Gene NIK (Human)

NIK

Species: Human
Alias: NIK, HSNIK, FTDCR1B, MAP3K14, HS
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q21.31,

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
NIK.NA RNA Sugen Kinome 4468 None Fasta, JSON
NIK.AA Protein Sugen Kinome 947 None Fasta, JSON
NIK.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of NIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NIK.AA STE-Unique 463-653 34 6.2e-103 348.27 In-house 367-616 (616) Show / Hide 
Range on Protein: 463-653
Range on HMM: 367-616/616
Sequence Identity: 34% (87 aa)

PWVNIFMELLEGGSLGQLVKEQGC---------LPEDRALYYLGQALEGLEYLHSRR--ILHGDVKADNVLLSSDG----SHAALCDFGHAVCLQPDGLG
.||.||||..|.|.|.|..|..||         .||.....|..|.|||||||||..  |.|.|.|..|.....||    .....||||||.|.|||...
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

K---------------------------------SLLTGDYIPGTETHMAPEVVLGR-----SCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG----PLC
|                                 ...|..|..||...|.|||...|     ..|.|||.||..||..||..||.||.|....    ..|
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

LKIASEPP--PVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR
..|...||  |...|||.|.|...|.|...|...|.||.||..|  ....
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase NIK.AA STE 400-647 22 5.4e-63 215.6 In-house 1-351 (359) Show / Hide 
Range on Protein: 400-647
Range on HMM: 1-351/359
Sequence Identity: 22% (79 aa)

ATHQLRLGRGSFGEVHRMEDK------QTGFQ---------CAVKKVRLEVFRA----------------------EELMACAGLT--SPRIVPLYGAVR
 ... ..|.|.||.|..  ..      .||..         .|.|...||  ..                      .|.  .  .   .| ||  ||.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------PWVNIFMELLEGGSLGQLVKE--------------QGCLPEDRALYYLGQALEG-LEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHA
 .        ...|.||...|||| ...|.              |...||.   |.. | |.| |.|||| .| | |.|..|.||      . |||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

VCLQPDGLGK----------SLL-TGDYIPGTETHMAPEVVLG------RSCDAKVDVWSSCCMMLHMLNGCHPWTQ-FFRGPLCLKIAS----------
 .|.... ..          .     . . ||  .|||||...        .|.|.|.||  |....|..|..||        . ... .          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----EPPPVREI----------------PPSCAPLTAQAIQEGLRKEPIHRVSAAEL
     .|||  .                 | .. |   . |.  |.|.| .| .| .|
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase NIK.AA S_TKc 400-655 27 3.5e-45 157.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 400-655
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

ATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEG--GSLGQLVKEQGC------LPEDR
 .    .|.|.||.|..  .| || ..|.|...       |.  .     | || ||.. ..   . ..||...|  |.| .. |..|.      .|| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

ALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDA-KVDVWSSCCMMLHML
| .|. | ...|||.||..|.| |.| .|.||..   |  .|||| |  |            . . ||   |||||.   . .  |.|.||  |..  ||
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

NGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGG-----KVNRAL
 |. |.       . .|.               |   . |.  |.|.| .| .| |.       |    .
CGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NIK.AA Pkinase 405-596 31 2.3e-41 147.31 Pfam 6-212 (293) Show / Hide 
Range on Protein: 405-596
Range on HMM: 6-212/293
Sequence Identity: 31% (67 aa)

RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----------ELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGG----SLGQLVK--EQGCL-
..|.||||.| .  .| || . |||.....  . .          |.   . | .| || ||......... . ||..|||    .|  ...  ..||. 
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-PEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHA----ALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVL-GRSCDAKVDVWS
 .|. .  |. | |.||||.||..|.| |.| .|.|.. .  |      .|||| | ...   . ..  . ..  ||   |||||.. |.  . |||.||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKVDMWS

SCCMMLHMLNGCHPW
  |..  ||.|  |.
CGCILYEMLCGRPPF
Kinase NIK.AA CAMK 405-596 19 7e-33 102.75 In-house 1-334 (425) Show / Hide 
Range on Protein: 405-596
Range on HMM: 1-334/425
Sequence Identity: 19% (66 aa)

