Gene p38g (Human)

p38g

Species: Human
Alias: P38GAMMA, ERK3, ERK6, p38g, MAPK12, PRKM12, SAPK-3, p38_gamma, SAPK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 22q13.33,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38g.NA RNA Sugen Kinome 1778 None Fasta, JSON
p38g.AA Protein Sugen Kinome 367 None Fasta, JSON
p38g.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON

Protein domain

Protein domains of p38g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38g.AA p38 27-311 68 3.2e-224 751.19 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-289/289
Sequence Identity: 68% (197 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTP-DETLDDFTDFYLVMPFMGTDLGKLMKH
|..||||||||||.||.|.| ||| |   ||||||.||||||..|||.||||||||||||||||.||||||| .. ..||.|.|.|..|||.|| ..||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG
..| .|.|||||||.|.||.|||.||||||||||.|.||||||||.||||||||..|.||||||.||||||||..||||.||||||||||||||||.|||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
.|||.|.||.|||..||||.|||..||.|..||.||.||....|.....||......|.|.|..||||||.||...|.|| ||..||||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38g.AA MAPK 27-311 50 2e-192 645.54 In-house 1-328 (328) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-328/328
Sequence Identity: 50% (165 aa)

YRDLQPVGSGAYGAVCSAVDGR------TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPD-----ETLDDFTDFYLVMPFMGT
|..|.|.|.|||| ||||.| |      .| ||||||. ||||.....||.|||..||.|. .|||.|.|||.|||.     ..|..| |.|.||..|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLGKLMKHEK-LGEDRIQFLVYQMLKG--LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----------------MTGYVVTRWYRAP
|| ...| .. | .|.||...||.|.|  | ||| |..|||||||.|..|||.|.|||.||||||..|.|                 ||.||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILN--WMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ-SDEAKNYMKGL---PELEKKDFASILTN----ASPL
|..||  ||.||..||.||||||.|||.| .|.||.|.|..||.. ||.|.|||. ||.|... |..|.|| ..|   |   ||...... |    |.|.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVNLLEKMLVLDAEQRVTAGEALAHPYF
|..|||||||.| ..| |. |||.||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38g.AA ERK 27-311 45 1.7e-144 486.37 In-house 1-307 (307) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-307/307
Sequence Identity: 45% (139 aa)

YRDLQPVGSGAYGAVCSAVDGR-----TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
|......| |||| ||||.|       ||.||||||  ..|  ....||..||..||.| . |||.|.|.|.. |.    .. | |.| ..| ||| .  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

KHE-KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR----QADSE-------MTGYVVTRWYRAPEVILNWMRYTQTVD
. .  | .| .|...||.| || ||| |..|||||||.|. ||..| ||| ||||||     ...        ||.||.||||||||..|.|  ||. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP-PAEFVQRLQSDEAKNYMKGLPE--LEKKDFASILTNAS--PLAVNLLEKMLVLDAEQRVTAG
|||.|||.|||. .|.||.| |...|. .| ...||| . | .|. .|..|..| | ||.   ..|.. .|  ||.  |.|..||||||| | ..| |. 
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

EALAHPYF
|.|.||||
ECLEHPYF
Kinase p38g.AA CMGC 27-311 26 1.3e-140 465.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-513/513
Sequence Identity: 26% (138 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAK--------------VAIKKLYRPFQSELFAK----------RAYRELRLLKHMR-----------------HEN
|  ....|.|.|| |....| ||. |              |||||. .||  |  ||          ||.||...|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPDET------------LDDFTDFYLVMPFMGTDLGKLMKHEK----------LGEDR------------IQFLV------YQMLKGLR--Y
...|.|.|.....            . .| ..|||. .|..|| ...|. .          | |              |....      ||.|.||   |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHAAG--IIHRDLKPGNLAVNEDCEL--------------------KILDFGLARQADSE------------------------MTGYVVTRWYRAPEVI
.| ..  |||||||| |. .|..|||                    || ||||||. ...                        .| |||||||||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNW---------MRYTQTVDIWSVGCIMAEMITG--------KTLFK-----------GSDHLDQLKEIMKVTGTP----------------PAEFVQRL
|.|         | ||...|.||||||.|||.||        |.||.           |..|.|||..|.|| |||                . |. ...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

Q--------------------SDEAKNYMKG---LPELEKKDFASILTN-----------------------------------ASPLAVNLLEKMLVLD
.                    |. |.|| .    .|.  .|.. ..  .                                   ..|.|..||.|||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

AEQRVTAGEALAHPYF
 ..| || .||.||||
PDKRITAEQALQHPYF
Kinase p38g.AA JNK 27-266 48 7.6e-120 404.45 In-house 1-249 (309) Show / Hide 
Range on Protein: 27-266
Range on HMM: 1-249/309
Sequence Identity: 48% (120 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP--FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--
|  |...|.|| | ||.| |  |. .|||||. ||  ||    .||||||. ..|.  |.|.|... .|||.|||..|.|.|.|| .|   |  .     
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWM-RYTQTVDIWSVGCIMAEM
..|. .|. .|.|||. | .. |..||||||||| |  ||.|| |||.|||.|| .|    || |||||.|||||||.  |  |.  |||||||||||||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

ITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL---P
|... ||.|.|| ||   |... ||| ..| ...| . ..||....   |
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQ-PHVRNYVENRNMDP
Kinase p38g.AA ERK1 27-311 46 2.7e-104 352.81 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-289/289
Sequence Identity: 46% (134 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG
| .|| .| |||| ||||.| ... .|||||.  ||    . .|  ||...|.  .|||.|.. |.   | |.. . | |.|   | ||| ||.|  .| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRAD-TIEQMRDVYIVQCLMETDLYKLLKTQHLS

EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI
 | | . .||.|.||.|||.| ..|||||| || .|  |.||| |||||| || |      .| || ||||||||..||   ||. .||||||||.|||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
  . .| |   ||||  |. | | |  . .. .  . |.||...||  .|  .|..  .| . |. ||.|||    ..|.|  ||||||| 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38g.AA ERK5 27-311 41 2.1e-101 343.21 In-house 1-295 (295) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-295/295
Sequence Identity: 41% (122 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-L
|. .  .| |||| ||||.  ..| .|||||.   |     ||| .|||..|.| ||.|.| . |.  | . . .. | | |.  |  || ...  .. .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS--------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
  . | . .||.|.||.|.|.| .||||||| || ||| ||||| |||.||             || || ||||||||...    ||| .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG-LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
|||. . .| |   ..||. ||.| |.||.  .|   .|  .||..  .|. . ||.  .   | . |..|| .||. .  .|.|. .|| ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38g.AA S_TKc 27-311 31 4.8e-97 329.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT---DLGKLMKHE
|. |...|.||.| |. ... .|| .||||..          ....||...||. .|.|.. |.|||         ...|.|| ....   || ...|. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

K-------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ-TVDIWSVGCI
.       . | ...|..||....| |.|  ||||||||| |. ..|  ..|| |||||||     | ...|.||.||||.     |.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA-------H
..||..|...|       |.....|. |                                     || | ....|.|. | |.| || |||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYF
|.|
PWF
Kinase p38g.AA ERK7 27-311 36 3.9e-95 322.35 In-house 1-292 (292) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-292/292
Sequence Identity: 36% (108 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK-HEK
|  .. .| |||| |  |.| ||.  ||.|| .  |. .  | | .||  .|. .. |.|.| |..|.  |  .    |.|||  || |||    .  . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR----DIYLVFEFMETDLHAVIRKGNI

LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---------QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCI
| .   |. .||.|. ..|.| . .||||||| |. .. .| .|. ||||||         ...  .| || ||||||||. |   |||. || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
..||..|| .| |.  ..|.  |..... | .| .. ..|. | | .. ... ..| .  ....... |..|| ..||.  ..|.|| .||.||| 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38g.AA Pkinase 27-311 29 2.3e-87 301.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR--ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-----DLGKL
|. ....|||..| |. ...  || .||.|.. .. ... . ... |  |....|...|.|.. |.|.|.        .. |.||....      ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

MK---HEKL--GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL----KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILNWMRYTQTV
..   | ..   |. ..| .||.|.|| |.|. ||||||||| |. .......    || |||||.|    .| ||....|.||.|||||.    |.. |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIMAEMITGKTLFKGS----DHLDQLKEIMKVTGTPPAEFVQRL--------QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD
|.||.|||..||..|...|.|.    . .||.. | .. |.|. .  . .        .  . .           . .    .|.|. .  .....| .|
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKD

AEQRVTAGEALAHPYF
 ..| || ..| ||.|
PKKRPTAEQILQHPWF
Kinase p38g.AA CDK 27-245 37 7.3e-80 255.16 In-house 1-244 (284) Show / Hide 
Range on Protein: 27-245
Range on HMM: 1-244/284
Sequence Identity: 37% (95 aa)

YRDLQPVGSGAYGAVCSAVDGRTG-----AKVAIKKLYRPFQ-----SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDF-----TDFYLVMPF
|  |. .| |.|| |  | | .||       ||.||.    .      | |   | ||  |||.. |.|.. |.||.. ... ...     . .|.|...
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQA---------DSEMTGYVVTRWYRAPEVI
| .|| |.|.        |. . .|.|.|| |.|  .|.|||||| |. .|.. |     ||| ||||||             ..|  |||.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNWMRYT--QTVDIWSVGCIMAEMIT---GKTLFKGSDHLDQLKEIMKVTGTP
|   .|.   ..|.||||||.|||.|   .| || |.  .|||. | .. |||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTP
Kinase p38g.AA MAPK-Unclassified 27-176 42 1.5e-63 217.41 In-house 1-157 (575) Show / Hide 
Range on Protein: 27-176
Range on HMM: 1-157/575
Sequence Identity: 42% (67 aa)

