Gene NEK2 (Human)

NEK2

Species: Human
Alias: NEK2, HsPK 21, HsPK_21, HsPK21, NEK2A, NLK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q32.3,

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
NEK2.NA RNA Sugen Kinome 2130 None Fasta, JSON
NEK2.AA Protein Sugen Kinome 445 None Fasta, JSON
NEK2.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON

Protein domain

Protein domains of NEK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK2.AA NEK2 8-271 59 8.99999999999e-220 736.4 In-house 1-319 (319) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-319/319
Sequence Identity: 59% (191 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQY
||||||||.||.|||.|.|||||||||||||..||.|.|.|.||||||.|.||.|||||||||||.||||.|.||||||||||||||...|.|..|||||
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LDEEFVLRVMTQLTLALKECHR----------------RSDGGHTVLHRDLKPANVFLDGKQN-------------------------------------
..|||..|.|.||..||.|||.                |.||.||.||||.||||.||| ..|                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRML
  ||||||||||.||||||||.||||||||||||||....|||||||||.|||.||.|||.|||.|..|..|..||..|.||||||.||..|||||..|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NLKDYHRPSVEEILENPLI
|...|||||.||||..|.|
NVDHYHRPSIEEILQHPQI
Kinase NEK2.AA NEK 8-271 47 3.6e-158 531.76 In-house 1-286 (286) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-286/286
Sequence Identity: 47% (137 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKI-----LVWKELDYGSMTEAEKQMLV-SEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCE-GGDLASV---
||.. .|| ||.|.. |.|||||||.     .|||. ..|.|.| |||... .||..|..|||||||.|||..|.. | .|.||||||| ||||.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGG-HTVLHRDLKPANVFLDGKQN----VKLGDFGLARILNHDTSFAKT-FVGTPYYMSPEQMNRM
| |......|..|| ......|. ||||..| |. |. . .||||.||.|.||. . |    ||.||||....|||.|..|.| .||||||||||...  
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

SYNEKSDIWSLGCLLYELCALMP--PFTAF--SQKELAGKIREG-KFRRIP-YR-YSDELNEIITRMLNLKDYHRPSVEEILENPLI
.||.|||||||||.|||.|.|.|  || |   ....|. ||..| .. .|| .| ||..|...|..||.    .|||...|||.|.|
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK2.AA NEK1 8-271 41 2.7e-95 322.91 In-house 1-276 (276) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-276/276
Sequence Identity: 41% (117 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQY
|... .|| ||.|.  . ..|.||. .| ||     | | |..  . ||..|. .||||||.|..  . . .  ||||||||.||||.  | . .   . 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD--GKQ---------------NVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNR
  |   .   .|. |||.  | |      .||||.|. |.||    .                 ||||||| ||.||| ...|.| .||||| |||  . 
FSEDQIMHWFCQICLALNHIHDR-----KILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQN

MSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI
  || ||||||||| |||||.|  || | . | |  || .| .  || .|| || . .. |..    |||||  ||| | |
KPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK2.AA NEK8 8-271 35 1.8e-93 267.2 In-house 1-278 (278) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-278/278
Sequence Identity: 35% (101 aa)

YEVLYTIGTGSYGRCQKIRRKSDG--KILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKER
||   ..| |. | |   |||.|.  .  .||. .   |.| | ||  .|...|  | ||||. |||  ..  ..|| |.|||..|| |.  | . ..  
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME--DNTLMIEMEYADGGTLYQMIQH-QQNK

QYLDEE----------------FVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGK-QNVKLGDFGLARILNHDTSFA--KTFVGTPYYMSPE
  ..|.                 .| ...|  .|.   |      | .||||||..|.|..     ||.||||.. |.| ... .  || ||||||||||
LFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQ-----HNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPE

QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG-KFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI
     .||.|||.|.||| |||.| |   | |  . .|  ||  . ..  |. .|| |.   ..  | .    |||. .|. .||.
MCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK2.AA S_TKc 8-271 34 5.3e-88 299.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEG--GDLASVITKGTKER
||.| .|| |..|.. | | |..|.|   |...         ... .|...|.. .|||||..|| . |   . ||.|||||.|  ||| ..| |  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--QYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNE-KSDIWSL
  ....|  . ..| |. .||. ||.     | ..||||||.|..||   ..|..||||||.|       .||.|||.||.|| .   .|.  |.|.||.
LRFPFPE-HARFYMYQICCALEYCHS-----HGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILE-------NPLI
||.|||...  |||    ....  ||.           |.|. ..| ..|.    .||.. |.|.        | .
GCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK2.AA NEK4 8-271 38 1.5e-75 257.27 In-house 1-257 (257) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-257/257
Sequence Identity: 38% (102 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQY
|. .  .| ||||    .| . |.|  | | ..       |..    |..||  ||||||| | .      .  ||||| .||||||     .  .  | 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

LDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLY
|.|. |.    |  .||   |..      .||||||  |.||  |  .|.||||..|.||    .||| .|||||||||      |. ||||||||| .|
LEEYQVVEWFVQIAMALQYMHEK-----HILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVY

ELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI
|.  |   | |     |  .| .|.   .|  || .| ...  ||. .   |||. .|.  | |
EMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK2.AA Pkinase 8-271 30 2e-72 251.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS--EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGG----DLASVITKG
|... .|| ||.|.. | ..|..||| . |.... .  . ..| ..   |. ....|.||||||.||   |  .. .|.||||||||    ||...|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

TKERQYL--DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV----KLGDFGLARIL-NHDTSFAKTFVGTPYYMSPEQMN-RMSY
 ...  .  .|. . ..|.|.  .|. ||..      ..||||||.|...| . ..    |..|||||. . .   | ..||.|||.||.||  . .  |
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

NEKSDIWSLGCLLYELCALMPPFTAF------SQKELAGKIREGKFRRI-PYRYS-------------------DELNEIITRMLNLKDYHRPSVEEILE
  |.|.||.||.|||..   |||         .|...  .|.......  |. .|                   .|. ..|...|... . ||. |.||.
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

NPLI
 | .
HPWF
Kinase NEK2.AA STE 8-271 22 8.1e-71 241.59 In-house 1-359 (359) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YEVLYTIGTGSYG-RCQKIRRKSD--------------GKILVWKELDYGSMT---------------EAEKQMLVSEVNLLRELK--HPNIVRYYDRII
.| .  || |..|  ......| .              |.|   |.... . .               . |.| .  |........  |||||.||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DRT-----NTTLYIVMEYCEGGDLASVIT-K-GTKER--------QYLDEEFVLRVMTQLTLA-LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGD
.       ...|.|.|||..|| | ..|  | |....        ....|. . ..  |.  . |.  |.       . |||.||||..|     ||| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL-----VKLCD

FGLARILNH---------------DTS-FAKTFVGTPYYMSPEQMNRMS------YNEKSDIWSLGCLLYELCALMPPFTAFSQK---------------
||.. .|..               ...   .|||||| .|.|| .....      |..|.|||||||.. |..   ||.  ..                 
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

-ELAGKIREGKFRRIPY-------------------RYSDELNEIITRMLNLKDYHRPSVEEILE--NPLI
 |.  .| .|.  ..|                    ..|.|... | . |.    .||.... |.   | |
FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK2.AA CAMK 13-271 21 2.7e-65 209.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

TIGTGSYGRCQKIRRKSDG------------KILVWKELDYGSMT--------------------------EAEKQMLVSEVNLLRE-------LKHPNI
|.|.||.|   . ..|...            .    | .|   ..                          .  .... .|.....        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYDRIIDR----------TNTT--------LYIVM---EYCEGG----DLASVITKG------------TKERQYLDEEFVLRVMTQLTLALKECHRR
.. |. . |.          | ..        .|.||   |||.||    || . |..               || ...|. . |.. |.  |.. ||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS-

SDGGHTVLHRDLKPANVFLDGKQ-----------------NVKLGDFGLARILNH-----------------------DTSFAKTFVGTPYYMS-PEQMN
    | . |||||| |. || .                  |.|. |||.|.....                       ..   |||.|||.||. ||  |
----HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

RMS--------------YNEKSDIWSLGCLLYELCALMPPFTAF-------------SQKELAGKIREGKFRRIPYR---------------YSDE----
. .              |..|.|.||.|..|| .    ||| .              ...||  ||..||.. .|.                 |||    
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

----LNEIITRMLNLKDYHRPSVEEILENPLI
        | .||.    .|...|..|. | .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK2.AA Ciliate-E2 8-271 23 4.9e-63 215.23 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

YEVLYTIGTGSYG---RCQKIRR--------------------KSDGKILVWKELDYG--SMTEAEKQMLV---------SEVNLLRELKHPNIVRYYDR
|...  ||.|..|   .|....                     | ..||   | .      ... |....           | |.|..|.||||...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IIDRTNTTLYIVMEYCEGGDLASVI----TKGTKERQ---YLDEEFVLRVMTQLTL---------------ALKECHRRSDGGHTVLHRDLKPANVFLDG
 .. .....|.|||||.|||| . |    .| ..|..   |..|. ....|.|..                ||...| .   .. ..|||.|| |...  
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK---NN-IIHRDIKPENILF--

KQNVKLGDFGLARILNHDTS-------------------------------FAKTFVGTPYYMSPEQMNRMS---------YNEKSDIWSLGCLLYELCA
   .|. ||||..... |                                  ..|..|||.||.||  |. .         |..|.||||||..|||.. 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