RLGRGSFGEVHRMEDKQTG------------FQCAVKK-----------------------------------VRLEVFRAEELMACAG-----LTSPRI
 |||||||.|.. ..|.|.             ..|.|                                     | .|.|  |.|         |  | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VPLYGAVR------------EGPW--------VNIFM---ELLEGG----SLGQLVKEQGC---------------LPEDRALYYLGQALEGLEYLHSRR
. || .                          . ..|   |. .||     | . ..|.||               ..|. | .|  | .....|.||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHGDVKADNVLLSSDG----------------SHAALCDFGHAVCLQPD--------GLGKSLLTGD------------YIPGTETHMA-PEVVLG---
| | | | .|.||....                    ..||| |  ..|.        . |.. .  .               ||   || |||..|   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------RSCDAKVDVWSSCCMMLHMLNGCHPW
           . .. |.|.||  ...  || |. |.
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase NIK.AA TKL 406-581 20 3.4e-32 113.22 In-house 1-274 (364) Show / Hide 
Range on Protein: 406-581
Range on HMM: 1-274/364
Sequence Identity: 20% (59 aa)

LGRGSFGEVHRMEDKQ--------TGFQCAVKKVRLEV--------------------------------FRAEELMACAGLTSPRIVPLYGAVREGPW-
.|.|.||||.. . ..        ||   |||| . .                                 |. ||.| .  |  | ||...|.. ..|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VNIFMELLEGGS-LGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRR--------ILHGDVKADNVLLSSDGSH-------------A
              | ||. .||| | .|         .. .    ..  |..||||..        |.| | | .|.|. ... .             .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

ALCDFGHAVCLQPDGLGKSLL--------------TGDYIPGTETHMAPEVVLGR----------------SCDAKVDVWS
 .|||| . .....|  .                 |   . ||  .|||||  |                 . . |.||.|
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS
Kinase NIK.AA STE11 399-596 30 2.4e-30 107.04 In-house 1-238 (303) Show / Hide 
Range on Protein: 399-596
Range on HMM: 1-238/303
Sequence Identity: 30% (72 aa)

WATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFR-------------------AEELMACAGLTSPRIVPLYGAVR---EGPWVNIFMELLEGGS
|   .. .|.|.|| |..  .. ||   |||.....  .                   .||.    .|  ..||  ||. .   .   ||||||  .|||
WQKGEI-IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGS

LGQLVK-EQGC--LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGD-----YIPGTET-------
| .. .  .|.  ..|    .|  | |||| |||| .| | |.|..|.|| ||| .  | ||| |. |. ... ..   ..      ..||         
LSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTP

-HMAPEVVLGRS---CDAKVDVWSSCCMMLHMLNGCHPW
  |||||. .      ..|.|.||  | .. |. | .||
MWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPW
Kinase NIK.AA MEKK2 399-647 32 2e-27 96.46 In-house 1-256 (262) Show / Hide 
Range on Protein: 399-647
Range on HMM: 1-256/262
Sequence Identity: 32% (84 aa)

WATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----------ELMACAGLTSPRIVPLYGAVREGP--WVNIFMELLEGGSLGQLVKEQGC
|   .| || | || |    |  ||   |||.|. .   .|          |.     |  .|||  || .|.     . |||| . |||.   .|  | 
WRRGKL-LGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGA

LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMM
| |     |  | |||..|||.  | | |.|  |.|  | |    | ||| .  ||   .  .      . ||   |.|||. |     | ||||  | .
LTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSG-NVKLGDFGASKRLQ--TICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTV

LHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL
  ||    || ..       ||| . |   ..|.. .  . . ..   ..    | ||.||
VEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEEL
Kinase NIK.AA STE-Unique 401-462 31 3.1e-26 89.83 In-house 1-73 (616) Show / Hide 
Range on Protein: 401-462
Range on HMM: 1-73/616
Sequence Identity: 31% (23 aa)

THQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFR-----------AEELMACAGLTSPRIVPLYGAVREG
..| ..||||||.||....|...|.||.|...|..|.           ..|......|....||..||....|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase NIK.AA ASK 406-596 33 4.3e-25 80.26 In-house 2-197 (254) Show / Hide 
Range on Protein: 406-596
Range on HMM: 2-197/254
Sequence Identity: 33% (67 aa)

LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA-----EELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQ-GCLP--EDRALYYLG
||.|..| |.   |..|  . |.| .     |      ||.     |    ||   |.. |. .. ||||   |||| .|.. . | .   |.   .|  
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTK

QALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVL--GRSCDAKVDVWSSCCMMLHMLNGCHP
| ||||.||| ..| | |.| ||||.        . ||| .  |     |   .|  .  ||   |||||.    |   .  |.||  | |. |  |  |
QILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL----AGINPCTETFT-GTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPP

W
.
F
Kinase NIK.AA STE20 469-581 35 1.6e-24 86.69 In-house 87-212 (288) Show / Hide 
Range on Protein: 469-581
Range on HMM: 87-212/288
Sequence Identity: 35% (46 aa)

MELLEGGSLGQLVK---EQGC------LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTG---DYI
||...|||| ...|   . |.      . |.   | . ..|.||.||||..| | |.||||.||..||. . |.||| .  |.. | .     .   . .
MEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGE-VKLADFGVCAQLTKHG-R-D-TMQFKRNTF