YRDLQPVGSGAYGAVCSAVDGRT-GAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLD-DFTDFYLVMPFMGT---DLGKLMK
|   . .|||||| || |.| .. . .|||||. . |. .  .||. ||.|.| .. |.|.| . |.|...| .  .| | |.|| .| |   || .. |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

HEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR
     . .  || . || |.|| |.|.|.|||||||| || .|.|| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38g.AA MAPK-Unclassified 181-311 32 1.9e-42 147.32 In-house 404-575 (575) Show / Hide 
Range on Protein: 181-311
Range on HMM: 404-575/575
Sequence Identity: 32% (56 aa)

EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG-----------KTLFKGSD--------------------HLDQLKEIMKVTGTPPAEF
.||.||||||||||| .|    |.  |||||.||| |||.             . ||.|.|                    | ||.| |  . |.|| | 
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

VQRLQSDEAKNYMKGLPELEKKDFA-SILTNAS---------PLAVNLLEKMLVLDAEQRVTAGEALAHPYF
 .. ..| |. | ...      .|   .  .|.         ... ... |||. ..  | || .|| ||||
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38g.AA TyrKc 27-311 22 5.2e-14 3.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM--RHENVIGLLDVFTPDETLDDF---TDFYLVMPFM-GTDLGKLM
 . ..  |.||.| |. ..      .||.|.|          .  .||.|....   .|.|.. |. | | ..    |      ..|| .| . || .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

KHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----MTGYVV------TR------WYRAPEVILNWM
.  .  |  .      .|  .| .|.|  ..|||||   |  |.|.   || ||||.|  ...      . | .      ..      |. |||.| |  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

RYTQTVDIWSVGCIMAEMIT-GKTLFKGS----DHLDQLKEIMKVTGTPPAEFV----QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKML
..|   |.|| |  | |. | |..   |        ... |  |  . .|                              |      ...   .. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F----VCCPDEMYQIMKQCW

VLDAEQRVTAGEALAHPYF
  |.|.| |  |   | .|
HEDPEDRPTFSEI--HECF
Kinase p38g.AA CDK 286-311 53 5e-11 31.35 In-house 259-284 (284) Show / Hide 
Range on Protein: 286-311
Range on HMM: 259-284/284
Sequence Identity: 53% (14 aa)

NLLEKMLVLDAEQRVTAGEALAHPYF
.||.|||..| ..|..| .|| ||||
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase p38g.AA JNK 286-311 42 1.8e-07 23.92 In-house 284-309 (309) Show / Hide 
Range on Protein: 286-311
Range on HMM: 284-309/309
Sequence Identity: 42% (11 aa)

NLLEKMLVLDAEQRVTAGEALAHPYF
.|| .||| . ..|    .|| ||| 
DLLFRMLVINPDDRISVDDALQHPYI
Kinase p38g.AA Pkinase_Tyr 139-224 35 8.7e-05 16.83 Pfam 122-213 (270) Show / Hide 
Range on Protein: 139-224
Range on HMM: 122-213/270
Sequence Identity: 35% (34 aa)

KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT-------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKT
||. | .. ..|||||   |  |.|.   || ||||||   . .   |...       .|. |||.| .   .|   |.|| |  | |..| |..
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ
Kinase p38g.AA APH 134-179 20 0.007729 10.56 Pfam 159-206 (248) Show / Hide 
Range on Protein: 134-179
Range on HMM: 159-206/248
Sequence Identity: 20% (10 aa)

VYQMLKGLRYIHAAGIIHRDLKPGNLAVN--EDCELK--ILDFGLARQAD
....|. ..   .....|.|..|||. ..  .| .    ..|.. |. .|
LWAWLEAHWP--PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACWGD
Kinase p38g.AA Pkinase_Tyr 27-112 25 0.008953 10.02 Pfam 1-89 (270) Show / Hide 
Range on Protein: 27-112
Range on HMM: 1-89/270
Sequence Identity: 25% (24 aa)

YRDLQPVGSGAYGAVCSAVDG----RTGAKVAIKKLYRPFQSEL-FAKRAYRELRLLKHM-RHENVIGLLDVFT-PDETLDDFTDFYLVMPFM
 . ..  |.||.| |. ..       |. .||.|.|     .|  . .   ||....|.. .|.|.. |. | |  .|        |.||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYM
Kinase p38g.AA APH 29-82 18 0.33654 4.97 Pfam 1-49 (248) Show / Hide 
Range on Protein: 29-82
Range on HMM: 1-49/248
Sequence Identity: 18% (10 aa)

DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR
...|...|. ....  .... . .  . ..|.|      | .. ||.|.|.|..
WWRPISGGWSNRTYYRTTDD-R-PRYVLRRYPPP---WWAEELHREHRWLRHLA