Gene PAK1 (Human)

PAK1

Species: Human
Alias: MGC130000, MGC130001, PAKalpha, PAK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 11q13-11q14 ,

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PAK1.NA RNA Sugen Kinome 3484 None Fasta, JSON
PAK1.AA Protein Sugen Kinome 553 None Fasta, JSON
PAK1.kin_dom Protein Kinase Domain Sugen Kinome 248 None Fasta, JSON

Protein domain

Protein domains of PAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK1.AA PBD 74-132 60 2e-31 111.92 Pfam 1-60 (60) Show / Hide 
Range on Protein: 74-132
Range on HMM: 1-60/60
Sequence Identity: 60% (36 aa)

EISLP-SDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYN
.|| | ..|.||.|||.|. ||.|||||..|..|||.|.|.|.|||.|||||.||. ||.
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK1.AA PBD 75-110 52 1.6e-18 68.8 SMART 1-38 (38) Show / Hide 
Range on Protein: 75-110
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISLPS-DFEHTIHVG-FDAVTGEFTGMPEQWARLLQTS
||.|. .|.|..||| .|. ||||||.|.||..||...
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK1.AA PAKA 270-521 71 4e-196 657.84 In-house 1-260 (260) Show / Hide 
Range on Protein: 270-521
Range on HMM: 1-260/260
Sequence Identity: 71% (187 aa)

YTRFEKIGQGASGTVYTAMDVATGQE--VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC------M
|...|||||||||.||.| ...|.||  |||||||...||||||||||||||.|.|..|||||.||||| |||||||||..||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGE
||||||.|||||||.|||.||...|||||||||||||||||||.||||||||.|.||.||.|||||||||||||..|| |..||||||||||||||||||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
||||||.||||.|||||||.|....|.|.|  |.|||..||..||..| ||.|||.   |
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK1.AA STE20 270-517 50 1.3e-163 549.85 In-house 1-284 (288) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-284/288
Sequence Identity: 50% (143 aa)

YTRFEKIGQGASGTVYTAMDVATGQE----VAIKQMNLQQQ----PKKELIINEILVMRENKNPNIVNYLDSYLVG----DELWVVMEYLAGGSLTDVVT
|. .||||||..|.||.| .. ||..    ||||.||| ..    ...|.|..||..|.. |.||||.|..|||..    ||||.||||..||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTR----
...          |.| |||..|||.||.|..||||..||||||.|||||..||.|||.|||.|||.|.     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA--TNGTPELQN--PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ
 | |. |.|||||||.||||.||||||....|.||...|.  .|..|.|..  |.| |  |.||...||..|.||| .|..||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLK
Kinase PAK1.AA PAKB 271-521 56 3.4e-133 448.78 In-house 2-252 (252) Show / Hide 
Range on Protein: 271-521
Range on HMM: 2-252/252
Sequence Identity: 56% (141 aa)

TRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVC
. . ||| |  |.|  | .  ||. ||.|.|.|  |   ||  ||. .||. . ||||.  .|||||||||||||.. ||.|||.||.| |.| |||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

RECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPL
| .||||..||.  ||||||||| |||  || |||.|||||||.  |  ||  .|||||||||||. |  ||..||||||||| |||..||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
.|.  |  .  | |.|  | |   |.||.|.|  |...| .|.|||.   |
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK1.AA STE 270-517 34 7.2e-130 437.75 In-house 1-353 (359) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-353/359
Sequence Identity: 34% (124 aa)

YTRFEKIGQGASGTVYTAMDV------ATGQE---------VAIKQMNLQQQ-----------------PKKELIINEILVMRENK--NPNIVNYLDSYL
... ||||.||.||||.||..       ||..         .|||||||...                  ... |..|| .|.. .   ||||.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEYLAGGSLTDVVTETCMD---------------EGQIAAVCRECLQA-LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
..       ||||..|||..||||.|.. ....                | |||..||..|.. |..|||...||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITPE----------------QSKRSTMVGTPYWMAPEVVTR------KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-----------
|.|..                |.|| |.|||| ||||||...      | |. |.||||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GTPELQN-----------------PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ
    . | |..                 |.|.|  |.||.|.||..| .|| .|..||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase PAK1.AA YSK 270-521 45 1.2e-111 337.46 In-house 1-257 (257) Show / Hide 
Range on Protein: 270-521
Range on HMM: 1-257/257
Sequence Identity: 45% (117 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE---TCMDEGQ
.|. |.|| |  | || . |. |.. ||||  .| .     |.|  || .  . . |.| .|. ||| .  ||..|||..|||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMIEGEPP
|| . || |..|..|||...||||||. |.||  .| ||| |||  .|||  | || |.|||||||||||.     .|  |.||||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
|    |.|.. ||  |  |.|.  .. |  | .| . ||. | |.| ||||||  .  
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK1.AA S_TKc 270-524 33 9.7e-96 325.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 270-524
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG--GSLTDVVTETC-------
|.  .|||.|| |.|| . .. ||..||||...       | |..|| .... . ||||...|..   |.|..||||. |  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP-KVDIWSLGIMAIEMIE
..| ... .... ..|||..||...||||.| .||||     .|..|||...|.       .|..|||..|||||.    ||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ----VRKLRFQ
|.||.   .. . . .|              |  ..||...||..| ||| .| |.||    ...  . 
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK1.AA MST 270-517 44 5e-95 302.49 In-house 1-250 (254) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-250/254
Sequence Identity: 44% (113 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVV--TETCMDEGQ
..  ||.|||. | || | .  ||..||||...       . ||.||  | . |...|| | .||.     ..| |||| ..||. |..  |     | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYL
||....  || |. ||.|  ||||||. ||||  .|  || |||  .| |  . || | .|||||||||| .   |  |.||||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ
.  | ||. .| ..  | ...||. |  | ||. .||  . |.| .|..|||
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQ
Kinase PAK1.AA Pkinase 270-517 30 4.5e-93 320.3 Pfam 1-289 (293) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-289/293
Sequence Identity: 30% (89 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG----SLTDVVT---E
|.. .|||.|..|.|| .... ||..||.|..... . .......    || .|.. . |||| ..|..  .|....||||. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSV----KLTDFGFCAQI-TPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSL
.|.  .| ..  .... |..||..||. .||||.|..|||.  .| .    |..|||...|. .  .|  .| .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMIEGEPPYLNE----NPLRALYLIATNGTPELQNPEKLS---------------------AIFRDFLNRCLEMDVEKRGSAKELLQ
|.. .||. |.||. ..    | .. ...|. .. |.|  ..  .                       ..||...||..| .|| .|...||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase PAK1.AA FRAY 270-521 36 5e-80 248.2 In-house 1-277 (277) Show / Hide 
Range on Protein: 270-521
Range on HMM: 1-277/277
Sequence Identity: 36% (102 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP--KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV----VTETC---
|   | ||.||...|..|. .    ..|||  ||        . .| || .|  .. ||.| |  |..| .|||.|| || .||. |.    . .     
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

---MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLG
   .||  || . .| |..|...|.|. ||||||..|||.| ||.. . |||  | .        .  | |.|||| ||||||.     |  |.||||.|
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE--K-----LSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
| |||.. | .||    |   | |.  |  | |.  |  |      .  |.. .  ||  | .||  | |||. .  
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase PAK1.AA KHS 270-521 43 8e-80 268.15 In-house 1-258 (258) Show / Hide 
Range on Protein: 270-521
Range on HMM: 1-258/258
Sequence Identity: 43% (113 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAA
|    ..| |  | || | |..... .|.| . .. .   ..|  ||..|.. . |||| |  |||  | ||..|||  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMIEGEPPYL
|||| ||.|..|||.. .|||||  ||||  .| ||| |||  ||||   .||   .||||||||||  | ||  |.   |||..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRALYLIATNG--TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
.  |.|||.|..  .   |.|.. .| |..| .|.  .|  .  || .|. |||   .
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK1.AA MKC 270-517 37 7.1e-77 261.71 In-house 1-256 (260) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-256/260
Sequence Identity: 37% (97 aa)

YTRFEKIGQGASGTVYTAMDVA-----TGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVMEYLAGGSLTDVVTE-TCMD
|.  ...| |. |||| |  .        ..|||| |.     ..    ||| . .  . |||| |. |....| |.| |||.. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEP
| .|| ||.| ||.|. ||... .|||.|| ||    || .|| |||.|.  . | ...  |.| |.||.||    |...  .||||.|| . ||  |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLRALYLIATNGTPE---LQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ
|.  .... |  . ||||      .  |.. |  |.|||. ||.|| .|| .| .||.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLK
Kinase PAK1.AA STE11 270-517 35 1.9e-74 253.61 In-house 1-299 (303) Show / Hide 
Range on Protein: 270-517
Range on HMM: 1-299/303
Sequence Identity: 35% (106 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK----------K----ELIINEILVMRENKNPNIVNYLDSYLV---GDELWVVMEYLAGGSL
... |.||.|| ||||..|.| ||...|.||. .| . .          .    ..|  || .|.  . .||| |... |     |.. . ||| .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSKRST----------MVGTPY--------
 ..      .  .||  |    .  |..| .|||...|||||| .||||  ||  .||.||| . ..  . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKA---YGPKVDIWSLGIMAIEMIEGEPPYLNE--NPLRALYLIATNGTPELQNPEKLS------AIFRDFLNRCLEMDVEKRGSAKELLQ
||||||...     || |.||||||   |||. | ||. |   |.  |.. |... .|  . ||..|      .  ||||..|.| | .|| .| .|||
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ
Kinase PAK1.AA TyrKc 270-521 22 7.7e-26 93.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 270-521
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMREN--KNPNIVNYLDSYLVG-------DELWVVMEYLAGGSLTDVVTETC
 |  .|.| || |.|| ..     ..||.| ..      .| ...|. .|..   ..||||. .   . .       . |..|||| ..|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMV----GTP-----YWMAPEVVTRKAYGPKV
      .    |    .  |.|||...||||.   |.|.| .. || .||| .  |. .     ||   ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMAIEMIE-GEPPYLN-----ENPLRALYLIATNGTPELQNP-------EKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKL
|.|| |..  |.   |..|| .      .. ... .. . . ..           .  .....    .| . | |.| . .|.  ....
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase PAK1.AA Pkinase_Tyr 270-464 27 1.6e-22 76.93 Pfam 1-216 (270) Show / Hide 
Range on Protein: 270-464
Range on HMM: 1-216/270
Sequence Identity: 27% (60 aa)

YTRFEKIGQGASGTVYTAMDV----ATGQEVAIKQMNLQQQPK---KELIINEILVMREN-KNPNIVNYLDSYL-VGDE--LWVVMEYLAGGSLTDVVTE
 |  .|.|.|| |.|| .        |...||.| .. .  ..   .|  ..|. .|..  ..||||...   .  |.   ...|||| ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQ-SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
        .  ..   |..  ...|.|.|.. ||||.   |.|.. .. || .||| .  |  . .   ||.       |||||.   . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMIE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY