Gene NLK (Human)

NLK

Species: Human
Alias: DKFZp761G1211, NLK, LOC51701, FLJ21033
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17p11.1-p11.2,

Classification

Group: CMGC
Family: MAPK
Subfamily: nmo

Sequence

Name Sequence Type Origin Length Description Download
NLK.NA RNA Sugen Kinome 3555 None Fasta, JSON
NLK.AA Protein Sugen Kinome 527 None Fasta, JSON
NLK.kin_dom Protein Kinase Domain Sugen Kinome 290 None Fasta, JSON

Protein domain

Protein domains of NLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NLK.AA nmo 138-427 89 1.7e-255 795.3 In-house 1-292 (292) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-292/292
Sequence Identity: 89% (261 aa)

IEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLS
|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.|.|||||||||||||||||||||.||
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

SDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGR
|||||||||||||||||||||.|||||||||||||||||||||||||||||.|.|.|.|||||||||||||||||||.|||..|.|||||||||||||||
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

RILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSS--QATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
|||||||||||||..|||||||||.|.|..||||||||.||.|||.|.|.|||||||  .|||||||||||||.|||.||||.|||||||||
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase NLK.AA MAPK 138-427 43 6.9e-179 600.59 In-house 1-328 (328) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-328/328
Sequence Identity: 43% (144 aa)

IEPDRPIGYGAFGVVWSVTDPR------DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFF-KHDNVLSALDILQP------PHIDYFEEIYVVTELMQS
 ....|||.||.|||.|..| |      .||.||.||....|||...|||..||.|.|..| .|.|. . |||..|      .... |..||.|.|||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHKIIVSPQPLSSDHVKVFLYQILRG--LKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDES-------------RHMTQEVVTQYYRAP
|||.|| |.|||| ||.. |.||||||  |||.|||...|||.||.|.|||.|| ||||||||||... ...             .|||. |.|..||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILMG--SRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTAC-EGAKAHILRGP--HKQPSLPVLYTLSSQ----ATHE
||...  ..||. |.|.|||||||||.|. |..||. ...| |. ||...||||| | ..  |   . .. ...   ....    .... .     |...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVHLLCRMLVFDPSKRISAKDALAHPYL
|..||..||||||.|||....||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase NLK.AA ERK 143-427 45 3.7e-133 448.67 In-house 6-307 (307) Show / Hide 
Range on Protein: 143-427
Range on HMM: 6-307/307
Sequence Identity: 45% (137 aa)

PIGYGAFGVVWSVTDPR-----DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFK-HDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPL
.||.||.||| |..|       .|..|| || .|.| ... |||  ||.|.| .|| |.|. . .||. |  .. ...||.|.|||..|||.|| |.|.|
QIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQEL

SSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR-------HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGC
| ||.. |.||||.||||.|||...|||.||.|.||||||.||||||||||... . .        .||. |.| .||||||.   . |. |.||||.||
SDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGC

IFAELLGRRILFQAQSPIQQLDLITDLLGTP-SLEAMRTA-CEGAKAHILRGPH--KQPSLPVLYTLSSQAT--HEAVHLLCRMLVFDPSKRISAKDALA
||||.|||. ||.  . . |...|....||| | | ...   |.|.  |   |.  ..|    .... . |   ..|. || .||||||.|||.....|.
IFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPK--PWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLE

HPYL
|||.
HPYF
Kinase NLK.AA CMGC 138-427 25 3.6e-127 420.26 In-house 1-513 (513) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

IEPDRPIGYGAFGVVWSVTDPRDG--------------KRVALKKMPNVFQNLVSCK----------RVFRELKMLCFFK-----------------HDN
 | ...|| |..|||.. .| | .              ..||.||. |.| .   .|          | .||.|.|  ..                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLSALDILQPP---HIDY---------FEEIYVVTELMQSDLHKIIVSPQ---------PLSSDH------------VKVFL------YQILRGLK--YL
... .||....   . .|         |...| |.|.|. ||...| . |         |||  |            .| |.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--ILHRDIKPGNLLVNSNCVL--------------------KICDFGLARVEELD--------------------ESRHMTQEVVTQYYRAPEILM
||..  |.|||.|| |.|.|.|| |                    ||||||||| ..                      ..|..|..||| .|||||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSRHYS---------NAIDIWSVGCIFAELLGR--------RILFQ-----------AQSPIQQLDLITDLLGTPSLEAMRTA---------CE------
|..||.          .||.|||||||||.. .        ..||.            .| | ||..| ..||||. . ....          |      
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMI

