Gene NEK8 (Human)

NEK8

Species: Human
Alias: MGC138445, NEK12A, NEK8, JCK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q11.1,

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
NEK8.NA RNA Sugen Kinome 2942 None Fasta, JSON
NEK8.AA Protein Sugen Kinome 720 None Fasta, JSON
NEK8.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of NEK8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK8.AA NEK8 4-258 60 1.7e-237 685.83 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 60% (168 aa)

YERIRVVGRGAFGIVHLCLRKADQ--KLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLE
||||||||||||||..|..||.||  .|||.|||....|...|||.||||.|||..|.|||.|.||..|.||..|||.||||.||||...||...|.|.|
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EET-----------------ILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYT---VVGTPCYISPELCEGKPYN
||.                 ||..|.|...|.||.|.|.|||||||||||....|||||||||||||||...|....|   |||||.|.|||.|||||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

QKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSG-TFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLC
||||.|||||||||...|||||||.||||||.|||.. ...||||.||.|.|.||...|...|.|||..|.|||.|||
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK8.AA NEK 4-258 44 2.2e-150 505.89 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 44% (126 aa)

YERIRVVGRGAFGIVHLCLRKADQKL-----VIIKQIPVEQMTKEERQAAQ-NECQVLKLLNHPNVIEYYENFLEDK--ALMIAMEYAP-GGTLAEF---
||.|...|.|.|| |... || |.|      ...|.| .. |. .|.|.|| ||...|| |.|||...||. |.|..   |.| |||.  ||.|...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQKRC--NSLLEEETILHFFVQILLALHHVHTH-----LILHRDLKTQNILLDKHRM---VVKIGDFGISKILSSK-SKAYT-VVGTPCYISPELCEGKP
|.|.   . ..|||.|...|.|..|||...| .      |||||.|.||| |.| ..   .||||||||||.|... ..||| .||||.|.|||.|..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNQKSDIWALGCVLYELASL--KRAFEAA--NLPALVLKIMSG-TFAPISDR--YSPELRQLVLSLLSLEPAQRPPLSHIMAQPLC
||.|||||.|||||||...|  |..|||   |.|.|..||| | ...||...  ||..|..|. ..|  .| |||  . |...|..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK8.AA NEK1 4-258 43 3.8e-113 382.19 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 43% (120 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKA--LMIAMEYAPGGTLAEFIQKR--CNSL
|..|...| |.|| . |  .|.| ..  || | |..| ..||... ||  .|. . |||...|.| | |     | | |||. || |.  |...   . |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLD--KHRM--------------VVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQ
  | .|.|.|.|| ||| |.|   |||||.|.||| |   |  |              .||.|||||...|..    | |..||| |.|||.|. ||||.
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLC
|||||.||||||||  ||..|||.|...||||| .||..||. .|| ||. || ....  |  ||    |  .|  
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK8.AA NEK4 4-258 40 3.7e-91 309.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKA--LMIAMEYAPGGTLAEFIQKRCNSLLE
|. ..|||.| .| | |   . | |  ..| .   .  ..||.||  | |.|  | |||..|| | .  .    | | | .  || | .  ... | .||
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILS-SKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLK
|. ..  |||| .||   |   ||||||||||| | | . ..||||||||..|  .   | |..||| |.|||.   .||. |||||.||| .||.. ||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTK-KNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

RAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLC
 ||.| ... |. .|. |   |..  ||..| .||  .|.  | .|| .  |. .|  
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK8.AA S_TKc 4-258 31 3.8e-84 286.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPG--GTLAEFIQKRCN----
|| .|..|.|||| |..|  | ....| ||.|.         . ...| |.||  .|||.. .|. | . . | . |||..|  |.| ..|.||      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQ-KSDIWALGCVLYEL
. . | .. ... ||..|| . | | |.||||| .|||||.   ..||.|||....|      .|..||| |..||..   .|.  |.|.|..||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMA-------QPLC
.. .  |.  .. ..  ||.           |||.....  .|  .|..||    ...        |  
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK8.AA Pkinase 4-258 27 2.1e-76 264.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQN--ECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGG----TLAEFIQ---K
|...|..|.|.|| | .| .| ..|.| .|.|...   ....|.. .  |.|..| |||||....|. | ... . . |||..||     |...|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVV----KIGDFGISKI--LSSKSKAYTVVGTPCYISPELCE-GKPYNQKSDIW
.| . ..|... ... ||| .| . | . |.||||| .|||.| .....    ||.|||..|   . ..| ..|..||| |..||..  |..| .|.|.|
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCVLYELASLKRAFEAA------NLPALVLKIMS-GTFAPISDRYS-------------------PELRQLVLSLLSLEPAQRPPLSHIMAQPLC
..||.|||... .  |  .      .  ... .||.  .  ...  .|                   .|..... ..| . |..||   .|.  |  
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK8.AA CAMK 9-258 21 3.3e-72 231.77 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

VVGRGAFGIVHLCLRKADQ------------KLVIIKQIPVEQMT--------------------------KEERQAAQNECQVLKL-------LNHPNV
. |||.||.|.|| .| ..            . | || |. ....                           . |.  ..| ...|.       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IEYYE-------------------NFLE-DKALMIAM---EYAPGG----TLAEFIQKRCN-------------SLLEEETILHFFVQILLALHHVHTHL
|  ||                    | . || . . |   ||..||     | ..|... .               ..|.   ..| ||. |.|. | | 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKTQNILLDKHR----------------MVVKIGDFGISKILSS------------------------KSKAYTVVGTPCYIS-PELCEG-----
| |||||  |||||..                   .|| ||| .... .                          | .|..|||.|.. ||. .|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYNQKSDIWALGCVLYELASLKRAFEAA-------------NLPALVLKIMSGTFA-P------------------ISDR----YSPELR
         ..|..|.|.|..|..|| . . .  |..              |.. |  |||.| .  |                  |||      |.| .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QLVLSLLSLEPAQRPPLSHIMAQPLC
.|. ..|  .| .|. .. ... |  
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK8.AA STE 4-258 24 4.6e-71 242.41 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 24% (89 aa)

YERIRVVGRGAFGIVHLCLRK------ADQKL---------VIIKQIPVEQMTK---------------EERQAAQNECQVLKLLN--HPNVIEYYENFL
.|.|...|.|||| |......        ...         . |||...|. ..               ||.|  ..| ...| .|  |||...||  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------KALMIAMEYAPGGTLAEFIQ---KRCNSL---------LEEETILHFFVQILLA-LHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGIS
 .         | |.||| .||.| ..|.   .. ..|         ..|. | .. .||| . |.. | | | |||.| .||||      ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KILSS-----------------KSKAYTVVGTPCYISPELCEG------KPYNQKSDIWALGCVLYELASLKRAFEA-ANLPALVLKIMS----------
..|..                 ..| .|.|||| . .||  ..      |.|. |.||| |||.. |.|  |  .    .. |. .....          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GTFAPISD-------------------RYSPELRQLVLSLLSLEPAQRPPLSHIMA--QPLC
    |.  |. |                   ..|||... .   |  .| .||  |  .    |  
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK8.AA NEK2 4-258 31 1.4e-67 226.65 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 31% (101 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFL--EDKALMIAMEYAPGGTLAEFIQKRCN--SL
||   . |.| || .    || | |. . | |  ..|.  |.|.  .|| .|. | |||...||      . . | | |||  || |.  |.|  .    
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LEEETILHFFVQILLALHHVHT---------------------HLILHRDLKTQNILLDKHRM-------------------------------------
.||| |.  . |...||  .|                      | |||||.|  || ||                                         
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

-VVKIGDFGISKILS-SKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL
 ||| ||||  ..|  . | | | |||| | |||. .| .|| |||||..||..||...|.  |.| |  .|  ||  | | .|  .|| .|  .. . .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

SLEPAQRPPLSHIMAQPLC
 . . .||    |...|. 
NVDHYHRPSIEEILQHPQI
Kinase NEK8.AA ULK 4-246 26 1.5e-66 227.44 In-house 1-317 (329) Show / Hide 
Range on Protein: 4-246
Range on HMM: 1-317/329
Sequence Identity: 26% (85 aa)

