Gene NEK1 (Human)

NEK1

Species: Human
Alias: NEK1, DKFZp686D06121, DKFZp686K12169, MGC138800, NY-REN-55, KIAA1901
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q33-q34,

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
NEK1.NA RNA Sugen Kinome 5585 None Fasta, JSON
NEK1.AA Protein Sugen Kinome 1286 None Fasta, JSON
NEK1.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of NEK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK1.AA NEK1 4-258 69 8.70000000001e-209 699.9 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 69% (192 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGS--LYIVMDYCEGGDLFKRINAQ--KGVL
|.....|||||||||.|||..|||..|||||||...|..||||||..|||.||.|||||||.|.|||||||.  |||||.||.||||...||.|  ||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLT--KDG---------------TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN
|.||||..||.||||||.|.||||||||||||||||||  |.|               .|.||||||||.||.|.|.|.||||||||||||||.||||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
|||||.|||||||||||||.|||...|||||||..|..||.. ||||.|.|||||.||||||.|||||.|||..||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK1.AA NEK 4-258 53 6.2e-175 587.44 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 53% (152 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQ-----YVIKEINISRMSSKEREESR-REVAVLANMKHPNIVQYRESFEENG--SLYIVMDYCE-GGDLFKR---
| ...|||.|||||. .|....||..     ||.|.||...||.||....   || .|. .|||||| |..||.|..  .|.|||.||| ||||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

INAQK--GVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGT----VQLGDFGIARVLNSTVELART-CIGTPYYLSPEICENKP
|. ||  | .|.|.||.|||.|.|||||..|||     ||||||||.|||||||...    | .|||||..|||.|...|.| ..|||||.|||.|.|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWALGCVLYELCTL--KHAFEAG--SMKNLVLKIISG-SFPPVSLH--YSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
||||||||.|||||||.|||  ||.|||   .|..|..||. |  .||.. |  || ||..|.||.....| .|||.|.|||. ||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK1.AA NEK8 4-258 42 1.2e-136 392.67 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 42% (117 aa)

YVRLQKIGEGSFGKAILVKSTEDG--RQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQ
| |   .| |.|| ..|   .||.   . ..|.|| .|||.|||     |. ||.   ||||. | ..|.|...| |.| |..|| |   |. |.. || 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

ED-----------------QILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKD-GTVQLGDFGIARVLNSTVELA--RTCIGTPYYLSPEICENKPYN
|                  .||. |.|.|.|. |.|.  |||||.| ||||.|.. . | .|||||. ..|.    .  .| .|||||.|||.|| ||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG-SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
.|||.|||||||||.|.|| ||||    .||.||...  . |.| ||| ..|.||... .  |  |||.  |.    .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK1.AA NEK4 4-258 49 3.3e-131 442.2 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 49% (126 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFE-ENG-SLYIVMDYCEGGDLFKRINAQKGVLFQ
|  .. .| ||.|   ||... |..|||.| ..  . |..|| .  .|. .|  .||||||.| ||.| |||  ||||| .||||||...   ||. . .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKH
| |...||||| .||   |...||||| | |||||||   . .|||||.||||   ..|.| ||||||.|||.  |.||. |||||.||| .||. ||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
||.|  |  |. .|| |  ||..  || ||  || |. .. | .|||. .|. . .|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK1.AA S_TKc 4-258 30 1e-96 328.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEG--GDLFKRINAQKG----
|  |.|||.|.|||  ... ...||.. ||.|.         |  |||...| . .|||||.. ..|.. ..||.||.||.|  ||||..|  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

VLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNN-KSDIWALGCVLYEL
. | | ..  .. |||.||.. |...|.|||.| .||.|..  .. ..|||.||.|       .|..|||.|..||..   .|.  |.|.|..||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE-------KGFI
.. .  |.     ....|.|           | .............|..||..  .|.         ..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK1.AA Pkinase 4-258 25 1.1e-87 302.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRR--EVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGG----DLFKRINAQKG
|....|||.||||.  . .   .|.....|.|. .. .|..... ||  |........|||||.....||.....|.||.|||||    ||| .| ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VLF--QEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTV----QLGDFGIARVL-NSTVELARTCIGTPYYLSPEICE-NKPYNNKSDIWAL
  |  .|... ... ||. .|.. |...|.|||.|..||.. ..|..     ..|||.|... .   . . |  |||.|..||..  ...|  |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYELCTLKHAFEAG------SMKNLVLKIISGSFPPVSLHYS--------------------YDLRSLVSQLFKRNPRDRPSVNSILEKGFI
||.|||... .  |         ... .. .| .. ..  .   .                     ....... .....| .||.   ||.  ..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK1.AA NEK-Unclassified 4-258 39 1.1e-86 286.95 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-258/258
Sequence Identity: 39% (103 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQ
| ..  .| |  |   ||.     |  | .   ||.   | .      . .|. ..|| || | .|| ||  |.   |||.||.| .||  . .    | 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKR--KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKH
|  |  |..|.  |.  .| |||.||| | ||||||.| || .|||||.|... |.. ||||.||. ..|||.|. .||||.||.|.|||..||.||   
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

AFEAGSMKNLVLKIISGSF------PPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
.| . .|  .  ||  .         |||  || ||  ..  . .||.  |||   |.|  .|
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK1.AA NEK2 4-258 34 6.1e-76 255.18 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 34% (109 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQY--RESFEENGSLYIVMDYCEGGDLFKRINAQKG--VL
|  |. ||.||||.   |.  .||.  | |||.   | .||.     |. .|   ||||||.|  .   ..| .||||| |||||||   |   .     
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FQEDQILDWFVQICLALKHVHD---------------------RKILHRDIKSQNIFLTKDGT-------------------------------------
. |  |.  . |.|.||. .|                      . |||||||  ||||  |.                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF
  | ||||| ||.||     | | .||||| |||  .  .|| |||||..||..||.|.|.  |.| . . |  ||  | | ..   || .|  ...   
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

KRNPRDRPSVNSILEKGFI
. ... |||.. ||.  .|
NVDHYHRPSIEEILQHPQI
Kinase NEK1.AA CAMK 9-258 18 1.9e-72 232.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

KIGEGSFGKAILVKSTEDG------------RQYVIKEINISRMS--------------------------SKEREESRREVAVLAN-------MKHPNI
..|.|||||  |.. ....            ... || |. ....                           | |.. |||.... .       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYRESFEE-----------NGS---------LYIVM---DYCEGG----DLFKRINAQKG-------------VLFQEDQILDWFVQICLALKHVHDRK
..  | .|            . |         .|.||   .||.||    ||| .| ....               |.|..   .| ||| |... |...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKSQNIFLTKD-----------------GTVQLGDFGIARVLNSTV-----------------------ELARTCIGTPYYLS-PEICEN-----
| |||.|  || |...                 ... . ||| |.....                         .. .|. |||.| . ||. .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYNNKSDIWALGCVLYELCTLKHAFEAG-------------SMKNLVLKIISGSFPPVSLHYSY-----------------------DLR
         ..|. |.|.|..|..|| . . .  |..              ....|  ||..| .   . . |                        . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLVSQLFKRNPRDRPSVNSILEKGFI
.|.... ...| .|...  .|.  ..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK1.AA NEK11 4-258 40 5.9e-70 238.73 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-259/259
Sequence Identity: 40% (105 aa)

YVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GV
||  ||.| ||||   ||  |    |    |.||| .  .   |      |  .|. ..|| ||..  || |     |. .|||| ||  ||   |  | 
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCT
.| | ||..||.|. |    .|.|.|||||.||.|||| |   ...||||..|.|    .|| |  ||| |.|||    . |  |||||.| |.|||.| 
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI
. |||   .   .||.|. |  | .   |  .| ... ..  .||  |||   ||   ..
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK1.AA STE 4-258 22 1.1e-69 237.83 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 22% (82 aa)