LMPPFTAFSQKELAGKIREGKFRR------------IPYRYSDELNEIITR----MLNLKDYHRPS-VEEILENPLI
  |||    |. . .||.  ..              ..   |.|   .| .    ||. .   |..  |.||..| .
GKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK2.AA ULK 8-271 26 1.9e-61 210.43 In-house 1-329 (329) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-329/329
Sequence Identity: 26% (88 aa)

YEVLYTIGTGSYG-RCQKIRRKSD---GKILVWKELDYGSMTEAEKQ--------MLVSEVNLLRELK--------HPNIVRYYDRIIDRTNTTLYIVME
|..   .| ||.|  .. .  |..   ... . | .|  .| . ...        .| .|. ....||        |||||..||   . ... .||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGGDLASVITKGTK------ERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQN------------VKLGDFGLARILNHD
||.|||| . | |  |      | ..| |. .. .. |.  ..|| | .      . |||.||.|. .. .|             .|..|||.|. .. |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN-----IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

---TSFAKTFV------GTPYYMSPEQMN----RMSYN-EKSDIWSLGCLLYELCALMPP---FTAFSQK-----ELAGK-------IREGKFRRIP---
      ..|.|      |||.||.|.  .    .. |.  |.|||||||..||.    ||     ...|.     .|  .       |.  ...  .   
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGN

-YRYSDELNEIITRMLNLKDYHRPSVEEILENPLI
 .  |.|. ..| |||  .   | | ||....|..
DPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK2.AA ULK 8-271 26 4.6e-61 209.18 In-house 1-324 (324) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YEVLYTIGTGSYG--RCQKIRRKSD--GKILVWKELDYGSMTEAEKQ--------MLVSEVNLLRELK---HPN--IVRYYDRIIDRTNTTLYIVMEYCE
|..   .| ||.|   .. .  |..  ...   |  |  .| . ...        .| .|......||   |||  ||..||   . ... .||.||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLASVITKGTK-----ERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQN------------VKLGDFGLARILNHDT---
|||| . | |  |     | ..| |. .. .. |.  ..|| | .      . |||.||.|  .  .|             .|..|||.|.... ..   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN-----IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

SFAKTFV------GTPYYMSPEQMN----RMSYN-EKSDIWSLGCLLYELCALMPP---FTAFSQK----ELAGK-------IREGKFRRIP----YRYS
   .|.|      |||.||.|.  .    .. |.  |.|||||||..||.    .|     . .|.    .|  .       |.  ...  .    .  |
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

DELNEIITRMLNLKDYHRPSVEEILENPLI
.|. ..| |||  .   | | |||...|..
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK2.AA TyrKc 8-274 21 2.4e-16 41.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-274
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLREL--KHPNIVRYYDRIIDR-----TNTTLYIVMEYCEGGDLASVITK
 . . ..| | .|.  | . |   .  | .  ..       .... .| .....|  .|||||| |  ...          |.|||||...||| . . |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GTKERQYLDEEFVLRVMTQLTLALK--ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHD-------TSFAKTF-VGTP-----YYMSP
  ..   |  .  |  ..|        . .        . ||||   |. .. .. || .||||.| . .|           |.   |.        |.|
HRPK---LCMKDLLSFCWQIACGMEYLHSK-------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EQMNRMSYNEKSDIWSLGCLLYELCAL-MPPFTA-----FSQKELAGKIREGKFRRIPYR--------YSDELNEIITRMLNLKDYHRPSVEEILENPLI
| .|   ...|||.|| | ...|.. . ..|         | .|.  ....|. ...|           .||. .|...  . .   ||. .||     .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----H

ADL
 ..
ECF
Kinase NEK2.AA Pkinase_Tyr 43-94 33 8.5e-10 33.8 Pfam 39-94 (270) Show / Hide 
Range on Protein: 43-94
Range on HMM: 39-94/270
Sequence Identity: 33% (19 aa)

SMTEAE--KQMLVSEVNLLREL-KHPNIVRYYDRII--DRTNTTLYIVMEYCEGGDL
. .. .  .... .|......| .||||||.|  ..  .. |  .||||||...|||
GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL
Kinase NEK2.AA Pkinase_Tyr 183-212 40 2.7e-05 18.56 Pfam 181-210 (270) Show / Hide 
Range on Protein: 183-212
Range on HMM: 181-210/270
Sequence Identity: 40% (12 aa)

MSPEQMNRMSYNEKSDIWSLGCLLYELCAL
|.|| .| . ...|||.|| | |..|.. .
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK2.AA Pkinase_Tyr 135-169 40 0.010831 9.74 Pfam 130-164 (270) Show / Hide 
Range on Protein: 135-169
Range on HMM: 130-164/270
Sequence Identity: 40% (14 aa)

HTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHD
.   ||||   |. .. .  || .|||||| . .|
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYND