Gene NRBP2 (Human)

NRBP2

Species: Human
Alias: pp9320, TRG16, MGC138699, DKFZp434P086, NRBP2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 8q24.3,

Classification

Group: Other
Family: NRBP

Sequence

Name Sequence Type Origin Length Description Download
NRBP2.NA RNA Sugen Kinome 3768 None Fasta, JSON
NRBP2.AA Protein Sugen Kinome 507 None Fasta, JSON
NRBP2.kin_dom Protein Kinase Domain Sugen Kinome 276 None Fasta, JSON

Protein domain

Protein domains of NRBP2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NRBP2.AA NRBP 46-313 66 4.6e-166 557.99 In-house 1-261 (261) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-261/261
Sequence Identity: 66% (183 aa)

QGNMPGLQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAM
|...||.....|||||||||||||||..|..||.|.|.||||..||..|...||.||||.||||.||.|...||||||||.||||.||||||||||||.|
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

NARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWHRIFSNALRPPTALPDDLRSPIRAEREELRNLHFFPPEYG--EVADG-TA
|..||||||||||||||.||.|.|||||||||.||||||||||||||.||              ||......|..|||.||.|||.||||  ||.|. ||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVW--------------PDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTA

VDIFSFGMCALEMAVLEIQ---TNGDTR-VTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLFHRVLF
|||.|||||||||||||||   .||... ||||||.||.|||.||..|.||..||..||||||||..||||..||
VDIYSFGMCALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase NRBP2.AA WNK 56-192 38 1.8e-27 85.7 In-house 16-148 (261) Show / Hide 
Range on Protein: 56-192
Range on HMM: 16-148/261
Sequence Identity: 38% (53 aa)

FLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCT
. ..||| .||| |.||   |.|   .    ..   | |    |||||.. .||  .      .. .||   || || .||      | |. .  ..|| 
YRGLDTETWVEVAWCELQ--DQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKR----FKKMKPKVLRSWCR

QILSALSFLHACSP-PIIHGNLTSDTIFIQ-HNGLIKIG
|||. |.||| . | ||||  |  | |||   .| .|||
QILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG
Kinase NRBP2.AA TKL 98-192 22 3.6e-13 43.78 In-house 83-196 (364) Show / Hide 
Range on Protein: 98-192
Range on HMM: 83-196/364
Sequence Identity: 22% (29 aa)

DHPNIVKLHKYWLDTSE--ACAR-------VIFITEYVSSGS-LKQFLKKTKKNHKAMNARAWK---RWCTQILSALSFLHACS------PPIIHGNLTS
.|||||..  | .. .   .| .         ...||.. || | ...              |    ||. .| .....||..       ||||| .|.|
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS

DTIFIQHNGL--------------IKIG
. |..  |.               .||.
KNILVDENWTNVSNYMYNPNADWCCKIC
Kinase NRBP2.AA S_TKc 54-312 19 7.3e-12 -2.92 SMART 14-231 (231) Show / Hide 
Range on Protein: 54-312
Range on HMM: 14-231/231
Sequence Identity: 19% (53 aa)

STFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSS--GSLKQFLKKTKK--NHKAMNARA
. ... ... | .|   ...       .  | .|          .|||||||. .. |      .. ...||..   |.|....|| ..  ... ..   
KVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

WKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKI---GSVWHRIFSNALRPPTALPDDLRSPIRAEREELRNLHFFPPEYGEVADGT-AVDI
 .... ||..|| ..|     |||  |  . |.. .   |||   |.  .                        .     ... .||      |. ..|.
ARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL--GYGKCKCDW

FSFGMCALEMAVLEI--QTNGDTRVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLF-------HRVL
 |.| .  ||.. .   .   .  .. . |        .| ...||  || .||..||.|  .|        |  .
WSCGCILYEMLCGYPPFP---QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NRBP2.AA Ciliate-E2-Unclassified 96-191 24 5.5e-11 34.38 In-house 75-188 (352) Show / Hide 
Range on Protein: 96-191
Range on HMM: 75-188/352
Sequence Identity: 24% (29 aa)

LVDHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNH-------------KAMNARAWK-----RWCTQILSALSFLHACSPPIIHGNLT
|..||......... .... .  .....||.  |.|.|..|| ||.              |    .. |     ... |||..|..||     ||| ...
LLNHPHPFIVKMFYCFQDKQN--IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIK

SDTIFIQHNG---LIKI
 . |... ||    |||
PENILFDNNGKNYYIKI
Kinase NRBP2.AA STE 240-312 21 5.1e-10 31.7 In-house 246-359 (359) Show / Hide 
Range on Protein: 240-312
Range on HMM: 246-359/359
Sequence Identity: 21% (24 aa)

GTAVDIFSFGMCALEMAVLEIQ--TNGDTRVTEEAIAR---------------ARHSLSD----------------------PNMREFILCCLARDPARR
.| .|| |.| ...|||  .    .  ..|.  ...                    .| |                      |....||  || .||  |
DTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR

PSAHSLLF--HRVL
|.|. ||   |  .
PTASQLLKSEHPFI
Kinase NRBP2.AA CAMK 97-165 20 9.4e-10 26.86 In-house 95-196 (425) Show / Hide 
Range on Protein: 97-165
Range on HMM: 95-196/425
Sequence Identity: 20% (21 aa)

VDHPNIVKLHKYWLD-----------TSEA-----CARVIFIT---EYVSSG----SLKQFLKKTKKN-----------HKAMNARAWKRWCTQILSALS
.|||||.||. .. |           | .        ......   ||.| |     | ..... ...           .. .. |  .|.  ||.||. 
LDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH

FLH
..|
YCH
Kinase NRBP2.AA CDC2 98-192 31 2.5e-09 24.3 In-house 59-145 (301) Show / Hide 
Range on Protein: 98-192
Range on HMM: 59-145/301
Sequence Identity: 31% (30 aa)

DHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIG
|||||||||           ..  ..||..   ||..... ..  | |   . |    |||....|.|.    |.| .|  . |.|  .| |||.
DHPNIVKLHDVIHQ-----NKLYMVFEYLDM-DLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR--IMHRDLKPQNILIDKKGNIKIA
Kinase NRBP2.AA SgK071 124-176 35 2.8e-09 28.38 In-house 80-130 (283) Show / Hide 
Range on Protein: 124-176
Range on HMM: 80-130/283
Sequence Identity: 35% (19 aa)

EYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNL
.| . |.. .|.|. .|  |.|     .||| |.| |. .||     ||| .|
DYYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHHRN--IIHRDL
Kinase NRBP2.AA WNK 240-260 52 3e-09 25.95 In-house 182-202 (261) Show / Hide 
Range on Protein: 240-260
Range on HMM: 182-202/261
Sequence Identity: 52% (11 aa)

GTAVDIFSFGMCALEMAVLEI
...||...|||| ||||..|.
DESVDVYAFGMCMLEMATSEY
Kinase NRBP2.AA Pkinase 94-173 24 3.7e-09 33.48 Pfam 54-131 (293) Show / Hide 
Range on Protein: 94-173
Range on HMM: 54-131/293
Sequence Identity: 24% (21 aa)

LVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSSG----SLKQFLKKTKKNHKAM--NARAWKRWCTQILSALSFLHACSPPIIH
.  ..|||||.|. .. | .. .    ...||.  |    .|. ...   ..|...    .  |....|||..| ..|..   |||
MKRLNHPNIVRLYDWFEDKDHIY----MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH
Kinase NRBP2.AA TK 92-192 11 1.5e-08 23.98 In-house 93-293 (486) Show / Hide 
Range on Protein: 92-192
Range on HMM: 93-293/486
Sequence Identity: 11% (23 aa)

EQLV--LVDHPNIVKLHKYWLDTSE--------ACARVIFITEYVSSGS----LKQFLKKTKKN------------------------------------
...   | .|||||.|. . ..  .        .   .. ..||.. |.    |...|.| ...                                    
KMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNS

HKAMNARAWKR------------------------------------WCTQILSALSFLHACSP----PIIHGNLTSDTIFIQHNGL-----------IK
..  ......                                     .| || .....||..       ..|..|    . . .|.            .|
PC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IG
|.
IA
Kinase NRBP2.AA STE 98-191 22 6.8e-08 24.08 In-house 87-188 (359) Show / Hide 
Range on Protein: 98-191
Range on HMM: 87-188/359
Sequence Identity: 22% (25 aa)

D-HPNIVKLHKYWLDT---SEACARVIFITEYVSSGSLKQFLK---KTKKNHK-------AMNARAWKRWCTQILSA-LSFLHACSPPIIHGNLTSDTIF
. |||||| . . ..    ....  .  . ||.. ||| ...|   ...|...        ..    .. | ||| . |..||     |||  . .. |.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANIL

IQHNGLIKI
.     .|.
L-----VKL
Kinase NRBP2.AA TyrKc 72-312 16 1.5e-07 -100.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-312
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

LHFGDR--------------------KAFAAHEEKIQTVFEQLVL---V--DHPNIVKLHKYWLDTSEAC---ARVIFITEYVSSGSLKQFLKKTKKNHK
...|.                     |   ..   ..   . . .   .  .|||||.|. . .. ..       .  ..||.. |.||..|.|....  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

AMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIG----SVWHRIFSNALRPPTALPDD-LR----SPIRA----EREELRNLHFF
  . .    .|.|| .  ..||    ..||  |    . . .|. .||.    |              .. ||  .    . .|.     .  .  .   
-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSR-------------DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

PPEYGEVADG---TAVDIFSFGMCALEMAVLEIQTNGDT----RVTEEAIARARHS-------L--------SDPNMREFILCCLARDPARRPSAHSLLF
.||     .|   |. |..||| |  |.  .  |   .        .|.|.. ..                   . | . ...| ..||. ||.   .  
APECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--

HRVL
|. .
HECF
Kinase NRBP2.AA STE-Unique 283-312 53 3e-06 17.72 In-house 587-616 (616) Show / Hide 
Range on Protein: 283-312
Range on HMM: 587-616/616
Sequence Identity: 53% (16 aa)

PNMREFILCCLARDPARRPSAHSLLFHRVL
| ...||  || |.|  ||||| || |  |
PEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase NRBP2.AA Pkinase 239-312 18 2.5e-05 19.93 Pfam 189-293 (293) Show / Hide 
Range on Protein: 239-312
Range on HMM: 189-293/293
Sequence Identity: 18% (20 aa)

DGTAVDIFSFGMCALEMAV----LEIQ----TNGDTRVTEEAIARARHSLSD------------------------PNMREFILCCLARDPARRPSAHSL
.|..||..|.|    ||.        .    .  | ..  . | ... . .                         .....|| .||..||..||.|. .
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LFHRVL
| |  .
LQHPWF
Kinase NRBP2.AA STE-Unique 124-192 29 3.1e-05 13.89 In-house 374-452 (616) Show / Hide 
Range on Protein: 124-192
Range on HMM: 374-452/616
Sequence Identity: 29% (23 aa)

EYVSSGSLKQFLKKTKK-----NHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNG-----LIKIG
|| . |.|.| .| .       | . . .   ..  .||| .| .||    ||||..| .. ||.   |      .||.
EYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC
Kinase NRBP2.AA TKL 241-310 14 3.7e-05 14.53 In-house 268-364 (364) Show / Hide 
Range on Protein: 241-310
Range on HMM: 268-364/364
Sequence Identity: 14% (14 aa)

TAVDIFSFGMCALEMAVLEIQTN-GDTRVTE---------EAIARARHSLSDP-----------------NMREFILCCLARDPARRPSAHSLLFHR
...|..|||..  |..  ..     . .  .         . ..  .. .  |                  |.. . .| . ||  |||.  .| . 
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NRBP2.AA WNK 282-312 32 4.8e-05 12.13 In-house 231-261 (261) Show / Hide 
Range on Protein: 282-312
Range on HMM: 231-261/261
Sequence Identity: 32% (10 aa)

DPNMREFILCCLARDPARRPSAHSLLFHRVL
.|. .|.|. |. ..   |||.  || |  .
NPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase NRBP2.AA TK 277-310 17 0.063485 1.37 In-house 450-486 (486) Show / Hide 
Range on Protein: 277-310
Range on HMM: 450-486/486
Sequence Identity: 17% (7 aa)

RHSLSD-----PNMREFILCCLARDPARRPSAHSLLFHR
|. . .     . . .....| ..||..||.   |.   
RM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase NRBP2.AA CAMK 286-312 25 0.115784 0.32 In-house 399-425 (425) Show / Hide 
Range on Protein: 286-312
Range on HMM: 399-425/425
Sequence Identity: 25% (7 aa)

REFILCCLARDPARRPSAHSLLFHRVL
. .| ..| .|| .|....  | |  .
KDLIRKMLQVDPEKRMTIEQCLNHPWM