-----------------------GAKAHILR----GPHKQPSLPVLYTLSSQ--------------------------------ATHEAVHLLCRMLVFD
                       .|. .| .    .... ...  |.  ..                                 ....|..||..||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSKRISAKDALAHPYL
|.|||.|..||.|||.
PDKRITAEQALQHPYF
Kinase NLK.AA ERK5 139-427 45 3.2e-110 372.5 In-house 2-295 (295) Show / Hide 
Range on Protein: 139-427
Range on HMM: 2-295/295
Sequence Identity: 45% (134 aa)

EPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLS
..   || ||.||| |    . |..||.||.|| |  .   || |||||.|  |.|||..   |||.|   .  . ..||| .|| ||||.|| | ||..
KIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFT

SDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEEL----DESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAE
 .|.. |||||||||||.||| ..|||.|| ||||| || ||| |||.||        ..   ||. | | .|||||... |  |  |||.||||||| |
LEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGE

LLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR-TACEGAKAHILR-GPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
...|| .|  . .|.||.|| . ||.|.   .. .. .  .... .  | .||    . ..  .|   |. || |||.|.||.||..  || ||.|
MIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPK--DWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase NLK.AA p38 138-427 42 1.2e-109 370.57 In-house 1-289 (289) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-289/289
Sequence Identity: 42% (125 aa)

IEPDRPIGYGAFGVVWSVTDPRDGKR---VALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQP--PHIDYFEEIYVVTELMQSDLHKIIVS
 .  .|.| ||.| | .. | | |..   || ||.   ||  .  || .|||. |   .|.||...||.  |    .. |...|.||..|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

PQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFA
 | || ||..  .||||||||| ||||| ||| ||.|. || .| |.| ||||||         ||. |.|  ||||||.    || ...|||||||| |
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMA

ELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
||. .|.||  . .|.||  |. ..|||. | . . . | |.. |   |  .     . .. ..|.  |. || .||. || |||.|..|..|||.
ELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRR--DFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase NLK.AA ERK1 142-427 46 4.1e-93 315.66 In-house 5-289 (289) Show / Hide 
Range on Protein: 142-427
Range on HMM: 5-289/289
Sequence Identity: 46% (134 aa)

RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHV
. || ||.|.| |  | . ..|||.||.   |     |.|  ||.|.|  |||.|..   ||.. . |. . ..|.| .||  || |.. . |.|| ||.
QYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLSNDHI

KVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVE--ELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRI
  |||||||||||.||| .||||.|| |||.|  | ||||||||||.   | |    .|  | | .||||||.. |. |  .||||||||| ||.|  | 
CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP

LFQAQSPIQQLDLITDLLGTPSLEAMRTAC-EGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
.|  .  . || .|  .|| || . ..    | |.. .   ||| | .| .  |  .|   |. || .|| | | |||   .|||||||
IFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHK-PKVP-WARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase NLK.AA S_TKc 138-427 27 2e-91 310.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

IEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQS---DLHKIIVSPQ
 |  |.|| ||||.|. ... ..|..||.|...         ... ||...|   .|.|.   .|. |       ...|.|.|..     ||...|.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN-AIDIWSV
.      ..  |.. ..|||...|.|.|| ||.|||.|| |.|...  ..|||||||||.         |  ..| .|.|||.|    .|.  ..|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALA----
|||..|.| .. .|.      |.... ...|                                      ..|| ......|..||.||..| .||.    
GCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase NLK.AA ERK7 139-427 36 1.3e-89 304.03 In-house 2-292 (292) Show / Hide 
Range on Protein: 139-427
Range on HMM: 2-292/292
Sequence Identity: 36% (109 aa)

EPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFK-HDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLS
|  . .| ||.|.|| ..| | .. |||||.   |.| .   | |||  .|  |. |.|... .....    |    ||.| | | .||| .|   . | 
EIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNILK

SDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLAR----VEE-LDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFA
  |... .||.|| .||.||. ..|||.|| |.|..|.|..|.|||||||     ||  ..   .|  | |  |||||||.||..|  ..| ||.||| .
DIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILG

ELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
|.|  . .|.  | . |...| .... |. | .        . .|   ..|.  .    .  |. ..|. || |.||| | ||..|..||.||| 
EMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase NLK.AA CDK 184-427 36 6.6e-85 271.57 In-house 57-284 (284) Show / Hide 
Range on Protein: 184-427
Range on HMM: 57-284/284
Sequence Identity: 36% (97 aa)

RELKMLCFFKHDNVLSALDILQPPHIDYF------EEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCV
|| ..|    |.|. . .|.    . |.         .| | | |  || |..          .| ...|.|||| |.|| .|.|||.|| |.|.|.| .
REISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGE

-----LKICDFGLARVEEL--D---ESRHMTQEVVTQYYRAPEILMGSRHYS--NAIDIWSVGCIFAELLG---RRILFQAQSPIQQLDLITDLLGTPSL
     ||| ||||||      .   ..| .| ||||  |||||.|.||.|||   .||.|||||||||..    |. ||. .| | ||..| ...|||. 
VKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTE

EAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
.     ..                               .||..||..||.|||||..|| |||.
DNWPGVTKLPDY---------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase NLK.AA Pkinase 138-427 29 2e-82 284.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

IEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFR--ELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQS-----DLHKII
..  |.|| |.||.|.  ..  .||.||.|... . ..   ... .|  |....  ..|.|..  .|. .        .||.|.|...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

V--SPQPL--SSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVL----KICDFGLARV-EELDESRHMTQEVVTQYYRAPEILMGSRHYSNA
   .  ..  | ...| ..|||||||.|.|| ||.|||.|| |.|...|...    ||||||||.. . .  .. ||  ..| .|.|||...|...|. .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSVGCIFAELLGRRILFQAQ----SPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS
.|.||.|||..|.| .| .|. .    . . |. .|   .|.|  .   . |..   . .|        . . |.   .. |. ......| .||.||..
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

AKDALAHPYL
|...| ||..
AEQILQHPWF
Kinase NLK.AA MAPK-Unclassified 139-290 44 2.7e-66 226.58 In-house 2-161 (575) Show / Hide 
Range on Protein: 139-290
Range on HMM: 2-161/575
Sequence Identity: 44% (71 aa)

EPDRPIGYGAFGVVWSVTDPRD-GKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDY--FEEIYVVTELMQS---DLHKIIVS
|..  || ||.|.|   .| .  .. || || . .|.| . |||| ||.  |    | |..   ||. .       |  ||.|...||.   |||.|| |
EYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKS

PQ-PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLAR-VEE
.| ...  |.. |.|||||||||||||.|.||| || |||.| .| ..|||||..| .|.
NQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase NLK.AA MAPK-Unclassified 294-427 28 1.3e-38 134.65 In-house 402-575 (575) Show / Hide 
Range on Protein: 294-427
Range on HMM: 402-575/575
Sequence Identity: 28% (50 aa)

SRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGR-----------RILFQAQS--------------------PIQQLDLITDLLGTPSL
..|||| ||| .||||||.. .  |. ..||||.||||||.. .           |.|| .|.                     . |. .| | ||.|  
CYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPE

EAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQAT---------HEAVHLLCRMLVFDPSKRISAKDALAHPYL
| ..          ...  . .....     ..|           |.  ..  ||.|.|.|||.| .|| ||| 
EDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase NLK.AA TyrKc 138-427 19 1.1e-13 -1.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 138-427
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

IEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFF--KHDNVLSALDILQPPHIDYF---EEIYVVTELMQS-DLHKIIV
|. .. .| ||||.|.  |       || |.. .        .   ||....| .  .|.|..  . .   .    |   | ...|.|.|   ||.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SPQP-LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELD------ESRHMT----QEV--VTQYYRAPEILMGSRHY
...| |. ..   | .|| .|  |||| .. |||.   | ||..| . ||.||||.|  . |      ..  ..    ..   .     ||| .   . .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

SNAIDIWSVGCIFAELLGRRILFQAQ---SPIQQLDLITDLLGTPSLEAMRT----ACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFD
. . |.|| |    |.. .           ..   ..| ..     .. .      .                        .  .. |   .  .   .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------FVCCPDEMYQIMKQCWHED

PSKRISAKDALAHPYL
|..| . ..   | ..
PEDRPTFSEI--HECF
Kinase NLK.AA Pkinase_Tyr 214-293 40 3.4e-13 45.32 Pfam 81-165 (270) Show / Hide 
Range on Protein: 214-293
Range on HMM: 81-165/270
Sequence Identity: 40% (34 aa)

EIYVVTELMQS-DLHKIIVS----PQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDE
.||.|.|.|.  ||..   .    .|||.  .   . .|| .|. ||.| .. |||.   | ||..| | |||||||||  . |.
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase NLK.AA CDK 139-168 40 0.003468 5.86 In-house 2-36 (284) Show / Hide 
Range on Protein: 139-168
Range on HMM: 2-36/284
Sequence Identity: 40% (14 aa)

EPDRPIGYGAFGVVWSVTDPRDG-----KRVALKK
|    || |..|||    | ..|     . |||||
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKK
Kinase NLK.AA Pkinase_Tyr 138-153 43 0.053522 7.39 Pfam 1-16 (270) Show / Hide 
Range on Protein: 138-153
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

IEPDRPIGYGAFGVVW
|. .. .| ||||.|.
ITFGKKLGEGAFGEVY