YERIRVVGRGAFGIVHLCLRKAD----QKLVIIKQIPVEQMTKEERQ--------AAQNECQVLKLLN--------HPNVIEYYENFLED--KALMIAME
|. ... | |.|| |.    | .    ...|..|.|. ..| ... .          .||....| |.        |||....|. | ..  . . | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAPGGTLAEFIQKR--------CNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHR-----------MVVKIGDFGISKILSS----KS
| .||.| ..|.|.         .  |.|. ...|| ||| .. . | | | |||.| ||||....            .|.||.||| .| ...    . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KAYTVV------GTPCYISPELCE----GKPYN-QKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGT------------FAPISDR-------YS
 ..| |      ||| | .|.. .    .|||.  |.||| |||..||.   |  |.|     ..|.|.                 |.  .        |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PELRQLVLSLLSLEPAQR
||...|   .|  .. .|
PECKDLIRRMLQYDEKDR
Kinase NEK8.AA ULK 4-246 26 8.2e-66 224.96 In-house 1-312 (324) Show / Hide 
Range on Protein: 4-246
Range on HMM: 1-312/324
Sequence Identity: 26% (84 aa)

YERIRVVGRGAFG-IVHLCLRKAD---QKLVIIKQIPVEQMTKEERQ--------AAQNECQVLKLLN---HPN--VIEYYENFLED--KALMIAMEYAP
|. ... | |.||  |.    | .   ...| .|.|.  .| | . .          .|| |..| |.   |||  ....|. | ..  . . | ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLAEFIQKR-------CNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHR-----------MVVKIGDFGISKILSS----KSKAYT
||.| ..|.|.        .  |.|. ...|| ||. .. . | | | |||.| ||||. ..             |.||.||| .|.. .    . . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPCYISPELCE----GKPYN-QKSDIWALGCVLYELASLKRAFEAANLPALVLK--------------IMSGTFAPIS----DRYSPELRQ
 |      ||| | .|.. .    .|||.  |.||| |||..||.   |  |..     ..|.              |    . . .    .  |||...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LVLSLLSLEPAQR
|   .|  .. .|
LIRRMLQYDEKDR
Kinase NEK8.AA Ciliate-E2 4-247 23 1.3e-61 210.32 In-house 1-353 (365) Show / Hide 
Range on Protein: 4-247
Range on HMM: 1-353/365
Sequence Identity: 23% (87 aa)

YERIRVVGRGAFGIVHLCLRKADQKL------------------VIIKQIPVEQMTKEERQAAQNECQVLK----------------LLNHPNVIEYYEN
|. |.. |.|.||.| .| .. .||.                  | ||.. ...| | . ..  .| ....                .|||||.|..|| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--EDKALMIAMEYAPGGTLAEFIQKR---CNSLLE------EETILHFFVQILL---------------ALHHVHTHL-ILHRDLKTQNILLDKHRMV
|    |. . . |||. ||.| ..|...   .|. .|      |. |.... |||                ||.. |    |.|||.| .|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VKIGDFGISKILSSKSKAYT--------------------------------VVGTPCYISPELCEGKP---------YNQKSDIWALGCVLYELASLKR
.|| |||.||... ... .|                                ..||| | .||  .||.         |. |.|||.||..|||. . |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

AFEAANLPALVLKIMSGTFA-P----------------ISDRYSPELRQLVLS----LLSLEPAQRP
 |          .|. . .  |                . .  |.|  .|       .|  .| .|.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
Kinase NEK8.AA Pkinase_Tyr 4-199 25 1.1e-32 111.31 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 25% (55 aa)

YERIRVVGRGAFGIVHLCLRK----ADQKLVIIKQIPVEQMTKEE--RQAAQNECQVLKLL-NHPNVIEYYENFL-EDKA--LMIAMEYAPGGTLAEFIQ
 . ... |.|||| |...  |     ..  | .| .  |. ..|.  |..  .| ...| | .|||.. .|   . ...   ..| |||.|.| | .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KR--CNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYT-VVGT-----PCYISPE-LCEGKPYNQKS
|.   .  |  ...|.. .||  .. . . . . |||| . |.|... . ||||.||| .. .   .. |  ....         .|| . .|| .. ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKS

DIWALGCVLYELASL
|.|. | ...|. ..
DVWSFGVLMWEIFTY
Kinase NEK8.AA TyrKc 4-262 22 1.2e-18 69.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLL--NHPNVIEYYENFLED-------KALMIAMEYAPGGTLAEFIQK
 . ... |.||||.|...  |     | .| .  .      |..  .| .... |  .|||..  |   ...       . ||| |||.|.| | ....|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-----SKAYTVV----GTP--C---YISPELCEGKPY
. .  |  .. |.| .||     . | . . |||| . |.|... . .|||.||| |. . ..     || | ..    |.         .||    . .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NQKSDIWALGCVLYELASLKRAFEAA------NLPALVLKIMSGTFAPISDR--------YSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRAL
. |||.|. | ...|. ..             .   .. ....|   |. .          ..|. |. ..    .|..||  | |      .. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
RCC1 NEK8.AA RCC1 389-434 23 4e-06 22.63 Pfam 15-52 (52) Show / Hide 
Range on Protein: 389-434
Range on HMM: 15-52/52
Sequence Identity: 23% (11 aa)

LGAGGGSLLPGAVEQPQPQF-ISRFLEGQSGVTIKHVACGDFFTACL
||.    ...   ..  ||  .. .      | ...||||. .|..|
LGR----IHGDT-NCHVPQQIVEFL-G---NVRVVQVACGWQHTMAL
RCC1 NEK8.AA RCC1 442-486 42 1.8e-15 53.08 Pfam 6-52 (52) Show / Hide 
Range on Protein: 442-486
Range on HMM: 6-52/52
Sequence Identity: 42% (21 aa)

TFGSGSNGCLG--HGSLTDISQPTI-VEALLG-YEMVQVACGASHVLAL
|.|....|.||  ||.  . . |.  || | | .. ||||||..|..||
TWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8.AA RCC1 491-538 32 2.5e-14 49.38 Pfam 3-52 (52) Show / Hide 
Range on Protein: 491-538
Range on HMM: 3-52/52
Sequence Identity: 32% (17 aa)

ELFAWGRGDSGRLG--LGTRESHSCPQQ-VPMPPG-QEAQRVVCGIDSSMIL
....||..| |.||  .|.  . ..||| |. . | .. . | || . .|.|
RVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8.AA RCC1 541-604 13 0.062885 9.14 Pfam 1-52 (52) Show / Hide 
Range on Protein: 541-604
Range on HMM: 1-52/52
Sequence Identity: 13% (9 aa)

PGQALACGSNRFNKLG--LDHLSLGEEPVP-HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAV
 |.  ..|.|..  ||  ...      |..  .                  ..  ..  |  |..|.
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-G-------------NVRVVQVACGWQHTMAL
RCC1 NEK8.AA RCC1 607-656 35 4.3e-18 61.61 Pfam 1-52 (52) Show / Hide 
Range on Protein: 607-656
Range on HMM: 1-52/52
Sequence Identity: 35% (19 aa)

SGDCYTFGSNQHGQLG--TNTRRGSRAPCK-VQGLEG-IKMAMVACGDAFTVAI
.|..||.|.|..||||  ...    . |.. |..| | ..  .||||. .|.|.
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8.AA RCC1 659-709 25 7.8e-10 34.81 Pfam 1-52 (52) Show / Hide 
Range on Protein: 659-709
Range on HMM: 1-52/52
Sequence Identity: 25% (14 aa)

ESEVYSWGKGARGRLG--RRDEDAGLPRP-VQLDETHPYTVTSVSCCHGNTLLA
. .||.||.. .|.||    |..   |.. |..    .. |..|.| .  |.. 
DGRVYTWGCNDYGQLGRIHGDTNCHVPQQIVEFL-G-NVRVVQVACGWQHTMAL