YVRLQKIGEGSFG---KAILVKST---EDGRQ---------YVIKEINISRMSS---------------KEREESRREVAVLANMK--HPNIVQYRESFE
. ...|||.|.||   ||. .| .   . |..         . ||..|... ..               .|...  .|. .. ...  |||||.|  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------SLYIVMDYCEGGDLFKRINAQKGVLFQ------------EDQILDWFVQICLA-LKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR
 .|       .|.|.| |..|| | . |.  .|....            |.||    .||. . |.. |. .| |||||..||.|     | | |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLNS----------------TVELARTCIGTPYYLSPEICEN------KPYNNKSDIWALGCVLYELCTLKHAFEA-GSMKNLVLKIIS-----------
 |..                ...   |..||| . .||. ..      |.|. |.||| |||.. |..| |. .     |... .....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GSFPPVSL-------------------HYSYDLRSLVSQLFKRNPRDRPSVNSILE--KGFI
   |  ||                      ..| ...  ... ....|..||...  |.    ||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK1.AA Ciliate-E2 4-258 21 3e-66 226.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-365/365
Sequence Identity: 21% (79 aa)

YVRLQKIGEGSFGKAILVKSTEDGRQY------------------VIKEINISRMSSKEREESRREVAVL----------------ANMKHPNIVQYRES
|  ..|||.|.||.  ..|  ....|.                   ||.... .|. .. |.  .|  ..                 ...||||... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--ENGSLYIVMDYCEGGDLFKRINAQ----------KGVLFQEDQILDWFVQICL---------------ALKHVHDRK-ILHRDIKSQNIFLTKDGT
|.   . ..|.||.||.|||||..|. .          .   | | .|.. . ||.                ||.. | .. |.||||| .||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VQLGDFGIARVLNS-------------------------------TVELARTCIGTPYYLSPEICENKP---------YNNKSDIWALGCVLYELCTLKH
. . |||... ..                                  ....|..|||.|..||| ..|.         |. |.|||.||..|||... |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

AFEAGSMKNLVLKIISGSFPP-------------VSLHYSYDLRSLVSQ----LFKRNPRDRPS-VNSILEKGFI
 |    ...   . |. ..|                .. | .   | ..    .....|  |..  . ||.  ..
PF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK1.AA Pkinase_Tyr 4-199 23 2.5e-22 76.25 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 23% (50 aa)

YVRLQKIGEGSFG---KAILV-KSTEDGRQYVIKEINISRMSSKE--REESRREVAVLANM-KHPNIVQYRESFE-ENGS--LYIVMDYCEGGDLFKRIN
 . ..|.|||.||   |...  .  ... .  .| ..    ....  ||.  ||.... .. .|||||..      . ..  .|||| |...||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AQ--KGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL----NSTVELARTCIGTPYYLSPE-ICENKPYNNKSDI
..   .  .   ..|.. .||. .. . ..... |||.   |. .|....|  .||| || .    .  .  .  .      ..|| | ..| .. |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDV

WALGCVLYELCTL
|. | ...|..|.
WSFGVLMWEIFTY
Kinase NEK1.AA TyrKc 4-257 20 3.8e-21 77.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YVRLQKIGEGSFG---KAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM--KHPNIVQYRESFEEN-------GSLYIVMDYCEGGDLFKR
 . ..|.||| ||   |...       .|  .| .. .      ||. .||  .. .   .|||||.      .        . |.||| |...||| ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

INAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNST-------VELAR----TCI--GTPYYLSPEICENK
. . ..  .. .. |.. .||.    . |.... |||.   |. .....||  .||| .| . .                  .        ..||    .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYNNKSDIWALGCVLYELCTLKHAFEAG------SMKNLVLKIISGSFPPVSLH--------YSYDLRSLVSQLFKRNPRDRPSVNSILEKGF
 .. |||.|. | ...|..|.      |      | . .. .. .|  .|   .         . .. .. .|  ...| |||. . |  . |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF