------------------------------------------------------W

NSEGL--TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA-QGKI---VKICDFGLARD--IMHDSNYVSKGSTFLPVKWMAPESIF-DNLYTTLS
.. ..  .  .. .. ||..||.|.. |....||||   |.|.  .| |   |||||||||.   . ..| . .   |     .|||| |  .. |.. .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKV

DVWSYGILLWEIFSLGGTPYPGM------MVDSTFYNKIKSGYRMAKPDHAT-------------------SEVYEIMVKCWNSEPEKRPSFYHLSEIVE
|.||.|..|.| .. | .|.||         .  .... .  ..   |   .                   .|  ... .|..  |.|||.     .|..
DMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

N--L
   .
HPWF
Kinase PDGFRa.AA FGFR 593-690 43 4.7e-35 116.9 In-house 1-100 (293) Show / Hide 
Range on Protein: 593-690
Range on HMM: 1-100/293
Sequence Identity: 43% (43 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRS--QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR
|.|| .|| |.||.|. ..| |. ..  .  ..|||||||  .   .   | ||. .|   | | ||.||||.||  || |.| |||  | |  .| ..|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase PDGFRa.AA Ret 593-690 38 6.6e-26 85.44 In-house 1-100 (293) Show / Hide 
Range on Protein: 593-690
Range on HMM: 1-100/293
Sequence Identity: 38% (39 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPT-ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSG--PIYIITEYCFYGDLVNYLHKN
|.|. .|| | ||.|| ..|  .        |||||||   | |||  .| ||. .   .  | ... |.|||. ..  |  .| ||| || |  .|  .
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVN-HPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase PDGFRa.AA Tie 602-690 38 1.5e-25 74.15 In-house 2-87 (267) Show / Hide 
Range on Protein: 602-690
Range on HMM: 2-87/267
Sequence Identity: 38% (34 aa)

GAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR
| ||.|.  .   . .   .|.||.||.|  |   ...  | || .|  .| | ||.||.||| . | .|. .||  || |...| | |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase PDGFRa.AA S_TKc 593-949 16 1.3e-22 82.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 593-949
Range on HMM: 1-231/231
Sequence Identity: 16% (62 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDS
  ..|..|.||||||  ..  .        .||.|..|                                                              
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------------------------------------------------------------

FLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS-------DIQRSLYDRPASYKKKSM----LDS---EV
                                                       |.|..  .        .  . .|     ..  |    .|    ..
----------------------------------------------------EHIRREIQILKKHHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDL

KNLLSDDNSEG----LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTT
. .. . ...|    ..  .  ...||.....|.. |.. .||||   |.|| .   .||||||||| .          .      .|||| .    |..
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-LSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE----------I
  .|.|| |..|.| .. | .|.|    . . ..||.           ..|. ... ||.. .|||||.   . .          .
CKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDGFRa.AA UTK 593-693 34 7.4e-21 68.08 In-house 1-108 (296) Show / Hide 
Range on Protein: 593-693
Range on HMM: 1-108/296
Sequence Identity: 34% (37 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQA----LMSELK---IMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNY
. ||| ||.|||| | ....   |   ..|.|||| ....| .  ...    .| | .   .| ..  | |...|.| ||...|..|.|||.  |||..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHKNRDSF
| ..|...
LRRHRPTP
Kinase PDGFRa.AA Src 593-691 39 1.3e-19 63.23 In-house 1-90 (255) Show / Hide 
Range on Protein: 593-691
Range on HMM: 1-90/255
Sequence Identity: 39% (39 aa)

LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRD
. | | ||.| || | .|.  |       .||||| |||     . .|.  | .||. |  | ..|.|.  |..  ||||.|||   | |  ||.|...
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGE
Kinase PDGFRa.AA Fer 593-691 33 7.9e-16 50.49 In-house 1-105 (283) Show / Hide 
Range on Protein: 593-691
Range on HMM: 1-105/283
Sequence Identity: 33% (35 aa)

LVLGRVLGSGAFGKVVEG----TAYGLSRSQ-PVMKVAVKMLKPTARSSE-KQALMSELKIMTH-LGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNY
 .|| .||.||||.|  |    . .   ... .  .|.||..| .. . | .. .| | .||   .  | |.| . | |.   ||.|. |.|  |.| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LHKNRD
| || .
LKKNKN