Gene NEK11 (Human)

NEK11

Species: Human
Alias: NEK11, FLJ23495
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q21-q22.1,

Classification

Group: Other
Family: NEK
Subfamily: NEK11

Sequence

Name Sequence Type Origin Length Description Download
NEK11.NA RNA Sugen Kinome 2963 None Fasta, JSON
NEK11.AA Protein Sugen Kinome 645 None Fasta, JSON
NEK11.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of NEK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK11.AA NEK11 29-287 93 6.7e-238 796.61 In-house 1-259 (259) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-259/259
Sequence Identity: 93% (243 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGK
|||||||||||||||||||||||||||||||||||||||||||||||||.||||||.|.|||||.|||||.||||||||||||||||||..|||||||||
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCM
|||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCM

NHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL
.|||||||||||||.||||||||||.|||.|||.|||.|||||||||||||.||||||.
DHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK11.AA NEK 29-287 42 1.1e-145 490.33 In-house 1-286 (286) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-286/286
Sequence Identity: 42% (122 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRG--EELKVLKEISVGELNPNETVQAN-LEAQLLSKLDHPAIVKFHASFVEQD--NFCIITEYCE-GRDLDDK---
| ...|.|.||||.||.| .|. ..   |.| |.|.|..|.... |. .|   |...|..|.|| |||.. ||.|..   .||. |||| | ||..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER-----RILHRDLKSKNVFLKNN-----LLKIGDFGVSRLLMGSCDLATT-LTGTPHYMSPEALKHQG
|...||.|| |.|.|| .||||..|...|||.|     .|||||.|..|.|| .|     ..||||||.|..|. ..|.|.| ..|||.||||| .....
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDTKSDIWSLACILYEMCCM--NHAFAGS--NFLSIVLKIVEG-DTPSLPER--YPKELNAIMESMLNKNPSLRPSAIEILKIPYL
|. ||||||| |.|||||.   .|.| ..  |..| ..||..| . | .|..  | ..|. ....||.|.|..|||. .||. |..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK11.AA NEK1 29-287 39 1.7e-101 343.49 In-house 1-276 (276) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-276/276
Sequence Identity: 39% (111 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQA
|. ....|.|||| ..|| .|   .   . |.|||.| .  . |. ..  |. .|.|..|| |||.  ||.|  .    |. |||.| ||  ||.. |  
YHYIKQIGEGSFGKAWLVKHKEDGQ---HYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRK

GKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLK---NN---------------LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQG
|| |.| ||  ||.|. |.. ..| |.|||||.||.|.||    |                |.|.||||..|.|  . ..| |  ||| | |||    ..
GKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKP

YDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL
|. ||||||| |.||| |   |.| . |.   ||||..|  | .| .| .||     .|...||..|||.  ||. | .
YNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK11.AA NEK4 29-287 41 6.3e-93 315.04 In-house 1-257 (257) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-257/257
Sequence Identity: 41% (109 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQA
|   .  | ||.| |.||  .. |.     |.| .   .    |.  |  ||||||.| || ||..  |.   ..   .|.  .||| ||  | .. |  
YCHMKVVGKGSYGEVWLVRHRRDKK---QYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK--

GKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEM
... .|.|..|||.|  ..  ||||..|||||||  |.|| | |..||||||.|| |  .||.| |. ||| |||||    . || ||||||| | .|||
NQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEM

CCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL
  . |||   .  |.. .|..|  | .|  | ..|  ..  ||.| |  |||  .|.. ||.
ITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK11.AA S_TKc 29-287 32 1.1e-85 291.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEG--RDLDDKIQEYKQA
| . .|.|.|.||.||.. .||     ..  .|.|.          ..  | |.|.| .|| |||.. .|.. |......|||.|   || | |....  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G--KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDT-KSDIWSLACILY
|  . ||| ..  .. |......|.|...|.|||||  |..| .  .||.|||..|.|       ||. |||.||.|| |   ||.. |.|.||. ||||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK-------IPYL
||.|    |     .  ..|..           ..|.  ... .|.|.|. ||.| |.|.        |..
EMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK11.AA Pkinase 29-287 29 9.4e-82 282.7 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANL--EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGR----DLDDKIQE
|.. .|.||||||.||.  .|.  .   . ..|.|.. . .... ... .  |.|.. .|.|| ||... .| . |. ....|||||     || | |. 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