PGTETHMAPEVVLG-----RSCDAKVDVWS
 ||   |||||...        | |.|.||
VGTPYWMAPEVIQCMEGPDKGYDYKCDIWS
Kinase NIK.AA RSK 402-598 22 3.4e-24 85.55 In-house 1-214 (278) Show / Hide 
Range on Protein: 402-598
Range on HMM: 1-214/278
Sequence Identity: 22% (50 aa)

HQLR--LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTS--PRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGC---
...   .| |..  ... ....|| . |.| ..  ....         .   .  ..   | || |. | ...  . . ||...|| |.   .....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSS--DGSHAALCDFGHAVCLQPD--GLGKSLLTGDYIPGTETHMAPEVVL---GRS-CDAKVD
. ||.| .|. .    .|.||.. | | | | .|.|. .  .  |  |.||| .  . .|  .. ..        .|   ||||..    ...  |. .|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT------FCYTIEYMAPEMLKRANQQGGHDKACD

VWSSCCMMLHMLNGCHPWTQ
.||  . |  || || | ..
WWSLGVLMYEMLTGCPPFQG
Kinase NIK.AA PAKA 469-592 34 1.7e-21 72.31 In-house 77-199 (260) Show / Hide 
Range on Protein: 469-592
Range on HMM: 77-199/260
Sequence Identity: 34% (44 aa)

MELLEGGSLGQLVKEQG-----CLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHM
|| .|||.|  ....        ..|. . | . . | |||..||. . | |.| ||.|| .|||   . ||| .. |..  . ..        ||   |
MEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGS-VKITDFGFCAQLTQEQQKRNTMV-----GTPYWM

APEVVLGRSCDAKVDVWSSCCMMLHMLNG
||||....  | |||.||   |.. |. |
APEVIRRKQYDEKVDIWSLGIMAIEMIEG
Kinase NIK.AA Pkinase_Tyr 406-536 29 1.4e-13 46.57 Pfam 7-156 (270) Show / Hide 
Range on Protein: 406-536
Range on HMM: 7-156/270
Sequence Identity: 29% (45 aa)

LGRGSFGEVHRMEDK----QTGFQCAVKKV------R---LEVFRAEELMACAGL-TSPRIVPLYGAVR--EGP-WVNIFMELLEGGSLGQLVKE----Q
||.|.||||.. . |    .|. ..|||..      .   .| | . |.     |   | || |||..   ..|  . | ||. ..|.|    ..    .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

GCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFG
. |.  . | .  |  .|.|||.|... | |. | |.|..... ..  ||||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG
Kinase NIK.AA TyrKc 400-651 22 7e-13 -14.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 400-651
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

ATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE---ELMACAGL--TSPRIVPLYGAVREG-------PWVNIFMELLEGGSLGQLVKEQGC-
 |    ||.| ||||.. . |    |.|||... .  |..   |.     |    | || |||.....       . . | ||. ..|.| .  .. .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPD---GLGKSLLTGDYIPGTE---TH-------MAPEVVLGRSC
|. .  |..  |. .| |||||... | |  | |.|..... ..  .||| .  .  |   |       .||.  .|   ..       ||||.   . .
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DAKVDVWS---------SCCMMLHML---NGCHPWTQFFRGPLCLKIASEPPPVRE-----IPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKV
  | ||||         . ... .     .   .... ..   ..|    .|.  .       . | .   | ...  . .|  | . .|.  . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIE---YVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase NIK.AA STE20 405-434 38 1.1e-05 17.04 In-house 6-39 (288) Show / Hide 
Range on Protein: 405-434
Range on HMM: 6-39/288
Sequence Identity: 38% (13 aa)

RLGRGSFGEVHRMEDKQTGFQ----CAVKKVRLE
..|.||.|.|..  .|.|| .    .|.||. ||
KIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLE
Kinase NIK.AA PAKA 401-434 22 0.001966 8.09 In-house 2-37 (260) Show / Hide 
Range on Protein: 401-434
Range on HMM: 2-37/260
Sequence Identity: 22% (8 aa)

THQLRLGRGSFGEVHRMEDKQTGFQ--CAVKKVRLE
.    .| |. ||| . ....|. .  .|.|. ...
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMK
Kinase NIK.AA Pkinase_Tyr 563-581 47 2.650423 1.65 Pfam 181-199 (270) Show / Hide 
Range on Protein: 563-581
Range on HMM: 181-199/270
Sequence Identity: 47% (9 aa)

MAPEVVLGRSCDAKVDVWS
||||.   . .  | ||||
MAPECINYGKFTTKSDVWS