Gene MST1 (Human)

MST1

Species: Human
Alias: KRS2, DKFZp686A2068, MST1, Krs-2, STK4, YSK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 20q12,

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
MST1.NA RNA Sugen Kinome 6344 None Fasta, JSON
MST1.AA Protein Sugen Kinome 487 None Fasta, JSON
MST1.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of MST1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MST1.AA MST 30-281 75 6.1e-233 747.88 In-house 1-254 (254) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-254/254
Sequence Identity: 75% (192 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
||..||||.||||||||||||.||.|||||.|||..|||||||||||||||.|...||||||||  ||...||||||||.|||.||......||.|..||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

TILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADI
.||..||.||.|||...||||||||||||||.||..|||||||.|||||||||||||||||.||||||||||.|.|.||||||||||||||||.|||.||
CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI

HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|||||.||||..|||||..|| ||..|.|||..||.|.||||.||.|||||||.
HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase MST1.AA STE20 30-281 54 6.8e-177 593.96 In-house 1-288 (288) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-288/288
Sequence Identity: 54% (158 aa)

FDVLEKLGEGSYGSVYKAIHKETGQI----VAIKQVPVESD------LQEIIKEISIMQQCDSPHVVKYYGSYFKN----TDLWIVMEYCGAGSVSDIIR
.. |||.|.||||.||||.||.||..    ||||....|..      ...|.||||||.||..|..|||||||.|.    ..|||||||||.||..||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---LRNK-----TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD----TMA-KRNTVIGTPFWMAPEVIQE----
    ..|     ...|..||.|.. .|.||.||| ...|||||||.||||...| .|||||||..|||.    ||. ||||..|||.||||||||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-IGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP--TNPPPTFRK--PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
  ||.. .|||||||||||||||.|||.|.|||||.||||  .|||||...  |. ||..| |||..||.| ||.|.||.|||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MST1.AA YSK 30-281 54 8.10000000001e-148 448.37 In-house 1-257 (257) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-257/257
Sequence Identity: 54% (140 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI---IKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR--NKTLTED
|  .|. | ||.| |||.| . |...|||| .  |..  ||    .|| .  ||||| . |||||| | | |||.||||| ||..| .. .  .. . | 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ-FDEK

EIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIWSLGITAIEMAEGKP
 ||.||   ||||.|||  ||||||||| |.||. .|  ||.|||||||.|||. |||| .|||.|||||||..   .|.  ||||||||||.||| | |
YIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEP

PYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
||.| ||||. | || |.||.  . . .|..| .||  ||.| |||| .| .|| | |.
PYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MST1.AA STE 30-281 40 6.8e-147 494.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-359/359
Sequence Identity: 40% (146 aa)

FDVLEKLGEGSYGSVYKAIHKE---------------TGQIVAIKQVPVESD-------------------LQEIIKEISIMQQCD--SPHVVKYYGSYF
.. .||.|.|..|.||||....               ||.|.||||...|..                   .|.|.|||.||..|.  .|..|||||.||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KN-------TDLWIVMEYCGAGSVSDIIR---LRNKTLT----------EDEIATILQSTLKG-LEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAG
|.       ..|||.|||...||..|||.    ..|.|.          |..||.|....||| |.||| ...||||||..||||     .||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTDTMA----------------KRNTVIGTPFWMAPEVIQE------IGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN-----------
||||.||                ||||..||| ||||||||        ||.. .||||||.|.||||.||||..| |||||.||||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPTFRK-----------------PELWSDNFTDFVKQCLVKSPEQRATATQLLQ--HPFV
    |||..                   |. ||..| ||...||.| |..|.||.|||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MST1.AA PAKL 30-281 54 1e-130 440.58 In-house 1-256 (256) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-256/256
Sequence Identity: 54% (139 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV-ES-DLQEIIKEISIMQQCDSPHVVKYYGSYFKN-TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEI
|   ||||.||||||||||||.|.   |||  .. || . ..| |||.|   | .| .| |.||     . .|| |.|| .||. |.. .  |||.| .|
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA-KRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYA
. ||| ||||| |||    ||||||| |||||  .  |.|||||  || |.     |  ||||.|||||.|    ||  .|||||||||||||.| ||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

DIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|. ||||  |||  ||||| .|  ||  | ||. ||.|| ||.|. . .|| ||| 
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase MST1.AA PAKA 30-281 43 9.20000000001e-111 374.27 In-house 1-260 (260) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-260/260
Sequence Identity: 43% (114 aa)

FDVLEKLGEGSYGSVYKAIHKETGQI--VAIKQVPVESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNK----TL
....||.|.|. |.||.|. ..|.|   |||||  .. . .   || ||..| .|  . .|.|. ||  . .||.|||| ..|.  |.|   ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK
.|. || ... .|.|||..|    ||||||  ||||...|  |..||| . |||.   ||||. ||| |||||||.   |.   ||||||| ||||.|| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
||| .  | ||.. | ||  | .. |. ||..| ||...|| . ...||.|..||.||| 
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MST1.AA S_TKc 30-281 35 2.6e-106 360.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-231/231
Sequence Identity: 35% (94 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGA--GSVSDIIRLRNK-----TLT
...|.|.|.|..|.|||..||.||.|||||...     . |..||.|... . |..||.|...   ..|..|||||.   |.. |.|. |..      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VADIWSLGITAIEMAEGK
| ... ... ....|||.| .. ||||.|  ||||..  | |..|||.| ||       .|..|||..|||||.   ||..  .|.||.|.. .||. |.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQ-------HPFV
||.     | ..| .              |. . ||...||.| ||.| || ..||       ||..
PPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MST1.AA KHS 30-281 48 2e-104 352.19 In-house 1-258 (258) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-258/258
Sequence Identity: 48% (126 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
...| ..| | || |||| ........|.| . .|   |.. | .|| .|..|  | .| |.|||...  |||.|||||.||. || ..  . |.|  ||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

TILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITAIEMAEGKPPY
 . . ||.||.||| | |.|||||  ||||. .|. |||||||..|.| |.|||   ||||.||||||    .. |||   |||..||||||.|| .|| 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

ADIHPMRAIFMIPTNP--PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
 |.|||||.|..      ||. .  . ||..| .|||..|.|.| .| ||..|||||||
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase MST1.AA Ste20-DD1 30-281 47 2.6e-104 352.83 In-house 1-268 (268) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-268/268
Sequence Identity: 47% (127 aa)

FDVLEKLGEGSYGSVYKA-------IHKETGQIVAIKQVPVES-DLQE---IIKEISIMQQC-DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR
| ..|  | ||.| |          .     ...|.| | ..  |  |     ||| |.    | | .||| | | |   | ||||||  ||. ||. . 
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

NKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE----IGYNCVADIWSLGIT
 |.|.|..|| |.    ||| |||  | .||||||||.|.| || .|||||||   .  .  | ||||| |.||.||.|       ||   |||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|||||| |||  .. | | || ||  .||| . |  ||  | ||.|||| . |. |  | ||| |||.
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase MST1.AA NinaC 30-281 47 6.2e-102 344.94 In-house 1-267 (267) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-267/267
Sequence Identity: 47% (126 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIK-QVPVESDLQEIIKEISIMQQ-CDSPHVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIR---LRNK
. . |  | | || |.|.  |. |||.|.| | ...    ||  |  |... || | ||..|| |.|        ||.|||||  ||| |...    . .
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITA
 . |. || ||  .. ||  ||  . ||||.|  |||| |||  || ||||  ||. |  .||| .|||.|||||||      .  |   .|.|||||||
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

IEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
||.. |.|| ||.|||||.| || ||||| ..||.|.. | ||. ||| |  |.| . ...|.|||.
IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase MST1.AA SLK 30-281 43 4.2e-94 317.87 In-house 1-259 (259) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-259/259
Sequence Identity: 43% (112 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
....  ||.| .| |||| |||.... | | . ...  .|.. . || |. .|. |..|| |..|. . .||...|.|. | |  |.   ...|||| |.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

TILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKP
 . . .. .|..||  . ||||.||||||.  .|. .||||||. ... || || | ||||.||||||.     ..  | . ||||||||| ||||.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|. .. ||| .. |    |||  .|  || .| ||.|.|||| |..| |. ||.||..|
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase MST1.AA Pkinase 30-281 32 7.6e-92 316.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK------EISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAG----SVSDIIR-LRN
. ...|.|.||.|.|||..|| ||.|||.|.......  .  .      ||.||. ...|..|..|...  ......|||||. |    . .|.|.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTL--TEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSL
...  .|.|.  ..  .|.||||.| |. ||||.|  |||.. .||     |..|||.| |. .      .|. |||..||||||.   .|   .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITAIEMAEGKPPYADI----HPMRAIFMIPTNPPPTFRKPELWS---------------------DNFTDFVKQCLVKSPEQRATATQLLQHPFV
|.. .||. |.||. .     . .. ..||  . .| .. .. |.                     ... ||.| || | |..| ||.|.||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MST1.AA Pkinase_Tyr 30-281 28 1.4e-38 131.31 Pfam 1-270 (270) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-270/270
Sequence Identity: 28% (79 aa)

FDVLEKLGEGSYGSVYKAIHK----ETGQIVAIKQV--PVESD---LQEIIKEISIMQQC-DSPHVVKYYGSYF-KNTD--LWIVMEYCGAGSVSDIIRL
   ..|||||..|.|||.. |    .|.. ||.| .     ..   ... ..|..|| |  . |..|..||    .     ..|||||.  |.  |  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---NKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL--TDTM-AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSL
.   .. ||  ..  . .   ||.|||. .. ||||. | |.|.. ....| .||| |  .  .|.   ||       .|||||.|..  ..   |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITAIEMAE-GKPP-YADIHPMRAIFMI-PTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|..  |.   |. | |... . . . .|   .      .||. .|   |  |||  . ||.| | ...  | . 
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase MST1.AA TyrKc 30-281 26 1.2e-28 102.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-281
Range on HMM: 1-280/280
Sequence Identity: 26% (76 aa)

FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQC--DSPHVVKYYGSYFKN-------TDLWIVMEYCGAGSVSDIIRLRNKT
   ..||||| .| |||.. |   . ||.| .  .. ......|..|| .   . |..|. ||   .          |.|||||.  |.  | .| . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT----MAKRNTVI----GTP-----FWMAPEVIQEIGYNCVADI
|. ..   .     .| |||| .. ||||. | |.|.. ....| .||| .  ..|      .|   .     |.       |||||.|..  ..   |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGITAIEMAE-GKPPYAD-----IHPMRAIFMIPTN----PPPTFRKPEL----WSDNFTDFVKQCLVKSPEQRATATQLLQHPFV
|| |..  |.   |..|| .     . . ..|  . .     .||    | .     .|   .  |||    ||.| | ...  | . 
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Mst1_SARAH MST1.AA Mst1_SARAH 432-480 77 6.9e-36 118.32 Pfam 1-49 (49) Show / Hide 
Range on Protein: 432-480
Range on HMM: 1-49/49
Sequence Identity: 77% (38 aa)

DYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
|.||||||..|.||.|| .|||||||||||.||.||.||||||||.|||
DFEFLKSWSYEELQQRLASLDPMMEQEIEELRQRYQAKRQPILDAMEAK