YKQAGKIF--PENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLK-NNLL----KIGDFGVSRLL-MGSCDLATTLTGTPHYMSPEALK-HQGYDTKS
  .... |  .|.... .. |.| |..|.|...|.|||||. |.... |. .    ||.|||.....   .   .||..|||.||.|| .. .|.|..|.
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLACILYEMCCMNHAFAGS----------NFLSIVLKIVEGDTPSLPERY----------------PKELNAIMESMLNKNPSLRPSAIEILKIPYL
|.||. ||||||.| .  | |.           .  |  .... | | . ...                ..|.  .....|.|.|. ||.| .||. |..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK11.AA NEK8 59-287 34 1.3e-81 232.72 In-house 30-278 (278) Show / Hide 
Range on Protein: 59-287
Range on HMM: 30-278/278
Sequence Identity: 34% (85 aa)

VLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPEN----------------QIIEWFIQL
..|.| . .. ..|   |  | |.||.|.|| |.    .| |     |  ||..|  | ..||.  |. . ..|                 .|.  |.| 
IWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQH-QQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQM

LLGVDYMHERRILHRDLKSKNVFL-KN-NLLKIGDFGVSRLLMGSCDLAT--TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFL
...| .||.  |||||||  |.|. .  ...|||||| |  .      .|  |. ||| |||||  . . |. |||.|.| |.||||||   ||..|| .
CSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLP

SIVLKIVEG-DTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL
 .|.||. .     ....| .|.   ... | . |  |||| .|.. | .
ALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK11.AA Ciliate-E2 29-287 21 2e-69 236.98 In-house 1-365 (365) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-365/365
Sequence Identity: 21% (83 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEELK---------------VLKEISVGELNPNETVQANLEAQLL----------------SKLDHPAIVKFHAS
| ...|.|.|.||.||.....| .. . .|                 |.. .  ...|.  | . | ...                ..|.|| |.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--EQDNFCIITEYCEGRDLDDKIQEY-KQAGKIFP------ENQIIEWFIQLLL---------------GVDYMHERR-ILHRDLKSKNVFLKNNLLK
|    ..|. ...|||.| || | |..  |. .....      |..|.. . |.|                .. |.|..  |.|||.|  |...    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IGDFGVSR----------------LLMGSC----------------DLATTLTGTPHYMSPEALK---------HQGYDTKSDIWSLACILYEMCCMNHA
| ||| |.                ..|                   ... |. |||.||.|| |.         ..|||.|.||||| .|||||.. .. 
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FAGSNFLSIVLKIVEGDTPSLP------------------ERYPKELNAIMES----MLNKNPSLRPS-AIEILKIPYL
|         ... .    ..|                  .  ..|   ..      ||.|.|. |.. . .||. |..
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK11.AA NEK-Unclassified 82-287 39 1.1e-68 226.45 In-house 46-258 (258) Show / Hide 
Range on Protein: 82-287
Range on HMM: 46-258/258
Sequence Identity: 39% (85 aa)

LLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGK--IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGV
.||.| || || .| || |        .||.| .|| .||  |. .|   | |  |  |.||.   | | | |.|.|||||  |.|| .  .. .||||.
ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQ--KHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGI

SRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDT-------PSLPERYPKELNAIMESMLNKN
|| .    | | |  ||. .|||| .. | |. .||.||| ||.||||    .|   | ...  ||. .|        |     |   |  ..  || .|
SRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEP-VSKTYSTDLQQVIRFMLRRN

PSLRPSAIEILKIPYL
.  ||||.||.  .| 
FQQRPSATEIVEQDYI
Kinase NEK11.AA STE 29-287 26 5e-66 225.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-359/359
Sequence Identity: 26% (95 aa)

YVLQQKLGSGSFGTVYLVSDKKA----KRGEE--------LKVLKEISVGELNP--------------NETVQANL-EAQLLSKLD--HPAIVKFHASFV
. ...|.|.|.|||||.  ..|     | ||.        .   |.... . |.              .| .|  | | ....|..  || |||.. ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EQ-------DNFCIITEYCEGRDLDDKIQEYKQAGK----------IFPENQIIEWFIQLLLG-VDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRL
         |. .|. ||..|  ||| |....  ||           |||.||.    |.| |  .| |. .| |||.|. |..|     |. ||||.  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LMGSCD----------------LATTLTGTPHYMSPEALKH------QGYDTKSDIWSLACILYEMCCMNHAFAG-SNF---------------LSIVLK
|  |..                  .|..||| .|.|| ..       .|||||.||||| | . ||.. .. ..  ...               .  . .
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-C

IVEGDTPSLPE-------------------RYPKELNAIMESMLNKNPSLRPSAIEILK--IPYL
||.|. |.||.                   .. .|..  ..  |.|.|. ||.| . ||   | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK11.AA Ciliate-E2-Unclassified 29-287 25 1.6e-64 220.64 In-house 1-352 (352) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGE----ELKVLKEISVGELNPNETVQANLEAQLLSK------------------LDHPAIVKFHASFVEQDNFCI
| .....|.|.||.||.. .|| |       ..|. .....   . ..    | . .. .|                  ..|| |||..  |  ..|..|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITEYCEGRDLDDKIQEYKQ-------------AGKIFPENQII-----EWFIQLLLGVDYMHER-RILHRDLKSKNVFLKNN----LLKIGDFGVSR---
..||||| || . |...|.              .|||.|.|..      .| |.|.| .|.|.   |.|||.|  |....||     .|| ||| |.   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------LLMGSCDLATTLTGTPHYM----SPEALKHQGYD----TKSDIWSLACILYEMCCMNHAFAGSNFLS---------------IVLKIV
            . . . ....| .||| ||    .|| |. |.||     |.||||| .|||||.  .. | . |  .               ..... 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

EGDTPSLPE--------RYPKELNAIME----SMLNKNPSLRPSAIEILKIPYL
    .. |.        . ..|   . .    .||.|||. |... .||. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK11.AA ULK 29-287 27 3.2e-61 209.69 In-house 1-329 (329) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRG--EELKVLKEISVGELNPNETV--------QANLEAQLLSKLD--------HPAIVKFHASFVEQ--DNFCIIT
|.| ..||.||||.||   .|| |     |. . | |.  ..| ..          . . | ... ||.        || |||..  | ..  .|. ||.
YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

EYCEGRDLDDKIQEYKQ------AGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNL-------------LKIGDFGVSRLLMGS---C
|||.| ||.. |...|        .|...|...|. |.|.| |  ..|...| |||.|  |. ..|.              |||.||| .. .. .    
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

DLATTLT------GTPHYMSPEALK----HQGYD-TKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTP----------SLPERYP--------
....| .      ||| ||.|. |.    .. |.  |.||||| ||.|||      | .. | . .|.|..              . | ..|        
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

-KELNAIMESMLNKNPSLRPSAIEILKIPYL
 .|.  .   || .... | |  |....| .
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK11.AA Pkinase_Tyr 79-226 25 2.2e-27 93.39 Pfam 53-208 (270) Show / Hide 
Range on Protein: 79-226
Range on HMM: 53-208/270
Sequence Identity: 25% (40 aa)

EAQLLSKL-DHPAIVKFHASFV-EQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLK-NNLLKI
||.....| .|| ||....  . ...    .|..||... ||.|  .. .  .. ..  ..... .|   | .| ..... ||||  .|. .. ||  ||
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKI

GDFGVSRLL-MGSCD-LATTLTGTP-HYMSPEALKHQGYDTKSDIWSLACILYEMC
.||| .|..   .    ... .  |   |.||....  . ||||.||    ..|..
CDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase NEK11.AA TyrKc 29-287 22 7e-24 86.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-287
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

YVLQQKLGSGSFGTVYLVSDKKAKRGEEL---KVLKEISVGELNPNETVQANL--EAQLLSKL--DHPAIVKFHASFVEQ-------DNFCIITEYCEGR
 .| .|||.| ||.||.   |      .    |.||| .          .. .  ||....||  .|| ||....  ..|       .  .|..||... 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGS------CDLATTLT--GTP-----HYMS
||.| .....     ..  . ... .|   | .| |.... ||||   |. ...|.  ||.||| || .          |  .. .  |.        |.
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS------NFLSIVLKIVEGDTPSLPER--------YPKELNAIMESMLNKNPSLRPSAIEILKIPY
||....  . ||||.||    ..|..               .   .. .. .|. .  |.          |.|.  ||..  . .|. ||.  ||  . .
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

L
.
F
Kinase NEK11.AA Pkinase_Tyr 29-45 47 0.002362 11.98 Pfam 1-17 (270) Show / Hide 
Range on Protein: 29-45
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

YVLQQKLGSGSFGTVYL
 .. .|||.|.||.||.
ITFGKKLGEGAFGEVYK